Strategic Plan 2010-2015 OICR timeline from 2000 to 2010 The Government of The Government of Ontario Ontario asked Dr. Cabinet approved created the Ontario Cancer OCRN’s board of Calvin Stiller to lead a the Stiller Committee Research Network (OCRN), a directors held its group to recommend recommendation to three-year initiative with three OCRN was first meeting. how a $50 million focus on translational components: The Government of incorporated Mr. George Glover investment in cancer research related to Cancer Research Fund Ontario hired as a federal was appointed the research could have development of new Virtual Information Network Dr. Robert Phillips to not-for-profit first chair of the the greatest impact. cancer therapies. Tumour Bank Network. set up and run OCRN. corporation. board of directors. 05 . 2000 12 . 2000 11 . 2001 09 . 2000 09 . 2001 01 . 2002 Dr. Bette Stephenson The Ontario Innovation Trust provided The Government of Ontario Drs. funding to explore what it would announced it would spend Stephenson The Government of take for Ontario to make a significant $1 billion over 10 years to and Stiller The Cancer Ontario announced impact on cancer; Mr. George Connell, create a cancer research Dr. John Evans submitted Research $50 million in Dr. Louis Siminovitch, Dr. Charles institute; Drs. Bette was appointed their report Fund held additional funding for Hollenberg, Ms. Michele Noble and Stephenson and Calvin Stiller chair of OCRN’s to the its first grant OCRN, extending its Dr. Patrick Lafferty began work on a were asked to spearhead the board of Government competition. mandate to four years. proposal. development of the institute. directors. of Ontario. 05. 2002 07 . 2002 10 . 2003 06 . 2002 03 . 2003 01 . 2004 OCRN’s board of directors was expanded to include Dr. Elizabeth Eisenhauer Dr. Phillip Sharp The Government representatives of the University OICR appointed Dr. Elizabeth Eisenhauer, of Ontario Health Network (UHN) (Princess Director, Investigational New Drug Program OICR’s board announced its Margaret Hospital), Cancer Ontario Premier Dalton NCIC Clinical Trials Group, Professor, Department of directors intent to create Care Ontario, the Council of McGuinty announced the of Oncology, Queen’s University and Co-Chair began a a new cancer Ontario Universities and the launch of the Ontario Institute Canadian Cancer Research Alliance and Dr. Phillip search for research institute Council of Academic Hospitals for Cancer Research (OICR) Sharp, Institute Professor, Center for Cancer the founding and asked OCRN of Ontario. It became the at a news conference at the Research, Massachusetts Institute of Technology, President to evolve into the founding board of directors of Hospital for Sick Children as co-chairs of, as well as seven members to, its and Scientific new institute. the new institute. in Toronto. Scientific Advisory Board (SAB). Director. 05. 2005 12. 2005 01. 2006 06 . 2005 12 . 2005 The Ministry of Research OICR joined the RNAi and Innovation Consortium based at the approved OICR’s Broad Institute of Harvard strategic plan. and MIT. The Consortium Dr. Hudson began The SAB will create research The Premier of Ontario consultation held its first 02. 2007 reagents consisting of announced the creation of the Dr. Tom Hudson was with the Ontario meeting specific RNAi inhibitors Cancer Stem Cell Consortium appointed President cancer research and Dr. Robert targeting human and at an event at MaRS with and Scientific Director. community and discussed Sutherland was mouse genes which will California Governor Arnold Dr. Phillips was external experts to strategic appointed be used to discover key Schwarzenegger. He also appointed Deputy develop a strategic directions Vice-President, genes underlying normal announced $30 million in Director. research plan. for OICR. Commercialization. physiology and disease. funding for this initiative. 07. 2006 03. 2007 05 . 2007 06 . 2006 09 . 2006 04 . 2007 OICR invested in five signature initiatives: OICR contributed funding Cancer Stem Cell OICR launched for the creation of the Centre Program ($17 million); the Intellectual for Probe Development and One Millimetre Cancer Property Commercialization (CPDC), Challenge ($12.5 million); Development and a Centre of Excellence for OICR awarded Imaging Pipeline Commercialization The Terry Fox Foundation Commercialization and Research, up to $500,000 Platform ($10 million); Program (IPDCP) announced the creation of the funded by the federal Networks each to four Cancer Research Fund to facilitate the Terry Fox Research Institute of Centres of Excellence. The recipients to ($8.7 million); and state- development and (TFRI). The TFRI established CPDC is the world’s first facility OICR hosted continue the of-the-art equipment in commercialization nodes across Canada and focusing on all areas related to its first Annual early commercial 11 research institutions of cancer-related launched the Ontario node in the development of molecular Scientific development of across Ontario discoveries. partnership with OICR. imaging probes. Meeting. their discoveries. ($9.8 million). 10. 2007 02. 2008 07 . 2007 02 . 2008 04 . 2008 04 . 2008 The Canadian Partnership Against Cancer (CPAC) announced the launch of The Canadian OICR invested The Premier of Ontario announced Partnership for Tomorrow Project with $42 $500,000 in DVS the launch of the International Cancer million in funding. The Project will study 300,000 Sciences Inc., for a Genome Consortium (ICGC) at a Canadians to explore how genetics, environment, novel technology news conference at MaRS. OICR was lifestyle and behaviours contribute to the OICR and the TFRI to facilitate the selected by the Consortium to house development of cancer. OICR is a partner in launched the Selective identification of the Data Coordination Centre and the project; its Ontario Health Study will follow Therapies Target biomarkers to study host the Secretariat for the ICGC. 150,000 people in Ontario for 20 years. Identification Program. and diagnose cancer. 06. 2008 07 . 2008 04 . 2008 06 . 2008 GE Healthcare announced that The Premier of Ontario OICR received Hamilton is the first site in the announced funding of $12.5 million world to receive new prototype $10 million through OICR from the Canada technologies for molecular breast OICR invested for the Ontario Regional Foundation The ICGC announced imaging research because of the $2.25 million in Biotherapeutics Program for Innovation the launch of eight strong research partnerships among five promising (ORBiT) to develop to support the cancer genome OICR-funded scientists at the early stage cancer therapies based on cells, Pancreatic Cancer projects by 11 Dr. Stiller was Centre for Probe Development and technologies genes and viruses, which Genome Project funding organizations. appointed Commercialization and the oncology to continue the can be programmed to and the Data Ontario scientists chair of OICR’s and nuclear medicine programs at early commercial target diseased tissue Coordination are sequencing board of McMaster University and Hamilton development of without harming normal Centre for the ICGC. pancreatic cancer. directors. Health Sciences. these discoveries. tissue. 01. 2009 04. 2009 06. 2009 11 . 2008 01. 2009 06 . 2009 Pfizer Global Research and Development announced an investment of $6 million in the POP-CURE Project, a partnership of Pfizer, OICR, and the Ontario Cancer Dr. Nicole Onetto Dr. Eric Lander Institute, the research arm of UHN’s Dr. Phillips retired as Deputy Director Princess Margaret Hospital. POP-CURE of OICR and Dr. Nicole Onetto was will discover and validate new targets for appointed Deputy Director. Dr. Sharp Mr. Frank Stonebanks the diagnosis, prognosis and treatment resigned as co-chair of the SAB. Dr. Sutherland retired as Vice- of colorectal cancer. The Government Dr. Eric Lander, President and Founding President, Commercialization and of Ontario awarded $900,000 to Pfizer Director of the Broad Institute of MIT Mr. Frank Stonebanks was appointed through its Biopharmaceutical Investment and Harvard was appointed co-chair of Vice-President, Commercialization Program for the POP-CURE project. the SAB (with Dr. Eisenhauer). and Chief Commercial Officer. 11. 2009 07 . 2009 02 . 2010 Table of Contents Background.......................................................................................... 5 Grand Challenges in Cancer Research....................................................... 9 Accelerating Translation – OICR’s Translation Priorities............................... 10 Innovation Programs.............................................................................. 23 Technology Platforms............................................................................. 26 Translation Programs............................................................................. 29 Other OICR Initiatives............................................................................ 32 Conclusion............................................................................................ 33 OICR Leaders........................................................................................ 34 Board of Directors.................................................................................. 38 Scientific Advisory Board......................................................................... 39 Background Vision The Ontario Institute for Cancer Research (OICR), launched December 2, 2005, is a new centre of excellence that is moving the province