TABLE 5.1 AUSCULTATORY FINDINGS IN 60 DOGS USED FOR IMMUNE SERUM PRODUCTION (VIA CARDIOCENTESIS) Total Period used for production 3-9 mo. 1-1.5 yr. 2-2.5 yr. 3-3.5 yr. Dogs Number of dogs in group 12 25 15 8 60 Individual dog numbers (1-60) Syst. mitral murmur grade 1 11,19 2,6,18,28 21,41,51 - 9 Syst. mitral murrnur grade 2 9 7,25,31 8,24 42 7 Syst. mitral murmur grade 3 32 26,27,30 5 12,16,29,52 9 Syst. tricuspid murmur gr. 2 - - - 16,29 2 Syst. tricuspid murmur gr. 3 - - - 12 1 Syst. aortic munnur grade 1 11,17,19,59 35,47 34,43,57 13 10 Syst. aortic munmur grade 2 55 - 20 22 3 Dfast. aortic murmur gr. 1 32,59 35 43 13 5 Oiast. aortic murmur gr. 2 11, 19 - 24,33 - 4 Oiast. aortic murmur gr. 3 - - 20 - 1 Oiast. tricuspid murmur gr. 1 - - - 29 1 Syst. cl ick - - - 23 1 Oiast. gallop - 31,60 21 22 4 Audible 4th heart sd. 32 35 - 16,29,42 5 Accentuated 2nd heart sd. - 2,18 - - 2 Split 2nd heart sd. 32,59 14,30 15 - 5 ; ~ Muffled heart sounds 46 2 57 13 4 Pericardia1 friction rub - - 15 16,22 3 Premature beats - 14,30,45 34,49 16,22,52 8 Paroxysmal tachycardia - 45 - 13,16 3 Bradycardia 32 15 12,16,22,29, 7 - 42 Nothing abnormal heard 10,37,56,58 1,3,4,36, 48,50 16 38,39,40, 44,53,54 . .4 162 TABLE 5.2 ELECTROCARDIOGRAPHIC FINDINGS IN 60 DOGS USED FOR IMMUNE SERUM PRODUCTION (VIA CARDIOCENTESIS) Total Pe~iod used fo~ p~oduction . 3-9 mo. 1-1 • 5 y~. 2-2.5 y~. 3-3 .5y~. Dogs Numbe~ of dogs in g~oup 12 25 15 8 60 Ave~age numbe~ of ca~diac 20 50 100 150 punctu~es pe~ dog Individual dog numbe~s (1-60) A~~ythmias Vent~fcula~ p~ematu~e beats 10 30,36 l24,34,49 13,16,52 9 Pa~oxysmal vent. tachyca~dia 7,45 2 Pa~oxysmal atrial tachyca~dia 13 Conduction defects Incomplete A-V block 2 8,20 23 4 Inc. A-V block &dropped beats - 35 43,51 13 4 Complete A-V block 32 15 12'L6,22,1 7 29, 2 Right bundle b~anch block 1 11,59 2,3,7,26,35 8,20,24 13 I 16 40,44,60 49,50 Left bundle branch block 27 57 I - 2 QRS) .07 (nonspecific patte~n) 14,25,36 I- 21 1 - 6 - 45,53 Concealed conduction I - I - 134 S-T segment deviation I 9,55 7,26,53 I 20,21,43 8 mo~e than 0.1 my. No~mal electroca~diog~am 17,19,37 1,4,6,18, 5,33,41, I ­ I 20 46,56,58 28,31,38, 48 39,47,54 No~mal electrocardiogram ~ 1 37,56,58 1,4,38, 148 I - 9 Nonnal heart sounds 39,54 163 ': 1 : ~~~~~44~~ ~~.~ , :: ::I:; ::li;:: !:l'i!!li1 jljl, ,. : 'I " " .,;, .. ,. .lI" . I',L,. J J t­ : i',li!I'til l:ti: I:: :i '::: .:....; .. ... ! i j l l! t t . ! f t -I ~.• -H f.mlUllll~j 1111 ;n ,I ;;;. : ~, Figure 5.1 Paroxysmal ventricular tachycardia in dog # 45. :illl:u!llili l I t tIR t ~~~ 1 ~~~ II ~t ll l l ll l llll l llll l t~ ~it Figure 5.2 Early ventricular ectopic beats with normal post-ectopic beat P-R inter­ vals in dog # 34• ._- ..-..----- -_. --- - -,- "-- ----'- - --------e'----- · · ·~--- '------- -----------­ ~-- . - - Figure 5.3 Late ventricular ectopic beats witb prolong~d post-ectopic bawt P-R intervals (Concealed retrograde A-V conduction) ~ dog , 34. I f J..Ol+ --- ~- ... --.- .-... :: ; ; I 'I':" i : J ' I' 'I ' i 111111 11i I ' I i: 1'1" :" , ~F"::< I':;:;;"1 :;!1'-:' 'I' i :!,,:', ;'I ';:;i ' I![!illi I!!:'" i! ;li i1 iii/ ilfjffi'II'n il: i"1i I III'I1I! ,!, il!!I' 1 ri!II 111, !l1llll!I, ( !'II' !! r HI1 r"jlrqrilT II! illl llillfTTTT"li! !i l;;111 I'!11i :, i,i! I;: :: I:::'I: '! I::; , ., ..., ." I !.., ~ ,! ! " ! ! I i I! I , I" I I ~ 1 : 'I t I • ! . i ! I ~ I ol f, I I !!' I I j . : ". , , " " " ,, ! I: :",-] ! ". 'I: i : 'I';;, I i ,'I',' 1'1 i 'I!' ,1'11' 1'" (' 1111' 1'11111] q ri1-rllll fl jl'll" Ii 111'1 fli fl fl"l fI' t~l""l l'I 10" 1' ,1-. ; II' !'j'll i If; 1',1i ; I" ," \" ,"I'" ' ,:, : ;:: :: i; ;:!: : II! :'! L I! l! ! II! 1I! I III III: I Ii tlJ I (1 ,I!:!!! f ,I ! I I : II! ill! II Ii ::! j ;;;: i ::; j::; : ;: , I .. '\ " , " , ,,' "::/il " :F:r:r17i\PET_rrmP~~~TUl~mnTnr:jrUl~i'Y ' ~ : I i:i: I~ : ;.j ' ~ IU~f 111 \' .... ; Lll :: ~~j : .. , tI! 'ii ' , L !' I : W t L1lUl, J.UL:L1JjH~l l flj ,~:: ';;: ::iJlU;~ : ' !l ,:' ~ ' ~'., ; , ,, " ':: ;:p III , 11 IlJff1t!1 T ' ! - ; II d,: Ill! HP \;;,r:/::: ' :::I~ ~ ::;, :,:i, :,:, .. ': , j .. " :;i I : ; ~J T ~ ~ ,-~ " 111 p.:; It Il,lt ti;; I::: !,!i I' ,; ; i:: it:: :::; 1 : ~~:"' ,I~; ::ll::! ! t::J.r+ : H, Y IHf{ rI:- fI" 1j' ' - ..~'l+' T :l1i 1.!h; - ,,'"~ t:1 !l,1 j: tH\1 i ;"i"~ !! "L1 1": 1:/it 1 : q' ,; :;::,", " .. liL, ' ; ~r ' I lt-!- .,- ",t++-+ H'~ , -'I t ·" ,,,' " , '1 ,", .. i t+U:l± +t- +1-1-' i I-f H rIH ' 1+,-1" ·'1' . t' H ... 1 ,.... WI'iTutr:riI ,tt, , --tn!1 'HtrrtHttli' t Ui; :i+t : tt-pl Hi ~ CAMBRIDGE ' 'it H+Htti- • + 't ·· -I Figure 5.4 Incomplete A-V block and right bundle branch block in dog # 2. l::~~1 ~-~~~ l n;1IHffhWJutfl-@}HHmYWlnwJ-mw#liammJtlj:lffilllUUttUrnIDmllimnun lmm If!wftltiWtmri! -i !~ !lit ,;H 1-'- --' "---••- - ~ " ' - ' --" :ul::;: 1:1il/rftllamHtfUMlIWillUiUIDrrijlllUlliHmmnmInmUUUlH-rrrmmmnllftHllmmUmnJUmmnmnlnmmnmmnrrmlf!lll nll li;; : ::;: I[IT: I!; illHf~mlffimnm { nmOOtIWHUUtJflJmtmlIUUHJill:iliJ I Wfnl : l~HmtWttillUHlHU!li IrWHJJtHltUUnUHU tlH IHHIi;; H: i-til! 1111 11 \!I; ~ ;: i ttt" it: -, f!ttlmfWEUlTI~mrnEElffiiJlEIDlfllil:IniHnHHI " I~HJL±±LittljJt:l±lJit:lii , t'ljJ l ilU 'IHI-!:l Lt:tlJjJWftl-tI1Jt LlHEIi ;f;I;-j ii,ltril l!!! !Ii; ! ; +, ,t IT , ttl - mlmtl -ttl+t~r-~~imttl:ttti~~j.Hktttt-+t .ittlt-l+ttriftHiti=i-1-tH I .J:1.tH:l t-JiitH-t:ll+ltU, t ,H! i+hl ~ :" : t'l : II - I ! ! , t'" '~ ; ~r; : i-H" It,' t,i pm#" l fuuW~Mm_£LrnI£lf!lBHlf LU1t]lHHi=lli l ±tI :LI*tjJIHUiiJ±IJ 'I Ht, t±llt l ±t:J:U~ttti W~ I ttl tilt ~j, ;: it;! t I I Ji I, ;A: ,A:..iT ,.. ,· 'I.. .uI'-ftttA,i j tIt 1, J! ' " - , " . - - mtl : ii - tl j ittHhjHH:ji~t.. t t-tmH~+-rttt -tWltiJll ~- I t jj, tAl:tttiftlAh II 'I ".H!I A "I .. Iill I IH, : , ~ I1 .... !;;:;:. ~ ;j; j _ ~;"I ! ~h ~: , '''''':' 'I ' ~ ' T I, T,'l ,! ', Y "tlL I ' , IJI-' ~': !' ct'r.i,i _tLL'1"L'~f:-;;' ; ; 1 1 iiTIlfu l ri E~i~;~~ ijll ttr m=rt t ~tt : .m11U~ JItlHI 114 Ii J illiW1 rta tff-l ffitt~ ,-. J 1+ ' ltU:t:/ It ff l HII ' , 11. .nJJUli_._ _J~~tl-Hm#Hfit Figure 5.5 Paroxysmal atrial tachycardia with right bundle branch Dlock and 2:1 or 1:1 A-V conduction in dog # 13. PIfTIT;Emmril1TmTmrTITI+ITT:;;:n;;;:;;;;~- CAM CO NO, 40._ ' inJ-Et :1fltbttffllHt!tj1 [1 ~wln;:~: p:: .j , rr,. j !t,·, ~ ~ l: ~- f : r ; . '~'" .ttl'·' Jlf J:rm' -n~~yLf Hl±.ill.9l1 n-Etl!Jl.!J1 ~~Hi Figure 5.6 Complete A-V block in dog # 22. 165 LE.AD I (X axis) LEAD AVF (Y axis) LEAD VIO* (Z axis) ili; I"i 111 ! :: :}~ '; ] ): rmn, nvIi ill, , ' IiiiI, II! i lilj!I, !llii ii,',' qil llil" , I :!~ I ~ ~ 1 :i;i l:l! ! : !i l ;~!l l i;:: I ;::: I T: I :; ::1:::: ': : ;;:; :: ;1 Hill J11! d' li 'I 11111 :lll ltlil ilq . Itl ill! " II .• • • .. • i : 1;. , . \I!\ II-I'I '." " i ' II' ! H!], I I jIiii r' i : til, Ill'd! I I , ii' ,l ll'lf '!l idl ll h i II II I ', : "I " , . , ': ~ rJ.J.' , .. ' , I . ' IiU' .' :Lfm [tn ntfHff~Jammmllll r~ ~4: ~ Figure 5.7 Right bundle branch block in dog # 11. J I AVF VlO , mn rnrrnnm1i r mlj.l;-rT;~-rr-.-""- [',I H,tl 'I 'I "J+'llI!l!!I 'llllnr'!I ,l f,1+11rT ln:,I, 1' 1:[1"" i " .,:~:" I,:i::,', +1fl l' r i, ~ll n 'f!ITlmmnIi' "i! I"!'i: :1 IIi:''t, ' I";:!:I,I:::',., :1,; .J . 1!! I' 'Ilt l jl! t 1ft: ! . ! ' t , ·· ..•. , . ~mrnrrnm Iiii Figure 5.8 Left bundle branch block in dog # 57. I AVF VIO ' t ::!,!11fI, ,' i ' l l~i1 1 n!1 f~f-l rt-l,','H-rl-rrl,l!If1 1ftr. IH}Ut ltH ; tll' LI, di ) I! I'n"Lt II Ifit !11 1 ' ,' I .t ~n-rm l mf t ffITUmll rf l Hfll lllnll l! rrn /flll l!III I!;!! I!ii:i 111 11II 1111.11 11I! II!Ii II f! r J! ~ 1:l1I 1 1 1 1In [ r"" I ]111fAL-l-. .JJ. ::UfEJ. +1+1. f.. ,H f-j~+. ... : 1:1 1, 1! ' 'I 'Iijijl"'" ..­ I .... j.-" 11FIIl lil!1 ;:11 II:!! 1 1 "I:P: jlti:' . 1 • L . 1, t! 1": 1 j ;:, i! ITIII'I:, Ii:'! I'": I:I "" II I jll IIII I . , · i.i:W Ii:rj.l ffitHllf"·, 1: "j rmmTlI III III11:: Figure 5.9 Nonspecific ventricular conduction delay in dog # 21.