Stanford Health Issue Date: 05/2017 Stanford Antimicrobial Safety and Sustainability Program Severe Sepsis and Septic Shock Antibiotic Guide Table 1: Antibiotic selection options for healthcare associated and/or immunocompromised patients • Healthcare associated: intravenous therapy, wound care, or intravenous chemotherapy within the prior 30 days, residence in a nursing home or other long-term care facility, hospitalization in an acute care hospital for two or more days within the prior 90 days, attendance at a hospital or hemodialysis clinic within the prior 30 days • Immunocompromised: Receiving chemotherapy, known systemic cancer not in remission, ANC <500, severe cell-mediated immune deficiency Table 2: Antibiotic selection options for community acquired, immunocompetent patients Table 3: Antibiotic selection options for patients with simple sepsis, community acquired, immunocompetent patients requiring hospitalization. Risk Factors for Select Organisms P. aeruginosa MRSA Invasive Candidiasis VRE (and other resistant GNR) Community acquired: • Known colonization with MDROs • Central venous catheter • Liver transplant • Prior IV antibiotics within 90 day • Recent MRSA infection • Broad-spectrum antibiotics • Known colonization • Known colonization with MDROs • Known MRSA colonization • + 1 of the following risk factors: • Prolonged broad antibacterial • Skin & Skin Structure and/or IV access site: ♦ Parenteral nutrition therapy Hospital acquired: ♦ Purulence ♦ Dialysis • Prolonged profound • Prior IV antibiotics within 90 days ♦ Abscess ♦ Recent abdominal surgery immunosuppression • 5 or more days of hospitalization prior to onset • Pneumonia ♦ Necrotizing Pancreatitis • Acute renal replacement therapy prior to onset ♦ Severe, rapidly progressive necrotizing ♦ Systemic steroids or other • Septic shock pneumonia immunosuppressive agents • Known colonization with MDROs ♦ Note: absence of nasal colonization is strong evidence against MRSA pneumonia Antibiotic Allergies Penicillin allergy (life-threatening): • Substitute with aztreonam (except those with a history of type I hypersensitivity reaction to CEFTAZIDIME) • If there is a history of type I immediate hypersensitivity (e.g., urticaria, angioedema, anaphylaxis, bronchospasm), substitute aztreonam for piperacillin/tazobactam, meropenem, or cefepime (unless the reaction was to ceftazidime). For a history of other serious reactions (Type II, III, or IV – e.g., hemolytic anemia, thrombocytopenia, serum sickness, erythema multiforme, SJS/TEN, DRESS, etc), avoid the specifically implicated drug, but others in the class may be used, except for cephalosporins with same R group side chains. If a beta-lactam agent is preferred, may consider consulting Allergy & Immunology for consideration of graded challenge, de-sensitization, or to rule out possible drug allergies when the patient is clinically stable. Fluoroquinolone allergy: • If there is a history of an immediate reaction to one fluoroquinolone, avoid use of any of the class. Vancomycin allergy: • Avoid if there is a history of bullous reaction, or of associated thrombocytopenia. If there is a history of possible immediate reaction or macular skin reactions, carefully assess the history. If the reaction involved flushing, pruritus, or urticaria, then, premedicate with an antihistamine (diphenhydramine or hydroxyzine) and acetaminophen, hold/reduce opiates (if possible), and infuse at ½ or 1/3 rate over 2-3 hours. Stanford Health Issue Date: 05/2017 Stanford Antimicrobial Safety and Sustainability Program Table 1: Antibiotic selection options for healthcare associated and/or immunocompromised patients with severe sepsis/septic shock Severe Sepsis or Septic Shock Antibacterial A Antibacterial B +/- +/- (Healthcare associated OR (Select one of the following) (Select one of the following) Antibacterial C Antifungal Immunocompromised) (Select one of the following) Undifferentiated or Vascular • Piperacillin-tazobactam 4.5g IV • Vancomycin Loading Dose + Tobramycin 7mg/kg IV Q24H - if Caspofungin 70mg IV Access Device Infection Q8H extended infusion vancomycin 15mg/kg at risk of P. aeruginosa infection ONCE + caspofungin 50 • Cefepime 2g IV Q8H extended • Linezolid 600mg IV q12h - if at risk mg IV Q24H infusion of VRE infection - if at risk of invasive • Meropenem 1g IV Q8H candidiasis extended infusion – if at risk for ESBL infection • Aztreonam 2g IV q8h Pneumonia • Piperacillin-tazobactam 4.5g IV • Vancomycin Loading Dose + Q8H extended infusion vancomycin 15mg/kg • Meropenem 1g IV Q8H • Linezolid 600mg IV Q12H extended infusion – if at risk for ESBL infection PLUS • Cefepime 2g IV Q8H extended infusion • Levofloxacin 750mg IV Q24H • Aztreonam 2g IV q8h • If fluoroquinolone allergy: Azithromycin 500mg IV Q24H plus Tobramycin 7mg/kg IV Q24H - if at risk of P. aeruginosa infection Urinary Tract Infection • Piperacillin-tazobactam 4.5g IV • Vancomycin Loading Dose + +/- Tobramycin 5mg/kg IV Q8H extended infusion vancomycin 15mg/kg Q24H - if at risk of P. aeruginosa • Meropenem 1g IV Q8H • Linezolid 600mg IV Q12H - if at risk infection extended infusion – if at risk for of VRE infection ESBL infection • Aztreonam 2g IV q8h Intra-Abdominal Infection • Piperacillin-tazobactam 4.5g IV • Vancomycin Loading Dose + Caspofungin 70mg IV Q8H extended infusion vancomycin 15mg/kg ONCE + caspofungin 50 • Meropenem 1g IV Q8H • Linezolid 600mg IV q12h - if at risk mg IV Q24H extended infusion – if at risk for of VRE infection5 - if at risk of invasive ESBL infection candidiasis • Cefepime 2g IV Q8H extended infusion plus Metronidazole 500mg IV Q8H • Aztreonam 2g iv q8h plus Metronidazole 500mg iv q8h Stanford Health Issue Date: 05/2017 Stanford Antimicrobial Safety and Sustainability Program Severe Sepsis or Septic Shock Antibacterial A Antibacterial B +/- +/- (Healthcare associated OR (Select one of the following) (Select one of the following) Antibacterial C Antifungal Immunocompromised) (Select one of the following) Skin/Skin Structure Infection – Vancomycin Loading Dose + Cefazolin 2g IV Q8H Pure cellulitis vancomycin 15mg/kg Skin/Skin Structure Infection • Piperacillin-tazobactam 4.5g IV Vancomycin Loading Dose + vancomycin with Special Risks Q8H extended infusion 15mg/kg (Special Risks: malignancy on • Meropenem 1g IV Q8H chemotherapy, neutropenia, severe cell- extended infusion – if at risk for mediated immunodeficiency, immersion injuries, animal bites, diabetic foot ulcer) ESBL infection • Cefepime 2g IV Q8H extended infusion plus Metronidazole 500mg IV Q8H • Aztreonam 2g iv q8h plus Metronidazole 500mg iv q8h Necrotizing Fasciitis (including • Piperacillin-tazobactam 4.5g IV • Vancomycin Loading Dose + ± Clindamycin 600mg IV Q8H Fournier’s Gangrene), Q8H extended infusion vancomycin 15mg/kg (use in combination with Clostridial Gas Gangrene or • Meropenem 1g IV Q8H • Linezolid 600mg IV Q12H vancomycin for toxin Myconecrosis extended infusion – if at risk for suppression) ESBL infection • Cefepime 2g IV Q8H extended infusion plus Metronidazole 500mg IV Q8H • Aztreonam 2g iv Q8H plus Metronidazole 500mg iv q8h Bacterial Meningitis – Ceftriaxone 2g IV Q12H Vancomycin Loading Dose + vancomycin • Ampicillin 2g IV Q4H (>50 “Spontaneous” 15mg/kg year of age OR immunocompromised) • If penicillin allergy: Meropenem 2g IV Q8H extended infusion Bacterial Meningitis – Post- • Cefepime 2g iv q8h extended Vancomycin Loading Dose + vancomycin Trauma or Neurosurgery infusion 15mg/kg • Meropenem 2g IV Q8H extended infusion • Aztreonam 2g iv Q8H plus Ciprofloxacin 400mg IV Q8H Stanford Health Issue Date: 05/2017 Stanford Antimicrobial Safety and Sustainability Program Table 2: Antibiotic selection options for community acquired, immunocompetent patients with severe sepsis/septic shock Severe Sepsis or Septic Shock Antibacterial A Antibacterial B +/- (Community acquired AND (Select one of the following) (Select one of the following) Antibacterial C Immunocompetent) (Select one of the following) Undifferentiated • Ertapenem 1g IV q24h Vancomycin Loading Dose + • Piperacillin-tazobactam 4.5g IV Q8H vancomycin 15mg/kg extended infusion • Cefepime 2g IV Q8H extended infusion • Aztreonam 2g IV Q8H Pneumonia • Ceftriaxone 2g IV q24H plus Azithromycin +/- Vancomycin Loading Dose (existing EPIC 500mg IV q24h entry) + vancomycin 15mg/kg • Ceftriaxone 2g IV q24H plus Doxycycline 100mg IV Q12H • Levofloxacin 750mg IV q24h Urinary Tract Infection • Ertapenem 1g IV q24h Vancomycin Loading Dose + • Aztreonam 2g iv q8h vancomycin 15mg/kg (Especially if GPC on Gram stain of urine) Intra-Abdominal Infection • Piperacillin-tazobactam 4.5g IV Q8H Vancomycin Loading Dose + extended infusion vancomycin 15mg/kg • Ertapenem 1g IV q24h • Aztreonam 2g iv q8h plus Metronidazole 500mg iv q8h Skin/Skin Structure Infection – • Cefazolin 2g IV Q8H Vancomycin Loading Dose + Pure cellulitis vancomycin 15mg/kg Skin/Skin Structure Infection • Piperacillin-tazobactam 4.5g IV Q8H Vancomycin Loading Dose + with Special Risks extended infusion vancomycin 15mg/kg (Special Risks: malignancy on chemotherapy, • Meropenem 1g IV Q8H extended infusion neutropenia, severe cell-mediated • Cefepime 2g IV Q8H extended infusion + immunodeficiency, immersion injuries, animal bites, diabetic foot ulcer) Metronidazole 500mg IV Q8H • Aztreonam 2g IV Q8H plus Metronidazole 500mg IV Q8H Bacterial Meningitis – Ceftriaxone 2g IV q12h Vancomycin Loading Dose + Ampicillin 2g IV Q4H (>50 years of age) “Spontaneous” vancomycin 15mg/kg Stanford Health Issue Date: 05/2017 Stanford Antimicrobial Safety and Sustainability