crossmark HIV Genome-Wide Protein Associations: a Review of 30 Years of Research Guangdi Li,a,b Erik De Clercqb Department of Metabolism and Endocrinology, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, National Clinical Research Center for Metabolic Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan, Chinaa; KU Leuven-University of Leuven, Rega Institute for Medical Research, Department of Microbiology and Immunology, Leuven, Belgiumb Downloaded from SUMMARY ..................................................................................................................................................680 INTRODUCTION ............................................................................................................................................680 LITERATURE SELECTION....................................................................................................................................682 VIRAL ENTRY................................................................................................................................................684 GP120-GP41 Interaction ..................................................................................................................................684 GP41Env-MatrixGag Interaction ............................................................................................................................684 GP120-Tat Interaction ....................................................................................................................................686 http://mmbr.asm.org/ REVERSE TRANSCRIPTION..................................................................................................................................686 RT-Integrase Interaction ..................................................................................................................................688 RT-Nucleocapsid Interaction .............................................................................................................................688 RT-Vif Interaction .........................................................................................................................................690 RT-Tat Interaction.........................................................................................................................................690 RT-Nef Interaction ........................................................................................................................................690 Protease-Tat Interaction ..................................................................................................................................690 RT-tRNALys3-Vpr Association ..............................................................................................................................690 VIRAL INTEGRATION........................................................................................................................................690 Integrase-RT Interaction ..................................................................................................................................692 Integrase-Rev Interaction.................................................................................................................................692 on June 29, 2016 by KU Leuven University Library Integrase-Matrix Interaction ..............................................................................................................................692 Matrix-Vpr Interaction ....................................................................................................................................692 Integrase-Nef Interaction .................................................................................................................................695 Integrase-dsDNA-Vpr Association ........................................................................................................................695 Integrase-dsDNA-Nucleocapsid Association .............................................................................................................695 Integrase-TNPO3/CypA-Capsid Association ..............................................................................................................695 VIRAL TRANSCRIPTION AND TRANSLATION...............................................................................................................695 Tat-Rev Interaction .......................................................................................................................................696 Tat-Vpr Interaction........................................................................................................................................697 Tat-Nef Interaction .......................................................................................................................................697 Tat-Nucleocapsid Interaction.............................................................................................................................697 Vif-Vpr Interaction ........................................................................................................................................697 Rev-CRM1-MatrixGag Association .........................................................................................................................697 Rev-CG1-Vpr Association .................................................................................................................................698 Tat-p300/SWI/SNF-Integrase Association ................................................................................................................698 VIRAL ASSEMBLY AND BUDDING ..........................................................................................................................698 MatrixGag-GP41Env Interaction ............................................................................................................................698 NCGag-Vif Interaction .....................................................................................................................................699 NCGag-Vpr Interaction ....................................................................................................................................700 p6Gag-Vpr Interaction.....................................................................................................................................700 p6Gag-Vpx Interaction ....................................................................................................................................700 GP41Env-Nef Interaction ..................................................................................................................................700 Gag-RT Interaction .......................................................................................................................................700 MatrixGag-RNA-NCGag Association ........................................................................................................................701 (continued) Published 29 June 2016 Citation Li G, De Clercq E. 2016. HIV genome-wide protein associations: a review of 30 years of research. Microbiol Mol Biol Rev 80:679–731. doi:10.1128/MMBR.00065-15. Address correspondence to Guangdi Li, [email protected], or Erik De Clercq, [email protected]. Supplemental material for this article may be found at http://dx.doi.org/10.1128 /MMBR.00065-15. Copyright © 2016, American Society for Microbiology. All Rights Reserved. September 2016 Volume 80 Number 3 Microbiology and Molecular Biology Reviews mmbr.asm.org 679 Li and De Clercq CapsidGag-LysRS-Vpr Association .........................................................................................................................701 Gag-AIP1-Nef .............................................................................................................................................701 NCGag-Tsg101/AIP1-P6Gag Association ...................................................................................................................701 Vif-APOBEC3G-Integrase Association.....................................................................................................................702 Vif-MAPK/HCK-Nef Association ...........................................................................................................................702 Vpu-CD4-GP120Env Association ..........................................................................................................................702 Vpu-Tetherin/CD4-Nef Association.......................................................................................................................703 Vpu-CK2-Rev Association.................................................................................................................................703 Vpu-UBP-MatrixGag Association...........................................................................................................................703 VIRAL MATURATION .......................................................................................................................................703 Protease-Gag/GagPol Interaction ........................................................................................................................705 Downloaded from Protease-Vif Interaction...................................................................................................................................705