UvA-DARE (Digital Academic Repository) Mutational profiling of glioblastoma Bleeker, F.E. Publication date 2009 Document Version Final published version Link to publication Citation for published version (APA): Bleeker, F. E. (2009). Mutational profiling of glioblastoma. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. 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UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl) Download date:28 Sep 2021 Sequenced genes Gene Gene Name Cytoband Ch ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 9q31.1 4 ADAM12 A disintegrin and metalloproteinase domain 12 10q26.3 5 ADAMTS18 A disintegrin and metalloproteinase with thrombospondin 16q23 5 motifs 18 ADAMTSL3 ADAMTS-like 3 15q25.2 4 AIM1 Absent in melanoma 1 protein 5p13.3 5 AKT1 V-akt murine thymoma viral oncogene homolog 1 14q32.32 6,7 AKT2 V-akt murine thymoma viral oncogene homolog 2 19q13.1-q13.2 3 ALK Anaplastic lymphoma kinase 2p23 5 ATM Ataxia telangiectasia mutated 11q22-q23 3 ATP8B1 ATPase, Class I, type 8B, member 1 18q21.31 4 ATR Ataxia telangiectasia and Rad3 related 3q22-q24 3 BRAF V-raf murine sarcoma viral oncogene homolog B1 7q34 3 BRD2 Bromodomain containing 2 6p21.3 3 CUBN Cubilin (intrinsic factor-cobalamin receptor) 10p12.31 4 DDR1 Discoidin domain receptor tyrosine kinase 1 6p21.3 3 DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 10p15.3 4 DYRK2 Dual-specificity tyrosine-(Y)-phosphorylation regulated 12q15 3 kinase 2 EDD1 Hyperplastic discs protein homolog 8q22 5 EGFL6 EGF-like-domain, multiple 6 Xp22 4 EGFR Epidermal growth factor receptor (erythroblastic leukemia 7p12 3 viral (v-erb-b) oncogene homolog, avian) EPHA3 EPH receptor A3 3p11.2 4 EPHA3 EPH receptor A3 3p11.2 3 EPHA5 EPH receptor A5 4q13.1 3 EPHA6 EPH receptor A6 3q11.2 3 EPHB2 EPH receptor B2 1p36.1-p35 3 EPHB6 EPH receptor B6 7q33-q35 4 ERBB2 V-erb-b2 erythroblastic leukemia viral oncogene homolog 17q21.1 3 2 neuro/glioblastoma derived oncogene homolog (avian) ERBB4 V-erb-a erythroblastic leukemia viral oncogene homolog 2q33.3-q34 3 4 (avian) FBXW7 F-box and WD-40 domain protein 7 (archipelago homolog 4q31.3 4 Drosophila) FGFR1 Fibroblast growth factor receptor 1 8p11.2-p11.1 3 FGFR2 Fibroblast growth factor receptor 2 10q26 3 FGFR3 Fibroblast growth factor receptor 3 4p16.3 3 FGFR4 Fibroblast growth factor receptor 4 5q35.1-qter 3 FLNB Filamin B, beta (actin binding protein 278) 3p14.3 4 FLT1 Fms-related tyrosine kinase 1 (vascular endothelial 13q12 3 growth factor/vascular permeability factor receptor) FLT3 Fms-related tyrosine kinase 3 13q12 3 FRAP1 FK506 binding protein 12-rapamycin associated protein 1 1p36.2 3 GAB1 GRB2-associated-binding protein 1 4q31.21 5 GNAS GNAS complex locus 20q13.3 4 GUCY1A2 Guanylate cyclase soluble subunit alpha-2 11q21-q22 5 IDH1 Isocitrate dehydrogenase 1 (NADP+), soluble 2q33.3 9,10 IRS4 Insulin receptor substrate 4 Xq22.3 5 KDR Kinase insert domain receptor (a type III receptor tyrosine 4q11-q12 3 kinase) 164 Proefschrift Bleeker.indd 164 21-5-2009 15:04:38 Sequenced genes Gene Gene Name Cytoband Ch KIAA0999 Serine/threonine-protein kinase QSK 11q23.3 5 KIT V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene 4q11-q12 3 homolog MACF1 Microtubule-actin crosslinking factor 1 1p32-p31 4 MAP2K4 Mitogen-activated protein kinase kinase 4 17p11.2 3 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 19p13.3-p13.2 5 MET Met proto-oncogene (hepatocyte growth factor receptor) 7q31 3 MLL3 Myeloid/lymphoid or mixed-lineage leukemia 3 7q36.1 4 MMP2 Matrix metalloproteinase-2 16q13-q21 5 MYLK4 MYLK4 myosin light chain kinase family, member 4 6p25.2 5 MYO18B Myosin-XVIIIb 22q11.2-q12.1 5 NAV3 Neuron navigator 3 12q14.3 5 NOTCH1 Neurogenic locus notch homolog protein 1 9q34.3 5 NRAS Neuroblastoma RAS viral (v-ras) oncogene homolog 1p13.2 3 NTRK2 Neurotrophic tyrosine kinase, receptor, type 2 9q22.1 3 NTRK3 Neurotrophic tyrosine kinase, receptor, type 3 15q25 3 OBSCN Obscurin, cytoskeletal calmodulin and titin-interacting 1q42.13 4 RhoGEF OR51E1 Olfactory receptor 51E1 11p15.4 5 PAK4 P21 protein (Cdc42/Rac)-activated kinase 4 19q13.2 3 PDGFRA Platelet-derived growth factor receptor, alpha polypeptide 4q11-q13 3 PDPK1 3-Phosphoinositide dependent protein kinase-1 16p13.3 3 PI3KCA Phosphoinositide-3-kinase, catalytic, alpha polypeptide 3q26.3 3 PKHD1 Polycystic kidney and hepatic disease 1 (autosomal 6p12.2 4 recessive) PRKD1 Serine/threonine-protein kinase D1 14q11 5 PRPF4B Serine/threonine-protein kinase PRP4 homolog 6p25.2 5 PTEN Phosphatase and tensin homolog 10q23.3 3 RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 5q13 5 RET Proto-oncogene tyrosine-protein kinase receptor ret 10q11.2 5 precursor RPS6KC1 Ribosomal protein S6 kinase, 52kDa, polypeptide 1 1q41 3 SIX4 Sine oculis homeobox homolog 4 14q23 5 SMAD2 Mothers against decapentaplegic homolog 2 18q21.1 5 SMAD4 Mothers against decapentaplegic homolog 4 18q21.1 5 SORL1 Sortilin-related receptor precursor 11q23.2-q24.2 5 SPTAN1 Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 9q33-q34 4 STK11 Serine/threonine kinase 11 19p13.3 3 SYNE1 Spectrin repeat containing, nuclear envelope 1 6q25 4 TAF1 Transcription initiation factor TFIID subunit 1 Xq13.1 5 TCF7L2 Transcription factor 7-like 2 10q25.3 5 TECTA Tectorin alpha 11q22-q24 4 TGFBR2 Transforming growth factor, beta receptor II (70/80kDa) 3p22 3 TGM3 Transglutaminase-3 20q11.2 5 TP53 Tumor protein p53 17p13.1 3 ZNF668 Zinc finger protein 668 16p11.2 4 Table 1. Genes sequenced in this thesis Sequenced genes are listed alongside their full names, chromosomal locations, Entrez gene ID and the chapter in which they have been sequenced. Abbreviation: Ch, chapter. 165 Proefschrift Bleeker.indd 165 21-5-2009 15:04:38.