Table S1 (Goes with Figure 1) Table S1. SigClust classification of 56 Trp53 null mouse mammary tumors. GSE# SigClust Result Host-IR Status Genotype GSM691237.CEL Basal-like IR-host WT GSM691250.CEL Basal-like IR-host WT GSM691236.CEL Claudin-low IR-host WT GSM691241.CEL Claudin-low IR-host WT GSM691256.CEL Claudin-low IR-host WT GSM691257.CEL Claudin-low IR-host WT GSM691247.CEL p53 null IR-host WT GSM691254.CEL p53 null IR-host WT GSM691246. CEL UlUnclass ifidified-1 IR-hthost WT GSM691249.CEL Unclassified-1 IR-host WT GSM691251.CEL Unclassified-1 IR-host WT GSM691253.CEL Unclassified-1 IR-host WT GSM691255.CEL Unclassified-1 IR-host WT GSM691235.CEL Luminal IR-host WT GSM691238.CEL Luminal IR-host WT GSM691239.CEL Luminal IR-host WT GSM691242.CEL Luminal IR-host WT GSM691243. CEL Luminal IR-host WT GSM691244.CEL Luminal IR-host WT GSM691245.CEL Luminal IR-host WT GSM691248.CEL Luminal IR-host WT GSM691252.CEL Luminal IR-host WT GSM691240.CEL Unclassified-2 IR-host WT GSM691228.CEL Basal-like Sham WT GSM691229.CEL Claudin-low Sham WT GSM691230.CEL Claudin-low Sham WT GSM691231.CEL Claudin-low Sham WT GSM691226.CEL Luminal Sham WT GSM691227.CEL Luminal Sham WT GSM691233.CEL Luminal Sham WT GSM691234.CEL Luminal Sham WT GSM691232.CEL Unclassified-2 Sham WT David.N.4.Het.122110.CEL Claudin-low IR-host TGFb +/- GSM691272.CEL Claudin-low IR-host TGFb +/- GSM691274.CEL Claudin-low IR-host TGFb +/- GSM691275.CEL Claudin-low IR-host TGFb +/- GSM691276.CEL Claudin-low IR-host TGFb +/- David.N.1.Het.122110.CEL p53 null IR-host TGFb +/- David.N.49.Het.122110.CEL p53 null IR-host TGFb +/- David.N.50.Het.122110.CEL p53 null IR-host TGFb +/- David.N.47.Het.122110.CEL Unclassified-1 IR-host TGFb +/- David.N.55.Het.122110.CEL Unclassified-1 IR-host TGFb +/- GSM691279.CEL Unclassified-1 IR-host TGFb +/- David.N.26.Het.122110.CEL Luminal IR-host TGFb +/- David.N.35.Het.122110.CEL Luminal IR-host TGFb +/- GSM691273.CEL Luminal IR-host TGFb +/- GSM691278.CEL Luminal IR-host TGFb +/- GSM691280.CEL Luminal IR-host TGFb +/- GSM691277.CEL Unclassified-2 IR-host TGFb +/- GSM691281.CEL Unclassified-2 IR-host TGFb +/- GSM691258.CEL Basal-like Sham TGFb +/- GSM691262.CEL Basal-like Sham TGFb +/- GSM691259.CEL Claudin-low Sham TGFb +/- GSM691263.CEL Claudin-low Sham TGFb +/- GSM691261. CEL p53 nu ll Sham TGFb + /- GSM691260.CEL Luminal Sham TGFb +/- Table S2 (Goes with Figure 2). Genes in the 323-irradiated host signature Affy Probe Symbol Direction Affy Probe Symbol Direction Affy Probe Symbol Direction Affy Probe Symbol Direction Affy Probe Symbol Direction 1456878_at AI646023 UP 1427285_s_at Malat1 UP 1423523_at Aass DOWN 1456741_s_at Gpm6a DOWN 1454934_at Ppm1f DOWN 1453239_a_at Ankrd22 UP 1431385_a_at Mbtps1 UP 1425032_at Abpb DOWN 1455466_at Gpr133 DOWN 1457029_at Ppp4r1l DOWN 1432344_a_at Aplp2 UP 1419504_at Mogat1 UP 1418754_at Adcy8 DOWN 1424613_at Gprc5b DOWN 1429463_at Prkaa2 DOWN 1417561_at Apoc1 UP 1451858_at Mrgpra2 UP 1424393_s_at Adhfe1 DOWN 1416411_at Gstm2 DOWN 1418666_at Ptx3 DOWN 1418687_at Arc UP 1426941_at Muc15 UP 1447839_x_at Adm DOWN 1417883_at Gstt2 DOWN 1417741_at Pygl DOWN AU02009 1455172_at 4 UP 1438730_at Nav1 UP 1419706_a_at Akap12 DOWN 1420872_at Gucy1b3 DOWN 1434914_at Rab6b DOWN 1423456_at Bzw2 UP 1435981_at Nav2 UP 1451675_a_at Alas2 DOWN 1440145_at H60a DOWN 1420603_s_at Raet1a DOWN 1443227_at Bzw2 UP 1447885_x_at Nedd9 UP 1438967_x_at Amhr2 DOWN 1452145_at H6pd DOWN 1455840_at Rapgef5 DOWN 1426043_a_at Capn3 UP 1453614_a_at Nfe2l3 UP 1453287_at Ankrd33b DOWN 1418645_at Hal DOWN 1437902_s_at Rarres2 DOWN 1421952_at Capn6 UP 1435486_at Pak3 UP 1432006_at Ap2a2 DOWN 1420589_at Has3 DOWN 1449461_at Rbp7 DOWN 1428735_at Cd69 UP 1437318_at Pak3 UP 1416371_at Apod DOWN 1417714_x_at Hba-a1 DOWN 1424382_at Rcn3 DOWN 1455435_s_at Chdh UP 1436124_at Pcyt1b UP 1435050_at Arfgef3 DOWN 1417184_s_at Hbb-b1 DOWN 1415905_at Reg1 DOWN 1437578_at Clca2 UP 1418210_at Pfn2 UP 1441618_at Arhgap29 DOWN 1451229_at Hdac11 DOWN 1418003_at Rgc32 DOWN 1419463_at Clca2 UP 1449374_at Pipox UP 1452303_at Arhgef10 DOWN 1448239_at Hmox1 DOWN 1450693_at Rgs17 DOWN 1435504_at Clip4 UP 1449586_at Pkp1 UP 1460346_at Arsa DOWN 1424367_a_at Homer2 DOWN 1452899_at Rian DOWN 1425476_at Col4a5 UP 1448558_a_at Pla2g4a UP 1452308_a_at Atp1a2 DOWN 1457671_at Homer2 DOWN 1436044_at Scn7a DOWN 1417497_at Cp UP 1430700_a_at Pla2g7 UP 1448211_at Atp6v0e2 DOWN 1452388_at Hspa1a DOWN 1417580_s_at Selenbp1 DOWN 1455579_at Csn1s2a UP 1418203_at Pmaip1 UP 1440293_at C230081A13Rik DOWN 1422196_at Htr5b DOWN 1420558_at Selp DOWN 1420369_a_at Csn2 UP 1447623_s_at Prkd1 UP 1427355_at Calca DOWN 1425324_x_at Igh DOWN 1429459_at Sema3d DOWN 1419697_at Cxcl11 UP 1420352_at Prss22 UP 1422639_at Calcb DOWN 1437876_at Il20rb DOWN 1439768_x_at Sema4f DOWN 1418652_at Cxcl9 UP 1419669_at Prtn3 UP 1424770_at Cald1 DOWN 1450297_at Il6 DOWN 1419100_at Serpina3n DOWN 1454106_a_at Cxxc1 UP 1449310_at Ptger2 UP 1418509_at Cbr2 DOWN 1436755_at Itih5 DOWN 1419082_at Serpinb2 DOWN 1436345_at D1Mgi54 UP 1421073_a_at Ptger4 UP 1420380_at Ccl2 DOWN 1423180_at Kcnb1 DOWN 1419149_at Serpine1 DOWN 1435940_at Dclk1 UP 1419229_at Rhox4a UP 1417266_at Ccl6 DOWN 1454701_at Lars DOWN 1416702_at Serpini1 DOWN 1426005_at Dmp1 UP 1455347_at Rtel1 UP 1419684_at Ccl8 DOWN 1456156_at Lepr DOWN 1438042_at Shox2 DOWN 1458000_at Dsg1a UP 1424704_at Runx2 UP 1419144_at Cd163 DOWN 1425644_at Lepr DOWN 1426550_at Sidt1 DOWN 1415857_at Emb UP 1417719_at Sap30 UP 1449918_at Cd209g DOWN 1440147_at Lgi2 DOWN 1419437_at Sim2 DOWN 1425272_at Emp2 UP 1459897_a_at Sbsn UP 1423166_at Cd36 DOWN 1435321_at Limch1 DOWN 1417623_at Slc12a2 DOWN 1433670_at Emp2 UP 1420764_at Scrg1 UP 1450884_at Cd36 DOWN 1435106_at Limch1 DOWN 1448780_at Slc12a2 DOWN 1442542_at Eya4 UP 1450734_at Sec16b UP 1432022_at Cdgap DOWN 1424596_s_at Lmcd1 DOWN 1420334_at Slc12a8 DOWN 1419490_at Fam19a5 UP 1425002_at Sectm1a UP 1450140_a_at Cdkn2a DOWN 1456909_at LOC676974 DOWN 1418395_at Slc47a1 DOWN 1436576_at Fam26f UP 1419478_at Sectm1b UP 1452309_at Cgnl1 DOWN 1433536_at Lrp11 DOWN 1420504_at Slc6a14 DOWN 1429682_at Fam46c UP 1441941_x_at Serpinb5 UP 1433720_s_at Chchd10 DOWN 1418061_at Ltbp2 DOWN 1433933_s_at Slco2b1 DOWN 1418596_at Fgfr4 UP 1420378_at Sftpd UP 1454866_s_at Clic6 DOWN 1429379_at Lyve1 DOWN 1418493_a_at Snca DOWN 1438558_x_at Foxq1 UP 1423024_at Sh2d1b1 UP 1449456_a_at Cma1 DOWN 1449283_a_at Mapk12 DOWN 1416967_at Sox2 DOWN 1422735_at Foxq1 UP 1422856_at Slc12a3 UP 1448730_at Cpa3 DOWN 1434140_at Mcf2l DOWN 1458203_at Spire1 DOWN G530011 1440342_at O06Rik UP 1427339_at Slc30a2 UP 1416194_at Cyp4b1 DOWN 1449989_at Mcpt2 DOWN 1452604_at Stard13 DOWN 1418776_at Gbp8 UP 1460541_at Slc7a6 UP 1458934_at D5Ertd505e DOWN 1427040_at Mdfic DOWN 1430165_at Stk17b DOWN 1439015_at Gfra1 UP 1449340_at Sostdc1 UP 1418174_at Dbp DOWN 1452905_at Meg3 DOWN 1423280_at Stmn2 DOWN 1448485_at Ggt1 UP 1435438_at Sox8 UP 1429298_at Ddah1 DOWN 1455531_at Mfsd4 DOWN 1455610_at Synm DOWN 1416715_at Gjb3 UP 1423323_at Tacstd2 UP 1436661_at Dpp10 DOWN 1436021_at Mfsd4 DOWN 1418107_at Tcea2 DOWN 1422179_at Gjb4 UP 1422188_s_at Tcrg-V2 UP 1436479_a_at Dpp7 DOWN 1424123_at Mfsd7c DOWN 1423340_at Tcfap2b DOWN 1424927_at Glipr1 UP 1448069_at Tm4sf1 UP 1421276_a_at Dst DOWN 1419605_at Mgl1 DOWN 1419537_at Tcfec DOWN 1424825_a_at Glycam1 UP 1449033_at Tnfrsf11b UP 1422411_s_at Ear1 DOWN 1421977_at Mmp19 DOWN 1420191_s_at Tmem191c DOWN 1457227_at Gm11266 UP 1418309_at Tnfrsf11b UP 1425295_at Ear11 DOWN 1450430_at Mrc1 DOWN 1435261_at Tmtc1 DOWN 1449009_at Gm12185 UP 1422740_at Tnfrsf21 UP 1417236_at Ehd3 DOWN 1432205_a_at Mtus2 DOWN 1450798_at Tnxb DOWN 1447870_x_at Gm2292 UP 1439680_at Tnfsf10 UP 1427484_at Eml5 DOWN 1424933_at Myo5c DOWN 1426175_a_at Tpsab1 DOWN 1452353_at Gpr155 UP 1418158_at Trp63 UP 1418829_a_at Eno2 DOWN 1421385_a_at Myo7a DOWN 1420772_a_at Tsc22d3 DOWN 1430332_a_at Gusb UP 1455377_at Ttll7 UP 1449324_at Ero1l DOWN 1447271_at Nck1 DOWN 1424649_a_at Tspan8 DOWN 1443783_x_at H2-Aa UP 1429946_at Ttn UP 1455267_at Esrrg DOWN 1422520_at Nefm DOWN 1419584_at Ttc28 DOWN 1418536_at H2-Q7 UP 1423719_at U46068 UP 1433514_at Etnk1 DOWN 1446990_at Nfia DOWN 1448260_at Uchl1 DOWN 1442130_at Hsh2d UP 1421694_a_at Vcan UP 1448876_at Evc DOWN 1456087_at Nfia DOWN 1451651_at Vsig4 DOWN 1438441_at Id4 UP 1418175_at Vdr UP 1448929_at F13a1 DOWN 1432517_a_at Nnmt DOWN 1437556_at Zfhx4 DOWN 1423260_at Id4 UP 1460657_at Wnt10a UP 1443904_at Fads6 DOWN 1435184_at Npr3 DOWN 1455786_at Zfp820 DOWN 1454159_a_at Igfbp2 UP 1457499_at Wwp2 UP 1438402_at Fam171a1 DOWN 1418157_at Nr2f1 DOWN 1449314_at Zfpm2 DOWN 1455048_at Igsf3 UP 1436365_at Zbtb7c UP 1416978_at Fcgrt DOWN 1438448_at Otop1 DOWN 1428812_at 1700040L02Rik DOWN 1421628_at Il18r1 UP 1430674_at 1700016C15Rik UP 1418243_at Fcna DOWN 1426259_at Pank3 DOWN 1429203_at 2410076I21Rik DOWN 1421304_at Klra2 UP 1436431_at 1700025G04Rik UP 1449555_a_at Fetub DOWN 1417273_at Pdk4 DOWN 1430823_at 2700029L08Rik DOWN 1427352_at Krt79 UP 1425233_at 2210407C18Rik UP 1420086_x_at Fgf4 DOWN 1435553_at Pdzd2 DOWN 1433320_at 4930519N06Rik DOWN 1417812_a_at Lamb3 UP 1419643_s_at 2310057J18Rik UP 1435459_at Fmo2 DOWN 1448995_at Pf4 DOWN 1442113_at 5330417C22Rik DOWN 1433783_at Ldb3 UP 1453261_at 2610035D17Rik UP 1451648_a_at Folr2 DOWN 1418471_at Pgf DOWN 1441799_at 6030422H21Rik DOWN 1430551_s_at Lipm UP 1430162_at 3830417A13Rik UP 1438232_at Foxp2 DOWN 1438774_s_at Pgm2l1 DOWN 1433837_at 8430408G22Rik DOWN 1418723_at Lpar3 UP 1431577_at 5430437J10Rik UP 1426594_at Frmd4b DOWN 1435771_at Plcb4 DOWN 1459344_at 9630019E01Rik DOWN