Supplementary Table 3. Alternative exon usage following PRMT6 knockdown in MCF-7 cells. Table shows gene symbol, NCBI link, gene annotation, significant alternative exon usage and alternative exon usage corrected with Benjamini and Hochberg False Discovery Rate (FDR). Gene Symbol NCBILink Annotation Gene Alt. Exon Usage Significant Alt. Exon Usage corrected with Benjamini and Hochberg FalseDiscovery Rate (FDR) hmcn1 NM_031935 hemicentin 1 1.37E-38 1.18E-34 nin NM_020921 ninein (GSK3B interacting protein) 1.22E-38 2.10E-34 sytl2 NM_206928 synaptotagmin-like 2 2.48E-35 1.43E-31 sptlc1 NM_006415 serine palmitoyltransferase long chain base subunit 1 1.37E-31 5.88E-28 antxr1 NM_018153 anthrax toxin receptor 1 1.62E-27 5.59E-24 slc7a5p1 NR_002593 solute carrier family 7 (cationic amino acid transporter y+ system) member 5 pseudogene 1 2.66E-26 7.63E-23 myo6 NM_004999 myosin VI 2.52E-25 6.20E-22 zhx1 NM_007222 zinc fingers and homeoboxes 1 2.41E-23 5.19E-20 kiaa1429 NM_015496 KIAA1429 8.71E-22 1.67E-18 ctnnd1 NM_001331 catenin (cadherin-associated protein) delta 1 2.34E-17 4.03E-14 thrap1 NM_005121 thyroid hormone receptor associated protein 1 2.73E-17 4.28E-14 ncoa4 NM_005437 nuclear receptor coactivator 4 7.87E-17 1.13E-13 dock1 NM_001380 dedicator of cytokinesis 1 1.04E-16 1.38E-13 utrn NM_007124 utrophin 1.21E-16 1.48E-13 mina NM_153182 MYC induced nuclear antigen 4.74E-16 5.44E-13 myef2 NM_016132 myelin expression factor 2 7.29E-16 7.85E-13 fam62b NM_020728 family with sequence similarity 62 (C2 domain containing) member B 4.67E-15 4.74E-12 dst NM_183380 dystonin 9.08E-15 8.69E-12 epb41l1 NM_012156 erythrocyte membrane protein band 4.1-like 1 1.34E-14 1.21E-11 ncoa3 NM_181659 nuclear receptor coactivator 3 1.84E-14 1.59E-11 stag2 NM_001042749 stromal antigen 2 3.78E-14 3.10E-11 pten NM_000314 phosphatase and tensin homolog (mutated in multiple advanced cancers 1) 3.97E-14 3.11E-11 prmt3 NM_005788 protein arginine methyltransferase 3 4.59E-14 3.44E-11 pspc1 NM_001042414 paraspeckle component 1 5.34E-14 3.83E-11 atp2a2 NM_170665 ATPase Ca++ transporting cardiac muscle slow twitch 2 1.09E-13 7.52E-11 ipo7 NM_006391 importin 7 1.31E-13 8.36E-11 camsap1l1 NM_203459 calmodulin regulated spectrin-associated protein 1-like 1 1.31E-13 8.66E-11 ugcg NM_003358 UDP-glucose ceramide glucosyltransferase 2.42E-13 1.49E-10 paics NM_001079524 phosphoribosylaminoimidazole carboxylase phosphoribosylaminoimidazole succinocarboxamide synthetase5.10E-13 3.03E-10 isoc1 NM_016048 isochorismatase domain containing 1 1.11E-12 6.19E-10 gtf2i NM_033000 general transcription factor II i 1.11E-12 6.37E-10 smg1 NM_015092 PI-3-kinase-related kinase SMG-1 1.57E-12 8.46E-10 ube3a NM_130839 ubiquitin protein ligase E3A (human papilloma virus E6-associated protein Angelman syndrome) 1.88E-12 9.83E-10 asph NM_004318 aspartate beta-hydroxylase 2.10E-12 1.06E-09 ttc3 NM_001001894 tetratricopeptide repeat domain 3 2.59E-12 1.27E-09 ptpn13 NM_080685 protein tyrosine phosphatase non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 4.11E-12 1.91E-09 c1orf21 NM_030806 chromosome 1 open reading frame 21 4.06E-12 1.94E-09 dhx15 NM_001358 DEAH (Asp-Glu-Ala-His) box polypeptide 15 4.88E-12 2.21E-09 atp6v0a4 NM_130841 ATPase H+ transporting lysosomal V0 subunit a4 7.06E-12 3.12E-09 hexb NM_000521 hexosaminidase B (beta polypeptide) 8.60E-12 3.70E-09 osbp NM_002556 oxysterol binding protein 1.51E-11 6.36E-09 ppp1cb NM_002709 protein phosphatase 1 catalytic subunit beta isoform 2.06E-11 8.44E-09 fancd2 NM_033084 Fanconi anemia complementation group D2 2.85E-11 1.14E-08 ak7 NM_152327 adenylate kinase 7 3.04E-11 1.17E-08 setd7 NM_030648 SET domain containing (lysine methyltransferase) 7 3.01E-11 1.18E-08 ldha NM_005566 lactate dehydrogenase A 3.35E-11 1.23E-08 crot NM_021151 carnitine O-octanoyltransferase 3.30E-11 1.24E-08 yme1l1 NM_139313 YME1-like 1 (S. cerevisiae) 3.87E-11 1.39E-08 stau1 NM_001037328 staufen RNA binding protein homolog 1 (Drosophila) 5.24E-11 1.84E-08 kif5b NM_004521 kinesin family member 5B 5.76E-11 1.98E-08 mbnl2 NM_144778 muscleblind-like 2 (Drosophila) 9.12E-11 3.08E-08 bccip NM_016567 BRCA2 and CDKN1A interacting protein 9.78E-11 3.18E-08 acbd5 NM_145698 acyl-Coenzyme A binding domain containing 5 9.72E-11 3.22E-08 ppm1b NM_002706 protein phosphatase 1B (formerly 2C) magnesium-dependent beta isoform 1.35E-10 4.32E-08 dhx40 NM_024612 DEAH (Asp-Glu-Ala-His) box polypeptide 40 1.79E-10 5.61E-08 xrn2 NM_012255 5'-3' exoribonuclease 2 1.83E-10 5.63E-08 rcn1 NM_002901 reticulocalbin 1 EF-hand calcium binding domain 2.04E-10 6.16E-08 bms1 NM_014753 BMS1 homolog ribosome assembly protein (yeast) 2.23E-10 6.63E-08 slc9a3r1 NM_004252 solute carrier family 9 (sodium/hydrogen exchanger) member 3 regulator 1 3.68E-10 1.07E-07 them4 NM_053055 thioesterase superfamily member 4 3.78E-10 1.09E-07 abr NM_021962 active BCR-related gene 3.97E-10 1.12E-07 iqgap1 NM_003870 IQ motif containing GTPase activating protein 1 4.09E-10 1.14E-07 armcx6 NM_019007 armadillo repeat containing X-linked 6 4.39E-10 1.20E-07 rtn4 NM_020532 reticulon 4 5.73E-10 1.54E-07 brwd1 NM_033656 bromodomain and WD repeat domain containing 1 7.83E-10 2.04E-07 hsmpp8 NM_017520 M-phase phosphoprotein mpp8 7.78E-10 2.06E-07 cnot2 NM_014515 CCR4-NOT transcription complex subunit 2 8.74E-10 2.25E-07 pa2g4 NM_006191 proliferation-associated 2G4 38kDa 9.09E-10 2.30E-07 cse1l NM_001316 CSE1 chromosome segregation 1-like (yeast) 1.22E-09 3.05E-07 sulf1 NM_015170 sulfatase 1 1.25E-09 3.07E-07 ncor1 NM_006311 nuclear receptor co-repressor 1 1.31E-09 3.17E-07 mon2 NM_015026 MON2 homolog (S. cerevisiae) 1.50E-09 3.60E-07 ehbp1 NM_015252 EH domain binding protein 1 1.61E-09 3.80E-07 ddx6 NM_004397 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 1.78E-09 4.14E-07 ran NM_006325 RAN member RAS oncogene family 1.86E-09 4.22E-07 fer1l3 NM_133337 fer-1-like 3 myoferlin (C. elegans) 1.89E-09 4.22E-07 ywhae NM_006761 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide 1.85E-09 4.25E-07 enosf1 NM_017512 enolase superfamily member 1 2.85E-09 6.30E-07 thoc2 NM_020449 THO complex 2 3.01E-09 6.56E-07 ppp3r1 NM_000945 protein phosphatase 3 (formerly 2B) regulatory subunit B alpha isoform 3.43E-09 7.38E-07 npnt NM_001033047 nephronectin 4.17E-09 8.76E-07 flj20273 AF262323 RNA-binding protein 4.12E-09 8.76E-07 prdm4 NM_012406 PR domain containing 4 4.60E-09 9.54E-07 baz1a NM_013448 bromodomain adjacent to zinc finger domain 1A 4.81E-09 9.87E-07 polr3k NM_016310 polymerase (RNA) III (DNA directed) polypeptide K 12.3 kDa 5.82E-09 1.18E-06 sec14l1 NM_003003 SEC14-like 1 (S. cerevisiae) 8.13E-09 1.63E-06 hipk1 NM_198269 homeodomain interacting protein kinase 1 8.73E-09 1.73E-06 uros NM_000375 uroporphyrinogen III synthase (congenital erythropoietic porphyria) 8.96E-09 1.75E-06 esr1 NM_000125 estrogen receptor 1 1.20E-08 2.33E-06 helz NM_014877 helicase with zinc finger 1.27E-08 2.43E-06 dstn NM_001011546 destrin (actin depolymerizing factor) 1.52E-08 2.87E-06 vezt NM_017599 vezatin adherens junctions transmembrane protein 1.71E-08 3.21E-06 kiaa0265 NM_014997 KIAA0265 protein 1.82E-08 3.36E-06 acp1 NM_004300 acid phosphatase 1 soluble 2.77E-08 5.07E-06 cnot1 NM_016284 CCR4-NOT transcription complex subunit 1 3.18E-08 5.76E-06 ppp1r10 NM_002714 protein phosphatase 1 regulatory (inhibitor) subunit 10 3.60E-08 6.45E-06 rps6kb1 NM_003161 ribosomal protein S6 kinase 70kDa polypeptide 1 3.95E-08 6.94E-06 atad2 NM_014109 ATPase family AAA domain containing 2 3.93E-08 6.97E-06 zmynd11 NM_212479 zinc finger MYND domain containing 11 4.52E-08 7.87E-06 prex1 NM_020820 phosphatidylinositol 3 4 5-trisphosphate-dependent RAC exchanger 1 4.90E-08 8.44E-06 rad51c NM_058216 RAD51 homolog C (S. cerevisiae) 5.01E-08 8.55E-06 epb41l2 NM_001431 erythrocyte membrane protein band 4.1-like 2 5.20E-08 8.78E-06 ybx1 NM_004559 Y box binding protein 1 5.43E-08 9.00E-06 pex1 NM_000466 peroxisome biogenesis factor 1 5.42E-08 9.07E-06 tegt NM_003217 testis enhanced gene transcript (BAX inhibitor 1) 5.56E-08 9.12E-06 znf217 NM_006526 zinc finger protein 217 6.09E-08 9.89E-06 idh1 NM_005896 isocitrate dehydrogenase 1 (NADP+) soluble 6.15E-08 9.90E-06 nomo1 NM_014287 NODAL modulator 1 6.31E-08 1.01E-05 bptf NM_004459 bromodomain PHD finger transcription factor 6.44E-08 1.01E-05 mthfd1l NM_015440 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 6.42E-08 1.01E-05 osbpl1a NM_133268 oxysterol binding protein-like 1A 6.80E-08 1.06E-05 appbp1 NM_001018159 amyloid beta precursor protein binding protein 1 7.09E-08 1.09E-05 pggt1b NM_005023 protein geranylgeranyltransferase type I beta subunit 7.52E-08 1.15E-05 psmd12 NM_002816 proteasome (prosome macropain) 26S subunit non-ATPase 12 7.73E-08 1.17E-05 azin1 NM_148174 antizyme inhibitor 1 8.40E-08 1.25E-05 fus NM_001010850 fusion (involved in t(12;16) in malignant liposarcoma) 8.33E-08 1.25E-05 xbp1 NM_001079539 X-box binding protein 1 1.00E-07 1.47E-05 calm1 NM_006888 calmodulin 1 (phosphorylase kinase delta) 1.09E-07 1.58E-05 tia1 NM_022173 TIA1 cytotoxic granule-associated RNA binding protein 1.09E-07 1.59E-05 sdccag1 NM_004713 serologically defined colon cancer antigen 1 1.11E-07 1.59E-05 mrlc2 NM_033546 myosin regulatory light chain MRLC2 1.13E-07 1.60E-05 dicer1 NM_177438 Dicer1 Dcr-1 homolog (Drosophila) 1.17E-07 1.65E-05 trim37 NM_001005207 tripartite motif-containing 37 1.19E-07 1.67E-05 rp11-217h1.1 NM_032121 implantation-associated protein 1.21E-07 1.68E-05 edd1 NM_015902 E3 ubiquitin protein ligase HECT domain containing 1 1.26E-07 1.73E-05 garnl1 NM_014990 GTPase activating Rap/RanGAP domain-like 1 1.29E-07 1.76E-05 purb NM_033224 purine-rich element binding protein B 1.34E-07 1.82E-05 prkar1a NM_212472 protein kinase cAMP-dependent regulatory type I alpha (tissue specific extinguisher 1) 1.35E-07 1.82E-05 usp10 NM_005153 ubiquitin specific peptidase 10 1.42E-07 1.88E-05 sulf2 NM_198596 sulfatase 2 1.41E-07 1.88E-05 ckap5 NM_001008938 cytoskeleton associated protein 5 1.49E-07 1.96E-05 unc13b NM_006377 unc-13 homolog B (C.