Anti-WIPF1 monoclonal antibody (DCABH-201724) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. Immunogen A synthetic peptide of human WIPF1 is used for rabbit immunization. Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Protein A Conjugate Unconjugated Applications WB, ELISA Size 1 mg Buffer In 1x PBS, pH 7.4 Preservative None Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. GENE INFORMATION Gene Name WIPF1 WAS/WASL interacting protein family, member 1 [ Homo sapiens (human) ] Official Symbol WIPF1 Synonyms WIPF1; WAS/WASL interacting protein family, member 1; WIP; PRPL-2; WASPIP; WAS/WASL- interacting protein family member 1; protein PRPL-2; WASP-interacting protein; Wiskott-Aldrich syndrome protein interacting protein; Entrez Gene ID 7456 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Protein Refseq NP_001070737 UniProt ID O43516 Chromosome Location 2q31.1 Pathway Fc-epsilon receptor I signaling in mast cells; Fcgamma receptor (FCGR) dependent phagocytosis; Immune System; Innate Immune System; Regulation of actin dynamics for phagocytic cup formation; Function actin binding; profilin binding; protein binding; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.