- Institute for scientific and technical information - Covid-19 Thesaurus Covid-19 Thesaurus Version 1.2 (Last updated: 2021-01-07) This resource contains 1203 terminological entries. This bilingual thesaurus (French-English), developed at Inist-CNRS, covers the concepts from the emerging COVID-19 outbreak which reminds the past SARS coronavirus outbreak and Middle- East coronavirus outbreak. This thesaurus is based on the vocabulary used in scientific publications for SARS-CoV-2 and other coronaviruses, like SARS-CoV and MERS-CoV. It provides a support to explore the coronavirus infectious diseases . A French version of the thesaurus is also available. The thesaurus is browsable online on the terminological portal Loterre: https://www.loterre.fr Legend • Syn: Synonym. • → : Corresponding Preferred Term. • FR: French Preferred Term. • NT: Narrower Term. • BT: Broader Term. • RT: Related Term. • URI: Concept's URI (link to the online view). This resource is licensed under a Creative Commons Attribution 4.0 International license: TABLE OF CONTENTS Alphabetical Index 4 Terminological Entries 5 List of entries 174 Tree 201 Alphabetical Index from 2002 to 2019 p. 8 -8 from 3 LNP-mRNAs to 3 LNP-mRNAs p. 9 -9 from 501Y.V2 to 501Y.V2 p. 10 -10 from A222V mutation to azithromycin p. 16 -24 from B lymphocyte to Butantan Institute p. 28 -31 from C reactive protein to cytotoxic T lymphocyte p. 38 -48 from D-dimer to dyspnea p. 49 -53 from E protein to extracorporeal membrane oxygenation p. 55 -59 from facilitating antibody to fusion peptide p. 62 -64 from G clade to GX-19 p. 67 -70 from haemophagocytic lymphohistiocytosis to hypokalemia p. 75 -78 from IFITM protein to ivermectin p. 87 -92 from JAK-STAT to Johnson & Johnson p. 93 -94 from K417N mutation to kinase p. 95 -95 from L clade to lymphopaenia p. 96 -99 from M protein to myocarditis p. 108 -108 from N protein to Nyctereutes procyonoides p. 116 -116 from O clade to oxygen therapy p. 117 -120 from P681H mutation to pyroptosis p. 126 -131 from QazCovid-in to quaternary prevention p. 132 -132 from randomized controlled trial to Russian research organization p. 139 -139 from S clade to systemic manifestation p. 149 -152 from T lymphocyte to tyrosine kinase 2 p. 155 -160 from U.S. association to urine p. 163 -163 from V clade to VXA-CoV2-1 p. 169 -170 from waist-hip ratio to Wuhan city p. 171 -171 from Yunnan Walvax Biotechnology to Yunnan Walvax Biotechnology p. 172 -172 from zoonotic coronavirus to zoonotic virus p. 173 -173 Covid-19 Thesaurus | 4 Terminological Entries Covid-19 Thesaurus | 5 > 60 years old → over the age of 60 years 6 | Covid-19 Thesaurus 1 1 ab polyprotein → polyprotein 1ab Covid-19 Thesaurus | 7 2002 2019-nCoV infection 2 → coronavirus disease 2019 2019-new coronavirus 2002 → SARS-CoV-2 BT: date RT: SARS-CoV 2019-novel coronavirus FR: 2002 → SARS-CoV-2 URI: http://data.loterre.fr/ark:/67375/C0X-WP7M3RJ5-P 2019 coronavirus disease 2003 → coronavirus disease 2019 BT: date RT: SARS-CoV FR: 2003 2019 novel coronavirus URI: http://data.loterre.fr/ark:/67375/C0X-PZ5RND87-N → SARS-CoV-2 2003 SARS 2019 novel coronavirus disease → severe acute respiratory syndrome → coronavirus disease 2019 2004 2019 novel coronavirus infection BT: date → coronavirus disease 2019 RT: HCoV-NL63 FR: 2004 URI: http://data.loterre.fr/ark:/67375/C0X-TDXWGLQ0-3 2019 Novel (New)coronavirus → SARS-CoV-2 2005 BT: date 27e10 antigen RT: HCoV-HKU1 → calprotectin FR: 2005 URI: http://data.loterre.fr/ark:/67375/C0X-XK1480WW-J 2′-O-Mtase 2012 → non-structural protein 16 BT: date RT: MERS-CoV 2′-O-ribose-methyltransferase FR: 2012 URI: http://data.loterre.fr/ark:/67375/C0X-T085B191-J → non-structural protein 16 2019 BT: date RT: SARS-CoV-2 FR: 2019 URI: http://data.loterre.fr/ark:/67375/C0X-T8F40QV6-8 2019-nCoV → SARS-CoV-2 2019-nCoV acute respiratory disease → coronavirus disease 2019 2019-nCoV ARD → coronavirus disease 2019 2019-nCoV disease → coronavirus disease 2019 8 | Covid-19 Thesaurus 3 LNP-MRNAS 3 3'-to-5' exonuclease → non-structural protein 14 3C-like protease → non-structural protein 5 3C-like proteinase → non-structural protein 5 3CLpro → non-structural protein 5 3CL protease → non-structural protein 5 3 LNP-mRNAs Syn: BNT162b2 BT: mRNA vaccine RT: · Biopharmaceutical New Technologies · Comirnaty · Medicines and Healthcare products Regulatory Agency · Pfizer FR: 3 LNP-mRNAs URI: http://data.loterre.fr/ark:/67375/C0X-VRVTQD8N-L 3′ to 5′ endonuclease, N7-methyltransferase → non-structural protein 14 Covid-19 Thesaurus | 9 501Y.V2 5 501Y.V2 BT: new coronavirus variant RT: · E484K mutation · K417N mutation · N501Y mutation The 501.V2 variant, or simply 501.V2, is a variant of SARS-CoV-2— the virus that causes COVID-19. The variant was first detected in the Nelson Mandela Bay metropolitan area of the Eastern Cape province of South Africa and reported by the country's health department on 18 December 2020. (Wikipédia) FR: 501Y.V2 URI: http://data.loterre.fr/ark:/67375/C0X-DRTDFGBJ-L EQ: https://en.wikipedia.org/wiki/501.V2_variant https://fr.wikipedia.org/wiki/Variante_501.V2 10 | Covid-19 Thesaurus 501Y.V2 9 9-O-acetylated sialic acid → N-acetyl-9-O-acetyl neuraminic acid Covid-19 Thesaurus | 11 A222V MUTATION acute liver failure BT: systemic manifestation A Acute liver failure is the appearance of severe complications rapidly after the first signs (such as jaundice) of liver disease, and indicates that the liver has sustained severe damage (loss of function of 80–90% of A222V mutation liver cells). (Wikipedia) BT: mutation in S gene FR: insuffisance hépatique aiguë FR: mutation A222V URI: http://data.loterre.fr/ark:/67375/C0X-QPWJD408-W URI: http://data.loterre.fr/ark:/67375/C0X-TDG4S5BH-W EQ: https://en.wikipedia.org/wiki/Acute_liver_failure https://fr.wikipedia.org/wiki/Insuffisance_h %C3%A9patique_aigu%C3%AB AAK1 → adaptor-associated protein kinase 1 acute lung injury → acute pneumonia accessory protein BT: viral protein acute pneumonia NT: · protein 10 Syn: acute lung injury · protein 3a BT: pneumonia · protein 3b · protein 6 Pneumonia is an inflammatory condition of the lung affecting primarily · protein 7a the small air sacs known as alveoli. Symptoms typically include some · protein 7b combination of productive or dry cough, chest pain, fever and difficulty breathing. The severity of the condition is variable. (Wikipedia) · protein 8a · protein 8b FR: pneumonie aiguë · protein 9b URI: http://data.loterre.fr/ark:/67375/C0X-RS9TSXB4-L EQ: https://fr.wikipedia.org/wiki/Pneumonie_aigu%C3%AB FR: protéine accessoire https://en.wikipedia.org/wiki/Pneumonia URI: http://data.loterre.fr/ark:/67375/C0X-SBLZ50QV-1 ACE2 acute renal failure Syn: acute kidney injury → angiotensin converting enzyme 2 BT: systemic manifestation RT: dialysis ACE inhibitor Acute kidney injury (AKI), previously called acute renal failure (ARF), is → angiotensin-converting-enzyme inhibitor an abrupt loss of kidney function that develops within 7 days. (Wikipedia) FR: insuffisance rénale aiguë acidophil URI: http://data.loterre.fr/ark:/67375/C0X-ZG5GRGPR-X EQ: https://en.wikipedia.org/wiki/Acute_kidney_injury → eosinophil https://fr.wikipedia.org/wiki/Insuffisance_r%C3%A9nale_aigu %C3%AB ACORES-2 acute respiratory distress syndrome BT: French trial RT: · angiotensin II receptor blocker Syn: adult respiratory distress syndrome · angiotensin-converting-enzyme inhibitor BT: · lung disease FR: ACORES-2 · systemic manifestation URI: http://data.loterre.fr/ark:/67375/C0X-X3N62DJS-S RT: · cellular fibromyxoid exudate · diffuse alveolar damage · prone positioning acquired immune system Acute respiratory distress syndrome (ARDS) is a type of respiratory → adaptative immunity failure characterized by rapid onset of widespread inflammation in the lungs. Symptoms include shortness of breath, rapid breathing, and bluish skin coloration.For those who survive, a decreased quality of life acquired immunity is common. (Wikipedia) → adaptative immunity FR: syndrome de détresse respiratoire aiguë URI: http://data.loterre.fr/ark:/67375/C0X-KP4M5WK3-W EQ: https://en.wikipedia.org/wiki/ acrp30 protein Acute_respiratory_distress_syndrome → adiponectin https://fr.wikipedia.org/wiki/Syndrome_de_d %C3%A9tresse_respiratoire_aigu%C3%AB acute kidney injury → acute renal failure 12 | Covid-19 Thesaurus ADAPTOR-RELATED PROTEIN COMPLEX 2 acute respiratory failure adaptative immunity BT: systemic manifestation Syn: · acquired immune system FR: insuffisance respiratoire aiguë · acquired immunity URI: http://data.loterre.fr/ark:/67375/C0X-JH9FGN83-5 · adaptive immune response BT: immunity Ad26 NT: · adaptative immune cell · adaptative immunity function → type 26 adenovirus · cell-mediated immunity · humoral immunity Ad26.COV2.S The adaptive immune system, also referred as the acquired immune BT: adenovirus vaccine vector system, is a subsystem of the immune system that is composed of RT: · Janssen Pharmaceutica specialized, systemic cells and processes that eliminates pathogens by preventing their growth. The acquired immune system is one of the · non-replicant viral vector two main immunity strategies found in vertebrates (the other being the · type 26 adenovirus innate immune system). (Wikipedia) FR: Ad26.COV2.S URI: http://data.loterre.fr/ark:/67375/C0X-G2S0XCZH-M FR: immunité adaptative URI: http://data.loterre.fr/ark:/67375/C0X-T5PB7QGB-3 EQ: https://en.wikipedia.org/wiki/Adaptive_immune_system Ad5 https://fr.wikipedia.org/wiki/Syst %C3%A8me_immunitaire_adaptatif → type 5 adenovirus adaptative immunity function Ad5-nCoV BT: adaptative immunity Syn: