University of Birmingham Uterotonic agents for preventing postpartum haemorrhage Gallos, Ioannis D; Williams, Helen M; Price, Malcolm J; Merriel, Abi; Gee, Harold; Lissauer, David; Moorthy, Vidhya; Tobias, Aurelio; Deeks, Jonathan J; Widmer, Mariana; Tunçalp, Özge; Gülmezoglu, Ahmet Metin; Hofmeyr, G Justus; Coomarasamy, Arri DOI: 10.1002/14651858.CD011689.pub2 License: None: All rights reserved Document Version Publisher's PDF, also known as Version of record Citation for published version (Harvard): Gallos, ID, Williams, HM, Price, MJ, Merriel, A, Gee, H, Lissauer, D, Moorthy, V, Tobias, A, Deeks, JJ, Widmer, M, Tunçalp, Ö, Gülmezoglu, AM, Hofmeyr, GJ & Coomarasamy, A 2018, 'Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis', Cochrane Database of Systematic Reviews, vol. 2018, no. 4, CD011689. https://doi.org/10.1002/14651858.CD011689.pub2 Link to publication on Research at Birmingham portal Publisher Rights Statement: Checked for eligibility:17/05/2018 Gallos ID, Williams HM, Price MJ, Merriel A, Gee H, Lissauer D, Moorthy V, Tobias A, Deeks JJ, Widmer M, Tunçalp Ö, Gülmezoglu AM, Hofmeyr GJ, Coomarasamy A. 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Oct. 2021 Cochrane Database of Systematic Reviews Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis (Review) Gallos ID, Williams HM, Price MJ, Merriel A, Gee H, Lissauer D, Moorthy V, Tobias A, Deeks JJ, Widmer M, Tunçalp Ö, Gülmezoglu AM, Hofmeyr GJ, Coomarasamy A Gallos ID, Williams HM, Price MJ, Merriel A, Gee H, Lissauer D, Moorthy V, Tobias A, Deeks JJ, Widmer M, Tunçalp Ö, Gülmezoglu AM, Hofmeyr GJ, Coomarasamy A. Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis. Cochrane Database of Systematic Reviews 2018, Issue 4. Art. No.: CD011689. DOI: 10.1002/14651858.CD011689.pub2. www.cochranelibrary.com Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis (Review) Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. TABLE OF CONTENTS HEADER....................................... 1 ABSTRACT ...................................... 1 PLAINLANGUAGESUMMARY . 3 SUMMARY OF FINDINGS FOR THE MAIN COMPARISON . ..... 4 BACKGROUND .................................... 7 OBJECTIVES ..................................... 8 METHODS ...................................... 8 Figure1. ..................................... 11 RESULTS....................................... 16 Figure2. ..................................... 17 Figure3. ..................................... 18 Figure4. ..................................... 20 Figure5. ..................................... 21 Figure6. ..................................... 22 Figure7. ..................................... 23 Figure8. ..................................... 24 Figure9. ..................................... 25 Figure10. ..................................... 26 Figure11. ..................................... 27 Figure12. ..................................... 28 Figure13. ..................................... 29 Figure14. ..................................... 30 Figure15. ..................................... 31 Figure16. ..................................... 32 Figure17. ..................................... 33 Figure18. ..................................... 34 Figure19. ..................................... 35 Figure20. ..................................... 36 Figure21. ..................................... 37 Figure22. ..................................... 38 Figure23. ..................................... 39 Figure24. ..................................... 40 Figure25. ..................................... 41 Figure26. ..................................... 42 Figure27. ..................................... 43 Figure28. ..................................... 44 Figure29. ..................................... 45 Figure30. ..................................... 46 Figure31. ..................................... 47 Figure32. ..................................... 48 Figure33. ..................................... 49 Figure34. ..................................... 50 Figure35. ..................................... 51 Figure36. ..................................... 52 Figure37. ..................................... 53 Figure38. ..................................... 54 Figure39. ..................................... 55 Figure40. ..................................... 56 Figure41. ..................................... 57 Figure42. ..................................... 58 Figure43. ..................................... 59 Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis (Review) i Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Figure44. ..................................... 60 Figure45. ..................................... 61 Figure46. ..................................... 62 Figure47. ..................................... 63 Figure48. ..................................... 64 Figure49. ..................................... 65 Figure50. ..................................... 66 Figure51. ..................................... 67 Figure52. ..................................... 68 Figure53. ..................................... 69 Figure54. ..................................... 70 Figure55. ..................................... 71 Figure56. ..................................... 72 Figure57. ..................................... 73 Figure58. ..................................... 74 Figure59. ..................................... 75 Figure60. ..................................... 76 Figure61. ..................................... 77 Figure62. ..................................... 78 Figure63. ..................................... 79 Figure64. ..................................... 80 Figure65. ..................................... 81 Figure66. ..................................... 82 Figure67. ..................................... 83 Figure68. ..................................... 84 Figure69. ..................................... 85 Figure70. ..................................... 86 Figure71. ..................................... 87 Figure72. ..................................... 88 Figure73. ..................................... 89 Figure74. ..................................... 90 Figure75. ..................................... 91 Figure76. ..................................... 92 Figure77. ..................................... 93 DISCUSSION ..................................... 93 AUTHORS’CONCLUSIONS . 95 ACKNOWLEDGEMENTS . 95 REFERENCES ..................................... 96 CHARACTERISTICSOFSTUDIES . 125 APPENDICES ..................................... 353 CONTRIBUTIONSOFAUTHORS . 354 DECLARATIONSOFINTEREST . 354 SOURCESOFSUPPORT . 355 DIFFERENCES BETWEEN PROTOCOL AND REVIEW . .... 356 Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis (Review) ii Copyright © 2018 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. [Intervention Review] Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis Ioannis D Gallos1, Helen M Williams1, Malcolm J Price2, Abi Merriel3, Harold Gee4, David Lissauer5, Vidhya Moorthy6, Aurelio Tobias1, Jonathan J Deeks7, Mariana Widmer8, Özge Tunçalp8, Ahmet Metin Gülmezoglu8, G Justus Hofmeyr9, Arri Coomarasamy1 1Tommy’s National Centre for Miscarriage Research, Institute of Metabolism and Systems Research, University of Birmingham, Birm- ingham, UK. 2School of Health and Population Sciences, University of Birmingham, Birmingham, UK. 3Bristol Medical School, Uni- versity of Bristol, Southmead Hospital, UK. 4Birmingham, UK. 5School of Clinical and Experimental Medicine, University of Birming- ham, Birmingham, UK. 6Department of Obstetrics and Gynaecology, Sandwell and West Birmingham NHS Trust, Birmingham, UK. 7Institute of Applied Health Research, University of Birmingham, Birmingham, UK. 8UNDP/UNFPA/UNICEF/WHO/World Bank