Inhalt Abkürzungen 3 Glossar 9 Referenzen 25 Antimikrobielle Therapie 26 Antimikrobielle non-Suszeptibilität / Resistenz 29 Multiresistenz 30 Ambler Klassifikation von ß-Lactamasen 32 Besondere Klassifikationen 33 BSL (Bio-Safety Level, Biologische Schutzstufe) 33 Priority Pathogens (NIAID) / Bioterrorism Agents (000) 34 Select agents (Tier 1 BSATs) 34 UN 2814 (Infectious substances Meeting humans) 34 WHO Pandemie Alert Phases 35 Pandemie Severity Index (PSI) 36 Baltimore Klassifikation von Viren 36 Viren Togaviridae [(+)ssRNAJ Chikungunya Virus: Chikungunya Virusinfektion 41 Onyong-Nyong Virus: Onyong-Nyong Virusinfektion 43 Semliki Forest Virus: Semliki Forest Virusinfektion 44 Ross River Virus: Ross River Virusinfektion 45 Mayaro Virus: Mayaro Virusinfektion 46 Rastern Equine Encephalitis Virus, Madariaga Virus: Rastern Equine Encephalitis, Madariaga Virusinfektion 47 Western Equine Encephalitis Virus: Western Equine Encephalitis 49 Venezuelan Equine Encephalitis Virus: Venezuelan Equine Encephalitis 50 Sindbis Virus: Sindbis Virusinfektion 52 Barmah Forest Virus: Barmah Forest Virusinfektion 53 Rubella Virus: Rubella Virusinfektion (Röteln), Congenitales Rubella Syndrom (CRS) 54 Flaviviridae [(+)ssRNA] Dengue Virus: Dengue Virusinfektion 56 Japanische Encephalitis Virus: Japanische Encephalitis (JE) 59 West Nil Virus, Kunjin Virus: West Nil Virusinfektion, Kunjin Virusinfektion 61 Usutu Virus: Usutu Virusinfektion 63 Murray Valley Encephalitis Virus: Murray Valley Encephalitis Virus Infektion, „Australien Encephalitis“ 64 Saint Louis Encephalitis Virus: Saint Louis Encephalitis 65 Zika Virus: Zika Virusinfektion 66 Gelbfieber Virus: Gelbfieber Virusinfektion 68 Wesselsbron Virus: Wesselsbron Virusinfektion Tick Borne Encephalitis Virus (TBEV, inkl. CEEV, RSSEV): Tick Borne Encephalitis Virus Infektion (inkl. FSME) 71 Alkhurma Virus: Alkhurma Virusinfektion...................................................................................................................... 73 Powassan Virus: Powassan Virusinfektion 74 Omsk Hemorrhagic Fever Virus: Omsk Haemorrhagisches Fieber 76 Kyasanur Forest Disease Virus: Kyasanur Forest Disease 77 Hepatitis C Virus: Hepatitis C Virusinfektion 78 Picornaviridae [(+)ssRNA] Hepatitis A Virus: Hepatitis A Virusinfektion 80 Rhinovirus: Rhinovirus Infektion 82 Poliovirus: Poliovirusinfektion, Poliomyelitis 83 Enterovirus (non-Poliovirus / non-Rhinovirus), Coxsackievirus, Echovirus: Enterovirusinfektion (inkl. Coxsackieviren, Echoviren) Cardiovirus: Cardiovirus Infektion & Parechovirus: Parechovirus Infektion 9( XIV Coronaviridae [(+)ssRNA] Coronaviren: Coronavirus Infektion................................................................................................................................91 SARS-Coronavirus: Severe Acute Respiratory Syndrome (SARS).............................................................................92 MERS-Coronavirus: Middle East Respiratory Syndrome (MERS)................................................................................94 Caliciviridae [(+)ssRNA] Norovirus spp. (inkl. Norwalk Virus): Norovirus / Norwalk virus Infektion....................................................................97 Sapoviren (inkl. Sapporo virus): Sapovirus Infektion.....................................................................................................99 Hepeviridae [(+)ssRNA] Hepatitis E Virus: Hepatitis E Virusinfektion................................................................................................................ 100 Astroviridae [(+)ssRNA] Astrovirus: Astrovirus Infektion....................................................................................................................................102 Retroviridae [ssRNA-RT] Humanes Immundefizienz Virus (HIV): HIV Erkrankung, akutes retrovirales Syndrom, AIDS...................................103 Human T-Lymphotropic Virus (HIEV): Adultes T-Zell Leukämie-Lymphom (ATLL), Tropische Spastische Paraparese (ISP)............................................................................................................................................................106 Bunyavirales [(-)ssRNA] Orthohantavirus spp. (Hantaviren): Orthohantavirus Infektion, HFRS, HPS..............................................................108 Orthobunyavirus spp: Orthobunyavirus Infektion........................................................................................................111 Krim-Kongo haemorrhagisches Fieber Orthonairovirus: Krim-Kongo haemorrhagisches Fieber........................... 113 Phlebovirus - Sandfly fever serocomplex (inkl. SFNV, TOSV, SFSV): Phlebotomus Fieber..................................... 115 Phlebovirus - Ritt Valley Fieber Phlebovirus: Ritt Valley Fieber (RVF)........................................................................ 117 Phlebovirus - Adria Virus: Adria Virusinfektion.............................................................................................................119 Phlebovirus - SETS Phlebovirus: Severe Fever with Thrombocytopenia Syndrome (SFTS).................................... 120 Phlebovirus - Heartland Virus: Heartland Virusinfektion..............................................................................................122 Arenaviridae [(-)ssRNA] Lassa mammarenavirus: Lassa Virusinfektion............................................................................................................123 Lujo Mammarenavirus: Lujo Haemorrhagisches Fieber (LUHF)................................................................................. 125 Lymphocytic choriomeningitis mammarenavirus: Lymphocytäre Choriomeningitis................................................. 126 Neuwelt / Tacaribe Arenavirus Komplex: Südamerikanische haemorrhagische Fieber...........................................128 Rhabdoviridae [(-)ssRNA] Rabies Lyssavirus: Rabies (Tollwut)..............................................................................................................................131 Lyssavirus spp. (Übersicht)...........................................................................................................................................134 Chandipura Vesiculovirus: Chandipura Virusinfektion.................................................................................................135 Vesicular Stomatitis Virusgruppe: Vesicular Stomatitis Virusinfektion....................................................................... 136 Filoviridae [(-)ssRNA] Filoviridae (inkl. Ebolavirus, Marburgvirus): Ebola Virus-Krankheit, Marburg Virus-Krankheit................................. 137 Paramyxoviridae [(-)ssRNAJ Parainfluenza Virus: Parainfluenza Virusinfektion.........................................................................................................141 Masern Morbillivirus: Masern Virusinfektion / Rubeola...............................................................................................143 Mumps Rubulavirus: Mumps Virusinfektion, Parotitis epidemica............................................................................. 145 Henipa Virusgruppe (inkl. Hendra henipavirus, Nipah henipavirus): Henipavirus Infektion...................................... 147 Pneumoviridae [(-)ssRNA] Respiratory Syncytial Virus: Respiratory Syncytial Virus (RSV) Infektion....................................................................149 Metapneumovirus: Metapneumovirus Infektion...........................................................................................................151 Orthomyxoviridae [(-)ssRNA] Influenzaviren: Influenza Virusinfektion........................................................................................................................152 Hepadnaviridae [dsDNA] Hepatitis B Virus: Hepatitis B Virusinfektion...............................................................................................................156 XV Deltaviren [(-)ssRNA] Hepatitis Delta Virus: Hepatitis D Virusinfektion.......................................................................................................... 159 Herpesviridae [dsDNA] Human alphaherpesvirus 1 -2 (HHV1 -2) / Herpes Simplex Virus (HSV1 -2): Herpes Simplex Virusinfektion...........161 Human alphaherpesvirus 3 (HHV3) / Varicella zoster Virus (VZV): Varicella zoster Virusinfektion, Varicella (Windpocken), Herpes Zoster (Gürtelrose).................................................................................................................164 Human gammaherpesvirus 4 (HHV4) / Epstein-Barr Virus (EBV): Epstein-Barr Virusinfektion, Mononucleosis infectiosa.......................................................................................................................................................................167 Human betaherpesvirus 5 (HHV5) / Cytomegalovirus (CMV): Cytomegalovirus-1nfektion, Cytomegalie............... 169 Humanes Herpesvirus 6/7 (HHV6, HHV7): Exanthema subitum / Roseola infantum........................................... 171 Human gammaherpesvirus 8 (HHV8) / Kaposi’s Sarcoma Associated Herpesvirus (KSHV): Kaposi-Sarkom..... 173 Papillomaviridae [dsDNA] Humane Papillomaviren (HPV): Papillomavirus Infektion, Papillome (Warzen)..........................................................175 Polyomaviridae [dsDNA] Humane Polyomaviren (inkl. JC / BK Polyomavirus): Progressive Multifokale Leukencephalopathie (PME)..........177 Adenoviridae [dsDNA] Adenovirus ssp.: Adenovirus Infektion.......................................................................................................................