2018 International Mock Board Exam Coalition West Coast City of Hope/Beckman Research Institute 3/10/18 (Southern CA) Duarte, CA West Coast UC Davis 3/24/18 (Northern CA) Davis, CA Midwest (MN) Mayo Clinic and University of Minnesota 4/7/18 Rochester, MN Midwest (MI) University of Michigan 4/13/18 Ann Arbor, MI Pacific Northwest Oregon National Primate Center 4/14/18 Beaverton, OR Northeast (NY) Tri-Institutional Training Program 4/20/18 New York, NY Mid-Atlantic (MD) Fort Detrick 5/8/18 Fort Detrick, MD Southeast (NC) NCSU Veterinary School 5/20/18 Raleigh, NC Midwest (CO) Colorado State University 5/25/18 Fort Collins, CO Southeast (GA) Yerkes National Primate Research Center 6/8/18 Atlanta, GA Asia Singapore 6/23/18 Europe Stockholm, Sweden 6/29/18 Mock ECLAM Exam Practical Section – Questions Referenced Answers – 53 Pages This examination is meant to be used as a study tool when preparing for the ACLAM or ECLAM Certifying Examinations. The material presented in this mock examination follows the ACLAM role delineation document, but is not necessarily reflective of the ACLAM or ECLAM Certifying Examinations. 1 2018 Exam Contributors Asia Bryan Emmett Ogden DVM, DACLAM – Coordinator Ralph M. Bunte DVM, DACVP Michelle Loh, DVM Jassia Pang DVM, DACLAM Christie Chrisma Domingo Panaligan DVM Yasmina Paramastri DVM, DACLAM Heng Yee Choy Sharon, DVM Europe Michael Wilkinson, DVM, CertLAS, PhD, DipECLAM - Coordinator Janet Rodgers, DVM, DACLAM, DipECLAM - Coordinator Thea Fleischmann Dr Vet Med, Dipl ECLAM Sergio Berdun Marin DVM, PhD, DiplECLAM Sandra Barbosa Perez DVM, MSc, DiplECLAM Mid-Atlantic (Maryland) LTC Sarah Bro, DVM, MPH, DACLAM – Coordinator Patty Chen, DVM, DACLAM – Coordinator Midwest (Colorado) Erin McWhorter, DVM, MS - Coordinator Jessica Ayers, DVM, DACLAM Lon Kendall, DVM, PhD, DACLAM Katie Knapek, DVM, MS Whitney McGee, DVM, PhD James Owiny, DVM, DACLAM Alexa Personett, DVM Brian Smith, DVM Midwest (Michigan) Portia Allen, DVM, MS, DACLAM - Coordinator Patrick Lester DVM, MS, DACLAM - Coordinator Daniel D. Myers, Jr., DVM, MPH, DACLAM - Coordinator Michael P. Bradley, DVM Kelsey Cornelius, DVM Carolyn Doerning, DVM Samantha Eckley, DVM Marian Esvelt, DVM Zachary T Freeman, DVM, PhD, DACLAM Lucy Kennedy, DVM, DACLAM Jennifer Lofgren, DVM, MS, DACLAM Tara Martin, DVM Jibing Yang, DVM, PhD Midwest (Minnesota) Jodi Scholz, DVM, DACLAM – Coordinator Sarah Hashway, DVM - Coordinator Northeast (New York) Christopher Cheleuitte, DVM, PhD - Coordinator Leslie Diaz, MPH, DVM, DACLAM Catalina Echeverri, DVM 2 2018 Exam Contributors Northeast (New York) Odessa Giardino, MS, CVT, RLATG Mariya Gugel, DVM Mandy Kain, MS, DVM Sean Kelly, DVM Kvin Lertpiriyapong, DVM, PhD, DACLAM Christine Lieggi, DVM, DACLAM Kathleen Ma, DVM Heather Martin, DVM, DACLAM Sebastien Monette, DMV, MVSc, PhD, DACVP Lee-Ronn Paluch, BVSc, DACLAM Rodolfo Ricart, MLAS, DVM, DACLAM Pacific Northwest Thea Brabb, DVM, PhD, DACLAM - Coordinator Nick Reyes, DVM, DACLAM - Coordinator Jennifer Sargent, DVM, MS, DACLAM – Coordinator Jeff Stanton, DVM, MA, DACLAM – Coordinator Alan Avalos, DVM Isaac Barber-Axthelm, DVM Melissa Berg, DVM Jourdan Brune, DVM Cassandra Cullin, DVM John DenHerder, DVM Jessica Felgenhauer, DVM Terri Iwata, DVM, DACLAM Jenna Klug, DVM Becky Lovasz, DVM Stacey Meeker, DVM, DACLAM Lauren Neidig, DVM Jasmine Streeter, DVM Southeast (Georgia) Sherrie Jean, DVM, DACLAM – Coordinator Jennifer S. Wood, DVM DACLAM Southeast (North Carolina) Victoria K. Baxter, DVM, PhD, DACLAM – Coordinator Steven Shipley, DVM, DACLAM - Coordinator Cecile Baccanale, DVM Dwight Bellinger, DVM, PhD, DACLAM Calvin Carpenter, DVM DACLAM Sheba Churchill, DVM, DACLAM Jenny Estes, DVM, MS Jeffrey Everitt, DVM, DACLAM, DACVP, FIATP Craig Fletcher, DVM, PhD, DACLAM Ilana Galex, DVM, MLAS Jareca Giles, DVM Virginia Godfrey, DVM, PhD, DACVP Anna Hampton, DVM, DACLAM, DACAW, CPIA Tracy Heenan, DVM, CPIA Angela King-Herbert, DVM, DACLAM 3 2018 Exam Contributors Southeast (North Carolina) David M. Kurtz, DVM, PhD, DACLAM Kathy Laber, DVM, MS, DACLAM Chelsea D. Landon, DVM, PhD Charles Tyler Long, DVM, DACLAM, DABT, CPIA Gwendolyn McCormick, DVM, MS, DACLAM Marnie Metzler, DVM, PhD Stephanie Montgomery, DVM, PhD, DACVP Judith Nielsen, DVM, DACLAM Derek Norford, DVM, MS, PhD Karen Oppelt, DVM Dorcas O’Rourke, DVM, MS, DACLAM Nicolette Petervary, VMD, DACAW Randall Reynolds, DVM, MS, DACLAM Allison R. Rogala, DVM, DACLAM Jem Scott-Emuakpor, DVM, MBA, DACLAM Felicitas Smith, DVM, DACLAM Brittany Southern, DVM Donna Webb-Wright, DVM Julia W. Whitaker, DVM, MS, DACLAM Lauren Wimsey, DVM West Coast (Northern California) Laurie Brignolo, DVM, DACLAM - Coordinator Stephen Felt, DVM, DACLAM – Coordinator Erin Katz, DVM – Coordinator Sam Baker, MA, VetMB, DACLAM Rachel Brownlee, DVM Kathy Heng, DVM Monika Huss, DVM, MS Marie-Josee Lemoy, DVM, DACLAM Betty Ma DVM, DACLAM Alexis Mackiewicz, DVM Andrea Moffitt, DVM Claude Nagamine, DVM, PhD, DACLAM Rhonda Oates DVM, MPVM, DACLAM Gregory Simonek, DVM Jacob Theil, DVM, MPVM José G. Vilches-Moure, DVM, PhD, DACVP Amber Rae Williams, DVM Kacie Woodward, DVM Brian Zude, DVM West Coast (Southern California) Trinka Adamson, MS, DVM, DACLAM - Coordinator Ari Aycock-Williams, DVM, DACLAM Charles Cates, DVM, DACLAM Yvonne Cornejo, DVM James Finlay, DVM, PhD, DACLAM Leo Holguin, DVM Melanie Sailor, MLAS, DVM Rose Tu, DVM 4 Question 1: This handling technique is appropriate for which of the following procedures. a. Catheter placement b. Venipuncture c. Physical Exam d. Anesthesia induction e. Cystocentesis Answer: c. Physical Exam Reference: 1) Quesenberry, Katherine E., and James W. Carpenter. Ferrets, Rabbits, and Rodents Clinical Medicine and Surgery. Elsevier/Saunders, 2012. pp. 14. 2) Ball, R. S. “Issues to Consider for Preparing Ferrets as Research Subjects in the Laboratory.”ILAR Journal, vol. 47, no. 4, Jan. 2006, pp. 348–357. doi:10.1093/ilar.47.4.348. Domain 1- Secondary Species; Ferret (Mustela putorius furo) Question 2: According to the Guide for the Care and Use of Laboratory Animals, what is the minimum floor space recommended when trio breeding mice (assume all adults are >25g and females are not removed once pregnant or after parturition)? a. 51 in.2 b. 75 in.2 c. 102 in.2 d. 117 in.2 e. 125 in.2 Answer: d. 117 in.2 (51 in.2 for each female + litter, plus 15 in.2 for the male) References: 1) National Research Council. 2011. Guide for the Care and Use of Laboratory Animals, 8th edition. The National Academies Press: Washington, DC. Chapter 3 – Environment, Housing, and Management, p. 57. Domain 4 – Primary Species; Mouse (Mus Musculus) Question 3: Which of the following correctly describes the rack configuration in images (A) and (B) and their attributes? a. (A)-library style configuration is more efficient (B)- internal room corridor style is easier to service b. (A)- internal room corridor style is more efficient (B)-library style configuration is easier to service c. (A)- library style configuration is easier to service (B)- internal room corridor style is more efficient d. (A)- internal room corridor style is the worst ergonomical arrangement (B)- library style configuration is the best ergonomical arrangement 5 Answer: a (A)-library style configuration is more efficient (B)- internal room corridor style is easier to service References: 1) Fox JG, Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, eds. 2015. Laboratory Animal Medicine, 3rd edition. Academic Press: San Diego, CA. Chapter 36 – Design and Management of Research Animal Facilities, p. 1549. 2) Hessler J, Lehner N. 2009. Planning and Designing Research Animal Facilities. 1st edition. Academic Press: San Diego, CA. Chapter 20- Rodent Facilities and Caging Systems. Domain 4; Primary Species—Mice (Mus musculus) Question 4: What strain of mouse is predisposed to this lesion? a. C57BL/6 b. C3H c. A/J d. 129 e. DBA2 Answer: d. 129 References: 1) Fox JG, Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, eds. 2015. Laboratory Animal Medicine, 3rd edition. Academic Press: San Diego, CA. Chapter 3 – Biology and Diseases of Mice, p. 50. 2) Barthold SW, Griffey SM, Percy DH. 2016. Pathology of Laboratory Rodents and Rabbits, 4th edition. Wiley-Blackwell: Ames, IA. Chapter 1 – Mouse, pp. 115-116. Domain 3; Primary Species – Mouse (Mus musculus) Question 5: Which is an Aspiculuris tetraptera egg? a. A b. B c. C d. D Answer: b. B References: 1) Hedrich Hans, ed., 2004. The Laboratory Mouse. Academic Press: San Diego, CA. Chapter 3.4 – Parasitic Infections of Laboratory Mice, p. 508-509. 2) http://dora.missouri.edu/mouse/pinworms/ 3) Fox JG, Anderson LC, Otto G, Pritchett-Corning KR, Whary MT, eds. 2015. Laboratory Animal Medicine, 3rd edition. Academic Press: San Diego, CA. Chapter 3 – Biology and Diseases of Mice, p. 124-125. Domain 1; Primary species (Mus musculus) Question 6: Letter D in this illustration represents what type of equipment? a. A canopy unit for ducting a Class I biosafety cabinet 6 b. A canopy unit for ducting a Class II, type A biosafety cabinet c. A canopy unit for ducting a Class II, type B1 biosafety cabinet d. A canopy unit for ducting a Class III biosafety cabinet Answer: b. A canopy unit for ducting a Class II, type A biosafety cabinet References: 1) Centers for Disease Control and Prevention, National Institutes of Health. 2009. Biosafety in Microbiological and Biomedical Laboratories, 5th edition. US Government Printing Office: Washington, DC. Appendix A: Biological Safety Cabinets, p. 316. Domain 5 Question 7: What does this test assess? a. Anxiety b. Learning c. Motor coordination and balance d. Exploration Answer: c. Motor coordination and balance References: 1) Crawley JN. 2003. Overview: behavioral phenotyping of rodents. Comp Med. 53(2): 140- 146. 2) Fox JG, Davisson MT, Quimby FW, Barthold SW, Newcomer CE and Smith AL, eds. 2007. The Mouse in Biomedical Research Volume III: Normative Biology, Husbandry and Models. 2nd edition. Chapter 15 – Behavioral Testing, p. 528. Domain 3; Primary Species – Mouse (Mus musculus) Question 8: A 4.5-year-old spayed ferret has a 2-year history of vulvar swelling and alopecia.