Yano_Supplemental_Table_S4 Gene ontology – Biological process 1 of 9 Fold List Pop Pop GO Term Count % PValue Bonferroni Benjamini FDR Genes Total Hits Total Enrichment DLC1, CADM1, NELL2, CLSTN1, PCDHGA8, CTNNB1, NRCAM, APP, CNTNAP2, FERT2, RAPGEF1, PTPRM, MPDZ, SDK1, PCDH9, PTPRS, VEZT, NRXN1, MYH9, GO:0007155~cell CTNNA2, NCAM1, NCAM2, DDR1, LSAMP, CNTN1, 50 5.61 2.14E-08 510 311 7436 2.34 4.50E-05 4.50E-05 3.70E-05 adhesion ROR2, VCAN, DST, LIMS1, TNC, ASTN1, CTNND2, CTNND1, CDH2, NEO1, CDH4, CD24A, FAT3, PVRL3, TRO, TTYH1, MLLT4, LPP, NLGN1, PCDH19, LAMA1, ITGA9, CDH13, CDON, PSPC1 DLC1, CADM1, NELL2, CLSTN1, PCDHGA8, CTNNB1, NRCAM, APP, CNTNAP2, FERT2, RAPGEF1, PTPRM, MPDZ, SDK1, PCDH9, PTPRS, VEZT, NRXN1, MYH9, GO:0022610~biological CTNNA2, NCAM1, NCAM2, DDR1, LSAMP, CNTN1, 50 5.61 2.14E-08 510 311 7436 2.34 4.50E-05 4.50E-05 3.70E-05 adhesion ROR2, VCAN, DST, LIMS1, TNC, ASTN1, CTNND2, CTNND1, CDH2, NEO1, CDH4, CD24A, FAT3, PVRL3, TRO, TTYH1, MLLT4, LPP, NLGN1, PCDH19, LAMA1, ITGA9, CDH13, CDON, PSPC1 DCC, ENAH, PLXNA2, CAPZA2, ATP5B, ASTN1, PAX6, ZEB2, CDH2, CDH4, GLI3, CD24A, EPHB1, NRCAM, GO:0006928~cell CTTNBP2, EDNRB, APP, PTK2, ETV1, CLASP2, STRBP, 36 4.04 3.46E-07 510 205 7436 2.56 7.28E-04 3.64E-04 5.98E-04 motion NRG1, DCLK1, PLAT, SGPL1, TGFBR1, EVL, MYH9, YWHAE, NCKAP1, CTNNA2, SEMA6A, EPHA4, NDEL1, FYN, LRP6 PLXNA2, ADCY5, PAX6, GLI3, CTNNB1, LPHN2, EDNRB, LPHN3, APP, CSNK2A1, GPR45, NRG1, RAPGEF1, WWOX, SGPL1, TLE4, SPEN, NCAM1, DDR1, GRB10, GRM3, GNAQ, HIPK1, GNB1, HIPK2, PYGO1, GO:0007166~cell RNF138, ROR2, CNTN1, GNAS, PPM1L, ERBB4, surface receptor linked 70 7.85 9.24E-07 510 564 7436 1.81 0.001944439 6.49E-04 0.001598537 ADCYAP1R1, USP9X, BMPR2, CTNND1, CD24A, EPHB1, signal transduction PHIP, IGF1R, PTK2, BAI1, BAI3, AGRN, PIK3R3, AGRP, CSNK1A1, PLAT, DVL3, NLK, TGFBR1, DGKH, KCNK2, EPHA3, NTRK3, SEMA6A, EPHA4, LAMA1, ITGA9, NOTCH2, RGS20, NXN, FYN, DCP1A, CDON, GSK3B, GRLF1, LRP6, ZRANB1, CACNA1D ENY2, HMGB2, CNBP, SOX5, PAX6, CASK, RORB, NFYB, SOX6, ZEB1, RORA, CNOT7, 9430076C15RIK, GO:0051254~positive ARID2, HNRPLL, CBFB, CTNNB1, APP, MEIS2, TCEA1, regulation of RNA 38 4.26 4.27E-06 510 247 7436 2.24 0.008947498 0.002244419 0.007381509 YAP1, AGRN, PLAGL2, ATF7IP, KLF12, SOX11, MED14, metabolic process RB1, WWTR1, NCOA2, CSRNP3, ZFP462, ETS1, HIPK2, PBX1, RBM14, NFIA, NFIB MYO5A, SYT1, GRIK2, CAPZA2, CLSTN1, HEXB, CACNB2, CD24A, CTNNB1, NRCAM, CTTNBP2, APP, GO:0019226~transmiss 27 3.03 6.70E-06 510 148 7436 2.66 0.014018365 0.002819528 0.011594273 PTK2, DMD, AGRN, PPP3CA, NRG1, SCD2, NRXN3, ion of nerve impulse NF1, NLGN1, NRXN1, QK, CTNNA2, GRM3, FYN, CACNA1C ENY2, HMGB2, CNBP, SOX5, PAX6, CASK, RORB, GO:0045893~positive NFYB, SOX6, ZEB1, RORA, CNOT7, 9430076C15RIK, regulation of ARID2, CBFB, CTNNB1, APP, MEIS2, TCEA1, YAP1, 37 4.15 9.01E-06 510 245 7436 2.20 0.018790947 0.003156631 0.015578904 transcription, DNA- AGRN, PLAGL2, ATF7IP, KLF12, SOX11, MED14, RB1, dependent WWTR1, NCOA2, CSRNP3, ZFP462, ETS1, HIPK2, PBX1, RBM14, NFIA, NFIB ENY2, HMGB2, CNBP, SOX5, PAX6, CASK, CTCF, RORB, NFYB, SOX6, ZEB1, RORA, CNOT7, GO:0010628~positive 9430076C15RIK, GLI3, ARID2, CBFB, CTNNB1, APP, regulation of gene 41 4.60 1.25E-05 510 289 7436 2.07 0.025921746 0.003744918 0.021568372 MEIS2, ETV1, TCEA1, YAP1, AGRN, PLAGL2, ATF7IP, expression KLF12, SOX11, MED14, RB1, WWTR1, NCOA2, CSRNP3, ZFP462, ETS1, DCP1A, HIPK2, PBX1, RBM14, NFIA, NFIB MYO5A, ADCY3, SYT1, GRIK2, CAPZA2, ADCY5, HEXB, CLSTN1, CTNND2, CACNB2, RORB, GRIN3A, CD24A, GO:0050877~neurologi CTNNB1, NRCAM, CTTNBP2, APP, PTK2, PDE1C, DMD, 40 4.48 1.27E-05 510 279 7436 2.09 0.026415026 0.003340679 0.021984306 cal system process PTN, PPP3CA, AGRN, NRG1, TUB, SCD2, RPGR, NRXN3, NF1, NLGN1, NRXN1, QK, CTNNA2, GRM3, FYN, GNB1, CACNA1C, PBX3, CACNA1D, FBXO11 DCC, ENAH, LIMS1, SHROOM3, PAX6, SOX6, CDH4, GLI3, EPHB1, CTNNB1, NRCAM, APP, PTK2, DMD, GO:0000902~cell 32 3.59 1.76E-05 510 203 7436 2.30 0.036326858 0.004103016 0.030386561 NUMB, ETV1, CLASP2, NRG1, DCLK1, DSCAM, morphogenesis CSNK1A1, PTPRZ1, TBCE, EVL, MYH9, WWTR1, CTNNA2, SEMA6A, LAMA1, EPHA4, NDEL1, DST ENY2, HMGB2, CNBP, SOX5, PAX6, CASK, RORB, GO:0045935~positive NFYB, SOX6, ZEB1, RORA, CNOT7, 9430076C15RIK, regulation of GLI3, ARID2, HNRPLL, CBFB, CTNNB1, APP, MEIS2, nucleobase, nucleoside, 42 4.71 1.97E-05 510 305 7436 2.01 0.040546096 0.004130546 0.033989246 ETV1, TCEA1, YAP1, AGRN, PLAGL2, ATF7IP, KLF12, nucleotide and nucleic SOX11, MED14, RB1, WWTR1, NCOA2, CSRNP3, acid metabolic process ZFP462, ETS1, DCP1A, HIPK2, BRE, PBX1, RBM14, NFIA, NFIB GO:0045944~positive HMGB2, CNBP, PAX6, SOX5, CASK, SOX6, ZEB1, regulation of RORA, CNOT7, ARID2, CBFB, CTNNB1, APP, MEIS2, transcription from 32 3.59 2.14E-05 510 205 7436 2.28 0.044143192 0.004095876 0.037073132 TCEA1, AGRN, YAP1, PLAGL2, KLF12, SOX11, MED14, RNA polymerase II RB1, WWTR1, NCOA2, ZFP462, CSRNP3, ETS1, HIPK2, promoter PBX1, RBM14, NFIA, NFIB Yano_Supplemental_Table_S4 Gene ontology – Biological process 2 of 9 Fold List Pop Pop GO Term Count % PValue Bonferroni Benjamini FDR Genes Total Hits Total Enrichment ENY2, HMGB2, CNBP, SOX5, PAX6, CASK, RORB, NFYB, SOX6, ZEB1, RORA, CNOT7, 9430076C15RIK, GO:0045941~positive GLI3, ARID2, CBFB, CTNNB1, APP, MEIS2, ETV1, regulation of 40 4.48 2.28E-05 510 286 7436 2.04 0.046838229 0.003989574 0.03939121 TCEA1, YAP1, AGRN, PLAGL2, ATF7IP, KLF12, SOX11, transcription MED14, RB1, WWTR1, NCOA2, CSRNP3, ZFP462, ETS1, DCP1A, HIPK2, PBX1, RBM14, NFIA, NFIB LIMS1, CADM1, CLSTN1, ASTN1, PCDHGA8, NLGN1, GO:0016337~cell-cell CTNND1, PCDH9, VEZT, CDH2, MYH9, CDH4, CD24A, 25 2.80 2.31E-05 510 140 7436 2.60 0.047566658 0.00374184 0.040018869 adhesion PCDH19, CTNNB1, CTNNA2, NRCAM, NCAM1, CDH13, FAT3, PVRL3, CDON, TTYH1, ROR2, RAPGEF1 DCC, ENAH, PTPRZ1, PAX6, TBCE, EVL, CDH4, GLI3, GO:0048812~neuron EPHB1, CTNNA2, NRCAM, SEMA6A, EPHA4, APP, projection 22 2.47 2.83E-05 510 115 7436 2.79 0.057817626 0.004244994 0.048902575 PTK2, NDEL1, DMD, NUMB, ETV1, DST, DCLK1, morphogenesis DSCAM PLAT, DCC, SGPL1, PLXNA2, CAPZA2, ATP5B, GO:0016477~cell TGFBR1, ASTN1, PAX6, ZEB2, CDH2, MYH9, YWHAE, 25 2.80 2.95E-05 510 142 7436 2.57 0.060209955 0.004131361 0.050989614 migration CD24A, NCKAP1, CTNNA2, CTTNBP2, EDNRB, PTK2, NDEL1, FYN, LRP6, CLASP2, NRG1, DCLK1 ENY2, HMGB2, CNBP, SOX5, PAX6, CASK, RORB, NFYB, SOX6, ZEB1, RORA, CNOT7, 9430076C15RIK, GO:0051173~positive GLI3, ARID2, HNRPLL, CBFB, CTNNB1, APP, MEIS2, regulation of nitrogen 42 4.71 3.40E-05 510 312 7436 1.96 0.069173172 0.004470106 0.058856143 ETV1, TCEA1, YAP1, AGRN, PLAGL2, ATF7IP, KLF12, compound metabolic SOX11, MED14, RB1, WWTR1, NCOA2, CSRNP3, process ZFP462, ETS1, DCP1A, HIPK2, BRE, PBX1, RBM14, NFIA, NFIB CAPZA2, ATP5B, CASK, EIF2A, D8ERTD82E, CTTNBP2, APP, CSNK2A1, SLK, PAK2, PAK3, FERT2, TLK1, BRD4, AKT3, PTPRK, PAN3, PTPRM, ROCK1, PTPRG, WNK1, PI4KA, CDK8, PTPRS, PTPRT, MARK3, PRKCE, MARK1, MAP4K3, ATP6V1A, MAP4K4, DDR1, GO:0006793~phosphor 68 7.62 3.60E-05 510 603 7436 1.64 0.072975671 0.004447461 0.062216111 EIF2AK1, HIPK1, HIPK2, ROR2, MAPK8, PPM1L, us metabolic process CAMK1D, ERBB4, SSH2, BMPR2, ABI1, EPHB1, IGF1R, PTK2, TTBK2, PPP2CA, PPP1R12A, TNKS, PPP3CA, DCLK1, GPD2, CSNK1A1, PTPRD, TAOK1, PTPRZ1, NLK, TGFBR1, MAP2K4, EPHA3, NTRK3, EPHA4, ICK, FYN, ATP6V1E1, RSRC1, GSK3B CAPZA2, ATP5B, CASK, EIF2A, D8ERTD82E, CTTNBP2, APP, CSNK2A1, SLK, PAK2, PAK3, FERT2, TLK1, BRD4, AKT3, PTPRK, PAN3, PTPRM, ROCK1, PTPRG, WNK1, PI4KA, CDK8, PTPRS, PTPRT, MARK3, PRKCE, MARK1, MAP4K3, ATP6V1A, MAP4K4, DDR1, GO:0006796~phosphat 68 7.62 3.60E-05 510 603 7436 1.64 0.072975671 0.004447461 0.062216111 EIF2AK1, HIPK1, HIPK2, ROR2, MAPK8, PPM1L, e metabolic process CAMK1D, ERBB4, SSH2, BMPR2, ABI1, EPHB1, IGF1R, PTK2, TTBK2, PPP2CA, PPP1R12A, TNKS, PPP3CA, DCLK1, GPD2, CSNK1A1, PTPRD, TAOK1, PTPRZ1, NLK, TGFBR1, MAP2K4, EPHA3, NTRK3, EPHA4, ICK, FYN, ATP6V1E1, RSRC1, GSK3B MYO5A, SYT1, GRIK2, NRXN3, CAPZA2, CLSTN1, GO:0007268~synaptic NLGN1, CACNB2, NRXN1, CD24A, CTNNB1, CTNNA2, 21 2.35 6.09E-05 510 112 7436 2.73 0.120391176 0.007101221 0.10530106 transmission CTTNBP2, APP, PTK2, GRM3, DMD, AGRN, PPP3CA, CACNA1C, NRG1 DCC, ENAH, PTPRZ1, PAX6, TBCE, EVL, CDH4, GLI3, GO:0007409~axonogen 20 2.24 7.70E-05 510 105 7436 2.78 0.149620401 0.00849385 0.133023852 EPHB1, CTNNA2, NRCAM, SEMA6A, EPHA4, APP, esis PTK2, NDEL1, NUMB, ETV1, DST, DCLK1 GO:0000904~cell DCC, ENAH, PTPRZ1, PAX6, TBCE, EVL, MYH9, CDH4, morphogenesis GLI3, EPHB1, CTNNB1, CTNNA2, NRCAM, SEMA6A, 23 2.58 8.80E-05 510 133 7436 2.52 0.169196272 0.009225269 0.15212438 involved in EPHA4, APP, PTK2, NDEL1, NUMB, ETV1, DST, DCLK1, differentiation DSCAM PLAT, DCC, SGPL1, PLXNA2, CAPZA2, ATP5B, GO:0048870~cell TGFBR1, ASTN1, PAX6, ZEB2, CDH2, MYH9, YWHAE, 25 2.80 9.13E-05 510 152 7436 2.40 0.174893647 0.009112654 0.157767323 motility CD24A, NCKAP1, CTNNA2, CTTNBP2, EDNRB, PTK2, NDEL1, FYN, LRP6, CLASP2, NRG1, DCLK1 PLAT, DCC, SGPL1, PLXNA2, CAPZA2, ATP5B, GO:0051674~localizati TGFBR1, ASTN1, PAX6, ZEB2, CDH2, MYH9, YWHAE, 25 2.80 9.13E-05 510 152 7436 2.40 0.174893647 0.009112654 0.157767323 on of cell CD24A, NCKAP1, CTNNA2, CTTNBP2, EDNRB, PTK2, NDEL1, FYN, LRP6, CLASP2, NRG1, DCLK1 DCC, ENAH, PAX6, RORB, GRIN3A, CDH4, GLI3, GO:0048666~neuron CD24A, EPHB1, NRCAM, APP, PTK2, DMD, NUMB, 28 3.14 1.02E-04 510 182 7436 2.24 0.192801733 0.009688487 0.175759342 development ETV1, DCLK1, DSCAM, RPGR, PTPRZ1, TBCE, EVL, CTNNA2, SEMA6A, EPHA4, NDEL1, GNAQ, PBX3, DST ENY2, HMGB2, CNBP, SOX5, PAX6, CASK, RORB, NFYB, SOX6, ZEB1, RORA, CNOT7, 9430076C15RIK, GO:0031328~positive GLI3, ARID2, CBFB, CTNNB1, APP, MEIS2, NPM1, regulation