PROGRAM AND ABSTRACTS Ninth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Individualized Medicine June 22-26, 2015, Bol, Island of Brač, Croatia European Centre of Excellence with the latest diagnostic, therapeutic and rehabilitation infrastructure. DIAGNOSTIC OPERATIONS REHABILITATION www.svkatarina.com www.facebook.com/sv.katarina Publisher: International Society for Applied Biological Sciences (ISABS) Domobranska 21, Zagreb, Croatia Editors: Manfred Kayser, Tamás Ördög, Stanimir Vuk–Pavlović, Dragan Primorac, Moses Schanfield Assistant Editors: Davor Derenčinović, Gordan Lauc, Damir Marjanović, Saša Missoni, Damir Primorac, Andrea Skelin, Jelena Šarac, Tena Šarić, Vlatka Zoldoš Prepress: PROGRAM AND Duje Rako and J Studio ABSTRACTS Printed by: Grafički zavod Hrvatske d.o.o., Zagreb, 2015 NINTH ISABS CONFERENCE IN FORENSIC, ANTHROPOLOGIC AND MEDICAL GENETICS Circulation: AND MAYO CLINIC LECTURES IN INDIVIDUALIZED MEDICINE 700 copies ISBN 978-953-57695-1-4 A CIP catalogue record for this book is available in the Online Catalogue of the National and University Library in Zagreb as 000908089 JUNE 22-26, 2015 Video and/or audio-taping of any session is not permitted without prior approval Bluesun hotel Elaphusa from the speakers and Scientific Committee of the 9th ISABS Conference in Bol, Island of Brač, Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Individualized Medicine CROATIA © Copyright ISABS 2015 www.isabs.hr [email protected] Zagreb, 2015 Table of Contents Conference floor layout TABLE OF CONTENTS Welcome note ………………………………………………….. 6 Foreword ………………………………………………………… 7 Conference Organizer …………………………………………. 8 ISABS Committees …………………………………………….. 10 Young Investigator Awards ……………………………………. 12 Scientific Program Information ……………………………….. 13 General Information ……………………………………………. 15 Invited speakers ………………………………………………... 16 Scientific Program ……………………………………………… 18 Keynote addresses …………………………………………….. 24 Abstracts of invited lectures ……..…………………………….. 28 Young investigator award presentations …………………….. 72 Submissions selected for podium presentations ……………. 76 Abstracts of poster presentations …………………………….. 93 Forensic Genetics ……..……………………………….. 94 Anthropological Genetics …..………………………….. 138 Medical Genetics ……..………………………………… 180 About Invited Speakers .……………………………………….. 236 Sponsor information ……………………………………………. 251 Author index …………………………………………………….. 262 Keyword index ………………………………………………….. 271 4 9th ISABS Conference in Forensic, Anthropologic and Medical Genetics 9th ISABS Conference in Forensic, Anthropologic and Medical Genetics 5 and Mayo Clinic Lectures in Individualized Medicine and Mayo Clinic Lectures in Individualized Medicine June 22-26, 2015, Bol, Island of Brač, Croatia June 22-26, 2015, Bol, Island of Brač, Croatia Welcome note Foreword WELCOME TO THE NINTH ISABS CONFERENCE IN FORENSIC, ISABS CONFERENCE JOINS FORCES WITH THE FP7 ANTHROPOLOGIC AND MEDICAL GENETICS PROJECTS PAIN-OMICS and INTEGRA-LIFE AND MAYO CLINIC LECTURES IN INDIVIDUALIZED MEDICINE! From the very beginning in 1997, ISABS Conferences have been the flagship of The conference is next in the series of biennial events organized by the International Croatian science, demonstrating that events of global importance can have their Society for Applied Biological Sciences, a society dedicated to the promotion of applied home in Croatia. Since the time of Antient Rome, for nearly 2000 years, Croatia molecular biology (www.isabs.hr). This conference is organized with participation of Mayo was on the forefront of science and education in Europe. However, after the end of Clinic, George Washington University, Penn State University, The Henry C. Lee Institute of World War I, the Treaty of Versailles exiled Croatia to the Balkans, with Forensic Science, University of New Haven, Universities of Zagreb, Split, Osijek and Rijeka, devastating consequences to its science and culture. After 95 years of exile, on Ruđer Bošković Institute, Croatian Academy of Engineering, Croatian Forensic Association, July 1stt, 2013, only three days after the conclusion of the 8th ISABS Conference, International Burch University, University of Botswana, Croatian Society of Human Croatia “returned home” as the 28th member state of the European Union. Genetics, Chindren’s Hospital Srebnjak, Genos Ltd, Institute for Anthropological Research, St. Catherine Hospital, Unfallkrankenhaus Berlin, Faculty of Law Zagreb, Ivan Vučetić Forensic Science Center, Croatian Academy of Technical Sciences, Croatian Academy of Research and innovation are strategic objectives of the European Union, and the Legal Sciences, City of Split and Split-Dalmatia County. As in the past, this conference is Horizon 2020 Program (former Framework Program) is its main tool for their organized under the auspices of the Croatian Academy of Sciences and Arts. Croatian promotion. Pain-OMICS is a multidisciplinary consortium of leading clinical, Medical Journal, the official journal of ISABS, will publish the conference papers in its ninth academic and SME researchers in pain and different omics technologies whereby special ISABS edition. the European Commission will invest almost 6 million Euros in the network of 10 research groups included in the project, among them Genos Ltd. and St. Since the initiation of the series in 1997, we have strived both to focus and broaden the Catherine Hospital from Croatia. As one of the European Union Seventh scope of the conferences. The focus has been on the application of cutting-edge analytical Framework Program (FP7)-funded projects dedicated to pain, Pain-OMICS aims methodology in forensic science. Since 2007 we have broadened the area of interest by the to identify new biomarkers to predict the transition from acute to chronic pain. introduction of molecular anthropology that, in large part, shares the methodology with forensic genetics. In 2009, we introduced selected topics from individualized medicine, Pain-OMICS is a collaborative research project applying a multidimensional-omics another applied discipline based on the advances in mapping of the human genome. In approach to data from over 5,000 patients with lower-back pain. Coordinated by 2011, the conference discussed the new molecular methods in early cancer diagnosis, new Professor Massimo Allegri at the University of Parma, Italy, this translational approaches to AIDS treatment, non-invasive prenatal diagnostics, gene and cell therapy, consortium aims to identify Pain-OMICS novel diagnostic and prognostic phenotype prediction from genetic information, identification of victims of mass disasters, biomarkers to improve patient outcomes. plant and animal DNA analysis, cold-case forensics, and selected topics in molecular anthropology. In 2013 we included genetics applied to crossing of forensic science, FP7 project IntegraLife aims to integrate research in five leading research groups anthropology and translational medicine, and also lectures from Nobel Laureates Aaron in the field of biochemistry, computational and molecular biology at the University Ciechanover, Robert Huber and Ada Yonath. of Zagreb and network them with 17 prominent European research institutions. By teaming up with ISABS Conferences, IntegraLife and Pain-OMICS hope to This year we are pleased to introduce up-to-date results in genomics of individualized medicine, a program in anthropology genetics concerning ancient and modern human improve the visibility of its researchers and enable them to initiate novel genome history, and human genetic history of the continents and forensic genetics program collaborations with leading researchers from Europe and the US. with special ephasys on new knowledge in Next Generation Sequencing (NGS) in forensics, DNA investigative intelligence, and advancements in forensic DNA routine. Also, Gordan Lauc/Vlatka Zoldoš the Nobel Laureate Robert Huber will hold a lecture. General sponsor of the conference is Belupo, Inc. As before, the conference is structured to allow close interaction of the international faculty and attendees. Together with formal presentations, there will be meet-the-professor sessions and other social occasions that are ment to enhance opportunities for scientific intercourse, but also to introduce the participants to the city of Bol, one of the best known tourist destinations in Croatia due to its unspoiled nature, beautiful beaches, cultural and historical attractions and well developed tourist and sport offers. Enjoy! Manfred Kayser and Tamás Ördög, Program/Conference Directors Dragan Primorac, Moses Schanfield, Stanimir Vuk-Pavlović Conference Founders 6 9th ISABS Conference in Forensic, Anthropologic and Medical Genetics 9th ISABS Conference in Forensic, Anthropologic and Medical Genetics 7 and Mayo Clinic Lectures in Individualized Medicine and Mayo Clinic Lectures in Individualized Medicine June 22-26, 2015, Bol, Island of Brač, Croatia June 22-26, 2015, Bol, Island of Brač, Croatia ISABS Committees ISABS Committees 9TH ISABS CONFERENCE, • Assistance to the Local Organizing Committee BOL, ISLAND OF BRAČ, CROATIA, JUNE 22-26, 2015 Anja Brtan Lea Južinić Lovre Čulina Mirna Kassal • Organizer Tatjana Enderić Marija Klasić Paula Greiner Karlo Skube International Society for Applied Biological Sciences Mihaela Jagrić Aleksandar Vojta The conference is organized under the auspices of the Croatian Academy of Lucija Jukić Science and Arts. • Professional conference organiser: • ISABS Founders Spektar putovanja d.o.o. -