Supplementary Table 1: Reference Reference Sample MSI Test / Study ID 829 gene 192 gene Type status Training classifier classifier Giacomin et al CRC cell line NCI-H508 MSS Training Y Y Giacomini et al CRC cell line LS-180 MSI Training Y Y Giacomini et al CRC cell line LS-174T MSI Training Y Y Giacomini et al CRC cell line SW-403 MSS Training Y Y Giacomini et al CRC cell line HCT116 MSI Training Y Y Giacomini et al CRC cell line LS411 MSI Test Giacomini et al CRC cell line T84 MSS Test Giacomini et al CRC cell line SW-480 MSS Training Y Y Giacomini et al CRC cell line COLO741 MSS Test Giacomini et al CRC cell line COLO320 MSS Test Giacomini et al CRC cell line DLD-1 MSI Training Y Y Giacomini et al CRC cell line COLO205 MSS Test Giacomini et al CRC cell line HT-29 MSS Training Y Y Giacomini et al CRC cell line SW620 MSS Training Y Y Giacomini et al CRC cell line LIM2412 MSI Test Giacomini et al CRC cell line SW-1116 MSS Training Y Y Giacomini et al CRC cell line LIM1215 MSI Test Giacomini et al CRC cell line RKO MSI Training Y Y Giacomini et al CRC cell line HCT15 MSI Training Y Y Giacomini et al CRC cell line GP5D MSI Training Y Y Giacomini et al CRC cell line SW48 MSI Training Y Y Giacomini et al CRC cell line SK-CO-1 MSS Training Y Y Giacomini et al CRC cell line HCA7 MSI Test Giacomini et al CRC cell line SNUC2B MSI Test Giacomini et al CRC cell line SW1417 MSS Test Giacomini et al CRC cell line SW948 MSS Test Giacomini et al CRC cell line GP2D MSI Training Y Y Giacomini et al CRC cell line LOVO MSI Training Y Y Giacomini et al CRC cell line SW-837 MSS Training Y Y Giacomini et al CRC cell line NCI-H747 MSS Training Y Y Giacomini et al CRC cell line CACO-2 MSS Training Y Y Koinuma et al Primary CRC 225 MSI Training Y Y Koinuma et al Primary CRC 263 MSI Training Y Y Koinuma et al Primary CRC 280 MSI Training Y Y Koinuma et al Primary CRC 305 MSI Training Y Y Koinuma et al Primary CRC 318 MSI Training Y Y Koinuma et al Primary CRC 336 MSI Training Y Y Koinuma et al Primary CRC 413 MSI Training Y Y Koinuma et al Primary CRC 416 MSI Training Y Y Koinuma et al Primary CRC 433 MSI Training Y Y Koinuma et al Primary CRC 479 MSI Training Y Y Koinuma et al Primary CRC 238 MSS Training Y Y Koinuma et al Primary CRC 249 MSS Training Y Y Koinuma et al Primary CRC 278 MSS Training Y Y 1 Koinuma et al Primary CRC 295 MSS Training Y Y Koinuma et al Primary CRC 298 MSS Training Y Y Koinuma et al Primary CRC 307 MSS Training Y Y Koinuma et al Primary CRC 308 MSS Training Y Y Koinuma et al Primary CRC 319 MSS Training Y Y Koinuma et al Primary CRC 419 MSS Training Y Y Koinuma et al Primary CRC 426 MSS Training Y Y Watanabe et al Primary CRC Patient_01 MSS Training Y Y Watanabe et al Primary CRC Patient_02 MSS Training Y Y Watanabe et al Primary CRC Patient_03 MSI Test Watanabe et al Primary CRC Patient_04 MSS Training Y Y Watanabe et al Primary CRC Patient_05 MSI Test Watanabe et al Primary CRC Patient_06 MSS Training Watanabe et al Primary CRC Patient_07 MSS Test Watanabe et al Primary CRC Patient_08 MSS Training Y Y Watanabe et al Primary CRC Patient_09 MSS Training Watanabe et al Primary CRC Patient_10 MSS Test Watanabe et al Primary CRC Patient_11 MSS Test Watanabe et al Primary CRC Patient_12 MSS Training Y Y Watanabe et al Primary CRC Patient_13 MSS Training Y Y Watanabe et al Primary CRC Patient_14 MSS Training Watanabe et al Primary CRC Patient_15 MSI Test Watanabe et al Primary CRC Patient_16 MSI Training Y Y Watanabe et al Primary CRC Patient_17 MSS Test Watanabe et al Primary CRC Patient_18 MSS Training Y Y Watanabe et al Primary CRC Patient_19 MSI Training Y Y Watanabe et al Primary CRC Patient_20 MSI Training Y Y Watanabe et al Primary CRC Patient_21 MSS Test Watanabe et al Primary CRC Patient_22 MSI Training Y Y Watanabe et al Primary CRC Patient_23 MSS Test Watanabe et al Primary CRC Patient_24 MSS Training Y Y Watanabe et al Primary CRC Patient_25 MSS Test Watanabe et al Primary CRC Patient_26 MSS Training Y Y Watanabe et al Primary CRC Patient_27 MSS Test Watanabe et al Primary CRC Patient_28 MSS Test Watanabe et al Primary CRC Patient_29 MSS Training Y Y Watanabe et al Primary CRC Patient_30 MSS Training Y Y Watanabe et al Primary CRC Patient_31 MSS Training Y Y Watanabe et al Primary CRC Patient_32 MSS Test Watanabe et al Primary CRC Patient_33 MSS Training Y Y Watanabe et al Primary CRC Patient_34 MSS Training Y Y Watanabe et al Primary CRC Patient_35 MSS Training Y Y Watanabe et al Primary CRC Patient_36 MSS Training Y Y Watanabe et al Primary CRC Patient_37 MSS Training Y Y Watanabe et al Primary CRC Patient_38 MSS Training Y Y Watanabe et al Primary CRC Patient_39 MSS Training Y Y Watanabe et al Primary CRC Patient_40 MSS Test Watanabe et al Primary CRC Patient_41 MSS Training Y Y 2 Watanabe et al Primary CRC Patient_42 MSS Training Y Y Watanabe et al Primary CRC Patient_43 MSS Training Y Y Watanabe et al Primary CRC Patient_44 MSS Test Watanabe et al Primary CRC Patient_45 MSS Training Y Y Watanabe et al Primary CRC Patient_46 MSS Training Y Y Watanabe et al Primary CRC Patient_47 MSI Training Y Y Watanabe et al Primary CRC Patient_48 MSI Training Y Y Watanabe et al Primary CRC Patient_49 MSS Training Y Y Watanabe et al Primary CRC Patient_50 MSS Training Y Y Watanabe et al Primary CRC Patient_51 MSS Training Y Y Watanabe et al Primary CRC Patient_52 MSS Training Y Y Watanabe et al Primary CRC Patient_53 MSS Test Watanabe et al Primary CRC Patient_54 MSI Test Watanabe et al Primary CRC Patient_55 MSS Training Watanabe et al Primary CRC Patient_56 MSS Training Y Y Watanabe et al Primary CRC Patient_57 MSS Training Watanabe et al Primary CRC Patient_58 MSS Training Y Y Watanabe et al Primary CRC Patient_59 MSS Training Y Y Watanabe et al Primary CRC Patient_60 MSI Training Y Y Watanabe et al Primary CRC Patient_61 MSI Training Y Y Watanabe et al Primary CRC Patient_62 MSI Test Watanabe et al Primary CRC Patient_63 MSI Training Y Y Watanabe et al Primary CRC Patient_64 MSI Training Y Y Watanabe et al Primary CRC Patient_65 MSI Training Y Y Watanabe et al Primary CRC Patient_66 MSI Training Y Y Watanabe et al Primary CRC Patient_67 MSI Training Y Y Watanabe et al Primary CRC Patient_68 MSI Training Y Y Watanabe et al Primary CRC Patient_69 MSI Training Y Y Watanabe et al Primary CRC Patient_70 MSI Training Y Y Watanabe et al Primary CRC Patient_71 MSI Training Y Y Watanabe et al Primary CRC Patient_72 MSI Test Watanabe et al Primary CRC Patient_73 MSI Test Watanabe et al Primary CRC Patient_74 MSI Training Y Y Watanabe et al Primary CRC Patient_75 MSI Training Y Y Watanabe et al Primary CRC Patient_76 MSI Test Watanabe et al Primary CRC Patient_77 MSI Training Y Y Watanabe et al Primary CRC Patient_78 MSI Training Y Y Watanabe et al Primary CRC Patient_79 MSI Test Watanabe et al Primary CRC Patient_80 MSI Training Watanabe et al Primary CRC Patient_81 MSI Training Y Y Watanabe et al Primary CRC Patient_82 MSI Training Y Y Watanabe et al Primary CRC Patient_83 MSS Test Watanabe et al Primary CRC Patient_84 MSS Test Aarhus University Hospital Primary CRC R001 MSS Training Y Y Aarhus University Hospital Primary CRC R002 MSI Training Y Y Aarhus University Hospital Primary CRC R003 MSS Test Aarhus University Hospital Primary CRC R004 MSS Training Y Y Aarhus University Hospital Primary CRC R005 MSS Training Y Y 3 Aarhus University Hospital Primary CRC R006 MSS Training Y Y Aarhus University Hospital Primary CRC R007 MSS Training Y Y Aarhus University Hospital Primary CRC R008 MSS Test Aarhus University Hospital Primary CRC R009 MSI Test Aarhus University Hospital Primary CRC R010 MSI Training Y Y Aarhus University Hospital Primary CRC R011 MSS Training Y Y Aarhus University Hospital Primary CRC R012 MSS Test Aarhus University Hospital Primary CRC R013 MSS Training Y Aarhus University Hospital Primary CRC R014 MSS Test Aarhus University Hospital Primary CRC R015 MSS Test Aarhus University Hospital Primary CRC R016 MSI Training Y Y Aarhus University Hospital Primary CRC R017 MSS Test Aarhus University Hospital Primary CRC R018 MSI Training Y Y Aarhus University Hospital Primary CRC R019 MSS Training Y Y Aarhus University Hospital Primary CRC R020 MSI Training Y Y Aarhus University Hospital Primary CRC R021 MSI Training Y Y Aarhus University Hospital Primary CRC R022 MSS Training Y Y Aarhus University Hospital Primary CRC R023 MSI Training Y Y Aarhus University Hospital Primary CRC R024 MSS Training Y Y Aarhus University Hospital Primary CRC R025 MSS Training Y Y Aarhus University Hospital Primary CRC R026 MSS Training Y Y Aarhus University Hospital Primary CRC R027 MSS Training Y Y Aarhus University Hospital Primary CRC R028 MSS Training Y Y Aarhus University Hospital Primary CRC R029 MSS Test Aarhus University Hospital Primary CRC R030 MSS Training Y Y Aarhus University Hospital Primary CRC R031 MSS Test Aarhus University Hospital Primary CRC R035 MSI Test Aarhus University Hospital Primary CRC R040 MSI Test Aarhus University Hospital Primary CRC R056 MSI Test Aarhus University Hospital Primary CRC R059 MSI Training Y Y Aarhus University Hospital Primary CRC R073 MSI Training Y Y Aarhus University Hospital Primary CRC R077 MSI Test Aarhus University Hospital Primary CRC R088 MSS Test Aarhus University Hospital Primary CRC R089 MSS Test Aarhus University Hospital Primary CRC R090 MSS Training Y Y Aarhus University Hospital Primary CRC R091 MSS Training Y Y Aarhus University Hospital Primary CRC R092 MSI Training Y Y Aarhus University Hospital Primary CRC R093 MSS Training Y Y Aarhus University Hospital Primary CRC R094