Total Total Studies Sample Mean Fold Gene Name Description Studies Sample Range with FC Sizes Change Sizes with FC 4 Studies - Greatest sample size Proliferating cell 4 [21,22,51, 1.20 to PCNA 4 249 249 3.34 nuclear antigen 54] 4.80 General 4 [17,21,22, 1.50 to GTF3A transcription factor 54] 4 235 235 3.03 3.35 IIIA SRY (sex 4 [21,22,48, 2.02 to SOX4 determining region 54] 3 244 199 2.41 2.72 Y)-box 4 SRY (sex 4 [21,22,48, determining region 54] Y)-box 9 1.89 to SOX9 (campomelic 3 280 235 2.36 2.25 dysplasia, autosomal sex- reversal) Vascular 4 [21,55,56, 1.81 to VEGFA endothelial growth 59] 2 270 224 2.07 2.33 factor A 4 Studies – Moderate sample size Ets variant gene 4 (E1A enhancer 4 [22,48,51, 2.08 to ETV4 3 234 189 32.64 binding protein, 54] 92.00 E1AF) Matrix metallopeptidase 1 4 [17,20,21, 3.47 to MMP1 4 162 162 8.26 (interstitial 22] 21.00 collagenase) Chemokine (C-X-C 4 [17,20,21, 2.48 to CXCL3 4 162 162 7.28 motif) ligand 3 22] 13.00 Nucleophosmin (nucleolar 4 4.27 to NPM1 3 174 129 7.10 phosphoprotein [8,19,48,54] 12.00 B23, numatrin) High mobility 4 [22,51,54, 2.90 to HMGA1 3 229 189 5.50 group AT-hook 1 58] 7.09 Ribosomal protein 4 2.39 to RPS2 3 169 129 5.16 S2 [8,19,54,57] 8.13 Ribosomal protein 4 [19,22,54, 2.16 to RPL8 3 183 143 3.50 L8 57] 5.35 Eukaryotic translation 4 [22,51,54, 2.53 to EIF3S9 initiation factor 3, 3 229 189 3.29 57] 4.30 subunit 9 eta, 116kDa Protein kinase, DNA-activated, 4 [21,22,54, 1.33 to PRKDC 3 221 199 2.49 catalytic 56] 3.23 polypeptide 4 Studies - Lowest sample size Matrix 4 [20,21,22, 3.32 to MMP7 metallopeptidase 7 4 158 158 9.39 49] 21.00 (matrilysin, uterine) Heat shock 60kDa 4 4.12 to HSPD1 protein 1 3 82 58 4.90 [8,47,50,59] 5.99 (chaperonin) RAN, member 4 3.30 to RAN 2 157 72 4.60 RAS oncogene [8,48,51,57] 5.90 family Poly(A) binding 4 3.00 to PABPC1 protein, 3 80 62 3.99 [8,19,22,53] 5.75 cytoplasmic 1 Heat shock protein 90kDa alpha 4 2.87 to HSP90AB1 3 106 82 3.72 (cytosolic), class B [8,22,47,59] 5.34 member 1 3 Studies – Greatest sample size Ribosomal protein 5.35 to RPL29 3 [48,54,57] 1 188 103 5.35 L29 5.35 Ribonucleotide 2.06 to RRM2 reductase M2 3 [22,51,54] 3 189 189 4.85 6.80 polypeptide Ribosomal protein 2.21 to RPS7 3 [22,48,54] 2 184 139 3.96 S7 5.71 Macrophage migration inhibitory 2.62 to MIF factor 3 [22,54,57] 2 179 139 3.68 4.74 (glycosylation- inhibiting factor) Formyl peptide 2.92 to FPRL1 3 [21,49,54] 3 195 195 3.67 receptor-like 1 5.15 Ectodermal-neural 2.62 to ENC1 cortex (with BTB- 3 [22,49,55] 3 232 232 3.34 3.92 like domain) Bone 2.92 to BMP4 morphogenetic 3 [22,54,58] 2 179 139 3.24 3.55 protein 4 1.48 to CPNE1 Copine I 3 [21,47,54] 3 187 187 3.04 4.41 Polymerase (RNA) 2.10 to POLR1D I polypeptide D, 3 [22,54,58] 2 179 139 2.51 2.91 16kDa TGFB-induced 1.38 to TGIF1 factor (TALE family 3 [21,22,54] 3 199 199 2.40 3.60 homeobox) TNF receptor- 2.17 to TRAP1 associated protein 3 [22,54,58] 2 179 139 2.28 2.38 1 MCM3 minichromosome 1.30 to MCM3 maintenance 3 [21,22,54] 3 199 199 2.22 2.98 deficient 3 (S. cerevisiae) Small nuclear ribonucleoprotein 1.01 to SNRPB 3 [21,22,54] 3 199 199 2.18 polypeptides B and 3.03 B1 Integrin, alpha 2 (CD49B, alpha 2 2.06 to ITGA2 3 [48,55,56] 1 231 164 2.06 subunit of VLA-2 2.06 receptor) Translocase of outer mitochondrial 1.66 to TOMM40 3 [21,22,54] 3 199 199 1.94 membrane 40 2.13 homolog (yeast) 3 Studies – Moderate sample size 1.11 to FN1 Fibronectin 1 3 [19,21,51] 3 114 114 9.94 15.00 Secreted phosphoprotein 1 2.23 to SPP1 3 [20,21,22] 3 126 126 6.23 (osteopontin, bone 12.00 sialoprotein I, early T-lymphocyte activation 1) Tumor-associated 4.53 to TACSTD2 calcium signal 3 [21,22,49] 3 128 128 6.04 7.84 transducer 2 4.46 to BGN Biglycan 3 [20,54,58] 2 173 133 5.23 6.00 WEE1 homolog (S. 1.16 to WEE1 3 [21,47,51] 3 134 134 4.70 pombe) 6.75 Ribosomal protein 4.05 to RPS19 3 [19,54,57] 2 147 107 4.59 S19 5.13 Serpin peptidase inhibitor, clade E (nexin, 1.64 to SERPINE1 3 [20,21,56] 2 112 90 4.32 plasminogen 7.00 activator inhibitor type 1), member 1 Chemokine (C-X-C 2.21 to CXCL2 3 [20,21,22] 3 126 126 4.23 motif) ligand 2 8.00 Fc fragment of IgG, low affinity 2.73 to FCGR3A 3 [21,51,52] 2 131 110 4.22 IIIa, receptor 5.70 (CD16a) Ribosomal protein 4.08 to RPL31 3 [48,53,54] 1 166 103 4.08 L31 4.08 Ribosomal protein 2.67 to RPS5 3 [19,54,57] 2 147 107 3.79 S5 4.90 Heat shock 10kDa 2.54 to HSPE1 protein 1 3 [17,22,54] 3 175 175 3.74 4.80 (chaperonin 10) Eukaryotic translation 3.26 to EIF3S6 3 [8,48,54] 2 170 125 3.73 initiation factor 3, 4.20 subunit 6 48kDa Homer homolog 1 2.55 to HOMER1 3 [20,49,54] 3 165 165 3.65 (Drosophila) 5.00 Ornithine 3.27 to ODC1 3 [8,54,57] 2 165 125 3.59 decarboxylase 1 3.90 High-mobility 2.30 to HMGB2 3 [8,48,54] 2 170 125 3.42 group box 2 4.54 Pyrroline-5- 1.23 to PYCR1 carboxylate 3 [17,21,57] 2 136 96 3.27 5.30 reductase 1 Ribosomal protein 2.02 to RPS18 3 [19,47,54] 3 131 131 3.25 S18 4.80 Tripartite motif- 2.02 to TRIM28 3 [19,22,54] 3 143 143 2.90 containing 28 4.57 Sorbitol 1.19 to SORD 3 [17,21,22] 3 132 132 2.86 dehydrogenase 4.70 Heterogeneous nuclear 2.81 to HNRPH1 3 [18,52,54] 1 142 103 2.81 ribonucleoprotein 2.81 H1 (H) Peptidylprolyl 2.50 to PPIB isomerase B 3 [22,46,54] 2 149 139 2.63 2.75 (cyclophilin B) IMP (inosine 2.32 to IMPDH2 monophosphate) 3 [8,54,57] 2 165 125 2.57 2.81 dehydrogenase 2 Glutathione S- 2.38 to GSTP1 3 [22,53,54] 2 157 139 2.43 transferase pi 2.48 Complement 1.42 to C2 3 [20,21,57] 2 130 90 2.21 component 2 3.00 Gamma-glutamyl hydrolase 1.47 to GGH (conjugase, 3 [21,22,58] 2 136 96 1.87 2.27 folylpolygammaglu tamyl hydrolase) Cyclin-dependent kinase inhibitor 3 1.11 to CDKN3 (CDK2-associated 3 [21,22,52] 2 117 96 1.80 2.48 dual specificity phosphatase) V-myb myeloblastosis 1.69 to MYBL2 viral oncogene 3 [21,52,58] 1 121 60 1.69 1.69 homolog (avian)- like 2 3 Studies – Lowest sample size Guanine nucleotide binding 8.30 to GNB2L1 protein (G protein), 3 [19,46,48] 1 59 4 8.30 8.30 beta polypeptide 2- like 1 Collagen, type I, 2.39 to COL1A1 3 [19,21,59] 2 88 64 8.20 alpha 1 14.00 3.88 to CLDN2 Claudin 2 3 [19,22,59] 2 64 40 7.44 11.00 Bone marrow 1.19 to BST2 stromal cell 3 [19,21,22] 3 100 100 6.82 3.28 antigen 2 S- 4.00 to AHCY adenosylhomocyst 3 [17,19,20] 3 70 70 5.78 7.33 eine hydrolase Lactate 2.05 to LDHB 3 [8,22,57] 2 98 58 4.26 dehydrogenase B 6.47 Ribosomal protein 4.10 to RPL30 3 [8,53,57] 1 80 22 4.10 L30 4.10 Complement factor 3.70 to CFB 3 [6,18,58] 1 94 36 3.70 B 3.70 Ribosomal protein 3.46 to RPL6 3 [8,48,57] 1 107 22 3.46 L6 3.46 Bone morphogenetic 3.42 to BMP7 protein 7 3 [49,52,58] 1 93 32 3.42 3.42 (osteogenic protein 1) Non-metastatic cells 1, protein 2.57 to NME1 3 [19,22,48] 2 85 40 3.37 (NM23A) 4.17 expressed in Eukaryotic translation 3.12 to EEF1A1 3 [8,46,48] 1 77 22 3.12 elongation factor 1 3.12 alpha 1 Chaperonin 2.40 to CCT7 containing TCP1, 3 [8,22,57] 2 98 58 2.94 3.47 subunit 7 (eta) Ribosomal protein 2.74 to RPSA 3 [19,46,48] 1 59 4 2.74 SA 2.74 Ribosomal protein 2.30 to RPL3 3 [8,19,57] 2 66 26 2.33 L3 2.36.