CATA LOG for cosmetic ingredients The Gentle Communication Between People and Chemistry Sakai Chemical Industry Co.,Ltd. Sakai Chemical Industry Co., Ltd. ［Tokyo］TEL +81-3-5823-3726 FAX +81-3-3861-1511 ［Osaka］TEL +81-72-223-4155 FAX +81-72-223-4177 URL http://www.sakai-chem.co.jp Contact E-mail [email protected] Issued date：April 1, 2019 Our company launched its business with the manufacture of zinc oxide in 1918. th 1ANNIVERSARY00 2020 おかげさまで100周年 At that time, zinc oxide was employed as a base material for face powders for women and actors. Today, in addition to its use in cosmetics 2018 and sunscreens, zinc oxide is used in a wide range of applications, including electronic materials, rubber products, and paints. In addition to zinc oxide products, Sakai Chemical Industry manufactures a wide variety of characteristic cosmetic ingredients, including titanium dioxide, flake-shaped barium sulfate, and spherical calcium carbonate. Cosmetic products such as foundations and sunscreens are required to be both extremely delicate and to fulfill specific functions. Requirements for these products include a smooth and moist texture, a natural-looking finish, and the outstanding ability to screen UV rays. Sakai Chemical Industry contributes to the realization of beautiful and healthy skin through our P.6-7 2010 Ref. P.9 unique particle size, particle shape control, and surface treatment technologies. Ref. P.4 Ref. Spherical zinc oxide formed by flake-shaped particles CANDY ZINC Ultrafine zinc oxide dispersion DIF Series Microfine titanium P.11 P.11 P.13 P.5 dioxide dispersion 2000 Ultrafine zinc oxide Ref. Ref. Ref. Ref. DIS Series FINEX Series Spherical calcium Pigment-grade titanium Inorganic fluorescent Microfine titanium carbonate Calmaru dioxide MKR Series materials for cosmetics 1918 Began manufacturing dioxide STR Series Lumate Series zinc oxide for face powder P.10 P.8 1990 Ref. Ref. Suncare & Skincare Material 1918 Makeup Material Flake-shaped barium Hexagonal flake-shaped sulfate H Series zinc oxide XZ Series 2 Sakai Chemical Industry Sakai Chemical Industry 3 Ultrafine Zinc Oxide FINEX Series Microfine Titanium Dioxide STR Series Ultrafine zinc oxide FINEX Series〈Powder〉 Microfine titanium dioxide STR Series〈Powder〉 Efficient shielding of UVA rays while keeping high transparency. High transparency and efficient UVB shielding; surface activity is controlled by dense surface coating. Grade List Grade List Primary Composition (%) Primary Composition(%) Quasi- Quasi- Characteristics Grade INCI name Characteristics Grade INCI name particle size Hydrated Hydrogen particle size Titanium Aluminum Hydrated Hydrogen Zinc oxide Triethoxycaprylylsilane drug Triethoxycaprylylsilane drug (nm) silica dimethicone (nm) dioxide hydroxide silica dimethicone FINEX-50 20 100 STR-100N 15 100 － － － Yes Non-coated grade Titanium dioxide －－ －－Yes Non-coated grade FINEX-30 35 Zinc oxide 100 － － － Yes in Titanium dioxide （ EU ） Hydrated silica FINEX-25 60 100 － － － STR-100A-LP 15 84 4 8 4 － Yes Aluminum hydroxide Zinc oxide Standard NANOFINE-50LP 20 96 － 4 － Yes Hydrogen dimethicone Hydrogen dimethicone Standard grade Titanium dioxide Zinc oxide STR-100C-LP 15Aluminum hydroxide 89 7－ 4 － Yes FINEX-33W 35 95 5 － － Yes Hydrated silica Hydrogen dimethicone Passivated grade FINEX-52W-LP2 20 Zinc oxide 86 10 4 － Titanium dioxide Hydrated silica Yes STR-100W-LP 15Hydrated silica 75－ 17 8 － Yes FINEX-33W-LP2 35 Hydrogen dimethicone 91 5 4 － Hydrogen dimethicone Titanium dioxide High-transparency grade FINEX-50S-LP2 20 96 － 4 － Fatty acid-treated Zinc oxide STR-100C-LF 15Aluminum hydroxide 84 9 － － － Yes FINEX-30S-LPT 35 96 － 4 － Yes grade Low-viscosity grade Hydrogen dimethicone Stearic acid （7% Stearic acid） FINEX-25-LPT 60 97 － 3 － Titanium dioxide No Texture-modified Zinc oxide STR-100W-OTS 15Hydrated silica 73 － 18－ 9 No Texture-modified grade FINEX-50-OTS 20 93 －－ 7 Yes in grade Triethoxycaprylylsilane （ EU ） Triethoxycaprylylsilane Hydrophilic Titanium dioxide STR-100W(G) 15 80－ 20 －－Yes passivated grade Hydrated silica UVA and UVB Titanium dioxide Optical characteristics of FINEX Series STR-40-OTS 35 95 －－ － 5 No shielding grade Triethoxycaprylylsilane ■Total light transmittance ■Parallel light transmittance 100 100 Electron microscope image and optical characteristics of STR series 80 80 ） ） ■STR-100A-LP TEM image ■Optical characteristics of STR series ％ ％ 60 100 （ （ 60 20nm（FINEX-50） 20nm（FINEX-50） 40 40 80 35nm（FINEX-30） 35nm（FINEX-30） High-dense silica ） Transmittance Transmittance 60nm（FINEX-25） 60nm（FINEX-25） Aluminum hydroxide ％ 20 20 60 280nm（Fine zinc oxide） 280nm（Fine zinc oxide） （ 0 0 40 300 400 500 600 700 800 400 500 600 700 800 15nm（STR-100N） Wavelength(nm) Wavelength(nm) Titanium dioxide Transmittance 20 35nm（STR-40N） 200nm（MKR-1） Characteristics vary based on the particle size. FINEX-25 has high UVA shielding performance, and FINEX-50 has high transparency. 0 5 nm 300 400 500 600 700 Wavelength(nm) Titanium dioxide is densely coated. High-density silica coating (passivated grade) STR-40 type has high UVA shielding performance, and STR-100 type has high transparency. ■FINEX-52W-LP2 TEM image ■Image of high density ■Difference in activity due to silica coating (Vaseline discoloration) silica coating A PWC 10% Vaseline paste was prepared, subjected to UV irradiation for 96 hours, and tested for discoloration. 30 Untreated zinc oxide (silica, silicone content 0%) Photochromism of titanium dioxide High-density silica layer 25 Silicone-treated zinc oxide (silica content 0%) Silica + siliconized zinc oxide (silica content 10%) Zinc oxide Silica + siliconized zinc oxide (silica content 15%) 20 Silica + siliconized zinc oxide (silica content 20%) Photochromism is a phenomenon in which exposure to High-dense silica light causes a color change in titanium dioxide. E 15 ⊿ After exposure 10 Test method STR's dense surface coating 5 Samples with different W/O realizes greater control in formulations were exposed to photocatalytic activity in Zinc oxide is densely coated by a silica layer. 0 Hydrogen dimethicone layer 0 10 20 30 40 50 60 70 80 90 100 sunlight for four hours and titanium dioxide than that UV irradiation time (hr) observed for color changes. STR- of the competitors' products. Competitor A Competitor B We can control photocatalytic activity of zinc 100A-LP STR- Competitor A Competitor B oxide by coating with high density silica. 100A-LP 4 Sakai Chemical Industry catalog for cosmetic ingredients 5 Ultrafine Zinc Oxide / Microfine Titanium Dioxide Dispersions Example Non-chemical Sunscreen Formulations ■O/W type gel cream ■W/O milk Characteristics・Including the aqueous dispersion AB series, which uses hydrophobic powder, Characteristics・Achieves high transparency and high UV shielding non-chemically. in the water phase achieves high UV shielding in a non-chemical O/W formulation. ・Including D5 dispersions allows for non-sticky, refreshing skin feel. Ultrafine Zinc Oxide Dispersion DIF Series ・Increased SPF and water resistance and improved friction compared to the conventional silica-coated powder formulation. [wt%] ※（ ）Powder concentration [wt%] Grade List Composition / Formulation No. SSS007 SSS011 SSS099 Composition / Formulation No. SSS088 SSS098 1 Propylene glycol dicaprate 6.5 10.0 10.0 1 DIF-AW4 38.0 (19) － Dispersoid Composition 2 Hydrogenated polyisobutene 11.5 12.0 9.0 2 DIF-5CS － 20.0 (10) Dispersion （Powder） Quasi- 3Dimethicone 1.5 1.5 1.5 3DIS-11A 24.0 (9.6) 24.0 (9.6) Characteristics Dispersion medium Primary ZnO surface treatment grade name particle size drug 40.7Behenyl alcohol 0.7 0.7 4Neopentylene glycol dicaprate 6.0 6.0 composition Powder grade content Hydrated Hydrogen nm Triethoxycaprylylsilane （wt%） （ ） （%） silica dimethicone 5 Sorbitan sesquistearate 0.5 0.5 0.5 5 Cyclopentasiloxane 3.5 12.3 Zinc oxide Water dispersions 6 Glyceryl stearate 0.3 0.3 0.3 6 Dimethicone 4.0 4.0 7 Sulfonic acid polymer 0.6 0.4 0.5 7 PEG-9 Polydimethylsiloxyethyl dimethicone 1.5 1.5 DIF-AB-33W 60 FINEX-33W-LP2 35 55 ◯◯ － Yes 8 Polysorbate 60 1.0 1.0 1.0 8 Cyclopentasiloxane, Dimethicone crosspolymer 1.0 1.0 High transparency Water 9 Bentonite 0.1 0.1 0.1 9 Polymethylsilsesquioxane 0.5 0.5 Good skin feel DIF-AB-3CS No 60 FINEX-30-OTS 35 58 －－ ◯ Yes in 10 Crystalline cellulose（2%） 2.5 2.5 2.5 10 Sodium citrate 0.2 0.2 (Prototype) （ EU ） 11 1,3-butylene glycol 6.0 4.0 6.0 11 Sodium chloride 0.5 0.5 Zinc oxide D5 dispersions 12 water 48.8 22.0 42.9 12 1,3-butylene glycol 3.0 5.0 13 DIS-AB-10W 20.0（10）※ 20.0 (10) － 13 water 17.8 25.0 Standard DIF-3ST2 50 FINEX-30S-LPT 35 48 －◯ － Yes 14DIF-AB-33W － 25.0 (15) － High transparency 15 DIF-AB-3CS －－25.0 (15) vivo SPF（n=2） 59.4 53.0 DIF-AW4 50 FINEX-52W-LP2 20 43 ◯◯ － Yes High passivity vivo UVAPF（n=2） 19.2 16.0 Cyclopentasiloxane vivo SPF（n=2） 47.8 56.0 31.3 High UV shielding DIF-3W4 60 FINEX-33W-LP2 35 54 ◯◯ － Yes vivo UVAPF（n=2） 16.9 19.2 20.0 ＜Creation procedure＞ High passivity A. Evenly mix ingredients 1 to 9. B. Evenly mix ingredients 10 to 13. No ＜Creation procedure＞ Good skin feel DIF-5CS 50 FINEX-50-OTS 20 46 －－ ◯ Yes in C. Add B to A and emulsify. （ EU ） A. Evenly mix ingredients 1 to 6 and heat to 80°C. B. Evenly mix ingredients 7 to 12 and heat to 80°C. Zinc oxide Ester oil dispersions C. Add A to B and emulsify. D. Bring C to 60°C or less and then add 13 to 15 and mix evenly. DIF-OP-3W 70 Ethylhexyl palmitate FINEX-33W-LP2 35 64 ◯◯ － Yes High passivity High concentration Comparison of sunlight resistance of inorganic and organic UV absorbers DIF-TL-3W 70 Isotridecyl isononanoate FINEX-33W-LP2