NEUROANATOMY www.neuroanatomy.org VOLUME 4 [2005] Supplement 1 4th National Congress of Neuroscience Mersin, Turkey, March 29–April 2, 2005 ABSTRACT BOOK Honorary Comittee Prof.Dr. Ugur Oral - Rector Prof.Dr. Suha Aydin - Dean Scientific Committee Prof.Dr. Turgay Dalkara Prof.Dr. Tamer Demiralp Prof.Dr. Murat Emre Prof.Dr. Lutfiye Eroglu Prof.Dr. Yucel Kanpolat Prof.Dr. Fatma Kutay Prof.Dr. Filiz Onat Prof.Dr. Cigdem Ozesmi Prof.Dr. Gonul Peker Prof.Dr. Sakire Pogun Prof.Dr. I. Hakki Ulus Prof.Dr. Pekcan Ungan Organizing Committee Prof.Dr. Huseyin Beydagi - Chairman Asst.Prof.Dr. Seyit Ankarali - Secretary Prof.Dr. Emin Erdal The conference is organized under the auspices of Assoc.Prof.Dr. Belgin Buyukakilli Turkish Council of Scientific and Technical Reseach, Assoc.Prof.Dr. Aynur Ozge TUBAS, Assoc.Prof.Dr. A. Hakan Ozturk BAD, Assoc.Prof.Dr. Kemal Yazici Asst.Prof.Dr. Tolgay Ergenoglu and Asst.Prof.Dr. Cetin Okuyaz Mersin University. e-ISSN 1303-1775 • p-ISSN 1303-1783 Honorary Editor Technical Editor Tuncalp Ozgen, MD M. Mustafa Aldur, MD-PhD Editors Managing Editors M. Dogan Aksit, DVM-PhD Mustafa Aktekin, MD-PhD Ruhgun Basar, DDS-PhD Alp Bayramoglu, MD-PhD M. Deniz Demiryurek, MD-PhD Deputy Editor C. Cem Denk, MD-PhD www.neuroanatomy.org H. Hamdi Celik, MD-PhD A. Hakan Ozturk, MD-PhD Associate Editors Eray Tuccar, MD-PhD Owned and Published by Mustafa K. Baskaya, MD Associate Technical Editor Safiye Cavdar, PhD Ilkan Tatar, MD Scott Lozanoff, PhD M. Mustafa Aldur, MD–PhD Scientific Advisory Board Department of Anatomy Erdogan Sendemir, MD Salih Murat Akkin, MD Hacettepe University Mustafa F. Sargon, MD-PhD Mehmet Alikasifoglu, MD-PhD Faculty of Medicine Selcuk Surucu, MD-PhD Ossama Al-Mefty, MD 06100 Ankara–Turkey A. 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Historical Neuroanatomy Reinhard Putz, MD Printed by Recep Mesut, MD Kayihan Sahinoglu, MD Variational Neuroanatomy Madjid Samii, MD-PhD Alaittin Elhan, PhD Mustafa Sarsilmaz, MD Hacettepe University Hospitals Printing House Terminology Laligam N. Sekhar, MD 06100, Ankara, Turkey Sezgin Ilgi, PhD Levent Sennaroglu, MD +90 312 305 30 68 Ahmet Sinav, MD Ankara, December 2004 Comparative Neuroanatomy Robert F. Spetzler, MD Orhan E. Arslan, DVM-PhD Ali Tascioglu, MD [5187 numaral› Bas›n Yasas› mucibince gösterilmesi zaruri bilgiler] Language Editors Ertugrul Tatlisumak, MD Sahibi ve Sorumlu Müdürü: Doç. Dr. M. Mustafa Aldur Selma Yorukan, MD Yönetim Yeri: Hacettepe Üniversitesi T›p Fakültesi Anatomi Anabilim Dal›, 06100 S›hhiye, Ankara. Ugur Ture, MD Telefon: 305 24 66 Faks: 478 52 00 Emine Ozkul, PhD Emel Ulupinar, MD-PhD Yay›n Türü: Yerel Süreli Yay›n Ayberk Kurt, MD-PhD Ismail H. Ulus, MD Yay›n Dili: ‹ngilizce Yay›nlanma Biçimi: Y›ll›k A. Kagan Karabulut, MD-PhD Statistical Advisor Bas›m Yeri: Ankara Bas›m Tarihi: Mart 2005 (Cilt 1’e ek olarak bas lmaktad r) Muzaffer Seker, PhD Ergun Karaagaoglu, PhD ı ı Bas›mc›: Hacettepe Üniversitesi Hastaneleri Bas›mevi, 06100 S›hhiye, Ankara. Telefon: 305 30 68 Selcuk Tunali, MD Medical Illustrator Ücretsiz olarak dağıtılır. Reklam kabul edilmez. Dogan Tuncali, MD Fikret Sen, MD Atila Muftuoglu, MD Professor of Anatomy President of Turkish Society of Anatomy February 7, 1950 [Gaziantep–Turkey] • January 16, 2005 [Istanbul–Turkey] This supplement of NEUROANATOMY is dedicated to Professor Atila Muftuoglu. We are deeply sorry for his sudden death. Dr Muftuoglu will be in our thoughts and prayers. Neuroanatomy (2005) 4 (Suppl 1): 1–46 Abstracts Presented at the 4th National Congress of Neuroscience; 29th March–2nd April 2004; Mersin University; Mersin–Turkey Published online 15 April, 2005 © http://www.neuroanatomy.org CONFERENCES involves a complex set of neurobehavioral functions that includes orienting attention, allocating additional attentional resources, directing investigatory activity, and assessing the meaning and impact of a novel event. Event-related K1 [NOT PRESENTED] potentials (ERPs) have been a major tool for investigating how the brain responds Ion channels and epileptogenesis to target and novel events. These patterned voltage changes in the ongoing Avanzini G. electroencephalogram, time-locked to cognitive events, have exquisite temporal Instituto Neurologico C. Besta, Milano, Italy resolution of underlying cognitive processes. [email protected] The focus of this lecture will be on cortical components of the cerebral network that subserves the processing of novel events. We will emphasize results from The implication of membrane channels and receptors in the generation of the our ERP laboratory and try to place them in the broader context of data derived epileptic discharges was suggested as early as in the Sixties, when high-frequency from other labs. action-potential discharges superimposed to a sustained depolarising envelope were recorded for the first time from neurons belonging to an epileptogenic The lecture will address the following major issues: 1) Significance of the topic of aggregate. This type of discharge, that was christened paroxysmal depolarising novelty processing to cognitive neuroscience and clinical work; 2) Brief overview shift (PDS) by Matsumoto and Ajmone Marsan (Exp Neurol, 80, 286, 1964), of ERP methodology; 3) P3 ERP component: standard methods and conventional was thought to be related to a dysfunction of ion-channel-dependent excitable view; 4) Variant of the novelty oddball paradigm—linking the novelty P3 to mechanisms. Only recently, however, direct demonstrations of genetically viewing duration and exploratory behavior; 5) Central role of the prefrontal determined ion channel defects resulting in epileptogenesis have been provided. cortex in the allocation of attention to novel events; 6) Contribution of the parietal lobes—updating internal models of the environment. In 1995 Phillips et al. (Nature Genetics, 10, 117, 1995) showed evidence of a mutation in the CHRNA4 gene coding for a subunit nicotinic receptor of We will review data which