SEWPROF Roundtable Spain John Ramsey TICTAC Communications Ltd St. George’s, University of London London SW17 0RE New Psychoactive Substances in Wastewater TICTAC’s contribution • ER – Dr. Bram Miserez • Discovery and characterisation of NPS • Test purchases • Amnesty bins • Police seizures • Prisons • Pooled urine collection • Dissemination of samples • Analysis of results New Psychoactive Substances in Wastewater TICTAC Communications Ltd. Typical UK “head shop” offering April 2013 Rock Stars Tablet 5-MeO-DALT Rockets Capsule Methylone AMT Tablet AMT Dutchy Herb 5F-AKB48, STS-135, MAM-2201 E-Scape Tablet 5-MAPB, 5/6-APB Puff Adder Herb 5F-AKB48, AKB48 Chillem Blue Herb 5F-AKB48, AKB48 Ethylphenidate Poke Powder Methiopropamine, Dimethocaine Methiopropamine Dust Till Dawn Powder Benzocaine, Methiopropamine Charly Sheen Powder Lidocaine, Methiopropamine, MDAI Clockwork Orange Herb 5F-AKB48 Gogaine Powder Lidocaine, Methiopropamine, Ethylphenidate Bomb Powder Methiopropamine, Benzocaine Magic Crystals Powder Benzocaine, Caffeine, Ethylphenidate China White Powder Methiopropamine, Benzocaine Barry White Powder Methiopropamine, MDPV, Lidocaine, 2-Aminoindane Methylone Blue Genie Tablet Methiopropamine, 5/6-APB Jack and Jills Tablet Ethylphenidate Disco Biscuts Tablet AMT Green Beans Capsule Methiopropamine, 5/6-APB 6APB Capsule Ethylone Blast Tablet 5-MeO-DALT Fury Xtreme Capsule 5/6-APB, Methiopropamine Pink Panters Capsule Methiopropamine Purple Bomb Tablet Ethylphenidate, 5-Meo-DALT, Methiopropamine Jumping Beans Tablet Methiopropamine AMT Matrix Fury Tablet Methoxetamine TICTAC Communications Ltd. New Psychoactive Substances in Wastewater Methylphenidate derivatives Methylphenidate (Ritalin ®) Ethylphenidate 3,4-CTMP Methylphenidate isoPropylphenidate HDMP-28 (methylnaphthidate) IsoPropylphenidate 3,4-CTMP Methylnaphthidate Ethylphenidate TICTAC Communications Ltd. New Psychoactive Substances in Wastewater This means that it will be unlawful to supply, possess with intent to supply, produce, and import or export ethylphenidate, 3,4-dichloromethylphenidate, methylnaphthidate (HDMP-28), isopropylphenidate and propylphenidate, and their simple derivatives, except under licence issued by the Home Office. TICTAC Communications Ltd. The driver for change new compounds are used as drugs because they fall outside legislation the law catches up The consequence is that vulnerable young people are exposed to a succession of compounds that have never been tested for safety TICTAC Communications Ltd. New Psychoactive Substances in Wastewater The response ? B2 / M1M Propylhexedrine analogue (3,4-methdioxy variant) 1-(hexahydrobenzo[d][1,3]dioxol-5-yl)-N-methylpropan-2-amine 500g B2 - £1500 or 1kg B2 - £2500 TICTAC Communications Ltd. New Psychoactive Substances in Wastewater TICTAC Communications Ltd. New Psychoactive Substances in Wastewater Synthetic cannabinoids detected by TICTAC March 2015 5-fluoro NPB-22 URB597 5-fluoro AB-PINACA AM2201 benzimidazole analog THJ 018 AB-PINACA JWH-018 indazole analog ADB-FUBINACA SDB-006 URB754 5-fluoro MN-18 THJ2201 FUB-PB-22 A-836339 EG 018 MDMB-CHMICA 5-fluoro AMB MDMB-CHMINACA TICTAC Communications Ltd. MDMB-CHMINACA URB754 endogenous agonist of the central cannabinoid (CB1) receptor A-836339 MDMB-CHMICA 5F-AB-PINACA higher affinity for the peripheral CB2 receptor analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice TICTAC Communications Ltd. Data from:- Dr. María Ibáñez Martínez O 5F-AB-PINA O NH2 NH N [M+H]+ N [M+Na]+ [M+Na]+ [M+H]+ C18H25FN4O2 F 31424 14 5F-AB-PINACA single peak by GCMS Internal standards TICTAC Communications Ltd. New Psychoactive Substances in Wastewater The challenge to SEWPROF is to move faster M Monitor market half life of new compounds TN 1/2 UK Time from first detection to disappearance from the local market Characterise new compound Minimum data set * Pharmacology / Toxicology * Dose * Duration of action Distribute standards Access or guess human/bacterial metabolism Access stability Develop and validate analytical method Implement TICTAC Communications Ltd..