US010589003B2 (12 ) United States Patent ( 10 ) Patent No.: US 10,589,003 B2 Raad (45 ) Date of Patent : Mar. 17 , 2020 ( 54 ) METHODS FOR COATING SURFACES WITH (58 ) Field of Classification Search ANTIMICROBIAL AGENTS CPC A61L 29/16 See application file for complete search history . (71 ) Applicant: The Board of Regents of the University of Texas System , Austin , ( 56 ) References Cited TX (US ) U.S. PATENT DOCUMENTS (72 ) Inventor: Issam Raad , Missouri City, TX (US ) 3,635,652 A 1/1972 Streck (73 ) Assignee : The Board of Regents of the 4,015,937 A 4/1977 Miyamoto et al . University of Texas System , Austin , 4,107,121 A 8/1978 Stoy TX (US ) (Continued ) ( * ) Notice: Subject to any disclaimer , the term of this FOREIGN PATENT DOCUMENTS patent is extended or adjusted under 35 EP 0300961 1/1989 U.S.C. 154 (b ) by 0 days . EP 0348947 6/1989 (Continued ) ( 21) Appl. No .: 15 /920,698 ( 22 ) Filed : Mar. 14 , 2018 OTHER PUBLICATIONS (65 ) Prior Publication Data U.S. Appl. No. 08 / 150,472 , Sherertz . (Continued ) US 2018/0303977 A1 Oct. 25 , 2018 Primary Examiner Dah - Wei D. Yuan Related U.S. Application Data Assistant Examiner - Andrew J Bowman (63 ) Continuation of application No. 11/ 560,300 , filed on (74 ) Attorney, Agent, or Firm - Parker Highlander PLLC Nov. 15 , 2006 , now abandoned . (60 ) Provisional application No. 60 / 738,198 , filed on Nov. ( 57 ) ABSTRACT 18 , 2005 . Disclosed are methods for coating or impregnating a surface with an antimicrobial agent that involve contacting the (51 ) Int. Ci. surface with a composition that includes an antimicrobial AGIL 29/16 ( 2006.01 ) agent and a solvent, and curing the surface by applying heat . AOIN 25/24 ( 2006.01 ) Also disclosed are methods for reducing the risk of devel AOIN 25/34 ( 2006.01 ) opment or progression of an infection in a subject in need of A61L 27/54 ( 2006.01 ) a medical device , that involve coating or impregnating a A61L 31/16 ( 2006.01 ) surface of the medical device with an antimicrobial agent (52 ) U.S. CI. and then curing the surface by applying heat, wherein the CPC A61L 29/16 ( 2013.01) ; AOIN 25/24 risk of development or progression of an infection is ( 2013.01 ) ; AOIN 25/34 ( 2013.01) ; A61L 27/54 reduced . ( 2013.01) ; A61L 31/16 ( 2013.01 ) ; AGIL 2300/406 (2013.01 ) ; A61L 2300/442 (2013.01 ) 18 Claims, 18 Drawing Sheets Durability of Spectrum compared to Heated Mino Rifampin catheters over 12 weeks - tested against MRSA 4798 35 30 25 ZoneofInhibition(mm) 20 15 10 5 0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75 80 85 Days Silicone Spectrum Silicone - MR1 US 10,589,003 B2 Page 2 ( 56 ) References Cited WO WO 2000/007574 2/2000 WO WO 2000/065915 11/2000 U.S. PATENT DOCUMENTS WO WO 2001/054661 8/2001 WO WO 2002/082907 10/2002 4,233,263 A 11/1980 Schaeffer WO WO 2007/024974 3/2007 4,349,029 A 9/1982 Mott 4,442,133 A 4/1984 Greco et al . OTHER PUBLICATIONS 4,592,920 A 6/1986 Murtfeldt 4,863,445 A 9/1989 Mayhan et al. 4,895,566 A 1/1990 Lee U.S. Appl. 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