UvA-DARE (Digital Academic Repository) The transcription factor KLF2 in vascular biology Boon, R.A. Publication date 2008 Link to publication Citation for published version (APA): Boon, R. A. (2008). The transcription factor KLF2 in vascular biology. General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. 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LocusLink Accession Gene Sequence Description Fold p-value ID number symbol change (FDR) 6347 NM_002982 CCL2 chemokine (C-C motif) ligand 2 (CCL2) . -15.41 6.7E-42 7123 NM_003278 TNA tetranectin (plasminogen binding protein) (TNA) . -8.34 2.5E-13 1282 NM_001845 COL4A1 collagen, type IV, alpha 1 (COL4A1) . -7.83 6.7E-42 7057 NM_003246 THBS1 thrombospondin 1 (THBS1) . -7.81 6.7E-42 5054 M16006 SERPINE1 plasminogen activator inhibitor-1 (PAI-1) mRNA, complete cds. -7.38 6.7E-42 7368 AL137342 UGT8 mRNA; cDNA DKFZp761G1111 (from clone DKFZp761G1111). -6.68 2.2E-08 1906 NM_001955 EDN1 endothelin 1 (EDN1) . -5.33 1.3E-37 64399 AY009951 HHIP hedgehog-interacting protein mRNA, complete cds. -4.70 3.2E-34 22918 NM_012072 C1QR1 complement component 1, q subcomponent, receptor 1 (C1QR1) . -4.37 3.5E-24 1848 NM_001946 DUSP6 dual specificity phosphatase 6 (DUSP6), transcript variant 1 . -4.25 6.7E-42 131583 AF147314 FAM43A full length insert cDNA clone YA84H07. -4.04 5.8E-11 7980 NM_006528 TFPI2 tissue factor pathway inhibitor 2 (TFPI2) . -3.96 4.1E-03 285580 AF131822 FLJ90723 clone 24905 mRNA sequence. -3.75 1.5E-40 367 L29496 AR androgen receptor mRNA, complete cds. -3.68 5.7E-03 AL117595 mRNA; cDNA DKFZp564C2063 (from clone DKFZp564C2063). -3.59 2.5E-41 23768 NM_013231 FLRT2 fibronectin leucine rich transmembrane protein 2 (FLRT2) . -3.57 9.2E-24 81567 AK025006 TXNDC5 cDNA: FLJ21353 fis, clone COL02771. -3.53 4.3E-14 2791 NM_004126 GNG11 guanine nucleotide binding protein (G protein), gamma 11 (GNG11) . -3.39 6.7E-42 2171 NM_001444 FABP5 fatty acid binding protein 5 (psoriasis-associated) (FABP5) . -3.37 3.2E-29 9976 NM_005127 CLECSF2 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 2 (activation-induced) (CLE. -3.20 2.8E-07 5898 NM_005402 RALA v-ral simian leukemia viral oncogene homolog A (ras related) (RALA) . -3.14 1.4E-35 3399 D28449 ID3 mRNA for helix-loop-helix protein 1R21, 5'UTR (sequence from the 5'cap to the start codon). -3.06 2.5E-20 388 D16875 RHOB HepG2 3' region cDNA, clone hmd1f06. -3.03 1.2E-27 10409 NM_006317 BASP1 brain abundant, membrane attached signal protein 1 (BASP1) . -3.02 1.3E-07 5881 NM_005052 RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3) . -2.96 7.4E-11 79705 AK026772 LRRK1 cDNA: FLJ23119 fis, clone LNG07978. -2.95 7.7E-15 1636 S81361 ACE angiotensin I-converting enzyme [, gastric HGT-1 cell line, mRNA Partial, 405 nt]. -2.95 2.2E-27 2798 NM_000406 GNRHR gonadotropin-releasing hormone receptor (GNRHR) . -2.91 2.2E-14 57509 AB033114 MTUS1 mRNA for KIAA1288 protein, partial cds. -2.90 2.4E-24 3576 M17017 IL8 beta-thromboglobulin-like protein mRNA, complete cds. -2.90 1.4E-10 51705 NM_016242 EMCN endomucin (EMCN) . -2.84 1.3E-08 1490 NM_001901 CTGF connective tissue growth factor (CTGF) . -2.83 2.9E-21 7289 NM_003324 TULP3 tubby like protein 3 (TULP3) . -2.82 6.2E-13 NM_014102 . -2.81 2.5E-11 27122 NM_013253 DKK3 dickkopf homolog 3 (Xenopus laevis) (DKK3) . -2.79 1.8E-09 29798 NM_013310 C2orf27 hypothetical protein AF038169 (AF038169) . -2.79 6.7E-42 9454 NM_004838 HOMER3 homer homolog 3 (Drosophila) (HOMER3) . -2.79 2.1E-20 5157 NM_006207 PDGFRL platelet-derived growth factor receptor-like (PDGFRL) . -2.78 2.7E-09 Page 1 / 11 Supplementary data: Genes repressed by KLF2 Dekker et al. 161198 AF161403 C14orf27 HSPC285 mRNA, partial cds. -2.74 1.9E-27 AF147305 full length insert cDNA clone YA80A03. -2.72 1.4E-11 10587 NM_006440 TXNRD2 thioredoxin reductase 2 (TXNRD2), nuclear gene encoding mitochondrial protein, transcript variant 1 . -2.72 1.8E-12 27 AK025877 ABL2 cDNA: FLJ22224 fis, clone HRC01703. -2.71 9.0E-14 652 NM_001202 BMP4 bone morphogenetic protein 4 (BMP4), transcript variant 1 . -2.69 1.9E-12 64943 AF131781 FLJ12442 clone 24901 mRNA sequence, complete cds. -2.66 1.7E-24 23308 AF289028 ICOSLG transmembrane protein B7-H2 ICOS ligand mRNA, complete cds. -2.66 6.0E-16 4070 NM_002353 TACSTD2 tumor-associated calcium signal transducer 2 (TACSTD2) . -2.65 5.1E-14 131566 AK001362 DCBLD2 cDNA FLJ10500 fis, clone NT2RP2000369. -2.64 4.5E-12 83641 AK024648 C10orf45 cDNA: FLJ20995 fis, clone CAE02480. -2.63 1.9E-03 3791 AF035121 KDR KDR/flk-1 protein mRNA, complete cds. -2.61 3.1E-12 162998 X64975 OR7D2 H.sapiens mRNA HTPCRH03 for olfactory receptor. -2.59 2.4E-32 55041 NM_017958 PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 (PLEKHB2) . -2.55 4.0E-09 1303 AL359627 COL12A1 mRNA; cDNA DKFZp586K2324 (from clone DKFZp586K2324). -2.54 9.7E-07 6594 NM_003069 SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1), tra . -2.53 3.6E-09 23370 AB011093 ARHGEF18 mRNA for KIAA0521 protein, partial cds. -2.52 1.4E-22 5569 NM_006823 PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha (PKIA), transcript variant 1 . -2.49 3.0E-16 29970 NM_014575 SCHIP1 schwannomin interacting protein 1 (SCHIP1) . -2.48 3.7E-08 25937 AL050107 WWTR1 mRNA; cDNA DKFZp586I1419 (from clone DKFZp586I1419); partial cds. -2.47 1.8E-12 51256 NM_016495 TBC1D7 TBC1 domain family, member 7 (TBC1D7) . -2.46 7.5E-26 2250 NM_004464 FGF5 fibroblast growth factor 5 (FGF5), transcript variant 1 . -2.46 4.2E-05 59277 AF278532 NTN4 beta-netrin mRNA, complete cds. -2.46 7.5E-13 8614 NM_003714 STC2 stanniocalcin 2 (STC2) . -2.45 3.9E-03 8862 NM_017413 APLN apelin (APLN) . -2.45 3.2E-03 5998 U27655 RGS3 RGP3 mRNA, complete cds. -2.44 2.8E-09 29057 NM_014138 TMEM29 PRO0659 protein (PRO0659) . -2.42 1.1E-12 AF100640 MB2 metastasis related protein (MB2) mRNA, partial cds. -2.42 1.8E-16 2167 NM_001442 FABP4 fatty acid binding protein 4, adipocyte (FABP4) . -2.41 2.3E-06 143686 AF086251 SESN3 full length insert cDNA clone ZD40A05. -2.41 5.5E-08 27344 NM_013271 PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor (PCSK1N) . -2.38 3.1E-20 359845 AF085987 MGC45871 full length insert cDNA clone YU05C01. -2.38 1.3E-07 1118 NM_003465 CHIT1 chitinase 1 (chitotriosidase) (CHIT1) . -2.38 2.1E-07 170692 AF086229 ADAMTS18 full length insert cDNA clone ZD16H11. -2.34 1.2E-05 6925 AK021980 TCF4 cDNA FLJ11918 fis, clone HEMBB1000272. -2.34 5.0E-11 55172 NM_018139 C14orf104 chromosome 14 open reading frame 104 (C14orf104) . -2.34 6.9E-04 6869 NM_001058 TACR1 tachykinin receptor 1 (TACR1), transcript variant long . -2.33 3.1E-09 26659 NM_017506 OR7A5 olfactory receptor, family 7, subfamily C, member 1 (OR7C1) . -2.31 2.5E-09 79709 AK025982 GLT25D1 cDNA: FLJ22329 fis, clone HRC05659. -2.31 9.0E-08 3763 NM_002240 KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6 (KCNJ6) . -2.31 7.9E-07 10367 AL117423 CBARA1 mRNA; cDNA DKFZp564C246 (from clone DKFZp564C246); complete cds. -2.30 3.3E-30 AK023061 cDNA FLJ12999 fis, clone NT2RP3000324. -2.29 2.1E-03 Page 2 / 11 Supplementary data: Genes repressed by KLF2 Dekker et al. 9518 NM_004864 GDF15 prostate differentiation factor (PLAB) . -2.27 4.6E-12 AK023522 cDNA FLJ13460 fis, clone PLACE1003373. -2.27 2.8E-09 5108 AJ297349 PCM1 t(8;10)(p21.3;q11.2) translocation breakpoint for partial RET/PCM-1 fusion gene. -2.27 2.4E-10 7020 NM_003220 TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A) . -2.27 7.5E-03 4904 NM_004559 NSEP1 nuclease sensitive element binding protein 1 (NSEP1) . -2.26 8.1E-12 7564 AF244088 ZNF16 zinc finger protein mRNA, complete cds. -2.26 1.7E-19 85007 AK024076 MGC15875 cDNA FLJ14014 fis, clone HEMBA1000290. -2.26 1.4E-15 10351 NM_007168 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 (ABCA8) . -2.25 2.1E-05 84651 U47646 ECG2 clone N5-2 mRNA, 3' end. -2.25 5.7E-03 1000 NM_001792 CDH2 cadherin 2, type 1, N-cadherin (neuronal) (CDH2) . -2.23 1.5E-11 80019 AK021869 UBTD1 cDNA FLJ11807 fis, clone HEMBA1006284. -2.23 8.5E-10 1401 X56692 CRP C-reactive protein, pentraxin-related . -2.23 7.5E-11 7189 NM_004620 TRAF6 TNF receptor-associated factor 6 (TRAF6), transcript variant 2 . -2.21 6.7E-42 64399 AK024689 HHIP cDNA: FLJ21036 fis, clone CAE09578.