Zhiyi Zuo, M.D., Ph.D. Phone: (434) 982 4481 (work) or (434) 227-1007 (Cell) Address: Department of Anesthesiology, University of Virginia Health System, PO Box 800710, Charlottesville, VA 22908 ACADEMIC POSITIONS 10/1990 - 11/1990: Attending Physician of Anesthesiology Sun Yat-Sen University of Medical Sciences, Guangzhou, China. 07/2000 – 06/2003: Assistant Professor of Anesthesiology University of Virginia, Charlottesville, VA. 12/2002 – 06/2003: Assistant Professor of Neuroscience (secondary appointment) University of Virginia, Charlottesville, VA. 07/2003 – 06/2005: Associate Professor of Anesthesiology University of Virginia, Charlottesville, VA. 07/2003 – 06/2007: Associate Professor of Neuroscience (secondary appointment) University of Virginia, Charlottesville, VA. 04/2004 – 06/2005: Assistant Professor of Neurosurgery (secondary appointment) University of Virginia, Charlottesville, VA. 07/2005 – 06/2007: Associate Professor of Anesthesiology (tenured) University of Virginia, Charlottesville, VA. 07/2005 – 06/2007: Associate Professor of Neurosurgery (secondary appointment) University of Virginia, Charlottesville, VA. 07/2007 – present: Professor of Anesthesiology (without term) University of Virginia, Charlottesville, VA. 07/2007 – present: Professor of Neuroscience (secondary appointment) University of Virginia, Charlottesville, VA. 07/2007 – present: Professor of Neurosurgery (secondary appointment) University of Virginia, Charlottesville, VA. 07/2007 – present: Robert M. Epstein Professor (without term) University of Virginia, Charlottesville, VA EDUCATION 09/1978 - 08/1983: M.D. Zhongshan Medical College, Guangzhou, China. 09/1985 - 08/1988: Master’s Degree of Anesthesiology Sun Yat-Sen University of Medical Sciences (formerly Zhongshan Medical College), Guangzhou, China. 12/1990 - 02/1994: Ph.D. Major: receptor physiology, pharmacology and biochemistry. University of Cambridge, Cambridge, UK. CLINICAL TRAINING 09/1983 - 08/1985: General Surgery Resident Yichun Medical Academic School, Jiangxi, China. 09/1985 - 07/1989: Anesthesia Resident Sun Yat-Sen University of Medical Sciences, Guangzhou, China. Zhiyi Zuo, MD, Ph.D. 1 08/1989 - 09/1990: Anesthesia Chief Resident Sun Yat-Sen University of Medical Sciences, Guangzhou, China. 07/1996 – 06/2000: Anesthesia Resident (combining program of internship and residency) Department of Anesthesiology, University of Virginia, Charlottesville, VA. RESEARCH TRAINING 09/1985 - 08/1988: Master’s Degree Candidate Sun Yat-Sen University of Medical Sciences, Department of Anesthesiology, Guangzhou, China Research areas: physiological and pharmacological studies related to anesthesia 12/1990 - 02/1994: Ph.D. Student University of Cambridge, Physiological Laboratory, Cambridge, UK Research area: C-type natriuretic peptide receptors (particulate guanylyl cyclase). 03/1994 – 06/1996: Research Associate University of Virginia, Department of Anesthesiology, Charlottesville, USA Research area: anesthetics and the nitric oxide signaling pathway ADDITIONAL TRAINING May 18 – 23, 2003: Financial management for non-financial managers. Darden Graduate School of Business Administration, University of Virginia, Charlottesville, USA Sept. 21 – 24, 2003: Strategic decision making. Darden Graduate School of Business Administration, University of Virginia, Charlottesville, USA 09/2018 – 12/2018: Leadership in Academic Matters, Office of the Executive Vice President and Provost, University of Virginia, Charlottesville, USA LICENSURE AND CERTIFICATION Permanent ECFMG Certificate, 1995, Certificate No.: 0-528-243-9. Commonwealth of Virginia Board of Medicine, 1999, License No.: 0101221056. North Carolina Medical Board, 2005, License No.: 2005-00817 Diplomat of the American Board of Anesthesiology, April 26, 2002, No.: 35045 MAJOR COMMITTEE AND ADMINISTRATIVE ACTIVITIES 08/1988 – 11/1990: Director of Operating Room, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 07/2004 – present: Vice Chair for Research/Research Committee Chair, Department of Anesthesiology, University of Virginia, USA. 2007 – present: Member, Promotion and Tenure Committee, Department of Anesthesiology, University of Virginia, USA. 2008 – 2011: Member, Scientific Advisory Committee, Association of University Anesthesiologists, USA. Zhiyi Zuo, MD, Ph.D. 2 2010 – present: Academic Chair, Department of Anesthesiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. 2010 – 2014: Member, Scientific Advisory Committee, Society of Neurosurgical Anesthesia & Critical Care, USA. 2012 – 2015: Member, Geriatric Anesthesia Committee, American Society of Aneshesiologists, USA. 2012 – 2014: President: International Chinese Academy of Anesthesiology 2013 – present: Member, Neuroscience Abstract Review Committee, American Society of Aneshesiologists, USA. 2015 – present: Chair, Promotion and Tenure Committee, Department of Anesthesiology, University of Virginia, USA. 2017 – present: Member, Promotion and Tenure Committee, School of Medicine, University of Virginia, USA. 2018 – present: President: World Association of Chinese Anesthesiologists GRANT SUPPORT 01/2001 – 12/2001: Hypoxic effects on glutamate transporters in rat neurons and glial cells. $20,279.8, Principal Investigator: Zhiyi Zuo Research and Development Committee, University of Virginia School of Medicine. 01/2001 – 12/2002: Inhalational anesthetics and glutamate transporters. $67,401.55, Principal Investigator: Zhiyi Zuo Foundation for Anesthesia Education and Research 07/2001 – 06/2003: The effects of reversed transport of glutamate on glutamate accumulation and neuronal survival under hypoxic and ischemic conditions. $132,000, Principal Investigator: Zhiyi Zuo American Heart Association-Mid-Atlantic Affiliate, Beginner Grant-in- Aid. 02/2003 – 01/2008: Volatile anesthetic modulation of glutamate transporters. RO1 GM065211 (year 1-5), $1,332,000 (total) Principal Investigator: Zhiyi Zuo National Institutes of Health, USA 01/2004 - 12/2007: Neuroprotection after isoflurane preconditioning. RO1 NS045983, $1,163,246 (total), Principal Investigator: Zhiyi Zuo National Institutes of Health, USA 07/2007 – 06/2013: Neuroprotection by RNA interference-produced autoregulation of inducible nitric oxide synthase expression Frontiers in Anesthesia Research Award, $500,000 Principal Investigator: Zhiyi Zuo International Anesthesia Research Society 07/2007 – 06/2009: Role of p38 mitogen-activated protein kinase in volatile anesthetic preconditioning-induced neuroprotection $132,000, Principal Investigator: Zhiyi Zuo American Heart Association-Mid-Atlantic Affiliate, Grant-in-Aid. 12/2007 – 11/2008: Volatile anesthetic modulation of glutamate transporter type 3 $99,691, Principal Investigator: Zhiyi Zuo Zhiyi Zuo, MD, Ph.D. 3 Vice President for Research and Graduate Studies Office, University of Virginia 08/2008 – 04/2012: Volatile anesthetic modulation of glutamate transporters. RO1 GM065211 (year 6-9), $1,172,610, Principal Investigator: Zhiyi Zuo National Institutes of Health, USA 09/2009 – 08//2011: Volatile anesthetic modulation of glutamate transporters. 3RO1 GM065211-S, $181,674, Principal Investigator: Zhiyi Zuo National Institutes of Health, USA 07/2010 – 06/2013: Effects of oral hypoglycemics and dietary restriction on tau phosphorylation in diabetic mice 10GRNT3900019, $154,000, Principal Investigator: Zhiyi Zuo American Heart Association-Mid-Atlantic Affiliate, Grant-in-Aid. 04/2011 – 03/2012: Identification of regulatory factor X-regulated genes $6,300, Principal Investigator: Zhiyi Zuo Research and Development Committee, University of Virginia School of Medicine. 09/2012 – 08/2016: Volatile anesthetic effects on aging brain 1R01GM098308, $1,200,800, Principal Investigator: Zhiyi Zuo National Institutes of Health, USA 02/2013 – 01/2014: Role of regulatory factor X1 in the human glioblastoma $61,648, Principal Investigator: Zhiyi Zuo Voices against brain tumor, USA 03/2014 – 02/2015: Anesthetic choice and amantadine on postoperative cognitive dysfunction $35,000, Principal Investigator: Zhiyi Zuo School of Medicine, Vice President for Research and Graduate Studies Office and department of Anesthesiology, University of Virginia 07/2014 – 06/ 2015: Environmental enrichment reduces postoperative cognitive dysfunction $45,000, Principal Investigator: Zhiyi Zuo Commonwealth of Virginia Alzheimer’s and Related Disease Research Fund. 08/2015 – 04/2017: Attenuation of postoperative cognitive dysfunction by amantadine 1R21 AG047472, $434,500, Principal Investigator: Zhiyi Zuo National Institutes of Health, USA 09/2017 – 07/2022: Glial cell line-derived neurotropic factor and postoperative cognitive impairment in young rats R01HD089999, $1,674,700, Principal Investigator: Zhiyi Zuo National Institutes of Health, USA 07/2017 – 04/2022: Photoacoustic Microscopy of the Awake Mouse Brain 1R01NS099261, $1,646,203, Principal Investigator: Song Hu (Role for Dr. Zuo: Co-Investigator, about 1/3 budget) National Institutes of Health, USA 09/2017 – 05/2019: Postoperative cognitive dysfunction and enriched environment 1R21AG056995, $434,500, Principal Investigator: Zhiyi Zuo National Institutes of Health, USA 04/2018 – 03/2023: Obesity-induced cerebral vascular remodeling and poor brain ischemic tolerance 1 R01 NS099118, $1,725,681, Principal Investigator: Zhiyi Zuo Zhiyi Zuo, MD, Ph.D. 4 National Institutes of Health, USA (Note: a K02 award from the National Institutes of Health, USA, had to be declined in 2004 due to the lack of my time for having