DUKE UNIVERSITY MEDICAL CENTER CURRICULUM VITAE Permanent Record and the Appointments and Promotions Committee Date Prepared: 04/28/2017 Name: Michael Lucas James, MD Primary academic appointment: Associate Professor Primary academic department: Anesthesiology Secondary appointment: Neurology Present academic rank and title: Associate Professor without Tenure, Track 1 Date and rank of first Duke Faculty appointment: 07/01/2006, Assistant Professor Medical Licensure: North Carolina License #200001390 Date of License: 09/26/2000 Specialty certifications and dates American Board of Psychiatry & Neurology 05/12/2004 Recertification 2014 Subspecialty Vascular Neurology 04/16/2009 American Board of Anesthesiology 05/25/2007 United Council of Neurological Subspecialties Neurocritical Care 12/31/2008 Date of birth: 09/26/1973 Place: Baton Rouge, LA USA Citizen of: United States of America Education: Institution Date (Year) Degree High School LSU Laboratory School 1991 College Vanderbilt University 1995 BS Professional LSU School of Medicine in New Orleans 1999 MD Scholarly societies: Psi Chi Professional training and academic career: Training: Position/Title Dates Duke University Medical Center Medical Intern 07/1999 – 06/2000 Neurology Resident 07/2000 – 06/2002 Neurology Chief Resident 07/2002 – 06/2003 Anesthesiology Resident 07/2003 – 06/2006 Neurocritical Care Fellow 07/2005 – 06/2006 Professional appointments: Assistant Professor Departments of Anesthesiology & Neurology Duke University 07/2006 – 10/2014 Associate Director Multidisciplinary Neuroprotection Laboratories, Department of Anesthesiology, Duke University 07/2010 – 06/2015 Associate Director Brain Injury Translational Research Center, Department of Neurology, Duke University 07/2009 – present Associate Professor Departments of Anesthesiology & Neurology Duke University 10/2014 – present Program Director Neuroanesthesiology Fellowship, Department of Anesthesiology Duke University 01/2015 – present Associate Director Clinical Endeavors in Anesthesia Research, Department of Anesthesiology Duke University 07/2015 – present Liaison Clinical Research, Duke-NUS Affairs Duke University 07/2016 – present Associate Professor Department of Clinical Science Duke-NUS Graduate Medical School 10/2016 – present Publications: Refereed journals: 1. James ML, Panni MK. Extremely prolonged unilateral block (20 hours) with spinal ropivacaine used for cervical cerclage placement. Anesth Analg. 2005 Mar;100(3):897-8. PMID: 15728090 2. James ML, Husain AM. Brainstem auditory evoked potential monitoring: when is change in wave V significant? Neurology. 2005 Nov 22;65(10):1551-5. PMID: 16301480 3. Bennett SS, Graffagnino C, Borel CO, James ML. Use of high frequency oscillatory ventilation (HFOV) in neurocritical care patients. Neurocrit Care. 2007;7(3):221-6. PMID: 17805492 4. James ML, Warner DS, Laskowitz DT. Preclinical models of intracerebral hemorrhage: a translational perspective. Neurocrit Care. 2008;9(1):139-52. PMID: 18058257 5. James ML, Sullivan PM, Lascola CD, Vitek MP, Laskowitz DT. Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. Stroke. 2009 Feb;40(2):632-9. PMID: 19109539 6. James ML, Blessing R, Bennett E, Laskowitz DT. Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans. J Stroke Cerebrovasc Dis. 2009 Mar-Apr;18(2):144-9. PMID: 19251191 7. James ML, Blessing R, Phillips-Bute BG, Bennett E, Laskowitz DT. S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage. Biomarkers. 2009 Sep;14(6):388-94. PMID: 19505208 8. James ML, Wang H, Venkatraman T, Song P, Lascola CD, Laskowitz DT. Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. J Neurotrauma. 2010 Jan;27(1):217-28. PMID: 19803787 9. Kim GS, Amato A, James ML, Britz GW, Zomorodi A, Graffagnino C, Zomorodi M, Olson DM. Continuous and intermittent CSF diversion after subarachnoid hemorrhage: a pilot study. Neurocrit Care. 2011 Feb;14(1):68-72. PMID: 20596794 10. James ML, Keifer JC. Posterior optic nerve ischemic neuropathy in the setting of phenoxybenzamine therapy after uneventful spinal fusion. J Neurosurg Anesthesiol. 2011 Apr;23(2):169-70. PMID: 21270647 11. James ML, Olson DM. Brainstem dysfunction as a predictor of death in the nonneurologically injured. Crit Care Med. 2011 Aug;39(8):2012-3. PMID: 21768813 12. Amato A, Britz GW, James ML, Graffagnino C, Zomorodi AR, Zomorodi ME, Olson DM. An observational pilot study of CSF diversion in subarachnoid haemorrhage. Nurs Crit Care. 2011 Sep- Oct;16(5):252-60. PMID: 21824230 13. Laskowitz DT, Lei B, Dawson HN, Wang H, Bellows ST, Christensen DJ, Vitek MP, James ML. The apoE-mimetic Peptide, COG1410, Improves Functional Recovery in a Murine Model of Intracerebral Hemorrhage. Neurocrit Care. 2011 Oct 12. PMID: 21989844 14. Indraswari F, Wang H, Lei B, James ML, Kernagis D, Warner DS, Dawson HN, Laskowitz DT. Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: A translational approach. J Neurotrauma. 2012 Jan 10. PMID: 22233347 15. James ML, Wang H, Cantillana V, Lei B, Kernagis DN, Dawson HN, Klaman LD, Laskowitz DT. TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. Anesthesiology. 2012 Jun;116(6):1299-311. PMID: 22487803 16. Macy GE, James ML. Guilty by association?*. Crit Care Med. 2012 Jul;40(7):2230-1. PMID: 22710208. 17. Sun W, Peacock A, Becker J, Phillips-bute BG, Laskowitz DT, James ML. Correlation of leukocytosis with neurological deterioration following supratentorial intracerebral hemorrhage. J Clin Neurosci. 2012 Aug;19(8):1096-100. Epub 2012 Jun 16. PMID: 22704946 18. Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS. Xenon Neuroprotection in Experimental Stroke: Interactions with Hypothermia and Intracerebral Hemorrhage. Anesthesiology. 2012 Nov 7. PMID: 23143806 19. James ML, Olson DM, Graffagnino C. A pilot study of cerebral and haemodynamic physiological changes during sedation with dexmedetomidine or propofol in patients with acute brain injury. Anaesth Intensive Care. 2012 Nov;40(6):949-57. Anesthesia & Intensive Care. 2012 Nov; 40(6). PMID: 23194203 20. Wang H, Anderson LG, Lascola CD, James ML, Venkatraman TN, Bennett ER, Acheson SK, Vitek MP, Laskowitz DT. ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Exp Neurol. 2013 Mar;241:67-74. Epub 2012 Dec 6. PMID: 23219883 21. Olson DM, Grissom JL, Williamson RA, Bennett SN, Bellows ST, James ML. Interrater Reliability of the Bedside Shivering Assessment Scale. Am J Crit Care. 2013 Jan;22(1):70-4. PMID: 23283091 22. James ML, Grau-Sepulveda MV, Olson DM, Smith EE, Hernandez AF, Peterson ED, Schwamm LH, Bhatt DL, Fonarow GC. Insurance Status and Outcome after Intracerebral Hemorrhage: Findings from Get with The Guidelines-Stroke. J Stroke Cerebrovasc Dis. 2013 Mar 26. PMID: 23537567 23. James ML, Andersen ND, Swaminathan M, Phillips-Bute B, Hanna JM, Smigla GR, Barfield ME, Bhattacharya SD, Williams JB, Gaca JG, Husain AM, Hughes GC. Predictors of electrocerebral inactivity with deep hypothermia. J Thorac Cardiovasc Surg. 2013 Apr 11. PMID: 23582829 24. Ouyang M, McDonagh DL, Phillips-Bute B, James ML, Friedman AH, Gan TJ. Comparison of Postoperative Nausea between Benign and Malignant Brain Tumor Patients undergoing Awake Craniotomy: A Retrospective Analysis. Curr Med Res Opin. 2013 Jun 4. [Epub ahead of print] PMID: 23731201 25. Ouyang M, McDonagh DL, Phillips-Bute B, James ML, Friedman AH, Gan TJ. Does Midline Shift Predict Postoperative Nausea in Brain Tumor Patients Undergoing Awake Craniotomy? A Retrospective Analysis. Curr Med Res Opin. 2013 Jun 4. [Epub ahead of print] PMID: 23731200 26. James ML, Dority J, Gray MC, Bellows ST, McDonagh DL, Brambrink AM. Survey of Anesthesiologists Practicing in American Neurointensive Care Units as Neurointensivists. J Neurosurg Anesth. 2013 Jul 24. PMID: 23887679 27. Khan S, Adogwa O, Gan TJ, Null UT, Verla T, Gokhale S, White WD, Britz GW, Zomorodi AR, James ML, McDonagh DL. Efffect of 6% hydroxyethylStarch 130/0.4 in 0.9% sodium chloride (Voluven®) on complications after subarachnoid hemorrhage: a retrospective analysis. SpringerPlus. 2013 Jul 15;2(1):314. PMID: 23888282 28. Lei B, Dawson HN, Roulhac-Wilson B, Wang H, Laskowitz DT, James ML. Tumor necrosis factor alpha antagonism improves neurobehavioral recovery in murine intracerebral hemorrhage. J Neuroinflammation. 2013 Aug 20;10(1):103. PMID: 23962089 29. Sun W, Pan W, Kranz PG, Hailey CE, Williamson RA, Sun W, Laskowitz DT, James ML. Predictors of late neurological deterioration after spontaneous intracerebral hemorrhage. Neurocrit Care. 2013 Aug 24. PMID: 2397979 30. Woo D, Rosand J, Kidwell C, McCauley JL, Osborne J, Brown MW, West SE, Rademacher EW, Waddy S, Roberts JN, Koch S, Gonzales NR, Sung G, Kittner SJ, Birnbaum L, Frankel M, Testai FD, Hall CE, Elkind MSV, Flaherty M, Coull B, Chong JY, Warwick T, Malkoff M, James ML, Ali LK, Worrall BB, Jones F, Watson T, Leonard A, Martinez R, Sacco RI, Langefeld CD. The Ethnic Variations of Intracerebral Hemorrhage (ERICH) Study protocol. Stroke. 2013 Sep 10. PMIID: 24021679 31. Olson DM, Zomorodi MG, James ML, Cox CE, Moretti EW, Riemen KE, Graffagnino C. Exploring the impact of augmenting sedation assessment with physiologic monitors. Aust Crit Care. 2013 Oct 5.