ISSN 1881-7831 Online ISSN 1881-784X DD&T Drug Discoveries & Therapeutics Volume 9, Number 1 February, 2015 www.ddtjournal.com ISSN: 1881-7831 Online ISSN: 1881-784X CODEN: DDTRBX Issues/Year: 6 Language: English Publisher: IACMHR Co., Ltd. Drug Discoveries & Therapeutics is one of a series of peer-reviewed journals of the International Research and Cooperation Association for Bio & Socio-Sciences Advancement (IRCA-BSSA) Group and is published bimonthly by the International Advancement Center for Medicine & Health Research Co., Ltd. (IACMHR Co., Ltd.) and supported by the IRCA-BSSA and Shandong University China-Japan Cooperation Center for Drug Discovery & Screening (SDU-DDSC). Drug Discoveries & Therapeutics publishes contributions in all fields of pharmaceutical and therapeutic research such as medicinal chemistry, pharmacology, pharmaceutical analysis, pharmaceutics, pharmaceutical administration, and experimental and clinical studies of effects, mechanisms, or uses of various treatments. Studies in drug-related fields such as biology, biochemistry, physiology, microbiology, and immunology are also within the scope of this journal. Drug Discoveries & Therapeutics publishes Original Articles, Brief Reports, Reviews, Policy Forum articles, Case Reports, News, and Letters on all aspects of the field of pharmaceutical research. All contributions should seek to promote international collaboration in pharmaceutical science. Editorial Board Editor-in-Chief: Fengshan WANG Shandong University, Ji'nan, China Kazuhisa SEKIMIZU Wenfang XU The University of Tokyo, Tokyo, Japan Shandong University, Ji'nan, China Co-Editors-in-Chief: Managing Editor: Xishan HAO Hiroshi HAMAMOTO Tianjin Medical University, Tianjin, China The University of Tokyo, Tokyo, Japan Munehiro NAKATA Tokai University, Hiratsuka, Japan Web Editor: Chief Director & Executive Editor: Yu CHEN The University of Tokyo, Tokyo, Japan Wei TANG The University of Tokyo, Tokyo, Japan Proofreaders: Senior Editors: Curtis BENTLEY Roswell, GA, USA Guanhua DU Thomas R. LEBON Chinese Academy of Medical Science and Peking Union Medical Los Angeles, CA, USA College, Beijing, China Xiao-Kang LI National Research Institute for Child Health and Development, Editorial and Head Office: Tokyo, Japan Masahiro MURAKAMI Pearl City Koishikawa 603, Osaka Ohtani University, Osaka, Japan 2-4-5 Kasuga, Bunkyo-ku, Yutaka ORIHARA Tokyo 112-0003, Japan The University of Tokyo, Tokyo, Japan Tel.: +81-3-5840-9697 Tomofumi SANTA Fax: +81-3-5840-9698 The University of Tokyo, Tokyo, Japan E-mail: [email protected] Hongbin SUN China Pharmaceutical University, Nanjing, China www.ddtjournal.com i Drug Discoveries & Therapeutics Editorial and Head Office Tel: +81-3-5840-9697, Fax: +81-3-5840-9698 Pearl City Koishikawa 603, 2-4-5 Kasuga, Bunkyo-ku, E-mail: [email protected] Tokyo 112-0003, Japan URL: www.ddtjournal.com Editorial Board Members Alex ALMASAN Rodney J. Y. HO Xingyuan MA Yuhong XU (Cleveland, OH) (Seattle, WA) (Shanghai) (Shanghai) John K. BUOLAMWINI Hsing-Pang HSIEH Ken-ichi MAFUNE Bing YAN (Memphis, TN) (Zhunan, Miaoli) (Tokyo) (Ji'nan, Shandong) Jianping CAO Yongzhou HU Sridhar MANI Yun YEN (Shanghai) (Hangzhou, Zhejiang) (Bronx, NY) (Duarte, CA) Shousong CAO Yu HUANG Tohru MIZUSHIMA Yasuko YOKOTA (Buffalo, NY) (Hong Kong) (Tokyo) (Tokyo) Jang-Yang CHANG Hans E. JUNGINGER Abdulla M. MOLOKHIA Takako YOKOZAWA (Tainan) (Marburg, Hesse) (Alexandria) (Toyama, Toyama) Fen-Er CHEN Amrit B. KARMARKAR Yoshinobu NAKANISHI Rongmin YU (Shanghai) (Karad, Maharashra) (Kanazawa, Ishikawa) (Guangzhou, Guangdong) Zhe-Sheng CHEN Toshiaki KATADA Weisan PAN Guangxi ZHAI (Queens, NY) (Tokyo) (Shenyang, Liaoning) (Ji'nan, Shandong) Zilin CHEN Gagan KAUSHAL Rakesh P. PATEL Liangren ZHANG (Wuhan, Hubei) (Philadelphia, PA) (Mehsana, Gujarat) (Beijing) Shaofeng DUAN Ibrahim S. KHATTAB Shivanand P. PUTHLI Lining ZHANG (Lawrence, KS) (Kuwait) (Mumbai, Maharashtra) (Ji'nan, Shandong) Chandradhar DWIVEDI Shiroh KISHIOKA Shafi qur RAHMAN Na ZHANG (Brookings, SD) (Wakayama, Wakayama) (Brookings, SD) (Ji'nan, Shandong) Mohamed F. EL-MILIGI Robert Kam-Ming KO Adel SAKR Ruiwen ZHANG (6th of October City) (Hong Kong) (Cairo) (Amarillo, TX) Hao FANG Nobuyuki KOBAYASHI Gary K. SCHWARTZ Xiu-Mei ZHANG (Ji'nan, Shandong) (Nagasaki, Nagasaki) (New York, NY) (Ji'nan, Shandong) Marcus L. FORREST Norihiro KOKUDO Yuemao SHEN Yongxiang ZHANG (Lawrence, KS) (Tokyo, Japan) (Ji'nan, Shandong) (Beijing) Takeshi FUKUSHIMA Toshiro KONISHI Brahma N. SINGH (Funabashi, Chiba) (Tokyo) (New York, NY) Harald HAMACHER Chun-Guang LI Tianqiang SONG (As of February 2015) (Tübingen, Baden-Württemberg) (Melbourne) (Tianjin) Kenji HAMASE Minyong LI Sanjay K. SRIVASTAVA (Fukuoka, Fukuoka) (Ji'nan, Shandong) (Amarillo, TX) Junqing HAN Xun LI Chandan M. THOMAS (Ji'nan, Shandong) (Ji'nan, Shandong) (Bradenton, FL) Xiaojiang HAO Jikai LIU Murat TURKOGLU (Kunming, Yunnan) (Kunming, Yunnan) (Istanbul) Kiyoshi HASEGAWA Xinyong LIU Hui WANG (Tokyo) (Ji'nan, Shandong) (Shanghai) Waseem HASSAN Yuxiu LIU Quanxing WANG (Rio de Janeiro) (Nanjing, Jiangsu) (Shanghai) Langchong HE Hongxiang LOU Stephen G. WARD (Xi'an, Shaanxi) (Jinan, Shandong) (Bath) ii www.ddtjournal.com CONTENTS Volume 9, Number 1, 2015 Reviews 1 - 12 Anti-tumor effects and cellular mechanisms of resveratrol. Guohua Han, Jufeng Xia, Jianjun Gao, Yoshinori Inagaki, Wei Tang, Norihiro Kokudo 13 - 22 Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity-mediated renal disorder in type 2 diabetic db/db mice. Chan Hum Park, Jeong Sook Noh, Hajime Fujii, Seong-Soo Roh, Yeong-Ok Song, Jae Sue Choi, Hae Young Chung, Takako Yokozawa 23 - 32 Chemical constituents and bioactivities of Panax ginseng (C. A. Mey.). Wenwen Ru, Dongliang Wang, Yunpeng Xu, Xianxian He, Yang-En Sun, Liyan Qian, Xiangshan Zhou, Yufeng Qin Original Articles 33 - 37 Antibiotic-producing bacteria from stag beetle mycangia. Atsushi Miyashita, Yuuki Hirai, Kazuhisa Sekimizu, Chikara Kaito 38 - 44 Tauroursodeoxycholic acid attenuates inorganic phosphateinduced osteoblastic differentiation and mineralization in NIH3T3 fibroblasts by inhibiting the ER stress response PERK-eIF2α-ATF4 pathway. Fang Liu, Yazhou Cui, Pinglan Ge, Jing Luan, Xiaoyan Zhou, Jinxiang Han 45 - 52 Enhanced anticancer activity of 5-FU in combination with Bestatin: Evidence in human tumor-derived cell lines and an H22 tumor-bearing mouse. Jin Li, Xuejian Wang, Jinning Hou, Yongxue Huang, Yingjie Zhang, Wenfang Xu 53 - 65 Anti-metastatic action of anacardic acid targets VEGF-induced signalling pathways in epithelial to mesenchymal transition. Puttananjaiah Shilpa, Keshavaiah Kaveri, Bharathi P Salimath Brief Reports 66 - 69 Construction of recombinant adenoviral vector carrying cyclinA2 gene Yu Han, Liu Hong, Cuiping Zhong, Jianhua Qiu www.ddtjournal.com iii CONTENTS (Continued ) 70 - 74 Circadian rhythm of serum 25 (OH) vitamin D, calcium and phosphorus levels in the treatment and management of type-2 diabetic patients. Tariq Masood, Rajeev S Kushwaha, Ranjana Singh, Shivani Sailwal, Himanshu Pandey, Amit Varma, Raj K Singh, Germaine Cornelissen Case Report 75 - 77 Combination chemotherapy with S-1 and docetaxel for cutaneous angiosarcoma resistant to paclitaxel. Ikko Kajihara, Hisashi Kanemaru, Taiga Miyake, Jun Aoi, Shinichi Masuguchi, Satoshi Fukushima, Masatoshi Jinnin, Hironobu Ihn Guide for Authors Copyright iv www.ddtjournal.com Drug Discoveries & Therapeutics. 2015; 9(1):1-12. 1 Review DOI: 10.5582/ddt.2015.01007 Anti-tumor effects and cellular mechanisms of resveratrol Guohua Han1, Jufeng Xia1, Jianjun Gao1,2, Yoshinori Inagaki1, Wei Tang1,*, Norihiro Kokudo1 1 Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; 2 Department of Pharmacology, School of Pharmaceutical Sciences, Qingdao University, Qingdao, Shandong, China. Summary Resveratrol (3, 5, 4'-trihydroxystilbene) is a phytoalexin contained in a variety of plants, such as grapes, berries and especially in the dried roots of Polygonum cuspidatum Sieb. et Zucc. It has been shown to exhibit anti-oxidative and anti-inflammation activity, and to reverse the effects of aging. Its ability to suppress cell proliferation, induce apoptosis and suppress the metastasis and invasion in a number of cell lines has prompted a large interest from people for its use as an anti-tumor component. In this review, evidence of resveratrol's anti-tumor effects and molecular mechanisms are recapitulated. First, we present the anti- apoptosis, anti-invasion/metastasis and anti-inflammation effect of resveratrol; second, the main signaling pathways involved in these activities are described and summarized with the studies of different tumors involved. Resveratrol not only induces apoptosis of tumor cells through intrinsic/extrinsic pathways and cell cycle arrest, but also inhibits the invasion and metastasis abilities of tumors via modulating collagen degradation-related molecular targets. Altogether, the present findings suggest the anti-tumor potential of resveratrol against various types of cancers. Keywords: Resveratrol, anti-tumor, apoptosis, invasion, metastasis, molecular mechanism 1. Introduction that regular moderate consumption of red wine confers less risk of cardiovascular diseases due to its relatively Resveratrol (3, 5, 4' -trihydroxystilbene) is a phytoalexin high resveratrol concentration (0.1-14.3 mg/L), widely contained in a variety of plants, such as grapes, peanuts, known as the