JNS-0000116541; No. of Pages 170 ARTICLE IN PRESS Journal of the Neurological Sciences (2019) xxx–xxx Contents lists available at ScienceDirect Journal of the Neurological Sciences journal homepage: www.elsevier.com/locate/jns WCN19 Journal Posters Part 1_V1 WCN19-0018 doi:10.1016/j.jns.2019.10.412 Poster shift 01 - Channelopathies/neuroethics/neurooncology/ pain - Part I/sleep disorders - Part I/stem cells and gene therapy - WCN19-1690 Part I/stroke/training in neurology - Part I and traumatic brain injury Poster shift 01 - Channelopathies/neuroethics/neurooncology/ The paradoxical protective effect of hepatic steatosis on severity pain - Part I/sleep disorders - Part I/stem cells and gene therapy - and functional outcome in patients with first-ever ischaemic Part I/stroke/training in neurology - Part I and traumatic brain stroke or transient ischaemic attack injury M. Baika, S.U. Kimb, H.S. Nama, J.H. Heoa, Y.D. Kima Cerebral distribution of cerebral emboli in patients with patent aYonsei University College of Medicine, Department of Neurology, Seoul, foramen ovale using 99MTC-MAA brain SPECT Republic of Korea b Yonsei University College of Medicine, Department of Internal medi- R. Nematiac, M. Jalalibd, M. Assadibd cine- Yonsei Liver Centre, Seoul, Republic of Korea a2Nuclear Medicine Research Center, Department of Molecular Imaging and Radionuclide Therapy MIRT- Bushehr Medical University Hospital- Background Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran There is very limited information on the relationship between non- bNuclear Medicine Research Center, Department of Molecular Imaging alcoholic fatty liver disease (NAFLD) and the severity or functional and Radionuclide Therapy MIRT- Bushehr Medical University Hospital- outcomes of ischaemic stroke or transient ischaemic stroke (TIA). We Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran investigated the correlation between NAFLD and stroke outcomes. cDepartment of Neurology- Bushehr Medical University Hospital, Faculty of Medicine, Bushehr University of Medical Sciences- Bushehr - Iran, Bushehr, Iran Methods dDepartment of Neurology- Bushehr Medical University Hospital, Faculty of NAFLD was assessed in 321 patients with first-ever acute Medicine, Bushehr University of Medical Sciences- Bushehr - Iran, Bushehr, ischaemic stroke or TIA, who underwent transient elastography from Iran January 2014 to December 2014. The association of liver steatosis with stroke severity, assessed using the National Institute of Health Background Stroke Scale (NIHSS), was investigated using robust regression One of the etiologies of stroke, especially in younger patients, is analysis. We also compared the functional outcome at 90 days patent foramen ovale (PFO). The aim of this study is distribution of according to the presence or burden of liver steatosis. brain emboli in patients with PFO. Results Methods NAFLD was observed in 206 (64.2%) patients. Patients with We injected 99mTc-macroaggragated albumin (MAA) in 51 NAFLD had less severe stroke (median NIHSS score 2 vs. 3, P = patients, while accomplishing valsalva maneuver, then they under- 0.012) and more favourable functional outcome at 90 days (85.3 vs. went brain scintigraphy. 70.5, P = 0.004). Patients with NAFLD were likely to have a 23.3% lower (95% confidence interval [CI], -39.2% to -3.2%, P = 0.026) Results NIHSS score and a 2.5-fold higher (95% CI, 1.08–5.67, P = The most intensity of MAA uptake was respectively in cerebellar, 0.033) possibility of favourable functional outcome in multivariate occipital, frontal and temporoparietal regions. analysis. Discussion Conclusions The study demonstrated that posterior circulation is dominant Our study shows that a higher burden of hepatic steatosis seems region of brain involve by cardiac emboli in subjects with PFO. to be associated with less severe stroke and better functional outcome after ischaemic stroke or TIA. doi:10.1016/j.jns.2019.10.413 0022-510X/$ – see front matter ARTICLE IN PRESS 2 Abstracts / Journal of the Neurological Sciences (2019) xxx–xxx WCN19-0057 Background Twenty until sixty percent of stroke patients experience sleep disorders, with different EEG patterns depending on stroke location. Poster shift 01 - Channelopathies/neuroethics/neurooncology/pain Non-treated sleep disorders can aggravate brain damage. - Part I/sleep disorders - Part I/stem cells and gene therapy - Part I/ stroke/training in neurology - Part I and traumatic brain injury Objective This study was conducted to investigate the correlation of Dyslipidemia in patients hospitalized for stroke at the Clinic of location of lesion and sleep disorders, and its impact on clinical Neuroscience Ibrahima Pierre Ndiaye, Fann National Teaching outcome in ischemic stroke. Hospital in Dakar – Senegal Methods M.L. Mansarea, T. Kamadoreb, F. Maoulyb, D. Amadou Gallob Sixtifive acute ischemic stroke patients were classified based on aDonka National Teaching Hospital, Neurology, Conakry, Guinea the location of stroke lesion and assessed for sleep disturbances by a bNeurosciences Clinic Ibrahima Pierre Ndiaye of Fann Hospital in Dakar, questionnaire. Clinical outcome was assessed by measuring NIHSS Neurology, Dakar, Senegal scores on the first day and the 10th day of treatment. Introduction Results The objective of our study was to study the lipid profile of The number of patients with supratentorial lesion was 57 patients patients hospitalized for stroke (Ischemic or Hemorrhagic) by (87%) and infratentorial lesion was 8 patients (12,3%). The number of identifying among them, those who presented dyslipidemias. patients with sleep disorders was 55 patients (84,6%) and without sleep disorders was 10 patients (15,4%). There was no association between Materials and method location of the lesion and sleep disturbance (p=0,598). The mean NIHSS We conducted a study on the lipidogram results of 609 patients delta among the group with sleep disorders was 0.73 ± 2.670 and hospitalized for stroke. All the variables were included in the model a among normal group was -1.10 ± 2.025. There is a correlation between priori without any selection, with, first, the lipid variables, then sleep disorders and poor clinical outcome (p=0,044). secondarily the age, the sex. Conclusion Results This study supports the influence of sleep disturbances on the The stroke rate was 72% for the ischemic form and 28% for the deterioration of clinical outcome of stroke. hemorrhagic form. It had increased with age regardless of the ischemic or hemorrhagic type. The extreme ages were 17 and 95 years old with doi:10.1016/j.jns.2019.10.415 an average of 62.8 years. Men accounted for 53% of cases and women 47% of cases. The averages and standard deviations of the lipid fractions analyzed were respectively: TC (1.89, 0.55); HDL (0.49, 0.24); LDL (1.24, 0.50) and TG (0.90, 0.41). After controlling for confounders WCN19-0076 by bivariate analysis, the result for pure dyslipidemia showed that HDL was significantly associated with stroke in the foreground [OR 1.77; 95% CI 1.15-2.72; p = 0.002] followed by LDL [OR 2.00; 95% CI 1.04- Poster shift 01 - Channelopathies/neuroethics/neurooncology/ 4.87; p = 0.03]. No significant association could be found between TG, pain - Part I/sleep disorders - Part I/stem cells and gene therapy - TC and stroke. The overall mortality rate was 25% (154 cases). Part I/stroke/training in neurology - Part I and traumatic brain injury Conclusion In this study, the occurrence of fatal stroke was associated with Clinical features of low back pain in an outpatient clinic significant lowering of HDL cholesterol. From our point of view, it is fi important to study this type of lipid pro le well. K. Karbozova Kyrgyz State Medical Academy, Neurology and Clinical Genetics, Keywords: Dyslipidemia, Stroke, Senegal Bishkek, Kyrgyzstan doi:10.1016/j.jns.2019.10.414 Objective To determine the clinical features of low back pain and the conditions associated with this symptom in family medicine center WCN19-0075 in Bishkek, Kyrgyzstan. Methods Poster shift 01 - Channelopathies/neuroethics/neurooncology/pain The study was included medical reports of patients with LBP at - Part I/sleep disorders - Part I/stem cells and gene therapy - Part I/ the age of 18-75 years attending in family medicine center №7in stroke/training in neurology - Part I and traumatic brain injury Bishkek from 2017 to 2018.The examination included a consultation of a neurologist, magnetic resonance imaging (MRI) of the spine, and Correlation of the location of stroke lesion and sleep disorders and blood tests. its effects on clinical outcome in acute ischemic stroke patients Results Z. Afif, E. Arisetijono, S.F. Iswari During the study period 184 (85 men and 99 women) had LBP. fi Universitas Brawijaya/Saiful Anwar General Hospital, Neurology, Ma- Among these patients 11 (5,98%) of them had a speci c cause of back lang, Indonesia pain: 3 - a traumatic spinal injury, 3 - a tumor lesion of the spine, 3 - ARTICLE IN PRESS Abstracts / Journal of the Neurological Sciences (2019) xxx–xxx 3 rheumatoid polyarthritis and tuberculosis were present in 2 patients. WCN19-0082 The remaining 173 (94,02%) patients had a nonspecific cause of back pain associated with degenerative spinal disease and included low back pain -94 (54,33%) , low back pain with nerve root pain Poster shift 01 - Channelopathies/neuroethics/neurooncology/pain suggestive of disk herniation 73 (42,2%), and low back pain with - Part I/sleep disorders - Part I/stem cells and gene therapy - Part I/ nerve root pain and lumbar spinal stenosis -6 (3,47%). When stroke/training in neurology - Part I and traumatic brain injury clarifying the anamnesis, it was revealed that the main initiating factor was inadequate physical activity and emotional stress. Differences in attitudes to ethic aspects of end of life care among patients with progressive neurological diseases and their family Summary members The obtained data once again emphasize the importance of careful collection of anamnesis and a physical examination to R.