SAFETY DATA SHEET Creation Date 07-Dec-2009 Revision Date 21-May-2012 Revision Number 3 SECTION 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product Identifier Product Description: 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in dimethylformamide Cat No. 374660000; 374660250; 374661000 Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals Uses advised against No Information available Details of the supplier of the safety data sheet Company Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium E-mail address [email protected] Emergency Telephone Number For information in the US, call: 001-800-ACROS-01 For information in Europe, call: +32 14 57 52 11 Emergency Number, Europe: +32 14 57 52 99 Emergency Number, US: 001-201-796-7100 CHEMTREC Phone Number, US: 001-800-424-9300 CHEMTREC Phone Number, Europe: 001-703-527-3887 SECTION 2. HAZARDS IDENTIFICATION Classification of the substance or mixture REGULATION (EC) No 1272/2008 Acute dermal toxicity Category 4 Acute Inhalation Toxicity - Vapors Category 4 Skin Corrosion/irritation Category 1 B Serious Eye Damage/Eye Irritation Category 1 Reproductive Toxicity Category 1B Classification according to EU Directives 67/548/EEC or 1999/45/EC For the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16 Symbol(s) T - Toxic R-phrase(s) R61 - May cause harm to the unborn child R34 - Causes burns Risk Combination Phrases R20/21 - Harmful by inhalation and in contact with skin _____________________________________________________________________________________________ ACR37466 Page 1 / 11 SAFETY DATA SHEET 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide _____________________________________________________________________________________________ SECTION 2. HAZARDS IDENTIFICATION Label Elements Signal Word Danger Hazard Statements H314 - Causes severe skin burns and eye damage H332 - Harmful if inhaled H312 - Harmful in contact with skin H360D - May damage the unborn child Precautionary Statements - EU (§28, 1272/2008) P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P308 + P313 - IF exposed or concerned: Get medical advice/ attention Other Hazards No information available. SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS Component EC-No. Weight % CAS-No 67/548/EEC CLP REACH No. Classification Classification - Regulation (EC) No 1272/2008 1-Propanephosphonic acid cyclic 50 68957-94-8 C; R34 Skin Corr. 1B 01-0000016872-65 anhydride (H314) 68957-94-8 Eye Dam. 1 (H318) _____________________________________________________________________________________________ ACR37466 Page 2 / 11 SAFETY DATA SHEET 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide _____________________________________________________________________________________________ SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS Dimethylformamide EEC No. 200-679-5 50 68-12-2 Xn; R20/21 Acute Tox. 4 01-2119475605-32 68-12-2 Xi; R36 (H312) Repr.Cat.2; R61 Acute Tox. 4 (H332) Eye Irrit. 2 (H319) Repr. 1B (H360D) Flam. Liq. 3 (H226) For the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16 SECTION 4. FIRST AID MEASURES Description of first aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required. Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately. Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with a respiratory medical device. Immediate medical attention is required. Notes to Physician Treat symptomatically SECTION 5. FIRE-FIGHTING MEASURES Extinguishing media Suitable Extinguishing Media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Cool closed containers exposed to fire with water spray. Extinguishing media which must not be used for safety reasons No information available. Special hazards arising from the substance or mixture Combustible material. Containers may explode when heated. Advice for fire-fighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors. _____________________________________________________________________________________________ ACR37466 Page 3 / 11 SAFETY DATA SHEET 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide _____________________________________________________________________________________________ SECTION 6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary measures against static discharges. Environmental precautions Should not be released into the environment. Methods and material for containment and cleaning up Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. SECTION 7. HANDLING AND STORAGE Precautions for Safe Handling Use only under a chemical fume hood. Wear personal protective equipment. Do not get in eyes, on skin, or on clothing. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Use explosion-proof equipment. Do not breathe vapors/dust. Do not ingest. Take precautionary measures against static discharges. Conditions for safe storage, including any incompatibilities Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat and sources of ignition. Specific End Uses SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Exposure limits Component European Union The United Kingdom France Belgium Spain Dimethylformamide Possibility of significant STEL: 20 ppm 15 min VME: 10 ppm 8 heures. TWA: 5 ppm 8 uren Skin uptake through the skin STEL: 61 mg/m3 15 min VME: 30 mg/m3 8 TWA: 15 mg/m3 8 uren VLA-ED: 10 ppm 8 TWA: 10 ppm 8 hr heures. STEL: 10 ppm 15 horas TWA: 30 mg/m3 8 hr Skin minuten VLA-ED: 30 mg/m3 8 Skin STEL: 30 mg/m3 15 horas minuten Huid _____________________________________________________________________________________________ ACR37466 Page 4 / 11 SAFETY DATA SHEET 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide _____________________________________________________________________________________________ Component Italy Germany Portugal The Netherlands Finland Dimethylformamide MAK: 5 ppm 8 Stunden. TWA: 10 ppm 8 horas TWA: 5 ppm 8 tunteina MAK: 15 mg/m3 8 Pele TWA: 15 mg/m3 8 Stunden. tunteina skin notation STEL: 10 ppm 15 Skin minuutteina Peak: 20 ppm STEL: 30 mg/m3 15 Peak: 60 mg/m3 minuutteina TWA: 10 ppm 8 Skin Stunden. exposure factor 2 TWA: 30 mg/m3 8 Stunden. exposure factor 2 Component Austria Denmark Switzerland Poland Norway Dimethylformamide Skin TWA: 10 ppm 8 timer Skin NDSCh: 30 mg/m3 15 TWA: 10 ppm 8 timer STEL: 40 ppm 15 TWA: 30 mg/m3 8 timer STEL: 20 ppm 15 minutach TWA: 30 mg/m3 8 timer Minuten Skin Minuten TWA: 15 mg/m3 8 STEL: 20 ppm 15 STEL: 120 mg/m3 15 STEL: 60 mg/m3 15 godzinach minutter. Minuten Minuten Skóra STEL: 45 mg/m3 15 TWA: 10 ppm 8 MAK: 5 ppm 8 Stunden minutter. Stunden MAK: 15 mg/m3 8 Skin TWA: 30 mg/m3 8 Stunden Stunden Component Bulgaria Croatia Ireland Cyprus Czech Republic Dimethylformamide TWA: 30.0 mg/m3 Skin Notation TWA: 10 ppm 8 hr. TWA: 30 mg/m3 8 TWA: 10 ppm 8 satima. TWA: 30 mg/m3 8 hr. hodinách. TWA: 30 mg/m3 8 STEL: 20 ppm 15 min Potential for cutaneous satima. STEL: 60 mg/m3 15 min absorption STEL: 20 ppm 15 Skin Ceiling: 60 mg/m3 minutama. STEL: 61 mg/m3 15 minutama. Component Estonia Gibraltar Greece Hungary Iceland Dimethylformamide Skin notation skin - potential for STEL: 120 mg/m3 15 TWA: 10 ppm 8 TWA: 10 ppm 8 cutaneous absorption percekben. klukkustundum. tundides. STEL: 20 ppm TWA: 30 mg/m3 8 TWA: 30 mg/m3 8 TWA: 30 mg/m3 8 STEL: 60 mg/m3 órában. klukkustundum. tundides. TWA: 10 ppm potential for cutaneous Skin notation STEL: 15 ppm 15 TWA: 30 mg/m3 absorption Ceiling: 20 ppm minutites. Ceiling: 60 mg/m3 STEL: 45 mg/m3 15 minutites. Component Latvia Lithuania Luxembourg Malta Romania Dimethylformamide STEL: 45 mg/m3 TWA: 10 ppm Skin notation TWA: 30 mg/m3 TWA: 30 mg/m3 TWA: 3.3 ppm 8 ore Skin notation TWA: 10 mg/m3 8 ore STEL: 15 ppm STEL: 10 ppm 15 STEL: 45 mg/m3 minute STEL: 30 mg/m3 15 minute _____________________________________________________________________________________________ ACR37466 Page 5 / 11 SAFETY DATA SHEET 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide _____________________________________________________________________________________________