189 (5) J Immunol 2012; 189:2067-2682; ; http://www.jimmunol.org/content/189/5 This information is current as of September 23, 2021. Downloaded from Why The JI? Submit online. • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists http://www.jimmunol.org/ • Fast Publication! 4 weeks from acceptance to publication *average Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription by guest on September 23, 2021 Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. VOL. 189 | NO. 5 | September 1, 2012 | Pages 2067–2686 2067 IN THIS ISSUE PILLARS OF IMMUNOLOGY 2069 Cytokine Mimicry with an Immunologic Reformation: The Discovery of a Decade Kenneth M. Murphy 2072 Pillars Article: Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI. Science. 1990. 248: 1230–1234 Kevin W. Moore, Paulo Vieira, David F. Fiorentino, Mary L. Trounstine, Tariq A. Khan, and Timothy R. Mosmann Downloaded from CUTTING EDGE 2079 Cutting Edge: Suppression of GM-CSF Expression in Murine and Human T Cells by IL-27 Andrew Young, Eimear Linehan, Emily Hams, Aisling C. O’Hara Hall, Angela McClurg, James A. Johnston, Christopher A. Hunter, Padraic G. Fallon, and Denise C. Fitzgerald http://www.jimmunol.org/ 2084 Cutting Edge: Influence of Tmevpg1, a Long Intergenic Noncoding RNA, on the Expression of Ifng by Th1 Cells Sarah P. Collier, Patrick L. Collins, Christopher L. Williams, Mark R. Boothby, and Thomas M. Aune 2089 Cutting Edge: IL-10–Mediated Tristetraprolin Induction Is Part of a Feedback Loop That Controls Macrophage STAT3 Activation and Cytokine Production Anthony Gaba, Sergei I. Grivennikov, Mahn Vu Do, Deborah J. Stumpo, Perry J. Blackshear, and Michael Karin by guest on September 23, 2021 2094 Cutting Edge: Lymphoid Tissue Inducer Cells Maintain Memory CD4 T Cells within Secondary Lymphoid Tissue David R. Withers, Fabrina M. Gaspal, Emma C. Mackley, Clare L. Marriott, Ewan A. Ross, Guillaume E. Desanti, Natalie A. Roberts, Andrea J. White, Adriana Flores-Langarica, Fiona M. McConnell, Graham Anderson, and Peter J. L. Lane On the cover: A section of murine mesenteric lymph node stained for expression of RORg (green), IL-7Ra (yellow), and 2 CD3 (blue) counterstained with a nuclear dye (gray). Clusters of lymphoid tissue inducer cells (RORg+IL-7Ra+CD3 ) are found at the subcapsular sinus and interfollicular areas, sites of entry and recirculation for lymphocytes. Withers, D. R., F. M. Gaspal, E. C. Mackley, C. L. Marriott, E. A. Ross, G. E. Desanti, N. A. Roberts, A. J. White, A. Flores-Langarica, F. M. McConnell, G. Anderson, and P. J. L. Lane. 2012. Cutting Edge: Lymphoid tissue inducer cells maintain memory CD4 T cells within secondary lymphoid tissue. J. Immunol. 189: 2094–2098. The Journal of Immunology (ISSN 0022-1767) is published twice each month by The American Association of Immunologists, Inc., 9650 Rockville Pike, Bethesda, MD 20814-3994, Phone: 301-634-7197, Fax: 301-634-7829. Subscription terms: New subscriptions and renewals begin January 1 and expire one year later (see http://www.jimmunol.org/subscriptions for prices and details). A special rate is available to members of The American Association of Immunologists, Inc. (see http://www.aai.org/ membership). The American Association of Immunologists, Inc., is not responsible for undeliverable issues. Replacement issues can be obtained, if available, at the regular price of single issues (see http://www.jimmunol.org/pdf/single_issue_purchase.pdf). Reprints of individual articles are available only from authors. Periodicals postage paid at Bethesda, MD 20814-3994, and at additional mailing offices. Country of origin U.S.A. Printed on acid-free recyclable paper. Postmaster: Send address changes 60 days in advance to The Journal of Immunology, Subscription Department, 9650 Rockville Pike, Bethesda, MD 20814-3994. Copyright Ó 2012 by The American Association of Immunologists, Inc. CELLULAR IMMUNOLOGY AND IMMUNE REGULATION 2099 NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-g and Perforin-Dependent Mechanisms Moyar Qing Ge, Adrian W. S. Ho, Yafang Tang, Kenneth H. S. Wong, Benson Y. L. Chua, Stephan Gasser, and David Michael Kemeny 2110 Immune Suppression and Resistance Mediated by Constitutive Activation of Wnt/b-Catenin Signaling in Human Melanoma Cells Tomonori Yaguchi, Yasufumi Goto, Kenji Kido, Hiroshi Mochimaru, Toshiharu Sakurai, Nobuo Tsukamoto, Chie Kudo-Saito, Tomonobu Fujita, Hidetoshi Sumimoto, and Yutaka Kawakami 2118 CD8+CD45RA+CCR7+FOXP3+ T Cells with Immunosuppressive Properties: A Novel Subset of Inducible Human Regulatory T Cells Masakatsu Suzuki, Ann L. Jagger, Christine Konya, Yasuhiro Shimojima, Sergey Pryshchep, Jo¨rgJ. Goronzy, and Cornelia M. Weyand 2131 A Genetically Encoded IL-1b Bioluminescence Resonance Energy Transfer Sensor To Monitor Inflammasome Activity Vincent Compan, Alberto Baroja-Mazo, Laricia Bragg, Alexei Verkhratsky, Julie Perroy, and Pablo Pelegrin Downloaded from 2138 The 3BP2 Adapter Protein Is Required for Chemoattractant-Mediated Neutrophil Activation Grace Chen, Ioannis Dimitriou, Laura Milne, Karl S. Lang, Philipp A. Lang, Noah Fine, Pamela S. Ohashi, Paul Kubes, and Robert Rottapel 2151 Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances http://www.jimmunol.org/ Therapeutic Autologous Vaccination in Mice Eyal Amiel, Bart Everts, Tori C. Freitas, Irah L. King, Jonathan D. Curtis, Erika L. Pearce, and Edward J. Pearce 2159 Cytokine Secretion by CD4+ T Cells at the Immunological Synapse Requires Cdc42-Dependent Local Actin Remodeling but Not Microtubule Organizing Center Polarity Karine Chemin, Armelle Bohineust, Stephanie Dogniaux, Marie Tourret, Sarah Guegan, Francesc Miro, and Claire Hivroz 2169 Decoding the Regulation of Mast Cell Exocytosis by Networks of Rab GTPases by guest on September 23, 2021 Nurit P. Azouz, Takahide Matsui, Mitsunori Fukuda, and Ronit Sagi-Eisenberg 2181 Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage Susan N. Thomas, Joseph M. Rutkowski, Miriella Pasquier, Emma L. Kuan, Kari Alitalo, Gwendalyn J. Randolph, and Melody A. Swartz 2191 Neutrophil Expression of Fas Ligand and Perforin Directs Effector CD8 T Cell Infiltration into Antigen-Challenged Skin Danielle D. Kish, Anton V. Gorbachev, Neetha Parameswaran, Neetu Gupta, and Robert L. Fairchild 2203 The Protein Tyrosine Phosphatase SHP-1 Regulates Phagolysosome Biogenesis Carolina P. Gomez, Marina Tiemi Shio, Pascale Duplay, Martin Olivier, and Albert Descoteaux 2211 GB Virus C Envelope Protein E2 Inhibits TCR-Induced IL-2 Production and Alters IL-2–Signaling Pathways Nirjal Bhattarai, James H. McLinden, Jinhua Xiang, Thomas M. Kaufman, and Jack T. Stapleton 2217 Airway Epithelial Expression of TLR5 Is Downregulated in Healthy Smokers and Smokers with Chronic Obstructive Pulmonary Disease Rui Wang, Joumana Ahmed, Guoqing Wang, Ibrahim Hassan, Yael Strulovici-Barel, Jacqueline Salit, Jason G. Mezey, and Ronald G. Crystal 2226 Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma Giovanni Forte, Rosalinda Sorrentino, Antonella Montinaro, Antonio Luciano, Ian M. Adcock, Piera Maiolino, Claudio Arra, Carla Cicala, Aldo Pinto, and Silvana Morello 2234 Resolution of Experimental Lung Injury by Monocyte-Derived Inducible Nitric Oxide Synthase Franco R. D’Alessio, Kenji Tsushima, Neil R. Aggarwal, Jason R. Mock, Yoshiki Eto, Brian T. Garibaldi, Daniel C. Files, Claudia R. Avalos, Jackie V. Rodriguez, Adam T. Waickman, Sekhar P. Reddy, David B. Pearse, Venkataramana K. Sidhaye, Paul M. Hassoun, Michael T. Crow, and Landon S. King 2246 Antibodies Generated against Conserved Antigens Expressed by Bacteria and Allergen-Bearing Fungi Suppress Airway Disease Nicholas W. Kin, Emily K. Stefanov, Brian L. P. Dizon, and John F. Kearney 2257 Rapid Differentiation of Monocytes into Type I IFN-Producing Myeloid Dendritic Cells as an Antiviral Strategy against Influenza Virus Infection Weiping Cao, Andrew K. Taylor, Renata E. Biber, William G. Davis, Jin Hyang Kim, Adrian J. Reber, Tatiana Chirkova, Juan A. De La Cruz, Aseem Pandey, Priya Ranjan, Jacqueline M. Katz, Shivaprakash Gangappa, and Suryaprakash Sambhara 2266 Nanotopography-Guided Migration of T Cells Keon Woo Kwon, Hyoungjun Park, Kwang Hoon Song, Jong-Cheol Choi, Hyungmin Ahn, Moon Jeong Park, Kahp-Yang Suh, and Junsang Doh Downloaded from 2274 Acquisition of MHC:Peptide Complexes by Dendritic Cells Contributes to the Generation of Antiviral CD8+ T Cell Immunity In Vivo Lesley A. Smyth, Catherine Hervouet, Thomas Hayday, Pablo D. Becker, Richard Ellis, Robert I. Lechler, Giovanna Lombardi, and Linda S. Klavinskis 2283 A GpC-Rich Oligonucleotide Acts on Plasmacytoid Dendritic Cells To Promote Immune Suppression http://www.jimmunol.org/ Claudia Volpi, Francesca Fallarino, Roberta Bianchi, Ciriana Orabona, Antonella De Luca, Carmine Vacca, Luigina Romani, Bruno Gran, Ursula Grohmann, Paolo Puccetti,