Table S3. List of predicted genes targeted by at least 5 miRNAs significantly up regulated in CD105+ MVs. Official symbol Gene name n° of targeting miRNAs TNRC6B trinucleotide repeat containing 6B 11 BNC2 basonuclin 2 9 BRWD1 bromodomain and WD repeat domain containing 1 8 MIB1 mindbomb homolog 1 (Drosophila) 8 ANKRD52 ankyrin repeat domain 52 8 FOXP1 forkhead box P1 8 ITGB8 integrin, beta 8 8 CNOT6L CCR4-NOT transcription complex, subunit 6-like 8 PTP4A1 protein tyrosine phosphatase type IVA, member 1 7 PPP1R15B protein phosphatase 1, regulatory (inhibitor) subunit 15B 7 TET3 tet oncogene family member 3 7 GMFB glia maturation factor, beta 7 PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 7 PTPRD protein tyrosine phosphatase, receptor type, D 7 TP53INP1 tumor protein p53 inducible nuclear protein 1 7 FNDC3B fibronectin type III domain containing 3B 7 FAT3 FAT tumor suppressor homolog 3 (Drosophila) 7 CCND2 cyclin D2 7 ONECUT2 one cut homeobox 2 7 RBM9 RNA binding motif protein 9 7 ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 7 BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 7 SMAD4 SMAD family member 4 7 MECP2 methyl CpG binding protein 2 (Rett syndrome) 7 UBN2 ubinuclein 2 7 PTEN phosphatase and tensin homolog 7 RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 7 DLC1 deleted in liver cancer 1 6 ENAH enabled homolog (Drosophila) 6 NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 6 KCMF1 potassium channel modulatory factor 1 6 IGF1 insulin-like growth factor 1 (somatomedin C) 6 ZNF148 zinc finger protein 148 6 TIAM1 T-cell lymphoma invasion and metastasis 1 6 CDK6 cyclin-dependent kinase 6 6 RP5-1022P6.2 hypothetical protein KIAA1434 6 ACVR2B activin A receptor, type IIB 6 CLCN5 chloride channel 5 6 HLF hepatic leukemia factor 6 TBC1D12 TBC1 domain family, member 12 6 FRMD4A FERM domain containing 4A 6 NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 6 PHF21A PHD finger protein 21A 6 CAMTA1 calmodulin binding transcription activator 1 6 ELL2 elongation factor, RNA polymerase II, 2 6 PDIK1L PDLIM1 interacting kinase 1 like 6 NFIB nuclear factor I/B 6 CPEB1 cytoplasmic polyadenylation element binding protein 1 6 SLC6A6 solute carrier family 6 (neurotransmitter transporter, taurine), member 6 6 CSNK1G1 casein kinase 1, gamma 1 6 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 6 SNX30 sorting nexin family member 30 6 NCKAP5 NCK-associated protein 5 6 CHIC1 cysteine-rich hydrophobic domain 1 6 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 6 ATXN1 ataxin 1 6 INO80D INO80 complex subunit D 6 SAMD12 sterile alpha motif domain containing 12 6 ARPP19 cAMP-regulated phosphoprotein, 19kDa 6 CUGBP2 CUG triplet repeat, RNA binding protein 2 6 CPEB4 cytoplasmic polyadenylation element binding protein 4 6 CPEB3 cytoplasmic polyadenylation element binding protein 3 6 MON2 MON2 homolog (S. cerevisiae) 6 DCX doublecortin 6 PLXNA4 plexin A4 6 FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) 6 YAF2 YY1 associated factor 2 6 PCNX pecanex homolog (Drosophila) 6 CPEB2 cytoplasmic polyadenylation element binding protein 2 6 ARHGAP26 Rho GTPase activating protein 26 5 KIAA1462 KIAA1462 5 AAK1 AP2 associated kinase 1 5 FAM46C family with sequence similarity 46, member C 5 CCNJ cyclin J 5 ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) 5 ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 5 JAZF1 JAZF zinc finger 1 5 ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 5 BEND4 BEN domain containing 4 5 PCGF5 polycomb group ring finger 5 5 KLHL3 kelch-like 3 (Drosophila) 5 ACVR1C activin A receptor, type IC 5 VGLL3 vestigial like 3 (Drosophila) 5 ERP44 endoplasmic reticulum protein 44 5 LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2 5 MLL3 myeloid/lymphoid or mixed-lineage leukemia 3 5 ZFAND5 zinc finger, AN1-type domain 5 5 RNF44 ring finger protein 44 5 DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 5 INSIG1 insulin induced gene 1 5 KLF12 Kruppel-like factor 12 5 C7orf60 chromosome 7 open reading frame 60 5 ZNF532 zinc finger protein 532 5 USP47 ubiquitin specific peptidase 47 5 BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 5 SULF1 sulfatase 1 5 DDX6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 5 FOXN2 forkhead box N2 5 MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 5 IGSF3 immunoglobulin superfamily, member 3 5 KPNA6 karyopherin alpha 6 (importin alpha 7) 5 GATAD2B GATA zinc finger domain containing 2B 5 LAMC1 laminin, gamma 1 (formerly LAMB2) 5 EPS15 epidermal growth factor receptor pathway substrate 15 5 EDEM3 ER degradation enhancer, mannosidase alpha-like 3 5 C5orf41 chromosome 5 open reading frame 41 5 CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 5 FXR1 fragile X mental retardation, autosomal homolog 1 5 EVI5 ecotropic viral integration site 5 5 SYT1 synaptotagmin I 5 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing APPL1 1 5 DCP2 DCP2 decapping enzyme homolog (S. cerevisiae) 5 DLGAP2 discs, large (Drosophila) homolog-associated protein 2 5 TSC1 tuberous sclerosis 1 5 KIAA0355 KIAA0355 5 CNOT6 CCR4-NOT transcription complex, subunit 6 5 HS2ST1 heparan sulfate 2-O-sulfotransferase 1 5 ETNK1 ethanolamine kinase 1 5 TMEM170B transmembrane protein 170B 5 EGR3 early growth response 3 5 BAHD1 bromo adjacent homology domain containing 1 5 MXD1 MAX dimerization protein 1 5 REEP1 receptor accessory protein 1 5 SOCS6 suppressor of cytokine signaling 6 5 DIXDC1 DIX domain containing 1 5 DOCK4 dedicator of cytokinesis 4 5 ZCCHC14 zinc finger, CCHC domain containing 14 5 UBFD1 ubiquitin family domain containing 1 5 MEF2D myocyte enhancer factor 2D 5 PDE7B phosphodiesterase 7B 5 HDAC4 histone deacetylase 4 5 LASS6 LAG1 homolog, ceramide synthase 6 5 HIPK2 homeodomain interacting protein kinase 2 5 HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 5 CLOCK clock homolog (mouse) 5 ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 5 catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat CTNND2 protein) 5 DENND5B DENN/MADD domain containing 5B 5 MYT1L myelin transcription factor 1-like 5 FRMD6 FERM domain containing 6 5 PLAG1 pleiomorphic adenoma gene 1 5 CCNJL cyclin J-like 5 CREB5 cAMP responsive element binding protein 5 5 MBNL1 muscleblind-like (Drosophila) 5 DNAL1 dynein, axonemal, light chain 1 5 SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 5 SP1 Sp1 transcription factor 5 FOXN3 forkhead box N3 5 PPARA peroxisome proliferator-activated receptor alpha 5 ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 5 ZNF609 zinc finger protein 609 5 CALCR calcitonin receptor 5 CCDC6 coiled-coil domain containing 6 5 LRRTM2 leucine rich repeat transmembrane neuronal 2 5 ZFYVE26 zinc finger, FYVE domain containing 26 5 DICER1 dicer 1, ribonuclease type III 5 JARID2 jumonji, AT rich interactive domain 2 5 .