Supplementary material Ann Rheum Dis Gene ontology (molecular Gene.NameGene ontology (biological process) Gene ontology (cellular component) function) extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; extracellular space [GO:0005615]; membrane [GO:0016020]; scavenger receptor activity Lgals3bp cell adhesion [GO:0007155] proteinaceous extracellular matrix [GO:0005578] [GO:0005044] extracellular matrix structural extracellular matrix organization [GO:0030198]; endoplasmic reticulum [GO:0005783]; extracellular constituent [GO:0005201]; hydrogen peroxide catabolic process [GO:0042744]; matrix [GO:0031012]; extracellular space heme binding [GO:0020037]; oxidation-reduction process [GO:0055114]; [GO:0005615]; proteinaceous extracellular matrix metal ion binding [GO:0046872]; Pxdn response to oxidative stress [GO:0006979] [GO:0005578] peroxidase activity carbohydrate biosynthetic process [GO:0016051]; N-acetylgalactosamine 4-O- dermatan sulfate proteoglycan metabolic process Golgi membrane [GO:0000139]; integral component sulfotransferase activity Chst14 [GO:0050655] of membrane [GO:0016021] [GO:0001537] cell-cell adhesion [GO:0098609]; cell migration [GO:0016477]; cell recognition [GO:0008037]; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [GO:0007157]; homophilic cell adhesion via plasma membrane adhesion cell adhesion molecule binding molecules [GO:0007156]; positive regulation of [GO:0050839]; dynein light chain natural killer cell mediated cytotoxicity directed binding [GO:0045503]; protein against tumor cell target [GO:0002860]; cell-cell adherens junction [GO:0005913]; cell homodimerization activity susceptibility to natural killer cell mediated surface [GO:0009986]; integral component of [GO:0042803]; receptor activity cytotoxicity [GO:0042271]; susceptibility to T cell plasma membrane [GO:0005887]; plasma [GO:0004872]; receptor binding Pvr mediated cytotoxicity [GO:0060370] membrane [GO:0005886] [GO:0005102] hydrolase activity [GO:0016787]; metal ion binding [GO:0046872]; nucleic acid binding [GO:0003676]; polysaccharide immune response [GO:0006955]; metabolic process binding [GO:0030247]; Enpp1 [GO:0008152] integral component of membrane [GO:0016021] scavenger receptor activity Wang G, et al. Ann Rheum Dis 2020; 79:1111–1120. doi: 10.1136/annrheumdis-2019-216911 Supplementary material Ann Rheum Dis angiogenesis [GO:0001525]; astrocyte cell migration [GO:0043615]; bone development [GO:0060348]; branching morphogenesis of an epithelial tube [GO:0048754]; cell migration [GO:0016477]; chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; endodermal cell differentiation [GO:0035987]; endothelial cell proliferation [GO:0001935]; head development [GO:0060322]; lung development [GO:0030324]; male gonad development [GO:0008584]; negative regulation of focal adhesion assembly [GO:0051895]; negative regulation of Notch signaling pathway [GO:0045746]; ossification [GO:0001503]; ovarian follicle development [GO:0001541]; positive regulation of B cell differentiation [GO:0045579]; positive regulation of cell growth [GO:0030307]; positive regulation of cell migration [GO:0030335]; positive regulation of cytoplasmic vesicle [GO:0031410]; cytosol macrophage migration [GO:1905523]; positive [GO:0005829]; extracellular matrix [GO:0031012]; integrin binding [GO:0005178]; regulation of myotube differentiation [GO:0010831]; extracellular space [GO:0005615]; integral metalloaminopeptidase activity proteolysis [GO:0006508]; response to estrogen component of membrane [GO:0016021]; [GO:0070006]; [GO:0043627]; response to hormone [GO:0009725]; intermediate filament cytoskeleton [GO:0045111]; metalloendopeptidase activity response to hypoxia [GO:0001666]; response to macropinosome [GO:0044354]; melanosome [GO:0004222]; peptidase mechanical stimulus [GO:0009612]; response to [GO:0042470]; nucleus [GO:0005634]; plasma activator activity [GO:0016504]; Mmp14 odorant [GO:1990834]; response to organic cyclic membrane [GO:0005886] zinc ion binding [GO:0008270] integral component of membrane [GO:0016021]; cadherin binding [GO:0045296]; nucleolus [GO:0005730]; plasma membrane G-protein coupled receptor Gprc5a [GO:0005886]; vesicle [GO:0031982] activity [GO:0004930] prenylated protein catabolic process [GO:0030327]; extracellular region [GO:0005576]; vacuolar prenylcysteine oxidase activity Pcyox1 prenylcysteine catabolic process [GO:0030328] membrane [GO:0005774] [GO:0001735] Wang G, et al. Ann Rheum Dis 2020; 79:1111–1120. doi: 10.1136/annrheumdis-2019-216911 Supplementary material Ann Rheum Dis bradykinin catabolic process [GO:0010815]; calcitonin catabolic process [GO:0010816]; ear development [GO:0043583]; embryonic digit morphogenesis [GO:0042733]; endothelin maturation [GO:0034959]; heart development cell surface [GO:0009986]; early endosome endopeptidase activity [GO:0007507]; hormone catabolic process [GO:0005769]; endosome [GO:0005768]; external [GO:0004175]; [GO:0042447]; peptide hormone processing side of plasma membrane [GO:0009897]; Golgi metalloendopeptidase activity [GO:0016486]; pharyngeal system development apparatus [GO:0005794]; integral component of [GO:0004222]; protein [GO:0060037]; positive regulation of receptor membrane [GO:0016021]; perinuclear region of homodimerization activity recycling [GO:0001921]; protein processing cytoplasm [GO:0048471]; plasma membrane [GO:0042803]; zinc ion binding Ece1 [GO:0016485]; substance P catabolic process [GO:0005886]; Weibel-Palade body [GO:0033093] [GO:0008270] Wang G, et al. Ann Rheum Dis 2020; 79:1111–1120. doi: 10.1136/annrheumdis-2019-216911 Supplementary material Ann Rheum Dis behavioral response to ethanol [GO:0048149]; cardiac muscle hypertrophy [GO:0003300]; cellular response to dopamine [GO:1903351]; cellular response to heat [GO:0034605]; cellular response to hydrogen peroxide [GO:0070301]; cellular response to retinoic acid [GO:0071300]; cellular response to transforming growth factor beta stimulus [GO:0071560]; maintenance of chromatin silencing [GO:0006344]; negative regulation of dendritic spine development [GO:0061000]; negative regulation of DNA binding [GO:0043392]; negative regulation of DNA binding transcription factor activity [GO:0043433]; negative regulation of neuron projection development [GO:0010977]; negative heat shock protein binding regulation of peptidyl-lysine acetylation [GO:0031072]; histone [GO:2000757]; negative regulation of transcription deacetylase binding by RNA polymerase II [GO:0000122]; positive [GO:0042826]; metal ion binding regulation of cell proliferation [GO:0008284]; [GO:0046872]; NAD-dependent positive regulation of epithelial to mesenchymal histone deacetylase activity (H3- transition [GO:0010718]; positive regulation of K14 specific) [GO:0032041]; NF- interleukin-1 production [GO:0032732]; positive kappaB binding [GO:0051059]; regulation of oligodendrocyte differentiation promoter-specific chromatin [GO:0048714]; positive regulation of proteolysis binding [GO:1990841]; RNA [GO:0045862]; positive regulation of receptor polymerase II repressing biosynthetic process [GO:0010870]; positive transcription factor binding regulation of transcription by RNA polymerase II cytoplasm [GO:0005737]; ESC/E(Z) complex [GO:0001103]; sequence- [GO:0045944]; positive regulation of tumor necrosis [GO:0035098]; NuRD complex [GO:0016581]; Sin3 specific DNA binding Hdac2 factor production [GO:0032760]; positive regulation complex [GO:0016580] [GO:0043565] Wang G, et al. Ann Rheum Dis 2020; 79:1111–1120. doi: 10.1136/annrheumdis-2019-216911 Supplementary material Ann Rheum Dis adhesion of symbiont to host [GO:0044406]; cell adhesion [GO:0007155]; cell adhesion mediated by integrin [GO:0033627]; cellular response to glucose stimulus [GO:0071333]; cellular response to leukemia inhibitory factor [GO:1990830]; establishment of endothelial barrier [GO:0061028]; leukocyte cell-cell adhesion [GO:0007159]; leukocyte migration [GO:0050900]; membrane to membrane docking [GO:0022614]; negative regulation of endothelial cell apoptotic process [GO:2000352]; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [GO:1902042]; positive regulation of cellular extravasation [GO:0002693]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; external side of plasma membrane [GO:0009897]; receptor-mediated virion attachment to host cell extracellular exosome [GO:0070062]; extracellular [GO:0046813]; regulation of cell adhesion matrix [GO:0031012]; extracellular space [GO:0030155]; regulation of ruffle assembly [GO:0005615]; immunological synapse [GO:1900027]; T cell activation via T cell receptor [GO:0001772]; integral component of plasma Icam1 contact with antigen bound to MHC molecule on membrane [GO:0005887] integrin binding [GO:0005178] alpha-galactosidase activity [GO:0004557]; galactoside binding [GO:0016936]; protein homodimerization activity extracellular region [GO:0005576]; Golgi apparatus [GO:0042803]; receptor binding Gla oligosaccharide metabolic process [GO:0009311] [GO:0005794]; lysosome [GO:0005764] [GO:0005102] metal ion binding [GO:0046872]; N-acetylglucosamine-6-sulfatase activity [GO:0008449]; sulfuric ester hydrolase activity Gns glycosaminoglycan metabolic process [GO:0030203] lysosome [GO:0005764] [GO:0008484] Wang G, et al. Ann Rheum Dis 2020; 79:1111–1120. doi: 10.1136/annrheumdis-2019-216911 Supplementary