CDH4 polyclonal antibody calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a Catalog Number: PAB1864 transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and Regulatory Status: For research use only (RUO) mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In Product Description: Rabbit polyclonal antibody raised addition, a role in kidney and muscle development is against synthetic peptide of CDH4. indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in Immunogen: A synthetic peptide (conjugated with KLH) cotransfected cell lines. Previously thought to interact in corresponding to N-terminus of human CDH4. an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. [provided by Host: Rabbit RefSeq] Reactivity: Human References: Applications: Flow Cyt, IF, IHC-P, WB-Ce 1. CDH4 is a novel determinant of osteosarcoma (See our web site product page for detailed applications tumorigenesis and metastasis. Tang Q, Lu J, Zou C, information) Shao Y, Chen Y, Narala S, Fang H, Xu H, Wang J, Shen J, Khokha R. Oncogene. 2018 Apr 3. [Epub ahead of Protocols: See our web site at print] http://www.abnova.com/support/protocols.asp or product 2. Frequent aberrant methylation of the CDH4 gene page for detailed protocols promoter in human colorectal and gastric cancer. Miotto E, Sabbioni S, Veronese A, Calin GA, Gullini S, Liboni A, Form: Liquid Gramantieri L, Bolondi L, Ferrazzi E, Gafa R, Lanza G, Negrini M. Cancer Res. 2004 Nov 15;64(22):8156-9. Purification: Ammonium sulfate precipitation 3. R-cadherin influences cell motility via Rho family GTPases. Johnson E, Theisen CS, Johnson KR, Recommend Usage: Western Blot (1:1000) Wheelock MJ. J Biol Chem. 2004 Jul Immunohistochemistry (1:10-50) 23;279(30):31041-9. Epub 2004 May 13. Immunofluorescence (1:10-50) Flow cytometry (1:10-50) The optimal working dilution should be determined by the end user. Storage Buffer: In PBS (0.09% sodium azide) Storage Instruction: Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. Entrez GeneID: 1002 Gene Symbol: CDH4 Gene Alias: CAD4, FLJ22202, FLJ40547, MGC126700, MGC138355, RCAD Gene Summary: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a Page 1/1 Powered by TCPDF (www.tcpdf.org).