JANUARY 2018 # 60 Upfront In My View Feature Business Monitoring big cat diets Catching the next wave Tracking down counterfeit PolyLC’s Andrew Alpert – by a whisker in IMS drugs with Minilab shares his lessons learned 13 18 34 – 43 44 – 48 Landmark Literature Ten experts select and reflect on standout papers that advanced analytical science in 2017. 22 – 33 www.theanalyticalscientist.com NORTH AMERICA SPP speed. USLC® resolution. A new species of column. • Drastically faster analysis times. • Substantially improved resolution. • Increased sample throughput with existing instrumentation. • Dependable reproducibility. Choose Raptor™ SPP LC columns for all of your valued assays to experience Selectivity Accelerated. www.restek.com/raptor www.restek.com/raptor Pure Chromatography Image of the Month Core Values Researchers at Scripps Institution of Oceanography have developed a new way to measure the average temperature of the world’s oceans over geological time. The scientists used a dual-inlet isotope ratio mass spectrometer to measure noble gases trapped in Antarctic ice caps, and showed that mean global ocean temperature increased by 2.57 ± 0.24 degrees Celsius over the last glacial transition (20,000 to 10,000 years ago). Seen here is an ice core from West Antarctica, drilled in 2012. Credit: Jay Johnson/IDDO. Reference: B Bereiter et al., “Mean global ocean temperatures during the last glacial transition”, Nature, 553, 39–44 (2018). Would you like your photo featured in Image of the Month? Send it to [email protected] www.theanalyticalscientist.com ISSUE 60 - JANUARY 2018 Editor - Charlotte Barker Contents [email protected] Deputy Editor - Joanna Cummings [email protected] Scientific Director - Frank van Geel [email protected] Content Director - Rich Whitworth [email protected] Editorial Director - Fedra Pavlou [email protected] Publishing Director - Lee Noyes [email protected] Business Development Manager - Sam Blacklock [email protected] Business Development Executive, Americas - Simone Virani [email protected] Head of Design - Marc Bird [email protected] Designer - Hannah Ennis [email protected] Digital Team Lead - David Roberts [email protected] Digital Producer Web/Email - Peter Bartley [email protected] Digital Producer Web/App - Abygail Bradley [email protected] Audience Insight Manager - Tracey Nicholls [email protected] Traffic & Audience Database Coordinator - Hayley Atiz [email protected] Traffic and Audience Associate - Lindsey Vickers [email protected] Traffic Manager - Jody Fryett [email protected] Social Media / Analytics Associate - Ben Holah [email protected] Events Manager - Alice Daniels-Wright [email protected] Marketing Manager - Katy Pearson [email protected] Financial Controller - Phil Dale [email protected] Accounts Assistant - Kerri Benson [email protected] Chief Executive Officer - Andy Davies [email protected] Chief Operating Officer - Tracey Peers [email protected] Editorial Advisory Board Monika Dittmann, Agilent Technologies, Germany Norman Dovichi, University of Notre Dame, USA Gary Hieftje, Indiana University, USA 14 Emily Hilder, University of South Australia, Australia Ron Heeren, Maastricht University, The Netherlands Tuulia Hyötyläinen, University of Örero, Finland Hans-Gerd Janssen, Unilever Research and Development, The Netherlands Robert Kennedy, University of Michigan, USA Samuel Kounaves, Tufts University, USA Marcus Macht, SCIEX, Germany Luigi Mondello, University of Messina, Italy Peter Schoenmakers, University of Amsterdam, The Netherlands Robert Shellie, Trajan Scientific and Medical, Australia Ben Smith, University of Florida, USA Frantisec Svec, University of California at Berkeley, USA 03 Image of the Month Upfront Ian Wilson, Imperial College London, UK Frank Bright, University at Buffalo, USA Chris Harrison, San Diego State University, USA 10 Sniffing Out a Test Change of address [email protected] 09 Editorial for Parkinson’s Hayley Atiz, The Analytical Scientist, Texere Publishing Ltd, Haig House, Haig Reflections and Resolutions, Road, Knutsford, Cheshire, WA16 8DX, UK by Charlotte Barker 11 Resisting Arrest General enquiries www.texerepublishing.com | [email protected] +44 (0) 1565 745 200 | [email protected] 12 Good Vibrations Distribution: The Analytical Scientist (ISSN 2051-4077), and The Analytical Scientist North America (ISSN 2514-7544), is published monthly by Texere Publishing On The Cover 13 Feline Forensics Ltd and is distributed in the US by UKP Worldwide, 3390 JANUARY 2018 # 60 Rand Road, South Plainfield, NJ 07080 Periodicals postage paid at South Plainfield, NJ Upfront In My View Feature Business Landmarks from New York to POSTMASTER: Send US address changes to Tracking big cat diets Catching the next wave Catching counterfeit drugs Andrew Alpert shares his 14 Mum’s the Word – by a whisker in IMS with MiniLab lessons learned 12 – 13 16 – 17 34 – 43 44 – 48 Landmark The Analytical Scientist C/O 3390 Rand Road, Literature Ten experts pick their top Wuhan feature in our round-up papers from the past year. 22 – 33 South Plainfield NJ 07080. Single copy sales £15 (plus postage, cost available on request of the top papers of 2017. 15 Cerebral Spectroscopy and [email protected]) Annual subscription for non-qualified recipients£110 Centers of Distinction www.theanalyticalscientist.com Reprints & Permissions – [email protected] The opinions presented within this publication are those of the authors and do not reflect the opinions of The Analytical Scientist or its publishers, Texere Publishing. Authors are required to disclose any relevant financial arrangements, which are presented at the end of each article, where relevant. © 2017 Texere Publishing Limited. All rights reserved. the Reproduction in whole or in parts is prohibited. 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Discover the Flavour/Fragrance TOF MS/FTIR Library: a comprehensive database of about 1500 compounds dedicated to the avour and fragrance eld. Improve the reliability of identi cation with this unique library with embedded Linear Retention Indices (LRI). Exploit CromatoPlus Spectra, a suitable postrun software for simultaneous spectral and LRI information lter to obtain an univocal peak assignment for the target compound. DANI Instruments Chromaleont www.dani-instruments.com www.chromaleont.it [email protected] [email protected] The Ultimate Flavor & Fragrance Characterization Solution: 34 GC-MS[TOF] / condensed phase FTIR with an extensive Flavor & Fragrance Library Combine the enhanced separation with a simple post-column split to high quality TOF mass spectrometry and condensed phase FTIR . Enhance the FTIR spectral matching through the speci city of the functional group and “ ngerprinting” regions thanks to the increased sensitivity and spectral resolution to ATR & KBr pellet transmission with condensed phase vs vapor phase. Discover the Flavour/Fragrance TOF MS/FTIR Library: a comprehensive database of about 1500 compounds dedicated to the avour and fragrance eld. Improve the reliability of identi cation with this unique library with embedded Linear Retention Indices (LRI). In My View Features 16 Janusz Pawliszyn previews 22 Landmark Literature Exploit CromatoPlus Spectra, a suitable postrun the sampling and sample Ten experts pick their top 50 software for simultaneous spectral and LRI preparation highlights of papers from the past year. 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