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Details available EULAR congress delegates Commercial Reprints Americas online at http://journals.bmj.com/content/subscribers Delegates receive a Continuous Professional Ray Thibodeau or contact the Subscription Manager in the UK (see Development package that includes a 12 month T: +1 267 895 1758 above right) complimentary subscription to ARD in print M: +1 215 933 8484 and/or online E: [email protected] Personal print or online only and institutional print subscriptions may be purchased online at http://journals.bmj.com/content/ For all other journal contacts subscribers (payment by Visa/Mastercard only) ard.bmj.com/contact-us Residents of some EC countries must pay VAT; for details, call us or visit http://journals.bmj.com/content/subscribers For more information on subscription rates or to subscribe online please visit ard/bmj.com/pages/contact-us/ Contents Volume 80 Issue 4 | ARD April 2021 ARDThe Eular Journal Impact Factor: 16.102 Editorial Spondyloarthritis April 2021 Volume 80 Issue 4 409 Rheumatoid arthritis, bone and drugs: a 469 Which factors are associated with bone 80 4 Volume 80 Volume Issue 4 409–546 Pages dangerous interweave marrow oedema suspicious of axial Annals of the S Minisola, J Pepe, C Cipriani spondyloarthritis as detected by MRI in the Rheumatic Diseases sacroiliac joints and the spine in the general The EULAR Journal ANNALS OF RHEUMATIC DISEASES ANNALS OF RHEUMATIC population? Viewpoint X Baraliakos, A Richter, D Feldmann, A Ott, 411 EULAR December 2020 viewpoints on R Buelow, C O Schmidt, J Braun SARS-CoV-2 vaccination in patients with RMDs J WJ Bijlsma 475 Immune response profiling of patients with THE HOME FOR INNOVATIVE RHEUMATOLOGY RESEARCH April 2021 ard.bmj.com spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo Review S Menegatti, V Guillemot, E Latis, Editor H Yahia-Cherbal, D Mittermüller, V Rouilly, Josef S Smolen 413 Microenvironment in subchondral bone: predominant regulator for the treatment of E Mascia, N Rosine, S Koturan, G A Millot, Associate Editors C Leloup, D Duffy, A Gleizes, S Hacein-Bey-Abina, osteoarthritis Francis Berenbaum Milieu Intérieur Consortium, J Sellam, F Berenbaum, Dimitrios Boumpas W Hu, Y Chen, C Dou, S Dong C Miceli-Richard, M Dougados, E Bianchi, L Rogge Gerd Burmester Mary Crow Kimme Hyrich Rik Lories Rheumatoid arthritis Osteoarthritis Iain McInnes 423 Concomitant use of oral glucocorticoids and Thomas Pap 487 10-Year natural course of early hip osteoarthritis David Pisetsky proton pump inhibitors and risk of osteoporotic in middle-aged persons with hip pain: a CHECK Désirée van der Heijde fractures among patients with rheumatoid Kazuhiko Yamamoto study arthritis: a population-based cohort study A C van Berkel, D Schiphof, J H Waarsing, Editorial office S Abtahi, J H M Driessen, A M Burden, J Runhaar, J M van Ochten, P J.E Bindels, Annals of the Rheumatic Diseases P C Souverein, J P van den Bergh, T P van Staa, BMJ Publishing Group Ltd S M.A Bierma-Zeinstra BMA House A Boonen, F de Vries Tavistock Square 494 Constitutional morphological features and risk London WCIH 9JR,UK 432 Switching between Janus kinase inhibitor T: +44 (0)20 3655 5889 of hip osteoarthritis: a case–control study using E: [email protected] upadacitinib and adalimumab following standard radiographs Twitter: @ARD_BMJ insufficient response: efficacy and safety in ISSN: 0003-4967 (print) H Abdulrahim, Q Jiao, S Swain, K Sehat, ISSN: 1468-2060 (online) patients with rheumatoid arthritis A Sarmanova, K Muir, W Zhang, M Doherty R M Fleischmann, R Blanco, S Hall, Disclaimer: The Editor of ARD has been granted G T D Thomson, F E Van den Bosch, C Zerbini, 502 Machine-learning, MRI bone shape and editorial freedom and ARD is published in L Bessette, J Enejosa, Y Li, Y Song, R DeMasi, accordance with editorial guidelines issued by important clinical outcomes in osteoarthritis: the World Association of Medical Editors and the I-H Song Committee on Publication Ethics. ARD is primarily data from the Osteoarthritis Initiative intended for healthcare professionals and its M A Bowes, K Kacena, O A Alabas, A D Brett, content is for information only. The Journal is 440 Parsing multiomics landscape of activated published without any guarantee as to its accuracy B Dube, N Bodick, P G Conaghan or completeness and any representations or synovial fibroblasts highlights drug targets warranties are expressly excluded to the fullest linked to genetic risk of rheumatoid arthritis extent permitted by law. Readers are advised to independently verify any information on which H Tsuchiya, M Ota, S Sumitomo, K Ishigaki, they choose to rely. Acceptance of advertising by A Suzuki, T Sakata, Y Tsuchida, H Inui, J Hirose, ARD