COVID-19 Rush Journal Club NOVEL CORONAVIRUS SARS-COV-2. Transmission electron micrograph of SARS-CoV-2 virus particles, iso- lated from a patient. Image captured and color-enhanced at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIAID Available at: https://www.flickr.com/photos/niaid/49597768397/in/al- bum-72157712914621487/. Accessed April 19, 2020. This document is a collection of efforts from students of Rush University. It provides brief reviews of research articles regarding COVID-19. We hope that this will be helpful to clini- cians, students, community leaders, and the general public. This document, however, does not act as a replacement of the original source documents. Please use the DOI on each page to read more. Student Editors Blake Beehler, MD John Levinson, MS2 Alice Burgess, MS2 Luke McCormack, MS2 Alyssa Coleman, MS3 Diana Parker, MS2 Shyam Desai, MD Elena Perkins, MS3 Joseph Dodson, MS1 Hannah Raff, MS3 Joshua Doppelt, MD Ayesan Rewane, MSCR Emily Hejna, MS2 Audrey Sung, MS3 Danesha Lewis, PhD student Literature Selection Christi Brown, MS2 Lindsay Friedman, MS3 Danesha Lewis, PhD Student Travis Tran, MS2 Student Editors in Chief Joseph deBettencourt, MS3 Alyssa Coleman, MS3 Lindsay Friedman, MS3 Leah Greenfield, MS2 Beth Hall, MD Morgan Sturgis, MS2 Travis Tran, MS2 Ashley Wehrheim, MS2 Kaitlyn Wehrheim, MS2 Bijan Zarrabi, MS2 Faculty Editors and Mentors Frank Cockerill, MD - Adjunct Professor of Medicine Mete Altintas, PhD - Director, Translational and Preclinical Studies Rachel Miller, PhD - Assistant Professor of Internal Medicine Michael Bradaric, PhD - Director of Pharmacology, Rush Medical College Brinda Bradaric, PhD - Assistant Professor, Dept of Health Sciences Jitesh Pratap, PhD - Assistant Professor, Dept of Cell and Molecular Medicine Steve Mangos, PhD - Director, Internal Medicine Drug Discovery and Imaging Core Graphic design Sam Auger, MD Beth Hall, MD Is there a study you’d like us to review? Do you have questions or feedback? Please email: [email protected] COVID-19Reviews are provided by students at Rush University and edited by Rush Rushfaculty. Journal Level Club of evidence in each study, if applicable, was assessed us- ing the Oxford guidelines as presented below. More information can be found at http://www.cebm.net/2016/05/ocebm-levels-of-evidence/ Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence Question Step 1 Step 2 Step 3 Step 4 Step 5 (Level 5) (Level 1*) (Level 2*) (Level 3*) (Level 4*) How common is the Local and current random sample Systematic review of surveys Local non-random sample** Case-series** n/a problem? surveys (or censuses) that allow matching to local circumstances** Is this diagnostic or Systematic review Individual cross sectional Non-consecutive studies, or studies without Case-control studies, or Mechanism-based monitoring test of cross sectional studies with studies with consistently consistently applied reference standards** “poor or non-independent reasoning accurate? consistently applied reference applied reference standard and reference standard** (Diagnosis) standard and blinding blinding What will happen if Systematic review Inception cohort studies Cohort study or control arm of randomized trial* Case-series or case- n/a we do not add a of inception cohort studies control studies, or poor therapy? quality prognostic cohort (Prognosis) study** Does this Systematic review Randomized trial Non-randomized controlled cohort/follow-up Case-series, case-control Mechanism-based intervention help? of randomized trials or n-of-1 trials or observational study with study** studies, or historically reasoning (Treatment Benefits) dramatic effect controlled studies** What are the Systematic review of randomized Individual randomized trial Non-randomized controlled cohort/follow-up Case-series, case-control, Mechanism-based COMMON harms? trials, systematic review or (exceptionally) observational study (post-marketing surveillance) provided or historically controlled reasoning (Treatment Harms) of nested case-control studies, n- study with dramatic effect there are sufficient numbers to rule out a studies** of-1 trial with the patient you are common harm. (For long-term harms the raising the question about, or duration of follow-up must be sufficient.)** observational study with dramatic effect What are the RARE Systematic review of randomized Randomized trial harms? trials or n-of-1 trial or (exceptionally) observational (Treatment Harms) study with dramatic effect Is this (early Systematic review of randomized Randomized trial Non -randomized controlled cohort/follow-up Case-series, case-control, Mechanism-based detection) test trials study** or historically controlled reasoning worthwhile? studies** (Screening) * Level may be graded down on the basis of study quality, imprecision, indirectness (study PICO does not match questions PICO), because of inconsistency between studies, or because the absolute effect size is very small; Level may be graded up if there is a large or very large effect size. ** As always, a systematic review is generally better than an individual study. How to cite the Levels of Evidence Table OCEBM Levels of Evidence Working Group*. "The Oxford 2011 Levels of Evidence". Oxford Centre for Evidence-Based Medicine. http://www.cebm.net/index.aspx?o=5653 * OCEBM Table of Evidence Working Group = Jeremy Howick, Iain Chalmers (James Lind Library), Paul Glasziou, Trish Greenhalgh, Carl Heneghan, Alessandro Liberati, Ivan Moschetti, Bob Phillips, Hazel Thornton, Olive Goddard and Mary Hodgkinson Table of Contents: Public Health (1/3) Section Manuscript Reviewer (Date Posted) Viner RM, et al. School closure and management practices during Joshua Doppelt coronavirus outbreaks including COVID-19: A rapid systematic (4/25) review. Lancet Child Adolesc Health 2020 [Epub ahead of print]. Berger ZD, et al. Covid-19: Control measures must be equitable Laura Hurley and inclusive. BMJ 368:m1141, 2020. (4/25) Yancy CW. Covid-19 and African Americans. JAMA 2020 [Epub Eiftu Haile ahead of print]. (4/27) Kim, S et al. (2020). A Brief Telephone Severity Scoring System and Josh Doppelt Therapeutic Living Centers Solved Acute Hospital-Bed Shortage (5/3) during the COVID-19 Outbreak in Daegu, Korea. Journal of Korean Medical Science, 35(15). Rosenbaum, L. (2020). The Untold Toll—The Pandemic’s Effects on Laura Hurley Patients without Covid-19. NEJM. (5/3) Atchison CJ et al. Perceptions and behavioural responses of the Katherine Tehaney general public during the COVID-19 pandemic: Cross-sectional (5/4) survey of UK adults. medRxiv 2020.04.01.20050039, 2020. Cheng, Hao-Yuan et al. “Contact Tracing Assessment of COVID-19 Josh Doppelt Transmission Dynamics in Taiwan and Risk at Different Exposure (5/9) Public Health Periods Before and After Symptom Onset.” JAMA Internal Medi- cine (2020). Leung, K et al. “First-wave COVID-19 transmissibility and severity Josh Doppelt in China outside Hubei after control measures, and second-wave (5/9) scenario planning: a modelling impact assessment.” The Lan- cet (2020). Wadhera R et al. “Variation in COVID-19 Hospitalizations and Josh Doppelt Deaths Across New York City Boroughs.” JAMA. Published online (5/18) April 29, 2020; DOI:10.1001/jama.2020.7197 Bayham J et al. “Impact of school closures for COVID-19 on the US Kat Tehaney health-care workforce and net mortality: a modeling study.” The (5/18) Lancet Public Health. Published Online, April 3, 2020; DOI: https:// doi.org/10.1016/ S2468-2667(20)30082-7 Wolf M et al. “Awareness, Attitudes, and Actions Related to Timothy Huang COVID-19 Among Adults with Chronic Conditions at the Onset of (5/18) the U.S. Outbreak”. Annals of Internal Medicine. Published Online, April 9, 2020; DOI: 10.7326/M20-1239 Vardavas CI et al. COVID-19 and smoking: A systematic review Kelly Harmon of the evidence. Tobacco Induced Diseases. 2020;18(March):20. (5/20) doi:10.18332/tid/119324. Table of Contents: Public Health (2/3) Section Manuscript Reviewer (Date Posted) Zheng Z et al. Risk factors of critical & mortal COVID-19 cases: Kelly Harmon A systematic literature review and meta-analysis. J Infect 2020 (5/20) [Epub ahead of print]. Wang B et al. Does comorbidity increase the risk of patients with Kelly Harmon COVID-19: evidence from meta-analysis. Aging (Albany NY). (5/20) 2020;12(7):6049‐6057. doi:10.18632/aging.103000 Roberton T et al. Early estimates of the indirect effects of the Kat Tehaney COVID-19 pandemic on maternal and child mortality in low-in- (5/20) come and middle-income countries: a modelling study. Lancet Glob Health 2020 [Epub ahead of print]. Xie X et al. Mental Health Status Among Children in Home Kat Tehaney Confinement During the Coronavirus Disease 2019 Outbreak in (5/21) Hubei Province, China. JAMA Pediatr. Published online April 24, 2020. doi:10.1001/jamapediatrics.2020.1619 Bialek S et al. Geographic Differences in COVID-19 Cases, Deaths, Eiftu Haile and Incidence - United States, February 12-April 7, 2020. MMWR (5/21) Wkly Rep 69(15):465-471, 2020. Hawks L, Woolhandler S, McCormick D. COVID-19 in Prisons and Alice Burgess Jails in the United States. JAMA Intern Med.Published online April (5/23) 28, 2020. doi:10.1001/jamainternmed.2020.1856 Public Health cont. Nussbaumer-Streit B et al., Quarantine alone or in combination Kelly Harmon with other public health measures to control COVID‐19: a rapid (6/1) review. Cochrane Database of Systematic Reviews 2020, Issue 4. Art. No.: CD013574. DOI: 10.1002/14651858.CD013574. Liu M et al., Internet searches for unproven COVID-19 therapies Kat Tehaney in the United States. JAMA Intern Med 2020 [Epub ahead of (6/1) print]. Yan L et al., An interpretable mortality prediction model for Kat Tehaney COVID-19 patients. Nat Mach Intell 2, 283–288 (2020). https:// (6/2) doi.org/10.1038/s42256-020-0180-7 Joensen LE et al., Diabetes and COVID-19: psychosocial con- Kat Tehaney sequences of the COVID-19 pandemic in people with diabetes (6/2) in Denmark-what characterizes people with high levels of COVID-19-related worries? [published online ahead of print, 2020 May 11].