ONLINE SUPPLEMENTARY TABLE Table 2. Differentially Expressed Probe Sets in Livers of GK Rats. A. Immune/Inflammatory (67 probe sets, 63 genes) Age Strain Probe ID Gene Name Symbol Accession Gene Function 5 WKY 1398390_at small inducible cytokine B13 precursor Cxcl13 AA892854 chemokine activity; lymph node development 5 WKY 1389581_at interleukin 33 Il33 BF390510 cytokine activity 5 WKY *1373970_at interleukin 33 Il33 AI716248 cytokine activity 5 WKY 1369171_at macrophage stimulating 1 (hepatocyte growth factor-like) Mst1; E2F2 NM_024352 serine-throenine kinase; tumor suppression 5 WKY 1388071_x_at major histocompatability antigen Mhc M24024 antigen processing and presentation 5 WKY 1385465_at sialic acid binding Ig-like lectin 5 Siglec5 BG379188 sialic acid-recognizing receptor 5 WKY 1393108_at major histocompatability antigen Mhc BM387813 antigen processing and presentation 5 WKY 1388202_at major histocompatability antigen Mhc BI395698 antigen processing and presentation 5 WKY 1371171_at major histocompatability antigen Mhc M10094 antigen processing and presentation 5 WKY 1370382_at major histocompatability antigen Mhc BI279526 antigen processing and presentation 5 WKY 1371033_at major histocompatability antigen Mhc AI715202 antigen processing and presentation 5 WKY 1383991_at leucine rich repeat containing 8 family, member E Lrrc8e BE096426 proliferation and activation of lymphocytes and monocytes. 5 WKY 1383046_at complement component factor H Cfh; Fh AA957258 regulation of complement cascade 4 WKY 1369522_a_at CD244 natural killer cell receptor 2B4 2B4; Nmrk NM_022259 regulation of NK- and T-cell function 4 WKY 1368762_at ubiquitin D Ubd NM_053299 antigen processing and presentation; IFN gamma regulated 4 WKY 1382950_at guanylate nucleotide binding protein 4 Gbp4; Gbp3 AA901350 guanylate-binding protein; IFN gamma regulated 4 WKY 1394846_at paired-Ig-like receptor A2 Pira2 AI237640 immune regulator 4 WKY 1389369_at vacuolar protein sorting 52 Vps52 BF289017 antigen processing and presentation 4 WKY 1370791_at defensin RatNP-3 precursor NP-3b U16683 defense response to bacteria & fungi; xenobiotic processing 4 WKY 1376311_at netrin G1 Ntng1 BM391312 cytokine/chemokine expression; leukocyte infiltration 4 WKY 1391481_at endogenous retrovirus RNA (ERV). Erv BE104424 hypertension related immunosuppressive activity 4 WKY 1367794_at alpha-2-macroglobulin A2m1 NM_012488 acute phase response; plasma proteinase inhibitor 4 WKY 1370428_x_at major histocompatability antigen Mhc AJ249701 antigen processing and presentation 4 WKY 1370822_at major histocompatability antigen Mhc AF307302 antigen processing and presentation 4 WKY 1389734_x_at major histocompatability antigen Mhc BI282965 antigen processing and presentation 4 WKY 1383449_at major histocompatability antigen Mhc AA801218 antigen processing and presentation 4 WKY 1397859_x_at major histocompatability antigen Mhc BI291927 antigen processing and presentation 3 WKY 1391579_at purinergic receptor P2X, ligand-gated ion channel, 7 P2rx7 AI385229 ATP-dependent activation & release of proinflammatory cytokines 3 WKY 1387839_at major histocompatability antigen Mhc NM_012646 antigen processing and presentation 3 WKY 1388255_x_at major histocompatability antigen Mhc AJ243338 antigen processing and presentation 3 WKY 1372727_at suppresor of cytokine signaling 2 Socs-2 BM384088 inhibition of cytokine signalling 3 WKY 1388233_at cytokine inducible SH2-containing protein Cis AF065161 inhibition of cytokine signalling 3 WKY 1378690_at lymphocyte antigen 6, locus A Ly6a BI291986 CD4+ T cell proliferation and cytokine production 3 WKY 1382319_at G protein-coupled receptor 68 Gpr68 BM389005 inhibition of cytokine signalling/LPS inflammatory response 3 WKY 1374558_at icos ligand inducible T-cell co-stimulator Icosl AI010316 positive regulator of IL-4 3 WKY 1370429_at major histocompatability antigen Mhc L40362 antigen processing and presentation 3 WKY 1370186_at proteosome (prosome, macropain) subunit, beta type 9 Psmb9; Lmp2 AI599350 antigen processing and presentation 3 WKY 1369427_at macrophage expressed gene 1 Mpeg1 NM_022617 complement activity 3 WKY 1397222_at tripartite motif protein 39 Trim39; Rnf23 AW528473 clustered within the class I region of MHC 3 WKY 1379994_at polycystic kidney and hepatic disease 1-like 1 Pkhd1l1 AI070694 possible role in cellular immunity 3 WKY 1385029_at caspase 12 Casp12 BE110921 apoptosis 3 WKY *1387605_at caspase 12 Casp12 NM_130422 inhibition of cytokine signalling 3 WKY 1373536_at carboxypeptidase B Cpb AW525196 fibrinolysis inhibitor 3 WKY 1382868_at sema domain, transmembrane domain (TM), and cytoplasmic domain Sema6a BM387083 apoptosis; signal transduction 3 WKY 1378418_at TRAF-interacting protein with forkhead-associated domain, family member B Tifab BI285027 cytokine signal transduction 5 GK 1369836_at interferon-induced protein with tetratricopeptide repeats 1, proinflammatory Ifit1; Garg16 NM_020096 IFN-gamma regulated; inhibits cellular stress response 5 GK 1373992_at interferon-inducible GTPase Iigp1 AI408440 IFN-gamma regulated; resistance to intracellular pathogens 5 GK *1377950_at interferon-inducible GTPase Iigp1 AA955213 IFN-gamma regulated; resistance to intracellular pathogens 5 GK 1368490_at CD14 antigen Cd14 NM_021744 LPS signalling 5 GK 1388236_x_at major histocompatability antigen Mhc M24026 antigen processing and presentation 5 GK 1371213_at major histocompatability antigen Mhc AJ005023 antigen processing and presentation 5 GK 1371119_at major histocompatability antigen Mhc L40364 antigen processing and presentation 5 GK 1369110_x_at major histocompatability antigen Mhc NM_012645 antigen processing and presentation 5 GK 1379818_at major histocompatability antigen Mhc BF288109 antigen processing and presentation 4 GK 1388485_at chemokine (C-X-C motif) ligand 14 Cxcl14; Brak BG380414 chemokine signalling 4 GK 1386695_at lymphocyte antigen 75 Ly75 BF565756 antigen processing and presentation 4 GK 1396714_at phospholipase A2, activating protein Plaa; Plap BF394289 endothelial and smooth muscle response to inflammation 4 GK 1396205_at major histocompatability antigen Mhc BI303419 antigen processing and presentation 4 GK 1370463_x_at major histocompatability antigen Mhc U50449 antigen processing and presentation 1 Table 2. Cont’d. A. Immune/Inflammatory (67 probe sets, 63 genes) Age Strain Probe ID Gene Name Symbol Accession Gene Function 4 GK 1396304_at major histocompatability antigen Mhc BI292055 antigen processing and presentation 3 GK 1396155_at immunoglobulin heavy chain: constant region and partial variable region Ighg BF283527 immunoglobulin 3 GK 1387902_a_at immunoglobulin kappa chain complex Igkc L22655 immunoglobulin 3 GK 1370056_at lymphocyte antigen 6 complex locus C Ly6-C antigen Ly6c NM_020103 CD4+ T cell proliferation and cytokine production 3 GK 1374334_at Immunoglobulin heavy chain (alpha polypeptide) Ighg AI412189 immunoglobulin 3 GK 1379357_at major histocompatability antigen Mhc AI408767 antigen processing and presentation 3 GK 1388342_at ets variant gene 3 Etv3 BI291344 macrophage differentiation 3 GK 1387366_at interleukin enhancer binding factor 3 Ilf3 NM_053412 double-stranded RNA-binding protein B. Lipid Metabolism (46 probe sets, 37 genes) Age Strain Probe ID Gene Name Symbol Accession Gene Function 5 WKY 1369663_at epoxide hydrolase 2, cytoplasmic Ephx2 NM_022936 eicosanoid breakdown; hypercholesterolemia 5 WKY 1367939_at retinol binding protein 1, cellular Rbp1 NM_012733 intracellular retinol carrier 5 WKY 1383303_at acyl-CoA synthetase medium-chain family member 3 Acsm3; Sa; Sah BI282211 fatty acid metabolism; hypertension 5 WKY 1377407_at Aa2-174 Cc1-38; Aa2-174 BI290154 fatty acid metabolism 4 WKY 1374610_at 1-acylglycerol-3-phosphate O-acyltransferase 9 Agpat9 AI599365 phospholipid biosynthesis 4 WKY 1368396_at carboxyl ester lipase Cel NM_016997 cholesterol, triglyceride catabolism 4 WKY 1368745_at solute carrier family 10, member 2 Slc10a2; Isbat NM_017222 bile salt transporter 4 WKY 1381732_at fatty acid binding protein 7 Fabp7 BF398558 fatty acid transporter 4 WKY 1369531_at sulfotransferase family, cytosolic, 1C, member 2 Sult1c2 NM_133547 degradation of bile acids through sulfation 4 WKY *1377672_at sulfotransferase family, cytosolic, 1C, member 2 Sult1c2 BI300997 degradation of bile acids through sulfation 4 WKY 1383600_at solute carrier family 13 (sodium-dependent citrate transporter), member 5 Slc13a5; Nact BG381311 citrate transport; fatty acid and cholesterol synthesis 3 WKY 1393551_at apolipoprotein A-II Apoa2 AI044529 apolipoprotein; HDL 3 WKY 1368784_at apobec-1 complementation factor Apobec-1 NM_133400 apolipoprotein synthesis; HDL 3 WKY 1388349_at creatine kinase, mitochondrial 2, sarcomeric Ckmt2 AA799557 phosphocreatine metabolism 3 WKY 1370257_at phospholipase A2, group IB Pla2g1b AI234860 phospholipid catabolism 3 WKY *1370024_at fatty acid binding protein 7 Fabp7 NM_030832 fatty acid transporter 3 WKY 1387766_a_at retinol binding protein 2, cellular Rbp2 NM_012640 vitamin A availability and storage 3 WKY 1369440_at ATP-binding cassette, sub-family G (WHITE), member 5 Abcg5; Sterolin 2 NM_130414 cholesterol absorption & transport 3 WKY 1385014_at nucleoside diphosphate linked moiety X-type motif 11 nudix BG377996 phosphohydrolase; regulation of CoA & acetylCoA levels 3 WKY 1387787_at myosin, light polypeptide 2, regulatory Myl2; Mlc2 NM_012605 trafficking of Bile Salt Export Protein 3 WKY *1388200_at myosin, light polypeptide 2, regulatory Myl2; Mlc2 BF419995 trafficking of Bile