Anti-TNFAIP1 (internal region) polyclonal antibody (DPABH-27067) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. Immunogen Synthetic peptide corresponding to the internal region of Human TNFAIP1. Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Immunogen affinity purified Conjugate Unconjugated Applications WB Format Liquid Size 100 μg Buffer pH: 7.40; Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride. Note: PBS is without Mg2+ and Ca2+ Preservative 0.02% Sodium Azide Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. GENE INFORMATION Gene Name TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) [ Homo sapiens ] Official Symbol TNFAIP1 Synonyms TNFAIP1; tumor necrosis factor, alpha-induced protein 1 (endothelial); EDP1; BTB/POZ domain- 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved containing adapter for CUL3-mediated RhoA degradation protein 2; B12; B61; MGC2317; BTB/POZ domain-containing protein TNFAIP1; hBACURD2; Entrez Gene ID 7126 Protein Refseq NP_066960 UniProt ID Q13829 Chromosome Location 17q22-q23 Function GTP-Rho binding; protein binding; contributes_to ubiquitin-protein ligase activity; voltage-gated potassium channel activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.