The American Journal of PATHOLOGY Official Publication of the American Association ofPathologists Editor-in-Chief Editorial Board Nelson Fausto Abul K. Abbas Ricardo V. Lloyd Brown University H. Clarke Anderson James L. Madara Dorothy F. Bainton Glenn Merlino Associate Editors Hector Battifora Alfred F. Michael Jeffrey Cossman Frederick Miller Sandra H. Bigner Riccardo Dalla-Favera George F. Murphy Duke University Dennis W. Dickson Brian J. Nickoloff Francis V. Chisari Robert E. Fechner Paul K. Pattengale Research Institute Victor J. Ferrans George Perry Scripps Isaiah J. Fidler R. Neal Pinckard Stanley R. Hamilton Michael A. Gimbrone, Jr. Jordan S. Pober Johns Hopkins University James E. Goldman Juan Rosai Nicholas K. Gonatas Russell Ross Agnes B. Kane Nancy L. Harris Eric P. Sandgren Brown University Aubrey J. Hough, Jr. Gary E. Striker Steven L. Kunkel Peter M. Howley Thomas W. Tillack Univers,ity of Michigan Philip M. lannaccone Manjeri A. Venkatachalam Harriet Isom Peter A. 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Manuscript submission: Mail five copies of the manuscript and four sets of figures to: Nelson Fausto, M.D., The American Journal of Pathol- ogy, 9650 Rockville Pike, Bethesda, MD 20814-3993. Information for Authors may be obtained from the same address. 1520 Huffnagle and Lipscomb AJP December 1992, Vol. 141, No. 6 10. Balmes JR, Hawkins JG: Pulmonary cryptococcosis. Semin 13. Wasser L, Talavera W: Pulmonary cryptococcosis in AIDS. Respir Med 1987, 9:180-186 Chest 1987, 92:692-695 11. Cameron ML, Bartlett JA, Gallis HA, Waskin HA: Manifesta- 14. Huffnagle GB, Yates JL, Lipscomb MF: T cell-mediated im- tions of pulmonary cryptococcosis in patients with acquired munity in the lung: A Cryptococcus neoformans pulmonary immunodeficiency syndrome. Rev Infect Dis 1991, 13:64- infection model using SCID and athymic nude mice. Infect 67 Immun 1991, 59:1423-1433 12. Kerkering TM, Duma RJ, Shadomy S: The evolution of pul- monary cryptococcosis: Clinical implications from a study of 15. Lim TS, Murphy JW, Cauley LK: Host-etiological agent in- 41 patients with and without compromising host factors. Ann teractions in intranasally and intraperitoneally induced cryp- Intern Med 1981, 94:611-616 tococcosis in mice. Infect Immun 1980, 29:633-641 STATEMENT OF OWNERSHIP, MANAGEMENT AND CIRCULATION (Act of August 2,1970: Section 3685, Title 39 United States Code) Date of Filing-October 1, 1992. Title of Publication-American Journal of Pathology; Frequency of Issue-Monthly; Annual Subscription Price-$160.00; Location of Known Office of Publication-100 Insurance Way, Suite 114, Hagerstown, MD 21740; Location of Headquarters or General Business Offices of the Publisher-J. B. Lip- pincott Company, East Washington Square, Philadelphia, PA 19106; Publisher-J. B. Lippincott Company, 227 East Washington Square, Philadelphia, PA 19106; Editor-Nelson Fausto, M.D., Department of Pathology and Laboratory Medicine, Division of Biology, Brown University, Providence, RI 02912; Managing Editor-Marcia Robinson, American Association of Pathologists, 9650 Rockville Pike, Bethesda, MD 20014; Owner-American Association of Pathologists, 9650 Rockville Pike, Bethesda, MD 20014; Known Bondholders, Mortgagees, and other security holders owning or holding 1 percent or more of total amount of bonds, mortgages, or other securities-Wolters Kluwer, U.S. Corporation, 1185 Avenue of the Americas, 37th Floor, New York, NY 10036. A. Total no. copies printed (net press run), average 5158, actual 5000; B. Paid circulation 1. Sales through dealers and carriers, street vendors and counter sales, average none, actual none; 2. Mail subscriptions, average 4625, actual 4719; C. Total paid circulation, average 4625, actual 4719; D. 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Index of Subjects Volume 141, 1992 Actin and electron microscopy of angiopathy in Alzhei- mRNA abundance in heart affected by anthracy- mer's disease, 249 clines, 1187 identification of proteins in amyloid deposits in Adhesion molecules nerves, 217 on endothelium in atherosclerosis, 1427 P2-microglobulin amyloid fibril synthesis in cell cul- regulated expression of VCAM-1 in melanoma, tures, 241 1323 Anemia in thymic B-cell lymphoma, 729 myocyte changes in, 227 VCAM-1 in AIDS encephalitis, 1021 Angiotensin 11 Aging and tenascin expression in vascular smooth mus- amyloidosis in, 767 cle cells, 377 AIDS Animal models of human disease and Epstein-Barr virus in CNS lymphoma, 441 non-insulin-dependent human diabetes, 761 and VCAM-1 in encephalitis, 1021 pulmonary cryptococcosis, 1517 Albumin Anthracyclines expression in hepatic hyperplasia and preneopla- and actin mRNA abundance in heart, 1187 sia, 623 Apolipoprotein Al Alcoholism role in amyloidosis, 1013 liver disease in, 69 Apoptosis Alpha-fetoprotein transfer between nuclei, 1471 expression in hepatic hyperplasia and preneopla- Arthritis sia, 623 and serum amyloid A transcription in synovium, Alzheimer's disease 525 and Alz-50 immunoreactivity in brain, 1459 Atherosclerosis amyloid angiopathy in, 249 adhesion molecules on endothelium in, 1427 ,-amyloid precursor protein in nucleus basalis, extracellular and cellular lipid deposits in, 925 357 and fatty streaklike lesions induced in culture amyloidosis in, 767 model of arterial intima, 1435 genesis of senile plaque in, 1151 macrophage differentiation in, 161 immunoelectron microscopy of neurofibrillary tan- macrophage scavenger receptors in, 591 gles in, 343 in transplanted organs, 1139 thrombospondin in, 783 Amyloid A transcription in arthritic synovium, 525 Basal cells Amyloid P repair mechanisms in airway epithelium, 753 in fibrils of fibrillary glomerulopathy, 409 Basophils serum levels affecting amyloid deposition, 451 analysis of release reactions in, 1309 P-Amyloid precursor protein Bauhinia purpurea in nucleus basalis in Alzheimer's disease, 357 as marker for Reed-Sternberg cells, 19 ,3-Amyloid protein bcl-2 gene in inclusion-body myositis, 31 lack of translocation in Hodgkin's disease, 193 Amyloidosis rearrangements in reactive lymphoid tissue, 291 in aging and Alzheimer's disease, 767 Bladder apolipoprotein Al in, 1013 cystitis in Lyme disease in mice, 1173 1521 1522 Index of Subjects AJP December 1992, Vol. 141, No. 6 Bleomycin CD5 monoclonal antibodies stimulating alveolar macrophages, 965 peripheral blood dendritic cell reactivity with, 789 Blood-brain barrier CD31 permeability in experimental brain metastases,