Centre for Arab Genomic Studies A Division of Sheikh Hamdan Award for Medical Sciences The atalogue for ransmission enetics in rabs C T G A CTGA Database CDKN2B Antisense RNA Alternative Names including vascular endothelial cells and smooth CDKN2BAS coronary muscle cells. Antisense Noncoding RNA in the INK4 Locus ANRIL Epidemiology in the Arab World Record Category Saudi Arabia Gene locus Abdulazeez et al., (2016) performed a case-control study in order to investigate the association of 12 WHO-ICD risk variants located at 9p21.3 with myocardial N.B.:Classification not applicable to gene loci. infarction (MI) in Saudi Arabian population. The study included 250 Saudi patients with CAD who Incidence per 100,000 Live Births had experienced an MI and 252 age matched N/A to gene loci healthy controls with no history of CAD. Results showed a significant difference in the genotypic OMIM Number distribution of four SNPs (rs564398, rs4977574, 613149 rs2891168, and rs1333042) in the CDKN2B-AS1 gene between cases and controls. The study Mode of Inheritance identified three protective haplotypes (TAAG, N/A AGTA and GGGCC) and a risk haplotype (TGGA) for the development of CAD. This study was in Gene Map Locus line with previous studies conducted worldwide 9p21.3 indicating that the SNPs located in the intronic region of the CDKN2B-AS1 gene were associated Description with CAD. The CDKN2BAS gene is located near the CDKN2A-CDKN2B gene and codes for an References antisense non-coding RNA. Although the exact AbdulAzeez S, Al-Nafie AN, Al-Shehri A, Borgio function of this gene and the ncRNA it codes for is JF, Baranova EV, Al-Madan MS, Al-Ali RA, Al- unknown, there is evidence pointing to the fact that Muhanna F, Al-Ali A, Al-Mansori M, Ibrahim MF, it may regulate the expression of nearby protein Asselbergs FW, Keating B, Koeleman BP, Al-Ali coding genes, including CDKN2A, CDKN2B, and AK. Intronic Polymorphisms in the CDKN2B-AS1 ARF. Functionally, this regulation may come about Gene Are Strongly Associated with the Risk of through its interaction with Polycomb Repressive Myocardial Infarction and Coronary Artery Disease Complex-1 (PRC1) and -2 (PRC2), resulting in in the Saudi Population. Int J Mol Sci. 2016; epigenetic silencing of other genes in this cluster. 17(3):395. PMID: 26999117 This region, at chromosome 9p21, is a significant Related CTGA Records genetic susceptibility locus for cardiovascular Myocardial Infarction, Susceptibility to, 1 disease, several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, External Links endometriosis, frailty in the elderly, and glaucoma. https://www.genecards.org/cgi- bin/carddisp.pl?gene=FNDC5 Molecular Genetics CDKN2B-AS1 gene is located on the short arm of Contributors chromosome 9. It contains 19 exons, spans 126.3 Pratibha Nair: 4.12.2016 kb, and overlaps at its 5′ end with CDKN2B. The Ameera Balobaid: 13.10.2016 gene is expressed in a range of tissue types, Copyright © Centre for Arab Genomic Studies 1 .