Evidence-Based Complementary and Alternative Medicine Special Invertebrate Models and Integrative Medical Applications: Regulations, Mechanisms, and Therapies Guest Editors: Chih-Yang Huang, Edwin L. Cooper, Catherine Fang-Yeu Poh, Wei-Wen Kuo, Tung-Sheng Chen, and Ronald Sherman Special Invertebrate Models and Integrative Medical Applications: Regulations, Mechanisms, and Therapies Evidence-Based Complementary and Alternative Medicine Special Invertebrate Models and Integrative Medical Applications: Regulations, Mechanisms, and Therapies Guest Editors: Chih-Yang Huang, Edwin L. Cooper, Catherine Fang-Yeu Poh, Wei-Wen Kuo, Tung-Sheng Chen, and Ronald Sherman Copyright © 2014 Hindawi Publishing Corporation. All rights reserved. This is a special issue published in “Evidence-Based Complementary and Alternative Medicine.” All articles are open access articles distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Board Mahmood A. Abdulla, Malaysia Jen-Hwey Chiu, Taiwan Ching-Liang Hsieh, Taiwan Jon Adams, Australia Jae Youl Cho, Korea Jing Hu, China Zuraini Ahmad, Malaysia W. Chi-shing Cho, Hong Kong Sheng-Teng Huang, Taiwan U. Paulino Albuquerque, Brazil Seung-Hun Cho, Republic of Korea BennyTanKwongHuat,Singapore Gianni Allais, Italy Chee Yan Choo, Malaysia Roman Huber, Germany Terje Alraek, Norway Li-Fang Chou, Taiwan Angelo Antonio Izzo, Italy Souliman Amrani, Morocco Ryowon Choue, Republic of Korea Suresh Jadhav, India Akshay Anand, India Shuang-En Chuang, Taiwan Kanokwan Jarukamjorn, Thailand Shrikant Anant, USA Joo-Ho Chung, Republic of Korea Yong Jiang , China Manuel Arroyo-Morales, Spain Edwin L. Cooper, USA Zheng L. Jiang, China S. M. B. Asdaq, Saudi Arabia Meng Cui, China Stefanie Joos, Germany Seddigheh Asgary, Iran R. K. Nakamura Cuman, Brazil ZeevLKain,USA Hyunsu Bae, Republic of Korea Vincenzo De Feo, Italy Osamu Kanauchi, Japan Lijun Bai, China Roc´ıo De la Puerta Vazquez,´ Spain Wenyi Kang, China Sandip K. Bandyopadhyay, India Martin Descarreaux, USA Dae Gill Kang, Republic of Korea Sarang Bani, India Alexandra Deters, Germany Shao-Hsuan Kao, Taiwan Vassya Bankova, Bulgaria S. S. K. Durairajan, Hong Kong Krishna Kaphle, Nepal Winfried Banzer, Germany Mohamed Eddouks, Morocco Kenji Kawakita, Japan Vernon A. Barnes, USA Thomas Efferth, Germany Jong Yeol Kim, Republic of Korea Samra Bashir, Pakistan Tobias Esch, USA Cheorl-Ho Kim, Republic of Korea Jairo Kenupp Bastos, Brazil Saeed Esmaeili-Mahani, Iran Youn Chul Kim, Republic of Korea Sujit Basu, USA Nianping Feng, China Yoshiyuki Kimura, Japan David Baxter, New Zealand Yibin Feng, Hong Kong Joshua K. Ko, China Andre-Michael Beer, Germany Patricia Dias Fernandes, Brazil Toshiaki Kogure, Japan Alvin J. Beitz, USA Josue Fernandez-Carnero, Spain Jian Kong, USA Yong Chool Boo, Republic of Korea Juliano Ferreira, Brazil Nandakumar Krishnadas, India Francesca Borrelli, Italy Fabio Firenzuoli, Italy Yiu Wa Kwan, Hong Kong Gloria Brusotti, Italy Peter Fisher, UK Kuang Chi Lai, Taiwan Ishfaq A. Bukhari, Pakistan W. F. Fong, Hong Kong Ching Lan, Taiwan Arndt Bussing,¨ Germany Joel J. Gagnier, Canada Lixing Lao, Hong Kong Rainer W. Bussmann, USA Siew Hua Gan, Malaysia Clara Bik-San Lau, Hong Kong Raffaele Capasso, Italy Jian-Li Gao, China Jang-Hern Lee, Republic of Korea Opher Caspi, Israel Gabino Garrido, Chile Myeong Soo Lee, Republic of Korea Han Chae, Korea M. Nabeel Ghayur, Pakistan Tat leang Lee, Singapore Shun-Wan Chan, Hong Kong A. Hassan Gilani, Pakistan Christian Lehmann, Canada Il-Moo Chang, Republic of Korea Michael Goldstein, USA Marco Leonti, Italy Rajnish Chaturvedi, India Mahabir P. Gupta, Panama Ping-Chung Leung, Hong Kong Chun Tao Che, USA Svein Haavik, Norway Lawrence Leung, Canada Hubiao Chen, Hong Kong Abid Hamid, India Kwok Nam Leung, Hong Kong Jian-Guo Chen, China N. Hanazaki, Brazil Ping Li, China Kevin Chen, USA KB Harikumar, India Min Li, China Tzeng-Ji Chen, Taiwan Cory S. Harris, Canada Man Li, China Yunfei Chen, China Thierry Hennebelle, France ChunGuang Li, Australia Juei-Tang Cheng, Taiwan Seung-Heon Hong, Korea Xiu-Min Li, USA Evan Paul Cherniack, USA Markus Horneber, Germany Shao Li, China Yong Hong Liao, China Xianqin Qu, Australia Evelin Tiralongo, Australia Bi-Fong Lin, Taiwan CassandraL.Quave,USA Stephanie Tjen-A-Looi, USA Wen Chuan Lin, China Roja Rahimi, Iran MichaThlfj Tomczyk, Poland Christopher G. Lis, USA Khalid Rahman, UK Yao Tong, Hong Kong Gerhard Litscher, Austria Cheppail Ramachandran, USA K. Wah-Keung Tsim, Hong Kong I-Min Liu, Taiwan Gamal Ramadan, Egypt Volkan Tugcu, Turkey Ke Liu, China Ke Ren, USA Yew-Min Tzeng, Taiwan Yijun Liu, USA Man Hee Rhee, Republic of Korea Dawn M. Upchurch, USA Gaofeng Liu, China Mee-Ra Rhyu, Republic of Korea MarynaVandeVenter,SouthAfrica Cun-Zhi Liu, China JoseLuisR´ ´ıos, Spain Sandy van Vuuren, South Africa Gail B. Mahady, USA Paolo Roberti di Sarsina, Italy Alfredo Vannacci, Italy Juraj Majtan, Slovakia Bashar Saad, Palestinian Authority Mani Vasudevan, Malaysia Subhash C. Mandal, India Sumaira Sahreen, Pakistan Carlo Ventura, Italy Jeanine L. Marnewick, South Africa Omar Said, Israel Wagner Vilegas, Brazil Virginia S. Martino, Argentina Luis A. Salazar-Olivo, Mexico Pradeep Visen, Canada James H. McAuley, Australia Mohd. Zaki Salleh, Malaysia Aristo Vojdani, USA Karin Meissner, Germany Andreas Sandner-Kiesling, Austria Y. Wang, USA Andreas Michalsen, Germany Adair Santos, Brazil Shu-Ming Wang, USA David Mischoulon, USA G. Schmeda-Hirschmann, Chile Chenchen Wang, USA Syam Mohan, Saudi Arabia Andrew Scholey, Australia Chong-Zhi Wang, USA Valerio´ Monteiro-Neto, Brazil Veronique Seidel, UK Kenji Watanabe, Japan Hyung-In Moon, Republic of Korea Senthamil R. Selvan, USA Jintanaporn Wattanathorn, Thailand Albert Moraska, USA Tuhinadri Sen, India Jenny M. Wilkinson, Australia Mark Moss, UK Hongcai Shang, China Darren R. Williams, Republic of Korea Yoshiharu Motoo, Japan Karen J. Sherman, USA Haruki Yamada, Japan Frauke Musial, Germany Ronald Sherman, USA Nobuo Yamaguchi, Japan MinKyun Na, Republic of Korea Kuniyoshi Shimizu, Japan Yong-Qing Yang, China Vitaly Napadow, USA Kan Shimpo, Japan Junqing Yang, China F. R. F. do Nascimento, Brazil Byung-Cheul Shin, Korea Ling Yang, China S. Nayak, Trinidad And Tobago Yukihiro Shoyama, Japan Eun Jin Yang, Republic of Korea Roland Ndip Ndip, South Africa K. N. S. Sirajudeen, Malaysia Xiufen Yang, China Isabella Neri, Italy Chang-Gue Son, Korea Ken Yasukawa, Japan T. B. Nguelefack, Cameroon Rachid Soulimani, France Min Ye, China Martin Offenbaecher, Germany Didier Stien, France M. Yoon, Republic of Korea Ki-Wan Oh, Republic of Korea Shan-Yu Su, Taiwan Jie Yu, China Yoshiji Ohta, Japan Mohd Roslan Sulaiman, Malaysia Zunjian Zhang, China Olumayokun A. Olajide, UK Venil N. Sumantran, India Jin-Lan Zhang, China Thomas Ostermann, Germany John R. S. Tabuti, Uganda Wei-Bo Zhang, China Stacey A. Page, Canada Rabih Talhouk, Lebanon Hong Q. Zhang, Hong Kong Tai-Long Pan, Taiwan Yuping Tang, China Boli Zhang, China Bhushan Patwardhan, India Wen-Fu Tang, China Ruixin Zhang, USA Berit Smestad Paulsen, Norway Lay Kek Teh, Malaysia Hong Zhang, China Andrea Pieroni, Italy Mayank Thakur, Germany Haibo Zhu, China Richard Pietras, USA Menaka C. Thounaojam, India Waris Qidwai, Pakistan Mei Tian, China Contents Special Invertebrate Models and Integrative Medical Applications: Regulations, Mechanisms, and Therapies, Chih-Yang Huang, Edwin L. Cooper, Catherine Fang-Yeu Poh, Wei-Wen Kuo, Tung-Sheng Chen, and Ronald Sherman Volume 2014, Article ID 843961, 2 pages Recent Advances in Developing Insect Natural Products as Potential Modern Day Medicines, Norman Ratcliffe, Patricia Azambuja, and Cicero Brasileiro Mello Volume2014,ArticleID904958,21pages Corals and Their Potential Applications to Integrative Medicine, Edwin L. Cooper, Kyle Hirabayashi, KevinB.Strychar,andPaulW.Sammarco Volume 2014, Article ID 184959, 9 pages Mechanisms of Maggot-Induced Wound Healing: What Do We Know, and Where Do We Go from Here?,RonaldA.Sherman Volume 2014, Article ID 592419, 13 pages Millipedes as Food for Humans: Their Nutritional and Possible Antimalarial Value—A First Report, HenrikEnghoff,NicolaManno,Sev´ erin´ Tchibozo, Manuela List, Bettina Schwarzinger, Wolfgang Schoefberger, Clemens Schwarzinger, and Maurizio G. Paoletti Volume2014,ArticleID651768,9pages Recommendations for the Use of Leeches in Reconstructive Plastic Surgery,KostaY.Mumcuoglu Volume 2014, Article ID 205929, 7 pages Marine Invertebrate Natural Products for Anti-Inflammatory and Chronic Diseases, Kalimuthu Senthilkumar and Se-Kwon Kim Volume 2013, Article ID 572859, 10 pages Recombinant Protein Production of Earthworm Lumbrokinase for Potential Antithrombotic Application, Kevin Yueju Wang, Lauren Tull, Edwin Cooper, Nan Wang, and Dehu Liu Volume 2013, Article ID 783971, 8 pages Honey as a Potential Natural Anticancer Agent: A Review of Its Mechanisms, Sarfraz Ahmed and Nor Hayati Othman Volume 2013, Article ID 829070, 7 pages Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2014, Article ID 843961, 2 pages http://dx.doi.org/10.1155/2014/843961 Editorial Special Invertebrate Models and Integrative Medical Applications: Regulations, Mechanisms, and Therapies Chih-Yang Huang,1,2 Edwin L. Cooper,3 Catherine Fang-Yeu Poh,4 Wei-Wen Kuo,5 Tung-Sheng Chen,1 and Ronald Sherman6 1 Graduate Institute of Basic Medical Science, China Medical University, Taichung