Contents Gray..................................................................................... Section: Introduction and Diagnosis 1 Introduction to Skin Biology ̈ 1 2 Dermatologic Diagnosis ̈ 16 3 Other Diagnostic Methods ̈ 39 .....................................................................................Blue Section: Dermatologic Diseases 4 Viral Diseases ̈ 53 5 Bacterial Diseases ̈ 73 6 Fungal Diseases ̈ 106 7 Other Infectious Diseases ̈ 122 8 Sexually Transmitted Diseases ̈ 134 9 HIV Infection and AIDS ̈ 155 10 Allergic Diseases ̈ 166 11 Drug Reactions ̈ 179 12 Dermatitis ̈ 190 13 Collagen–Vascular Disorders ̈ 203 14 Autoimmune Bullous Diseases ̈ 229 15 Purpura and Vasculitis ̈ 245 16 Papulosquamous Disorders ̈ 262 17 Granulomatous and Necrobiotic Disorders ̈ 290 18 Dermatoses Caused by Physical and Chemical Agents ̈ 295 19 Metabolic Diseases ̈ 310 20 Pruritus and Prurigo ̈ 328 21 Genodermatoses ̈ 332 22 Disorders of Pigmentation ̈ 371 23 Melanocytic Tumors ̈ 384 24 Cysts and Epidermal Tumors ̈ 407 25 Adnexal Tumors ̈ 424 26 Soft Tissue Tumors ̈ 438 27 Other Cutaneous Tumors ̈ 465 28 Cutaneous Lymphomas and Leukemia ̈ 471 29 Paraneoplastic Disorders ̈ 485 30 Diseases of the Lips and Oral Mucosa ̈ 489 31 Diseases of the Hairs and Scalp ̈ 495 32 Diseases of the Nails ̈ 518 33 Disorders of Sweat Glands ̈ 528 34 Diseases of Sebaceous Glands ̈ 530 35 Diseases of Subcutaneous Fat ̈ 538 36 Anogenital Diseases ̈ 543 37 Phlebology ̈ 552 38 Occupational Dermatoses ̈ 565 39 Skin Diseases in Different Age Groups ̈ 569 40 Psychodermatology ̈ 579 .....................................................................................Red Section: Therapy 41 Topical Therapy ̈ 583 42 Systemic Therapy ̈ 615 43 Radiation Therapy ̈ 644 44 Therapy During Pregnancy and Nursing ̈ 647 45 Operative Dermatology ̈ 651 46 Wound Healing ̈ 671 47 Dermatologic Emergencies ̈ 673 .....................................................................................Purple Section Appendix I Common Systemic Medications ̈ 681 Appendix II Favorite Compounding Recipes ̈ 689 Green..................................................................................... Section Appendix III Dermatologic Differential Diagnosis ̈ 702 Sterry, Dermatology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license. Sterry, Dermatology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license. Checklisten der aktuellen Medizin ............................................... Begründet von F. Largiadèr, A. Sturm, O. Wicki This edition has been supported by Sterry, Dermatology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license. Thieme Clinical Companions ...............................................Dermatology Wolfram Sterry, M.D. Professor and Chairman Department of Dermatology, Venereology, and Allergy Charité University Hospital Berlin, Germany Ralf Paus, M.D. Professor Department of Dermatology and Venereology University Hospital Schleswig-Holstein Luebeck, Germany Walter Burgdorf, M.D. Clinical Lecturer Department of Dermatology Ludwig Maximilian University Munich, Germany With contributions by Heike Audring, Ulrike Blume-Peytavi, Guido Bruning, Peter von den Driesch, Jorge Frank, Markus Friedrich, Christoph Garcia-Bartels, Sylke Gellrich, Ina Hadshiew, Michael Hertl, Wolfgang Kimmig, Stefan Peker, Andreas Plettenberg, Bertold Rzany, Peter Schulze, Wolfgang Schulze, Ute Siemann-Harms, Hans Sperl, Eggert Stockfleth, Hans-Juergen Tietz, Class Ulrich, Christiane Voit, Gerd Wolf, Margitta Worm, Torsten Zuberbier 345 illustrations Georg Thieme Verlag Stuttgart · New York Sterry, Dermatology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license. Library of Congress Cataloging-in-Publication Data Sterry Wolfram. [Checkliste Dermatologie. English] Dermatology / Wolfram Sterry, Ralf Paus, Walter Burgdorf ; with contributions by Heike Audring ... [et al.]. p. ; cm. -- (Thieme clinical companions) ISBN 1-58890-258-7 (alk. paper) -- ISBN 3-13-135911-0 (alk. paper) 1. Dermatology--Handbooks, manuals, etc. 2. Skin--Diseases--Handbooks, manuals, etc. [DNLM: 1. Skin Diseases--therapy--Handbooks. 2. Dermatology--Handbooks. 3. Sexually Transmitted Disease--therapy--Handbooks. 4. Skin Neoplasms--Handbooks. WR 39 S838c 2006a] I. Paus, Ralf. II. Burgdorf, Walter H. C. III. Title. IV. Series. RL74.S81513 2006 616.5--dc22 2006000851 1st German edition 1987 4th German edition 2000 2nd German edition 1992 5th German edition 2005 3rd German edition 1999 Illustrator: Helmut Holtermann, Dannenberg, Germany Important note: Medicine is an ever-changing science undergoing continual development. Research and clinical experience are continually expanding our knowledge, in particular our knowledge of proper treatment and drug therapy. Insofar as this book mentions any dosage or application, readers may rest assured that the authors, editors, and publishers have made every effort to ensure that such references are in accordance with the state of knowledge at the time of production of the book. Nevertheless, this does not involve, imply, or express any guarantee or responsibility on the part of the publishers in respect to any dosage instructions and forms of applications stated in the book. Every user is requested to examine carefully the manufacturers leaflets accompanying each drug and to check, if necessary in consultation with a physician or specialist, whether the dosage schedules mentioned therein or the contraindications stated by the manufacturers differ from the statements made in the present book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Every dosage schedule or every form of application used is entirely at the users own risk and responsibility. The authors and publishers request every user to report to the publishers any discrepancies or inaccuracies noticed. If errors in this work are found after publication, errata will be posted at www.thieme.com on the product description page. Some of the product names, patents, and registered designs referred to in this book are in fact registered trademarks or proprietary names even though specific reference to this fact is not always made in the text. Therefore, the appearance of a name without designation as proprietary is not to be construed as a representation by the publisher that it is in the public domain. This book, including all parts thereof, is legally protected by copyright. Any use, exploitation, or com- mercialization outside the narrow limits set by copyright legislation, without the publishers consent, is illegal and liable to prosecution. This applies in particular to photostat reproduction, copying, mimeo- graphing, preparation of microfilms, and electronic data processing and storage. ᭧ 2006 Georg Thieme Verlag KG, Rüdigerstraße 14, D-70469 Stuttgart Germany http://www.thieme.de Thieme New York, 333 Seventh Avenue, New York, NY 10001, USA http://www.thieme.com Typesetting by Götz, Ludwigsburg Printed in Germany by Götz, Ludwigsburg 10-ISBN: 3-13-135911-0 (GTV) 13-ISBN: 978-3-13-135911-7 (GTV) 10-ISBN: 1-58890-258-7 (TNY) 13-ISBN: 978-1-58890-258-0 (TNY) 1 2 3 4 5 6 Sterry, Dermatology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license. Preface . Preface We are happy to present you with our new book Dermatology in the Thieme Clinical Preface Companions series. A similar text has appeared in five German editions since 1987 and been highly successful. The goal of this book is to present everything one needs to diagnose and treat most cutaneous diseases in a compact, “one-stop” resource, care- fully edited by three experienced dermatologists. The therapeutic options represent best practice internationally and reflect the diversified experience of three dermato- logists, one of whom trained and worked in the USA for 20 years. The contents have been extensively reviewed with the help of a number of colleagues listed on the title page. Some of them have provided additional input for the English version, including Drs. Peter von den Driesch, Bertold Rzany, Christiane Voit, and Margitta Worm. In addition, Dr. Maja Hoffmann helped with the differential diagnos- tic considerations in the last chapter. We would especially like to thank Dr. Gerd Wolf, who provided constructive criticism and detailed information on topical therapy. Mr. Stephan Konnry at Thieme International guided the writing and production of this text. He was helped by Dr. Cliff Bergman and Dr. Christiane Brill-Schmid. We thank all three individuals for their cooperative spirit and valuable input. We hope that you will enjoy reading this Clinical Companion as an introduction to dermatology and, moreover, that you find it helpful, if not indispensable, in your clinical training and practice. We are eager to hear from you, with complaints, con- structive suggestions, or even praise. Wolfram Sterry, M.D. Ralf Paus, M.D. Walter Burgdorf, M.D. V . Sterry, Dermatology © 2006 Thieme All rights reserved. Usage subject to terms and conditions of license. Contributors Contributors Heike Audring, M.D. Michael Hertl, M.D. Prof. Ulrike Blume-Peytavi, M.D. Professor and Chairman Markus Friedrich, M.D. Department of Dermatology and Contributors Christoph Garcia-Bartels, M.D. Allergy Sylke Gellrich, M.D. Phillips University Prof. Bertold Rzany, M.D. Marburg, Germany Peter Schulze, M.D. Stefan Peker, M.D. Hans Sperl, M.D. Private Dermatology Practice Prof.