18th Meeting of the International Symposium on Olfaction and Taste hosted by the Association for Chemoreception Sciences (AChemS) Virtual Meeting Program & Abstracts August 3 - 7, 2020 Monday, August 3, 2020 10:00 - 11:30 AM Plenary Room 1 Welcome/Keynote Lecture Welcome By AChemS 2020 President Matt Wachowiak University of Utah Program Highlights Jay Gottfried University of Pennsylvania Awards Ceremony Linda Barlow University of Colorado Keynote: Making And Breaking Memories Sheena Josselyn Neurobiology Laboratory at the Hospital for Sick Children Q&A Pg 1 - 34 Live Symposia & Events Pg 34 - 36 On Demand Symposia Pg 37 - 66 On Demand Oral Abstracts Pg 66 - 126 On Demand Poster Abstracts 12:00 - 1:00 PM Ancillary Room 1 The Nose Knows about COVID-19 Outreach Events (LIVE ONLY - NOT RECORDED) Do you want to learn more about smell and taste? Please visit AChemS Education Corner. There you will find exciting demonstrations and exercises about smell and taste. While most of these activities have been developed with school-aged children in mind, they can be adjusted to any age. Chair(s): Valentina Parma & Yanina Pepino 2:00 - 4:00 PM Parallel Room 1 Gut Instincts: The Role of Intestinal Signals in Regulating Brain and Behavior Studies on the ‘gut-brain axis’ are gaining significant interest and fundamentally changing the way we think about the connections between mind and body. The mechanisms by which the chemical contents of the gut are detected, which intestinal cells are involved in this process, and how this signaling is conveyed to the brain via endocrine and/or neural pathways are topics of many new, exciting studies. In this symposium, we bring together experts in gut chemosensation to discuss this emerging field, highlighting recent breakthroughs, new techniques, and approaches to studying chemical signaling within the gut and from the gut to the brain. Chair(s): Lindsey Macpherson and Hojoon Lee Introduction. Lindsey Macpherson1, Hojoon Lee2 1University of Texas San Antonio, 2Northwestern University The Role Of Postingestional Feedback In Experience-Dependent Changes To Sugar Taste Lindsey Schier University of Southern California Q&A Gut Nutrient Sensing And Brain Reward Pathways Wenfei Han Mount Sinai School of Medicine The presentation will discuss recent evidence supporting a role for the gut-brain axis in controlling brain circuits involved in reward, emotion and motivation. It will be argued in particular that gut- innervating vagal sensory neurons function as reward neurons via their brainstem targets that in turn contact dopaminergic brain reward circuits in midbrain. Q&A A Neural Circuit For Sugar Choice Melanie Maya Kaelberer Duke University Q&A (Don Tucker Award Finalist) Epigenetics Of Sweet Taste And Obesity Anoumid Vaziri, Christina/E May, Morteza Khabiri, Brendan Genaw, Peter/L Freddolino, Monica Dus University of Michigan, Ann Arbor, MI, United States Diet composition can alter food preferences by changing the physiology of the sensory neurons, but the molecular mechanisms for these adaptations are not well understood. In rodents, and fruit flies excess dietary sugar decreases the perception of sweet stimuli increasing the preference for sweet foods and promotes weight gain. To understand how this occurs, we investigated the effects of a high sugar diet on the responses of the sweet sensing cells (Gr5a+) to sugar in D. melanogaster. In flies fed a high sugar diet, the Gr5a+ neurons show lower responses to sugar stimuli because of changes in the activity of the Polycomb Repressive Complex 2 (PRC2). The PRC2 is a chromatin modifying complex that mediates transcriptional repression through the repressive H3K27me3 modification. This complex is both necessary and sufficient to drive the sensory adaptations mediated by excess dietary sugar in the Gr5a+ neurons and prevent weight gain. Ribosomal profiling and targeted DNA Adenine Methyltransferase Identification in the Gr5a+ cells revealed transcription factors directly targeted by PRC2 and changed by the high sugar diet. This group of transcription factors target metabolic, signaling and synaptic genes that shape the activity of the sweet sensory neurons. Manipulations of these factors affected taste function suggesting that PRC2 alters the physiology of the Gr5a+ neurons by enacting a sugar-specific transcriptional program. Interestingly, sweet taste defects persist long after the animals are removed from the sugar diet environment and only reversed if constitutive maintenance by PRC2 is inhibited. Our results reveal how transcriptional pathways inside sensory neurons are altered to instruct forms of behavioral and synaptic plasticity that allow animals to adapt to changing food environments. Q&A Panel Discussion 2:00 - 4:00 PM Parallel Room 2 Olfactory Networks, Rhythms, and Behavior Sensory information from the environment tunes cognitive processing by shaping neuronal networks. Olfactory inputs, which can bypass the primary thalamic relay, are in an optimal position for directly shaping not only stimulus perception but also higher abilities, such as engram formation, emotion and executive behavior. The proposed symposium aims at providing a comprehensive overview on the recent advances in understanding how olfactory information controls the network dynamics and behavior across brain areas, ages (neonatal, juvenile, adult) and species (zebrafish, mouse, rat). The presentations will bring together researchers using cutting-edge tools to discuss olfactory modulation of functional circuits with the goal of integrating across fields to develop new models of olfactory-limbic cross-talk. Chair(s): Ileana Hanganu-Opatz Introduction Ileana Hanganu-Opatz Dev. Neurophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Olfactory Bulb And Piriform Cortex Interactions With The Hippocampal System Depend On Context And Learning Stage Leslie Kay Department of Psychology, Institute for Mind and Biology, The University of Chicago, Chicago, IL, United States Q&A Olfactory Cortical-Limbic Reciprocal Interactions And Their Impact On Odor Coding And Perception Donald Wilson Department of Child and Adolescent Psychiatry, The Child Study Center at NYU Langone Medical Center, New York, NY, United States Q&A Integration Of Olfactory And Limbic Information At The Level Of Habenula Emre Yaksi Kavli Institute for Systems Neuroscience-NTNU, , *, Norway Q&A Olfactory Control Of Developmental Prefrontal-Hippocampal-Entorhinal Communication And Cognitive Maturation Ileana Hanganu-Opatz Dev. Neurophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, *, Germany Q&A Panel Discussion Conclusions 2:00 - 4:00 PM Parallel Room 3 Principles of Gustatory Coding How do nervous systems detect and organize information about taste? A long-standing view is that gustation is simple: using a set of labeled lines, the gustatory system informs the organism when one of a small number of basic tastes is present. However, recent results from several groups challenge this model. This symposium highlights new views of taste processing in insects and vertebrates. Chair(s): Mark Stopfer Introduction Mark Stopfer NIH-NICHD Coding Of Individual Chemicals By The Gustatory System Yu-Shan Hung NIH/NICHD Q&A Cellular Context Determines Appetite And Aversive Taste Properties Of The Conserved Drosophila Gustatory Receptor 28 (Gr28) Protein Family Hubert Amrein Texas A&M University Q&A Combinatorial Cellular And Molecular Codes Underlie Salt Taste In Drosophila Michael Gordon University of British Columbia Q&A So Much Information, So Few Neurons: Taste Coding In Mammals Nirupa Chaudhari University of Miami Q&A Panel Discussion 5:00 - 7:00 PM Parallel Room 1 All Bulb All the Time The olfactory bulb is the gateway of olfactory information to the brain. There is a growing appreciation that the bulb is not a simple relay station of sensory inputs to higher brain centers. Rather, the bulb serves as a dynamic filter of olfactory information. The response of principal neurons in the bulb to odorants is influenced by a variety of factors, such as brain state, experience, and learning through a variety of mechanisms such as local inhibitory circuits and centrifugal feedback that includes glutamatergic, neuromodulatory, and gabaergic projections. This symposium aims to bring the latest findings on the mechanisms underlying flexible information coding in the olfactory bulb. Chair(s): Takaki Komiyama and Florin Albeanu Introduction Takaki Komiyama University of California San Diego Context-Dependent Plasticity Of Adult-Born Neurons Regulated By Cortical Feedback AN WU1,2, Bin Yu1,2,3, Qiyu Chen1,2, Lu Chen1,2, Takaki Komiyama1,2 1Neurobiology Section, and Center for Neural Circuits and Behavior, University of California San Diego, La Jolla, CA, United States, 2Department of Neurosciences, and Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, United States, 3Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, United States Q&A A Non-Canonical Feedforward Pathway For Computing Odor Identity Honggoo Chae CSHL Q&A Fast Dynamics Of The Odour Landscape Are Encoded In The Mouse Olfactory System And Guide Behaviour Andreas Schaefer UCL Q&A Exploring Granule Cells Diversity Marta Pallotto Center of Advanced European Studies and Research Q&A Olfactory Bulb Local Inhibition Improves Downstream Odor Representation By Synchronizing M/T Responses Rafi Haddad Weizmann Institute of Science Q&A 5:00 - 7:00 PM Parallel Room 2 Gustation