Supplementary Table 6 Early-onset Tumor Correlated Genes Entrez Probe Set ID Gene.Symbol Gene Title Gene R2 p serine hydroxymethyl 1425177_at Shmt1 transferase 1 (soluble) 20425 0.633960327 4.76232E-12 S-adenosylhomocysteine 1417125_at Ahcy hydrolase 269378 0.592710209 6.37583E-11 serine hydroxymethyl 1425178_s_at Shmt1 transferase 1 (soluble) 20425 0.585853686 9.56993E-11 ELOVL family member 6, elongation of long chain 1417404_at Elovl6 fatty acids (yeast) 170439 0.580927972 1.27603E-10 serine hydroxymethyl 1425179_at Shmt1 transferase 1 (soluble) 20425 0.576381865 1.65927E-10 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, 1426804_at Smarca4 member 4 20586 0.576190422 1.67762E-10 branched chain aminotransferase 1, 1430111_a_at Bcat1 cytosolic 12035 0.571872005 2.14729E-10 A kinase (PRKA) anchor 1419706_a_at Akap12 protein (gravin) 12 83397 0.569478339 2.45954E-10 DNA segment, Chr 7, ERATO Doi 316, 1446915_at --- expressed --- 0.565290298 3.11355E-10 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, 1426805_at Smarca4 member 4 20586 0.561107982 3.93153E-10 serine hydroxymethyl 1422198_a_at Shmt1 transferase 1 (soluble) 20425 0.560211498 4.13194E-10 ELOVL family member 6, elongation of long chain 1445641_at --- fatty acids (yeast) --- 0.557565123 4.7824E-10 trypsin domain containing 1441856_x_at Tysnd1 1 71767 0.553922978 5.84017E-10 sperm associated antigen 1427498_a_at Spag5 5 54141 0.552028064 6.47593E-10 phosphodiesterase 2A, 1447707_s_at Pde2a cGMP-stimulated 207728 0.550820419 6.91523E-10 branched chain aminotransferase 1, 1450871_a_at --- cytosolic --- 0.544934143 9.49912E-10 leukotriene B4 12- 1417777_at Ltb4dh hydroxydehydrogenase 67103 0.544070792 9.94856E-10 jumonji domain 1455982_at AU020939 containing 4 194952 0.543014627 1.05262E-09 ELOVL family member 6, elongation of long chain 1417403_at Elovl6 fatty acids (yeast) 170439 0.540568298 1.19903E-09 OTU domain, ubiquitin 1417575_at Otub2 aldehyde binding 2 68149 0.537476003 1.41225E-09 1452202_at Pde2a phosphodiesterase 2A, 207728 0.531077953 1.97481E-09 cGMP-stimulated 1452101_at Blmh bleomycin hydrolase 104184 0.529546003 2.13848E-09 1456308_x_at Trim28 tripartite motif protein 28 21849 0.526226057 2.53905E-09 RIKEN cDNA 2610318N02 1429268_at --- gene --- 0.52423078 2.81347E-09 RIKEN cDNA C530043G21 1451668_at C530043G21Rik gene 215015 0.523654077 2.89795E-09 1420454_at Rai1 retinoic acid induced 1 19377 0.523102397 2.98104E-09 cell division cycle 1423683_at Cdca4 associated 4 71963 0.521835856 3.18055E-09 topoisomerase (DNA) II 1458480_at Topbp1 beta binding protein 235559 0.520090055 3.47667E-09 OTU domain, ubiquitin 1417576_a_at Otub2 aldehyde binding 2 68149 0.519521857 3.57864E-09 budding uninhibited by benzimidazoles 1 homolog, beta (S. 1447363_s_at Bub1b cerevisiae) 12236 0.516494311 4.17222E-09 leucine-rich and death 1421397_a_at Lrdd domain containing 57913 0.515803631 4.32032E-09 budding uninhibited by benzimidazoles 1 homolog, beta (S. 1416961_at Bub1b cerevisiae) 12236 0.5154939 4.38836E-09 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate 1415916_a_at Mthfd1 synthase 108156 0.514631311 4.58332E-09 RIKEN cDNA 4833427B12 1452881_at 4833427B12Rik gene 272551 0.505246269 7.31988E-09 RIKEN cDNA 0610009D07 1436681_x_at 0610009D07Rik gene 66055 0.504350929 7.6508E-09 multiple substrate lipid kinase /// similar to multi- substrate lipid kinase /// similar to multi-substrate 1424582_at 2610037M15Rik lipid kinase 69923 0.501545917 8.78315E-09 transformed mouse 3T3 1451053_a_at Mdm1 cell double minute 1 17245 0.500628112 9.18741E-09 coiled-coil domain 1424429_s_at AI225782 containing 95 233875 0.499547382 9.68637E-09 RIKEN cDNA 6230427J02 1452903_at 6230427J02Rik gene 68176 0.49942827 9.74293E-09 1416859_at Fkbp3 FK506 binding protein 3 30795 0.498031873 1.04301E-08 12412 Cbx1 /// chromobox homolog 1 /// 1436266_x_at E430007M08Rik (Drosophila HP1 beta) 319869 0.497927999 1.0483E-08 1421317_x_at Myb myeloblastosis oncogene 17863 0.497137785 1.08943E-08 1426297_at Tcfe2a transcription factor E2a 21423 0.496380823 1.13027E-08 interleukin enhancer 1460669_at Ilf3 binding factor 3 16201 0.495278476 1.1924E-08 sperm associated antigen 1433892_at Spag5 5 54141 0.494523386 1.23683E-08 1427105_at 2610510J17Rik RIKEN cDNA 2610510J17 72155 0.494262414 1.25255E-08 gene 1418036_at Prim2 DNA primase, p58 subunit 19076 0.492877316 1.33926E-08 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate 1415917_at Mthfd1 synthase 108156 0.492219109 1.38247E-08 1452208_at Prdm4 PR domain containing 4 72843 0.492050995 1.39371E-08 RIKEN cDNA C230052I12 1454779_s_at C230052I12Rik gene 101831 0.491875854 1.40552E-08 cell division cycle 2 1448314_at Cdc2a homolog A (S. pombe) 12534 0.491735459 1.41506E-08 1416301_a_at Ebf1 early B-cell factor 1 13591 0.491349723 1.44159E-08 minichromosome maintenance deficient 7 1416030_a_at Mcm7 (S. cerevisiae) 17220 0.489653073 1.56403E-08 1422816_a_at Mutyh mutY homolog (E. coli) 70603 0.489119179 1.60458E-08 timeless interacting 1426612_at Tipin protein 66131 0.488717174 1.63578E-08 RIKEN cDNA 2610040C18 1453067_at 2610040C18Rik gene 69928 0.487050793 1.77145E-08 RIKEN cDNA C530043G21 1451667_at C530043G21Rik gene 215015 0.486092676 1.85428E-08 Nur77 downstream gene 1433720_s_at Ndg2 2 103172 0.484481356 2.00203E-08 DnaJ (Hsp40) related, 1447046_at --- subfamily B, member 13 --- 0.483295599 2.11792E-08 lethal giant larvae 1416621_at Llglh homolog 1 (Drosophila) 16897 0.482819487 2.16624E-08 1439820_at Ebf1 Early B-cell factor 1 13591 0.481646995 2.28981E-08 elongation factor 1 homolog (ELF1, S. 1423820_at 1110011K10Rik cerevisiae) 66126 0.481548627 2.30048E-08 1459348_at Ebf1 Early B-cell factor 1 13591 0.481118392 2.3477E-08 structure specific 1426788_a_at Ssrp1 recognition protein 1 20833 0.481044718 2.35588E-08 1442299_at Mrpl27 --- 94064 0.480719309 2.39234E-08 gem (nuclear organelle) 1436310_at Gemin5 associated protein 5 216766 0.4804075 2.42778E-08 1422547_at Ranbp1 RAN binding protein 1 19385 0.480112483 2.46178E-08 zinc finger, BED domain 1453848_s_at Zbed3 containing 3 72114 0.480059149 2.46798E-08 1422734_a_at Myb myeloblastosis oncogene 17863 0.479986029 2.4765E-08 enhancer of rudimentary 1430536_a_at Erh homolog (Drosophila) 13877 0.479467587 2.5377E-08 small nuclear 1437193_s_at Snrpb ribonucleoprotein B 20638 0.479262686 2.56229E-08 eukaryotic translation initiation factor 4E binding 1436158_at Eif4ebp2 protein 2 13688 0.478950388 2.60021E-08 1427764_a_at Tcfe2a transcription factor E2a 21423 0.478578886 2.64602E-08 expressed sequence 1458374_at C79407 C79407 217653 0.478079244 2.70885E-08 DNA segment, Chr 10, 1416850_s_at D10Ertd214e ERATO Doi 214, 52637 0.478032519 2.7148E-08 expressed Fanconi anemia, 1447935_at C730036B14Rik complementation group M 104806 0.477732991 2.75324E-08 1450194_a_at Myb myeloblastosis oncogene 17863 0.475722504 3.02508E-08 RIKEN cDNA 0610009D07 1417054_a_at 0610009D07Rik gene 66055 0.475454639 3.06319E-08 RIKEN cDNA 1810009N02 1429730_at 1810009N02Rik gene 69099 0.475318016 3.0828E-08 Tnf receptor-associated factor 5 /// similar to TNF receptor-associated factor 1448861_at Traf5 5 22033 0.475172567 3.10382E-08 RIKEN cDNA 2010317E24 1429405_at 2010317E24Rik gene 72080 0.475018737 3.12619E-08 1443325_at --- Transcribed locus --- 0.47500671 3.12795E-08 sperm associated antigen 1433893_s_at Spag5 5 54141 0.473606693 3.33895E-08 1416302_at Ebf1 early B-cell factor 1 13591 0.473237278 3.39687E-08 RIKEN cDNA 4833427B12 1428713_s_at 4833427B12Rik gene 272551 0.472732676 3.47754E-08 1452566_at --- --- --- 0.47248253 3.51821E-08 glutamate-cysteine ligase, 1424296_at Gclc catalytic subunit 14629 0.471979602 3.60137E-08 splicing factor, arginine/serine-rich 2 1415807_s_at Sfrs2 (SC-35) 20382 0.47194415 3.6073E-08 expressed sequence 1434767_at C79407 C79407 217653 0.471146457 3.74331E-08 synaptojanin 2 binding 1417834_at Synj2bp protein 24071 0.470670162 3.82685E-08 Nur77 downstream gene 1436990_s_at Ndg2 2 103172 0.470085569 3.93183E-08 high mobility group AT- 1416184_s_at Hmga1 hook 1 15361 0.468240262 4.2817E-08 SMT3 suppressor of mif 1415782_at Sumo2 two 3 homolog 2 (yeast) 170930 0.468128288 4.30386E-08 RNA binding motif protein, 1416177_at Rbmxrt X chromosome retrogene 19656 0.468024498 4.32451E-08 RIKEN cDNA 2810429O05 1418542_s_at 2810429O05Rik gene 52504 0.467747768 4.38002E-08 thymoma viral proto- 1422078_at Akt3 oncogene 3 23797 0.467707982 4.38805E-08 1448787_at Moap1 modulator of apoptosis 1 64113 0.466635452 4.61012E-08 chromobox homolog 2 1422059_at Cbx2 (Drosophila Pc class) 12416 0.466335982 4.67403E-08 Bromodomain containing 1446644_at --- 3 --- 0.465806707 4.78907E-08 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, 1448401_at Smarcd2 member 2 83796 0.465506135 4.85561E-08 RIKEN cDNA 9630023C09 1441977_at 9630023C09Rik gene 320378 0.464422041 5.10305E-08 mediator of RNA polymerase II transcription, subunit 9 1419377_at BC019367 homolog (yeast) 192191 0.464044583 5.19201E-08 pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 1417288_at Plekha2 2 83436 0.463877974 5.23175E-08 RIKEN cDNA 4122402O22 1453182_a_at 4122402O22Rik gene 77626 0.463439529 5.33774E-08 ubiquitin-like, containing PHD and RING finger 1439227_at --- domains, 1 --- 0.463166202 5.40485E-08 RIKEN cDNA 2410005H09 1424490_at 2410005H09Rik