SAFETY DATA SHEET
Creation Date 07-Dec-2009 Revision Date 21-May-2012 Revision Number 3 SECTION 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product Identifier Product Description: 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in dimethylformamide Cat No. 374660000; 374660250; 374661000
Relevant identified uses of the substance or mixture and uses advised against Recommended Use Laboratory chemicals Uses advised against No Information available
Details of the supplier of the safety data sheet Company Acros Organics BVBA Janssen Pharmaceuticalaan 3a 2440 Geel, Belgium E-mail address [email protected]
Emergency Telephone Number For information in the US, call: 001-800-ACROS-01 For information in Europe, call: +32 14 57 52 11
Emergency Number, Europe: +32 14 57 52 99 Emergency Number, US: 001-201-796-7100
CHEMTREC Phone Number, US: 001-800-424-9300 CHEMTREC Phone Number, Europe: 001-703-527-3887
SECTION 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture REGULATION (EC) No 1272/2008 Acute dermal toxicity Category 4 Acute Inhalation Toxicity - Vapors Category 4 Skin Corrosion/irritation Category 1 B Serious Eye Damage/Eye Irritation Category 1 Reproductive Toxicity Category 1B
Classification according to EU Directives 67/548/EEC or 1999/45/EC For the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16 Symbol(s) T - Toxic R-phrase(s) R61 - May cause harm to the unborn child R34 - Causes burns Risk Combination Phrases R20/21 - Harmful by inhalation and in contact with skin
______ACR37466 Page 1 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
SECTION 2. HAZARDS IDENTIFICATION Label Elements
Signal Word Danger Hazard Statements H314 - Causes severe skin burns and eye damage H332 - Harmful if inhaled H312 - Harmful in contact with skin H360D - May damage the unborn child
Precautionary Statements - EU (§28, 1272/2008) P280 - Wear protective gloves/ protective clothing/ eye protection/ face protection P261 - Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing P308 + P313 - IF exposed or concerned: Get medical advice/ attention
Other Hazards No information available.
SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS
Component EC-No. Weight % CAS-No 67/548/EEC CLP REACH No. Classification Classification - Regulation (EC) No 1272/2008 1-Propanephosphonic acid cyclic 50 68957-94-8 C; R34 Skin Corr. 1B 01-0000016872-65 anhydride (H314) 68957-94-8 Eye Dam. 1 (H318)
______ACR37466 Page 2 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS Dimethylformamide EEC No. 200-679-5 50 68-12-2 Xn; R20/21 Acute Tox. 4 01-2119475605-32 68-12-2 Xi; R36 (H312) Repr.Cat.2; R61 Acute Tox. 4 (H332) Eye Irrit. 2 (H319) Repr. 1B (H360D) Flam. Liq. 3 (H226)
For the full text of the R-phrases and H-Statements mentioned in this Section, see Section 16
SECTION 4. FIRST AID MEASURES
Description of first aid measures Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Immediate medical attention is required.
Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.
Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.
Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth resuscitation if victim ingested or inhaled the substance; induce artificial respiration with a respiratory medical device. Immediate medical attention is required.
Notes to Physician Treat symptomatically
SECTION 5. FIRE-FIGHTING MEASURES
Extinguishing media
Suitable Extinguishing Media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Cool closed containers exposed to fire with water spray.
Extinguishing media which must not be used for safety reasons No information available.
Special hazards arising from the substance or mixture
Combustible material. Containers may explode when heated.
Advice for fire-fighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.
______ACR37466 Page 3 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
SECTION 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Keep people away from and upwind of spill/leak. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary measures against static discharges.
Environmental precautions
Should not be released into the environment.
Methods and material for containment and cleaning up
Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.
SECTION 7. HANDLING AND STORAGE
Precautions for Safe Handling
Use only under a chemical fume hood. Wear personal protective equipment. Do not get in eyes, on skin, or on clothing. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Use explosion-proof equipment. Do not breathe vapors/dust. Do not ingest. Take precautionary measures against static discharges.
Conditions for safe storage, including any incompatibilities
Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat and sources of ignition.
Specific End Uses
SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Exposure limits Component European Union The United Kingdom France Belgium Spain Dimethylformamide Possibility of significant STEL: 20 ppm 15 min VME: 10 ppm 8 heures. TWA: 5 ppm 8 uren Skin uptake through the skin STEL: 61 mg/m3 15 min VME: 30 mg/m3 8 TWA: 15 mg/m3 8 uren VLA-ED: 10 ppm 8 TWA: 10 ppm 8 hr heures. STEL: 10 ppm 15 horas TWA: 30 mg/m3 8 hr Skin minuten VLA-ED: 30 mg/m3 8 Skin STEL: 30 mg/m3 15 horas minuten Huid
______ACR37466 Page 4 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
Component Italy Germany Portugal The Netherlands Finland Dimethylformamide MAK: 5 ppm 8 Stunden. TWA: 10 ppm 8 horas TWA: 5 ppm 8 tunteina MAK: 15 mg/m3 8 Pele TWA: 15 mg/m3 8 Stunden. tunteina skin notation STEL: 10 ppm 15 Skin minuutteina Peak: 20 ppm STEL: 30 mg/m3 15 Peak: 60 mg/m3 minuutteina TWA: 10 ppm 8 Skin Stunden. exposure factor 2 TWA: 30 mg/m3 8 Stunden. exposure factor 2
Component Austria Denmark Switzerland Poland Norway Dimethylformamide Skin TWA: 10 ppm 8 timer Skin NDSCh: 30 mg/m3 15 TWA: 10 ppm 8 timer STEL: 40 ppm 15 TWA: 30 mg/m3 8 timer STEL: 20 ppm 15 minutach TWA: 30 mg/m3 8 timer Minuten Skin Minuten TWA: 15 mg/m3 8 STEL: 20 ppm 15 STEL: 120 mg/m3 15 STEL: 60 mg/m3 15 godzinach minutter. Minuten Minuten Skóra STEL: 45 mg/m3 15 TWA: 10 ppm 8 MAK: 5 ppm 8 Stunden minutter. Stunden MAK: 15 mg/m3 8 Skin TWA: 30 mg/m3 8 Stunden Stunden
Component Bulgaria Croatia Ireland Cyprus Czech Republic Dimethylformamide TWA: 30.0 mg/m3 Skin Notation TWA: 10 ppm 8 hr. TWA: 30 mg/m3 8 TWA: 10 ppm 8 satima. TWA: 30 mg/m3 8 hr. hodinách. TWA: 30 mg/m3 8 STEL: 20 ppm 15 min Potential for cutaneous satima. STEL: 60 mg/m3 15 min absorption STEL: 20 ppm 15 Skin Ceiling: 60 mg/m3 minutama. STEL: 61 mg/m3 15 minutama.
Component Estonia Gibraltar Greece Hungary Iceland Dimethylformamide Skin notation skin - potential for STEL: 120 mg/m3 15 TWA: 10 ppm 8 TWA: 10 ppm 8 cutaneous absorption percekben. klukkustundum. tundides. STEL: 20 ppm TWA: 30 mg/m3 8 TWA: 30 mg/m3 8 TWA: 30 mg/m3 8 STEL: 60 mg/m3 órában. klukkustundum. tundides. TWA: 10 ppm potential for cutaneous Skin notation STEL: 15 ppm 15 TWA: 30 mg/m3 absorption Ceiling: 20 ppm minutites. Ceiling: 60 mg/m3 STEL: 45 mg/m3 15 minutites.
Component Latvia Lithuania Luxembourg Malta Romania Dimethylformamide STEL: 45 mg/m3 TWA: 10 ppm Skin notation TWA: 30 mg/m3 TWA: 30 mg/m3 TWA: 3.3 ppm 8 ore Skin notation TWA: 10 mg/m3 8 ore STEL: 15 ppm STEL: 10 ppm 15 STEL: 45 mg/m3 minute STEL: 30 mg/m3 15 minute
______ACR37466 Page 5 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
Component Russia - TWA Slovak Republic Slovenia Sweden Turkey Dimethylformamide Skin notation Ceiling: 60 mg/m3 TWA: 10 ppm 8 urah STV: 15 ppm 15 MAC: 10 mg/m3 TWA: 10 ppm TWA: 30 mg/m3 8 urah minuter TWA: 30 mg/m3 Potential for cutaneous STV: 45 mg/m3 15 absorption minuter STEL: 40 ppm 15 LLV: 10 ppm 8 timmar. minutah LLV: 30 mg/m3 8 STEL: 120 mg/m3 15 timmar. minutah Skin notation
Biological limit values Component European Union United Kingdom France Spain Germany Dimethylformamide Total N- N-Methylformamide: 15 N,N-Methylformamide: Methylformamide: 40 mg/L urine end of shift 35 mg/L urine end of mg/g creatinine urine N-Acetyl-S-(N- shift end of shift methylcarbamoyl) cysteine: 40 mg/L urine start of last shift of workweek
Component Austria Switzerland Poland Norway Ireland Dimethylformamide N-Methylformamide: 15 mg/L urine end of shift
Component Bulgaria Gibraltar Latvia Luxembourg Romania Dimethylformamide Methyl-formamide: 15 mg/L urine end of shift
Component Slovak Republic Turkey Dimethylformamide N-Methylformamide: 35 mg/L urine end of exposure or work shift
Derived No Effect Level (DNEL) No information available. Predicted No Effect Concentration No information available. (PNEC)
Exposure controls
Engineering Measures Use only under a chemical fume hood Ensure that eyewash stations and safety showers are close to the workstation location Use explosion-proof electrical/ventilating/lighting/equipment Personal protective equipment Eye Protection Safety glasses with side-shields Hand Protection Protective gloves Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced
______ACR37466 Page 6 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
Hygiene Measures Handle in accordance with good industrial hygiene and safety practice Environmental exposure controls No information available.
SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical State Liquid Appearance Yellow pH No information available. Boiling Point/Range 153°C / 307.4°F Melting Point/Range No information available. Flash Point 62°C / 143.6°F Autoignition Temperature 340°C / 644°F
Explosion Limits Lower 2.2 vol% Upper 16.8 vol% Water Solubility miscible Specific Gravity 1.090 Molecular Formula C9 H21 O6 P3 Molecular Weight 318.18
SECTION 10. STABILITY AND REACTIVITY
Reactivity
Chemical Stability
Moisture sensitive.
Possibility of Hazardous Reactions
Hazardous Polymerization Hazardous polymerization does not occur. Hazardous Reactions . None under normal processing..
Conditions to Avoid
Incompatible products, Excess heat, Keep away from open flames, hot surfaces and sources of ignition, Exposure to moist air or water.
Incompatible Materials
Strong oxidizing agents.
Hazardous Decomposition Products
Carbon monoxide (CO). Carbon dioxide (CO2). Oxides of phosphorus.
______ACR37466 Page 7 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
SECTION 11. TOXICOLOGICAL INFORMATION
Information on Toxicological Effects
Acute Toxicity
Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation (Dust) Dimethylformamide 3040 mg/kg ( Rat ) 1500 mg/kg (Rabbit) 3.2 g/kg ( Rat )
Chronic Toxicity Carcinogenicity There are no known carcinogenic chemicals in this product Component IARC UK 1-Propanephosphonic acid group 3 cyclic anhydride
Sensitization No information available. Mutagenic Effects No information available Reproductive Effects No information available. Developmental Effects May cause harm to the unborn child Target Organs None known. Endocrine Disruptor Information Component EU - Endocrine Disrupters EU - Endocrine Disruptors - Japan - Endocrine Disruptor Candidate List Evaluated Substances Information Dimethylformamide Group III Chemical
SECTION 12. ECOLOGICAL INFORMATION
Toxicity
Ecotoxicity effects Component Freshwater Algae Freshwater Fish Microtox Water Flea 1-Propanephosphonic Brachydanio rerio: LC50 > EC50 > 100 mgL/48h acid cyclic anhydride 100 mg/L/96h
______ACR37466 Page 8 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
Dimethylformamide EC50 = 7500 mg/L/96h Pimephales promelas: EC50 = 2000 mg/L 5 min EC50 = 7500 mg/L/48h LC50 = 10.6 g/L/96h EC50 = 570 mg/L 240 h Onchorhynchus mykiss: LC50 = 9.8 g/L/96h Lepomis macrochirus: LC50 = 6.3 g/L/96h
Persistence and degradability
Not readily biodegradable
Bioaccumulative potential
No information available.
Component log Pow 1-Propanephosphonic acid cyclic anhydride 0.49 Dimethylformamide -1.028
Mobility in soil
No information available.
Results of PBT and vPvB assessment
Other adverse effects
No information available
SECTION 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Waste from Residues / Unused Dispose of in accordance with local regulations Products
Contaminated Packaging Empty containers should be taken to local recyclers for disposal
SECTION 14. TRANSPORT INFORMATION
IMDG/IMO UN-No UN3265 Hazard Class 8 Packing Group II Proper Shipping Name Corrosive liquid, acidic, organic, n.o.s
______ACR37466 Page 9 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
SECTION 14. TRANSPORT INFORMATION ADR UN-No UN3265 Hazard Class 8 Packing Group II Proper Shipping Name Corrosive liquid, acidic, organic, n.o.s
IATA UN-No UN3265 Hazard Class 8 Packing Group II Proper Shipping Name Corrosive liquid, acidic, organic, n.o.s
SECTION 15. REGULATORY INFORMATION
Safety, health and environmental regulations/legislation specific for the substance or mixture
International Inventories
Component EINECS ELINCS NLP TSCA DSL NDSL PICCS ENCS CHINA AICS KECL 1-Propanephosphonic acid cyclic -- -X------anhydride Dimethylformamide 200-679-5 - X X - XXXXX
Legend
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory EINECS/ELINCS - European Inventory of Existing Commercial Chemical Substances/EU List of Notified Chemical Substances DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japan Existing and New Chemical Substances CHINA - China Inventory of Existing Chemical Substances AICS - Inventory of Chemical Substances KECL - Existing and Evaluated Chemical Substances
Chemical Safety Assessment
SECTION 16. OTHER INFORMATION
______ACR37466 Page 10 / 11 SAFETY DATA SHEET
1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in Revision Date 21-May-2012 dimethylformamide ______
SECTION 16. OTHER INFORMATION Full text of R-phrases referred to under sections 2 and 3 R34 - Causes burns R36 - Irritating to eyes R61 - May cause harm to the unborn child R20/21 - Harmful by inhalation and in contact with skin
Revision Date 21-May-2012 Revision Summary Reason for revision (M)SDS sections updated, 3. This safety data sheet complies with the requirements of Regulation (EC) No. 1907/2006 Disclaimer The information provided on this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text.
End of Safety Data Sheet
______ACR37466 Page 11 / 11