HORIZON2020 Programme Contract No. 733032 HBM4EU Scoping documents for 2018 Deliverable Report D 4.2 WP 4 Prioritisation and input to the Annual Work Plan Deadline: June, 2017 Upload by Coordinator: 28.06.2017 Entity Name of person responsible Short name of Received institution date Coordinator Marike Kolossa-Gehring UBA 27.06.2017 Grant Signatory Greet Schoeters VITO 23.06.2017 Pillar Leader Greet Schoeters VITO 23.06.2017 Work Package Catherine Ganzleben EEA 23.06.2017 Leader Task leader Greet Schoeters VITO 23.06.2017 Responsible author Greet Schoeters E-mail [email protected] Short name of Phone +32 14 33 5167 VITO institution Co-authors Carolin Tschersich (UBA), Robert Barouki (INSERM), Maria Uhl (EAA), Jana Klánová (MU), Milena Horvat (JSI), Alessandro Alimonti (ISS), Denis Sarigiannis (AUTH), Tiina Santonen (FIOH), Erik Lebret (RIVM) D 4.2 Scoping Documents for 2018 Security: Public WP 4 - Prioritisation and input to the Annual Work Plan Version: 3 Authors: Carolin Tschersich, Robert Barouki, Maria Uhl, Jana Klánová, Milena Horvat, Page: 2 Alessandro Alimonti, Denis Sarigiannis, Tiina Santonen, Erik Lebret, Greet Schoeters Table of contents Table of contents ............................................................................................................................ 2 1. Authors and Acknowledgements .............................................................................................. 5 2. Introduction .............................................................................................................................. 6 3. Prioritised substance group: Phthalates & DINCH.................................................................... 7 3.1. Background information .................................................................................................... 7 3.1.1. Hazardous properties................................................................................................. 7 3.1.2. Exposure characteristics ............................................................................................ 7 3.1.3. Technical aspects ...................................................................................................... 8 3.1.4. Policy relevance......................................................................................................... 8 3.2. Categorisation of substances ............................................................................................ 8 3.2.1. Additional information by ECHA: ................................................................................ 9 3.3. Objectives / Policy related questions ................................................................................. 9 3.3.1. Additional Comments: .............................................................................................. 13 3.4. References ..................................................................................................................... 14 4. Prioritised substance group: Bisphenols ................................................................................ 18 4.1. Background Information .................................................................................................. 18 4.1.1. Hazardous properties............................................................................................... 18 4.1.2. Exposure characteristics .......................................................................................... 18 4.1.3. Policy relevance....................................................................................................... 19 4.1.4. Technical aspects .................................................................................................... 20 4.1.5. Societal concern ...................................................................................................... 20 4.2. Categorisation of Substances ......................................................................................... 21 4.3. Objectives / Policy-related questions .............................................................................. 24 4.4. Research activities to be undertaken .............................................................................. 25 4.5. References ..................................................................................................................... 28 5. Prioritised substance group: Per- and polyfluoroalkyl substances (PFASs) ............................ 32 5.1. Background Information .................................................................................................. 32 5.1.1. Introduction .............................................................................................................. 32 5.1.2. Hazardous properties:.............................................................................................. 32 5.1.3. Policy relevance....................................................................................................... 33 5.1.4. Exposure characteristics .......................................................................................... 34 5.1.5. Technical aspects .................................................................................................... 37 5.1.6. Societal concern ...................................................................................................... 38 5.2. Categorisation of Substances ......................................................................................... 38 D 4.2 Scoping Documents for 2018 Security: Public WP 4 - Prioritisation and input to the Annual Work Plan Version: 3 Authors: Carolin Tschersich, Robert Barouki, Maria Uhl, Jana Klánová, Milena Horvat, Page: 3 Alessandro Alimonti, Denis Sarigiannis, Tiina Santonen, Erik Lebret, Greet Schoeters 5.3. Objectives / Policy-related questions .............................................................................. 50 5.4. Research activities to be undertaken .............................................................................. 51 5.5. References ..................................................................................................................... 56 6. Prioritised substance group: Flame retardants (FR) ............................................................... 60 6.1. Background Information .................................................................................................. 60 6.1.1. Hazardous Properties .............................................................................................. 60 6.1.2. Exposure Characteristics ......................................................................................... 61 6.1.3. Policy Relevance ..................................................................................................... 62 6.1.4. Societal Aspects ...................................................................................................... 63 6.2. Categorisation of Substances ......................................................................................... 65 6.3. Objectives / Policy-related questions .............................................................................. 69 6.4. Research activities to be undertaken .............................................................................. 69 6.5. References ..................................................................................................................... 77 7. Prioritised substance group: Cadmium (Cd) and Hexavalent Chromium (Cr VI) ..................... 87 7.1. Background Information .................................................................................................. 87 7.1.1. Hazardous properties:.............................................................................................. 87 7.1.2. Exposure characteristics: ......................................................................................... 88 7.1.3. Policy relevance....................................................................................................... 91 7.1.4. Technical aspects (Nordberg et al., 2015, Bernard et al 2016) ................................. 93 7.1.5. Societal concern: ..................................................................................................... 95 7.2. Categorisation of Substances ......................................................................................... 96 7.3. Objectives / Policy-related questions .............................................................................. 96 7.4. Research activities to be undertaken .............................................................................. 98 7.5. References ..................................................................................................................... 99 8. Prioritised substance group: PAHs and air pollutants ........................................................... 101 8.1. Background Information ................................................................................................ 101 8.1.1. Introduction ............................................................................................................ 101 8.1.2. Hazardous properties: e.g. ..................................................................................... 101 8.1.3. Air pollutants .......................................................................................................... 103 8.1.4. Exposure characteristics .......................................................................................