Guide to Combination Cancer Chemotherapy Regimens Dominic A. Solimando, Jr. J. Aubrey Waddell A Thomas Land Publication CONTENTS ABBREVIATIONS ...........................................................................ix INTRODUCTION ............................................................................xi REGIMENS 1. BREAST Cyclophosphamide, Doxorubicin, and Fluorouracil (CAF, FAC). 1 Cyclophosphamide, Methotrexate, and Fluorouracil (CMF) .............................................4 Docetaxel and Capecitabine (DC) ...............................................................8 Docetaxel and Carboplatin (AUC = 6) (DC) ........................................................12 Docetaxel and Cisplatin (DP) ..................................................................16 Docetaxel, Doxorubicin, and Cyclophosphamide (TAC) ..............................................24 Dose Dense Doxorubicin and Cyclophosphamide Followed by Paclitaxel .................................28 Doxorubicin and Cyclophosphamide ............................................................31 Doxorubicin and Cyclophosphamide Followed by Docetaxel ..........................................33 Doxorubicin and Docetaxel ...................................................................37 Fluorouracil, Epirubicin, and Cyclophosphamide (FEC50) (FEC) ........................................42 Fluorouracil, Epirubicin, and Cyclophosphamide (FEC100) (FEC) .......................................46 Gemcitabine and Capecitabine ................................................................49 Ixabepilone and Capecitabine (IC) ..............................................................53 Lapatinib and Capecitabine. 56 Paclitaxel and Gemcitabine. 59 Pemetrexed and Carboplatin (PC) ..............................................................63 2. GASTROINTESTINAL Gemcitabine and Capecitabine (Biliary, Gallbladder) ................................................67 Irinotecan and Cisplatin (IP) (Gastroesophageal) ...................................................71 Colon/Colorectal Capecitabine plus Oxaliplatin (XelOx/CapOx) ......................................................75 Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) .................................................79 High-Dose Fluorouracil and Leucovorin ..........................................................82 Irinotecan, Fluorouracil, and Leucovorin .........................................................86 Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX 4) ................................................89 Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX 6 and 7). 93 Protracted Venous Infusion Fluorouracil. .97 Weekly Fluorouracil and Leucovorin ...........................................................100 Gastric Docetaxel and Capecitabine (DC) .............................................................103 Docetaxel and Cisplatin (DP) .................................................................107 Docetaxel, Cisplatin, and Fluorouracil (DCF) .....................................................115 Epirubicin, Cisplatin and Capecitabine (ECX) .....................................................119 iii iv Contents Epirubicin, Cisplatin, and Fluorouracil (ECF) ......................................................123 Fluorouracil, Doxorubicin, and Mitomycin (FAM) ..................................................130 Irinotecan and Cisplatin (IP). 134 Esophageal Docetaxel and Capecitabine (DC) .............................................................138 Docetaxel and Cisplatin (DP) .................................................................142 Irinotecan and Cisplatin (IP). 150 Pancreatic Fluorouracil, Doxorubicin, and Mitomycin (FAM) ..................................................154 Gemcitabine and Capecitabine ...............................................................158 3. GENITOURINARY Docetaxel and Cisplatin (DP) (Urothelial) ........................................................162 Gemcitabine and Capecitabine (Renal Cell) ......................................................170 Bladder Intravesical Doxorubicin ....................................................................174 Intravesical BCG ..........................................................................180 Intravesical Gemcitabine ....................................................................182 Intravesical Mitomycin .....................................................................184 Methotrexate, Vinblastine, Doxorubicin, and Cisplatin (MVAC) ........................................190 Prostate Docetaxel and Capecitabine (DC) .............................................................197 Docetaxel and Estramustine .................................................................201 Docetaxel and Prednisone (DP) ...............................................................205 Gemcitabine and Capecitabine ...............................................................208 Mitoxantrone and Prednisone (MP) ............................................................212 Taxanes and Estramustine ..................................................................214 Testicular Bleomycin, Etoposide, and Cisplatin (BEP) .......................................................218 Cisplatin and Ifosfamide With Either Vinblastine or Etoposide (VIP) .....................................221 Etoposide and Cisplatin .....................................................................225 4. GYNECOLOGIC Docetaxel and Carboplatin (AUC = 6) (DC) (Cervical) ...............................................228 Gestational Trophoblastic Neoplasm Etoposide, Methotrexate, Actinomycin, Cyclophosphamide, and Vincristine (EMA/CO) ......................232 Hydroxyurea, Dactinomycin, Vincristine, Leucovorin, Cyclophosphamide, and Doxorubicin (Modified Bagshawe Regimen). .235 Ovarian Docetaxel and Carboplatin (AUC = 6) (DC) .......................................................238 Docetaxel and Carboplatin (AUC = 5) (DC) .......................................................242 Docetaxel and Cisplatin (DP) .................................................................245 Liposomal Doxorubicin .....................................................................253 Pemetrexed and Carboplatin (PC) .............................................................255 Contents v 5. HEAD AND NECK Cisplatin and Continuous Infusion Fluorouracil (CF) ................................................259 Docetaxel and Carboplatin (AUC = 6) (DC) .......................................................265 Docetaxel and Cisplatin (DP) .................................................................269 Docetaxel, Cisplatin, and Fluorouracil (DCF) .....................................................277 Docetaxel, Cisplatin, and Fluorouracil (TCF) ......................................................281 6. LUNG Carboplatin and Etoposide (CE) ...............................................................283 Cisplatin and Pemetrexed ...................................................................286 Docetaxel and Capecitabine (DC) .............................................................290 Docetaxel and Cisplatin (DP) .................................................................294 Etoposide and Cisplatin (EP) .................................................................302 Gemcitabine and Cisplatin (GC) ...............................................................305 Irinotecan and Carboplatin (IC) ...............................................................309 Irinotecan and Cisplatin (IP). 313 Paclitaxel and Carboplatin (PC or TC). 317 Pemetrexed and Carboplatin (PC) .............................................................320 Vinorelbine and Cisplatin (VC) ................................................................324 7. LEUKEMIAS Acute Lymphocytic (ALL) Hyper-fractionated Cyclophosphamide, Vincristine, Doxorubicin, and Dexamethasone Alternating With Methotrexate and Cytarabine (Hyper-CVAD). .328 Prednisone, Asparaginase, Vincristine, Daunorubicin, Cyclophosphamide, Cytarabine, Thioguanine, Mercaptopurine, and Methotrexate (Hoelzer Regimen) ...........................................332 Prednisone, Vincristine, Daunorubicin, and Asparaginase (PVDA) ......................................337 Acute Myelogenous (AML) Cytarabine and Daunorubicin (7 plus 3) .........................................................340 Cytarabine and Idarubicin (7 + 3) .............................................................342 Fludarabine, Cytarabine, and Filgrastim (FLAG) ...................................................345 High-Dose Cytarabine (HIDAC) ...............................................................348 High-Dose Cytarabine (HIDAC) Plus Daunorubicin .................................................350 Chronic Lymphocytic (CLL) Cyclophosphamide, Fludarabine, and Rituximab (CFR, FCR). 353 Cyclophosphamide, Vincristine, and Prednisone ..................................................356 8. LYMPHOMAS Hodgkin Lymphoma Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide, Vincristine, Procarbazine, and Prednisone (BEACOPP(BASELINE)) ......360 Bleomycin, Etoposide, Doxorubicin, Cyclophosphamide, Vincristine, Procarbazine, and Prednisone (BEACOPP(ESCALATED)). .365 Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine (ABVD) ........................................369 Mechlorethamine, Vincristine, Procarbazine, and Prednisone (MOPP) ..................................373 MOPP/ABVD