AAI ANNUAL MEETING ANNUAL AAI PROGRAM PREVIEW ISSUE PREVIEW PROGRAM TH 97 Volume 184 l No. 6 l March 15, 2010 184 l No. 6 l March Volume www.jimmunol.org THE journal OF Immunology VOL. 184 | NO. 6 | March 15, 2010 | Pages 2741–3300 PROGRAM PREVIEW MIMMUNOLOGYMUNOLOG 2010YTM Important Links For program updates and complete meeting information, visit Online Registration www.IMMUNOLOGY2010.org/Registration.htm www.IMMUNOLOGY2010.org Hotel Reservations www.IMMUNOLOGY2010.org/Housing.htm International Attendees www.IMMUNOLOGY2010.org/Visa.htm THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS | 97th ANNUAL MEETING May 7–11, 2010 | Baltimore Convention Center | Baltimore, Maryland | www.immunology2010.org IMMUNOLOGY 2010™ 97th Annual Meeting The American Association See you in Baltimore! of Immunologists All activities for the meeting will be held at the Baltimore May 7–11, 2010 N Baltimore, Maryland Baltimore Convention Center Convention Center (BCC) unless otherwise noted. www.immunology2010.org AAI PRESIDENT’S PROGRAM AAI President’s Address Presentation of AAI Lifetime FRIDAY, MAY 7 N 5:00 PM Achievement Award BCC BALLROOM I & II SATURDAY, MAY 8 N 5:00 PM N BCC BALLROOM I & II Betty A. Diamond, The Feinstein Institute for Chair: Betty A. Diamond, The Feinstein Institute Medical Research, AAI President for Medical Research, AAI President Antibodies and the brain: Award Recipient: Susan L. Swain lessons from lupus Trudeau Institute Matthew D. Scharff, Albert Einstein College The AAI Lifetime Achievement Award is the of Medicine, Introduction highest honor bestowed by the AAI Council upon an AAI member. This award recognizes Presentation of AAI Excellence a deserving member for a career of scientific in Mentoring Award achievement and for contributions to AAI and MONDAY, MAY 10 N 2:30 PM N BCC BALLROOM I & II fellow immunologists. The award will be presented prior to the start of Alan Sher’s AAI Distinguished Lecture. Chair: Betty A. Diamond, The Feinstein Institute for Medical Research, AAI President AAI Excellence in Mentoring Award AAI DISTINGUISHED LECTURES Award Recipient: Jack L. Strominger Generously supported by eBioscience, Inc. Harvard University Hidde Ploegh, MIT, Introduction SATURDAY, MAY 8 N 5:00 PM The AAI Excellence in Mentoring Award recognizes an BCC BALLROOM I & II AAI member’s exemplary career contributions to a future Alan Sher generation of scientists. The award will be presented prior NIAID, NIH to the start of the AAI President’s Symposium. Learning immunoregulation from parasites AAI President’s Symposium Neural and Immune Interactions: A New Frontier SUNDAY, MAY 9 N 5:00 PM MONDAY, MAY 10 N 2:30 PM–4:30 PM N BCC BALLROOM I & II BCC BALLROOM I & II Chair: Betty A. Diamond, The Feinstein Institute for Medical Research, AAI President Pamela S. Ohashi University of Toronto Kevin J. Tracey Britta Engelhardt Breaking T cell tolerance to tissue/tumor The Feinstein University of Bern antigens: a perspective nstitute for How immune cells Medical Research enter the central Reflex control of nervous system: MONDAY, MAY 10 N 5:00 PM mmunity anatomical pathways BCC BALLROOM I & II and molecular cues Mitchell Kronenberg La Jolla Institute for Allergy Madeleine W. Lawrence Steinman and Immunology Cunningham Stanford University Natural killer T cells ignite the immune University of Biomarkers guide Oklahoma Health patient selection for response to microbes by acting like Sciences Center argeting innate or innate immune cells Molecular mimicry in adaptive immunity in Dedicated to the memory of Eli Sercarz he immune system: multiple sclerosis effects on the brain IMMUNOLOGY 2010™ | THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS AAI MAJOR SYMPOSIA SATURDAY, MAY 8 | 8:00 AM–11:30 AM SUNDAY, MAY 9 | 8:00 AM–11:30 AM BCC BALLROOM I BCC BALLROOM I Major Symposium A—Immunoimaging: Visualizing Major Symposium C—Regulation of Immunity by the Immune Response in Real-Time by Multiphoton Transcriptional and Epigenetic Networks Microscopy Chair: Kenneth M. Murphy, Washington University School Chair: Michael D. Cahalan, University of California, Irvine of Medicine Co-chair: Matthew F. Krummel, University of California, Co-chair: Dan R. Littman, New York University School San Francisco of Medicine UÊ Michael D. Cahalan, University of California, Irvine U Mark Schlissel, University of California, Berkeley There and back again: immunoimaging in peripheral tissue Transcription factors and signaling pathways that regulate and in lymphoid organs the V(D)J recombinase UÊ Matthew F. Krummel, University of California, San Francisco U Katia Georgopoulos, Massachusetts General Hospital/ Visualization of effective and defective antigen presentation Harvard Medical School, Ikaros and the rise and fall of the in vivo immune system UÊ Ronald N. Germain, NIAID/NIH, Connecting the dots: U Tian Chi, Yale University, Two novel genetic approaches for dynamic in situ analysis of innate and adaptive immunity studying epigenetic control in T cells using intravital 2-photon microscopy U Keji Zhao, NHLBI/NIH, Epigenetic regulation of T cell UÊ Ellen A. Robey, University of California, Berkeley, Imaging of differentiation T cells and thymocytes in action using 2-photon microscopy U Diane J. Mathis, Harvard Medical School, The molecular UÊ Mark J. Miller, Washington University School of Medicine mechanism of Aire Regulation of leukocyte trafficking in mouse models of U Kenneth M. Murphy, Washington University School of inflammation and infection Medicine, Immune lineage decisions regulated by atypical UÊ Thorsten R. Mempel, Massachusetts General Hospital AP-1 factors T cell migration and function during an anti-tumor immune response BCC BALLROOM II Major Symposium D—New Insights into Mast Cell BCC BALLROOM II Function Major Symposium B—Follicular Helper T Cells: Chair: Stephen J. Galli, Stanford University Lineage and Function Co-chair: Melissa A. Brown, Northwestern University Chair: Michael G. McHeyzer-Williams, Scripps Research U Juan Rivera, NIAMS/NIH, Sphingosine kinases and Institute sphingosine-1-phosphate in mast cell biology and function Co-chair: Carola G. Vinuesa, Australian National University U Toshiaki Kawakami, La Jolla Institute for Allergy and U Shane Crotty La Jolla Institute for Allergy and Immunology Immunology PLC-B3 a tumor suppressor inhibits skin AAI MAJOR SYMPOSIA MONDAY, MAY 10 | 8:00 AM–11:30 AM TUESDAY, MAY 11 | 8:00 AM–11:30 AM BCC BALLROOM I BCC BALLROOM I Major Symposium E—Multi-scale Computational and Major Symposium G—Evolution of Immunocompetent Systems Approaches to Understanding Immunity Lymphocytes and Their Receptors Chair: Ronald N. Germain, NIAID/NIH Chair: Max D. Cooper, Emory University Co-chair: Denise E. Kirschner, University of Michigan Co-chair: Martin F. Flajnik, University of Maryland at Baltimore Medical School UÊ Ellen Hsu, State University of New York, The basis of allelic UÊ Ronald N. Germain, NIAID/NIH, Introduction exclusion? UÊ Douglas A. Lauffenburger, MIT, Quantitative analysis of UÊ Martin F. Flajnik, University of Maryland at Baltimore interleukin-7 receptor/ligand dynamics, signaling, and Immunoglobulins and gamma/delta T cell receptors: responses in naive T cells: combined experiment and How do we decide? modeling studies U John P. Cannon, University of South Florida, Genetics, UÊ Martin Meier-Schellersheim, NIAID/NIH, Computational structure and function of novel immune receptors cell biology–from molecular interactions to cellular UÊ Max D. Cooper, Emory University, Evolution of alternative communication adaptive immune systems UÊ Byron Goldstein, Los Alamos National Laboratory U Thomas Boehm, Max-Planck-Institute of Immunobiology From ligand-induced receptor aggregation to the Evolution of the thymus in vertebrates aggregation of LAT: a systems biology approach to UÊ Roy A. Mariuzza, University of Maryland Biotechnology modeling FcERI-mediated mast cell signaling Institute, Structural insights into the evolution of adaptive U Penelope A. Morel, University of Pittsburgh, Under- immunity standing local innate immune responses to pathogens U Denise E. Kirschner, University of Michigan Medical BCC BALLROOM II School Multi-scale and multi-systems approaches toward Major Symposium H—Negative Regulatory Networks understanding the immune response to Mycobacterium in Health and Disease tuberculosis infection Chair: Arlene H. Sharpe, Harvard Medical School U Christophe Benoist, Harvard Medical School The immunological genome project Co-chair: Dario A. A. Vignali, St. Jude Children’s Research Hospital BCC BALLROOM II U Arlene H. Sharpe, Harvard Medical School, Role of co-inhibitory pathways in regulating the balance between Major Symposium F—Innate Immunoregulation at T cell activation and tolerance Mucosal Interfaces U David G. Brooks, UCLA, Positive and negative regulation Chair: Richard S. Blumberg, Brigham & Women’s Hospital/ of immunity during viral persistence Harvard Medical School U Dario A. A. Vignali, St. Jude Children’s Research Hospital Co-chair: Bana Jabri, University of Chicago Dissecting regulatory T cell function UÊ Thaddeus S. Stappenbeck, Washington University School U Christopher A. Hunter, University of Pennsylvania School of of Medicine, Autophagy, Paneth cells and intestinal inflam- Veterinary Medicine, Additional roles for IL-27 in immune mation regulation UÊ Richard S. Blumberg, Brigham & Women’s Hospital/ U Jane Hoyt Buckner, Benaroya Research Institute at Virginia Harvard Medical School, ER stress and intestinal inflammation Mason, Mechanisms of impaired tolerance in type 1 diabetes UÊ Andrew J.