Metabolic Disease Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models. www.MedChemExpress.com 1 Metabolic Disease Inhibitors & Modulators (-)-(S)-Equol (-)-Fucose Cat. No.: HY-100583 (6-Desoxygalactose; L-(-)-Fucose; L-Galactomethylose) Cat. No.: HY-N1480 Bioactivity: (-)-(S)-Equol is a high affinity ligand for estrogen receptor Bioactivity: (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure β with a Ki of 0.73 nM. determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interactions. Purity: 99.82% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 100 mg (-)-PX20606 trans isomer (24R)-MC 976 ((-)-PX-102 trans isomer; (-)-PX-104) Cat. No.: HY-100443B Cat. No.: HY-15267A Bioactivity: (-)-PX20606 trans isomer is a FXR agonist with EC50s of 18 Bioactivity: (24R)-MC 976 is a Vitamin D3 derivative. and 29 nM for FXR in FRET and M1H assay, respectively. Purity: 98.39% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 1 mg 1 mg, 2 mg (24S)-MC 976 (R)-(+)-Etomoxir sodium salt Cat. No.: HY-15267B ((+)-Etomoxir sodium salt) Cat. No.: HY-50202A Bioactivity: (24S)-MC 976 is a Vitamin D3 derivative. Bioactivity: (R)-(+)-Etomoxir sodium salt is the R-form of Etomoxir sodium salt. Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I ( CPT-1). Purity: >98% Purity: 99.94% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg Size: 10mM x 1mL in Water, 5 mg, 10 mg, 50 mg (R)-(-)-Phenylephrine (R,S)-Ivosidenib (Phenylephrine) Cat. No.: HY-B0769 ((R,S)-AG-120) Cat. No.: HY-18767A Bioactivity: (R)-(-)-Phenylephrine is a selective α1-adrenoceptor agonist Bioactivity: (R,S)-Ivosidenib is a inhibitor of Isocitrate Dehydrogenase primarily used as a decongestant. (IDH1). Purity: >98% Purity: 99.40% Clinical Data: Launched Clinical Data: No Development Reported Size: 200 mg Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 50 mg, 100 mg (S)-2-Hydroxy-3-phenylpropanoic acid (S)-2-Hydroxysuccinic acid Cat. No.: HY-30220 Cat. No.: HY-Y1069 Bioactivity: (S)-2-Hydroxy-3-phenylpropanoic acid, a product of Bioactivity: (S)-2-Hydroxysuccinic acid is a dicarboxylic acid in naturally phenylalanine catabolism, is a NAPDH oxidase inhibitor. occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 100 mg 5 g 2 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] (±)-Carnitine chloride (±)-SLV319 (DL-Carnitine chloride) Cat. No.: HY-B1453 ((±)-Ibipinabant; (±)-BMS6462) Cat. No.: HY-14791A Bioactivity: (±)-Carnitine chloride exists in two isomers, known as D and Bioactivity: (±)-SLV319 is the racemate of SLV319. SLV319 is a potent and L. L-carnitine plays an essential role in the β-oxidation of selective cannabinoid-1 ( CB-1) receptor antagonist with an fatty acids and also shows antioxidant, and anti-inflammatory IC50 of 22 nM. activities. Purity: 98.0% Purity: 99.49% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 g 5 mg, 10 mg, 50 mg, 100 mg 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine 1,5-Anhydrosorbitol (1,2-DSPE) Cat. No.: HY-112530 Cat. No.: HY-113075 Bioactivity: 1,2-Distearoyl-sn-glycero-3-phosphorylethanolamine (DSPE) is a Bioactivity: 1,5-Anhydrosorbitol is a short-term marker for glycemic phosphoethanolamine (PE) lipid that can be used in the control. synthesis of liposomes. Purity: 97.0% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 100 mg 1-Deoxynojirimycin 1-Methyl-L-histidine (Duvoglustat) Cat. No.: HY-14860 Cat. No.: HY-W017006 Bioactivity: 1-Deoxynojirimycin (DNJ, Duvoglustat) is a potent Bioactivity: 1-Methyl-L-histidine is an objective indicator of meat α-glucosidase inhibitor, suppresses postprandial blood ingestion and exogenous 3-methylhistidine (3MH) intake. glucose, thereby possibly preventing diabetes mellitus. Purity: 98.0% Purity: 98.0% Clinical Data: Phase 2 Clinical Data: No Development Reported Size: 10mM x 1mL in Water, Size: 10mM x 1mL in DMSO, 5 mg, 10 mg, 25 mg, 50 mg 10 mg, 25 mg 1-Methyluric acid 10Z-Nonadecenoic acid Cat. No.: HY-W010031 Cat. No.: HY-113450 Bioactivity: 1-Methyluric acid acts on the urinary bladder mucosa and Bioactivity: 10Z-Nonadecenoic acid is a kind of long-chain fatty acid with increases the blood glucose, insulin, triglyceride, and anti-tumor activity. cholesterol levels. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 11-oxo-mogroside V 18-Hydroxycorticosterone Cat. No.: HY-N0501 Cat. No.: HY-W013179 Bioactivity: 11-oxo-mogroside V is a natural sweetener, isolated from the Bioactivity: 18-Hydroxycorticosterone is a corticosteroid and a derivative fruits of Momordica grosvenori, exhibits strong antioxidant of corticosterone, which can lead to serious electrolyte activity. It exhibits significant inhibitory effects on imbalances. - reactive oxygen species ( O2 , H2O2 and *OH) w… Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg Size: www.MedChemExpress.com 3 1alpha, 24, 25-Trihydroxy VD2 1alpha, 25-Dihydroxy VD2-D6 Cat. No.: HY-15156 Cat. No.: HY-15327 Bioactivity: 1alpha, 24, 25-Trihydroxy VD2 is a vitamin D analog. Bioactivity: 1alpha, 25-Dihydroxy VD2-D6 is a deuterated form of vitamin D. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg Size: 1 mg, 5 mg 2'-Deoxyinosine 2-Hydroxy-2-methylbutanoic acid Cat. No.: HY-W008638 Cat. No.: HY-W015874 Bioactivity: 2’-deoxyadenosine inhibits the growth of human colon-carcinoma Bioactivity: 2-Hydroxy-2-methylbutanoic acid, an unusual metabolite, is cell lines and is found to be associated with purine associated with 2-hydroxyglutaric aciduria and maple syrup nucleoside phosphorylase (PNP) deficiency. urine disease. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 10mM x 1mL in DMSO, 1 g 2-Methoxyestrone 2-Methylsuccinic acid Cat. No.: HY-113252 Cat. No.: HY-W010381 Bioactivity: 2-Methoxyestrone is a methoxylated catechol estrogen and Bioactivity: 2-Methylsuccinic acid is a normal metabolite in human fluids metabolite of estrone, with a pKa of 10.81. and the main biochemical measurable features in ethylmalonic encephalopathy. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: Size: 10mM x 1mL in DMSO, 1 g 2-Phenylethanamine 2-Phenylpropionic acid Cat. No.: HY-W010483 Cat. No.: HY-W015608 Bioactivity: 2-Phenylethanamine is believed to function as a neuromodulator Bioactivity: 2-Phenylpropionic acid is an intermediate in or neurotransmitter. alpha-Methylstyrene metabolism. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 g Size: 10mM x 1mL in DMSO, 1 g 2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol 21-Hydroxypregnenolone Cat. No.: HY-U00264 Cat. No.: HY-113020 Bioactivity: 2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol is a triglyceride. Bioactivity: 21-Hydroxypregnenolone is an essential intermediate in corticosterone synthesis. Purity: >98% Purity: >98% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 5 mg, 10 mg, 20 mg Size: 4 Tel: 609-228-6898 Fax: 609-228-5909 Email: [email protected] 24, 25-Dihydroxy VD2 24, 25-Dihydroxy VD3 (24,25-Dihydroxy vitamin D2) Cat. No.: HY-76801 Cat. No.: HY-76915 Bioactivity: 24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin Bioactivity: 24, 25-Dihydroxy VD3 is a compound which is closely related to D2; a synthetic analog of Vitamin D. 1,25-dihydroxyvitamin D3, the active form of vitamin D3, but like vitamin D3 itself and 25-hydroxyvitamin D3 is inactive as a hormone both in vitro and in vivo. Purity: 99.79% Purity: 98.20% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 1 mg, 10 mg Size: 1 mg, 5 mg 25-Hydroxy VD2-D6 3,5-Dihydroxybenzoic acid Cat. No.: HY-15328 Cat. No.: HY-W015560 Bioactivity: 25-Hydroxy VD2-D6 is a labelled metabolite of Vitamin D2. Bioactivity: 3,5-Dihydroxybenzoic acid a potential biomarker for the consumption of many food products, including beer, nuts, peanut, and pulses. Purity: >98% Purity: 99.74% Clinical Data: No Development Reported Clinical Data: No Development Reported Size: 10mM x 1mL in DMSO, Size: 10mM x 1mL in DMSO, 1 mg, 5 mg 5 g 3-(3-Methoxyphenyl)propionic acid 3-Amino-2-methylpropanoic acid Cat. No.: HY-W016482 Cat. No.: HY-W012974 Bioactivity: 3-(3-Methoxyphenyl)propionic acid is an organic acid, Bioactivity: 3-Amino-2-methylpropanoic acid could induce browning of white naturally occurring human metabolite and excreted in human fat and hepatic β-oxidation and is inversely correlated with urine. cardiometabolic risk factors.