Dementia and Antipsychotic Treatment: Literature Search Strategies Use of second generation antipsychotic agents for off-label uses including dementia These searches were conducted on 02/03/13 and were an extension of the search strategy used for the AHRQ review of Maglione et al. (2011). MEDLINE (PubMed) #1 Search atypical antipsychotic* OR atypical anti-psychotic* OR "risperidone"[MeSH 17550 Terms]OR "paliperidone palmitate"[Supplementary Concept] OR "asenapine"[Supplementary Concept] OR "iloperidone"[Supplementary Concept] OR "risperidone"[Supplementary Concept] OR "ziprasidone"[Supplementary Concept] OR "olanzapine"[Supplementary Concept] OR "quetiapine"[Supplementary Concept] OR "aripiprazole"[Supplementary Concept] OR olanzapine[tiab] OR quetiapine[tiab] OR risperidone[tiab] OR ziprasidone[tiab] OR aripiprazole[tiab] OR paliperidone[tiab] OR iloperidone[tiab] OR asenapine[tiab] #2 Search "Antipsychotic Agents"[MeSH] OR "Antipsychotic Agents"[Pharmacological 118317 Action] #3 Search "Sleep Initiation and Maintenance Disorders"[Mesh] OR insomni*[tiab] OR 932761 sleep*[tiab] OR "Anorexia Nervosa"[Mesh] OR "Anorexia"[Mesh] OR "Bulimia"[Mesh] OR "Bulimia Nervosa"[Mesh] OR anorexi*[tiab] OR bulimi*[tiab] OR substance abuse* OR drug abuse* OR alcohol abuse OR addict* OR drug dependen* OR cocaine OR heroin OR "Substance-Related Disorders"[Mesh] OR "Anxiety"[Mesh] OR "Anxiety Disorders"[Mesh] OR "Anti-Anxiety Agents"[Mesh] OR "Anti-Anxiety Agents "[Pharmacological Action] OR anxiety[tiab] OR anxious*[tiab] OR anti-anxiety[tiab] OR antianxiety[tiab] OR autism [tiab] OR autistic[tiab] OR "Attention Deficit Disorder with Hyperactivity"[Mesh] OR attention deficit disorder[tiab] OR adhd [tiab] OR "Tourette Syndrome"[Mesh] OR tourette*[tiab] OR "Obsessive-Compulsive Disorder"[Mesh] OR "Obsessive Behavior"[Mesh] OR "Stress Disorders, Post-Traumatic"[Mesh] OR "Personality Disorders"[Mesh] OR "Dementia"[Mesh] OR "Depressive Disorder, Major"[Mesh] OR obsessive*[tiab] OR posttraumatic stress[tiab] OR post-traumatic stress[tiab] OR post traumatic stress[tiab] OR ptsd[tiab] OR personality disorder*[tiab] OR dementia[tiab] OR major depress*[tiab] #4 Search "off-label" [tiab] OR "off label" [tiab] OR "offlabel" [tiab] 2874 #5 Search (#1 OR #2) AND (#3 OR #4) 27141 #6 Search ((animal*[tiab] OR "animals"[MeSH Terms]) NOT (human[tiab] OR humans[tiab] 3636066 OR "humans"[MeSH Terms])) #7 Search (#5) NOT #6 22076 #8 Search english[Language] 18108524 #9 Search (#7) AND #8 18687 #10 Search ("2010/09/01"[Date - Publication] : "2013/02/01"[Date - Publication]) 2240450 #11 Search (#9) AND #10 1624 PsycInfo S1 olanzapine OR quetiapine OR risperidone OR ziprasidone OR aripiprazole OR 10,413 paliperidone OR iloperidone OR asenapine S2 (atypical antipsychotic* OR atypical anti-psychotic*) 5,773 S3 (depression OR depressive OR anxiety OR anti-anxiety OR antianxiety OR 552,744 insomnia OR sleep* OR anorexi* OR bulimi* OR tourett* OR attention deficit disorder OR adhd OR substance abuse* OR drug abuse* OR alcohol abuse OR addict* OR drug dependen* OR cocaine OR heroin OR personality disorder* OR posttraumatic stress disorder OR post-traumatic stress OR ptsd or dementia OR "major depressive" OR obsessive-compulsive OR obsessive compulsive or dementia OR ((geriatric OR elderly) AND (agitation OR agitated))) S4 KW (off-label OR "off label" OR offlabel OR pharmacoepidemiolog*) OR TI (off- 168 label OR "off label" OR offlabel OR pharmacoepidemiolog*) S5 S1 OR S2 12,864 S6 S3 OR S4 548,086 S7 S5 AND S6 4,131 S8 LA english 3,126,642 S9 S7 AND S8 3,849 S10 S9 Limiters - Published Date from: 20100901-20130231 657 Cochrane Library #1 olanzapine: ti,ab, kw or quetiapine: ti,ab, kw or risperidone: ti,ab, kw or 3631 ziprasidone: ti,ab, kw or aripiprazole: ti,ab, kw #2 asenapine: ti,ab, kw or iloperidone: ti,ab, kw or paliperidone: ti,ab, kw 107 #3 #1 or #2 3697 #4 "schizophrenia": ti,ab, kw or "bipolar disorder": ti,ab, kw 9459 #5 #3 not #5 1496 Limited to Systematic Reviews and Controlled Trials 1457 Use of antipsychotic agents for patients with dementia These searches were conducted on in January 2015 and were designed to encompass all possible literature that addressed the use of antipsychotic agents in individuals with dementia, including literature already covered by the prior search and the searches used in the AHRQ review on use of atypical antipsychotic agents for off-label indications.