Safrole, Isosafrole, Dihydrosafrole

Safrole, Isosafrole, Dihydrosafrole

th Amendment IFRA STANDARD Safrole, Isosafrole, Dihydrosafrole CAS-No.: 94-59-7 Empirical formula: Not applicable. Structure: Synonyms: History: Initial reviews: October 1976, July 1987 Current revision date: Not applicable Implementation dates: For new submissions*: Not applicable For existing fragrance Not applicable compounds*: Next review date Not applicable * This date applies to the supply of fragrance compounds (formulas) only, not to the finished products in the marketplace RECOMMENDATION: PROHIBITED / RESTRICTED RESTRICTIONS: Limits in the finished product: Skin contact products: Leave on products: 0.01% Rinse-off products:: 0.01% Including household cleaning products Non skin contact 0.01% products: Note box: Fragrance material specifications: Safrole as such should not be used as a fragrance ingredient; essential oils containing safrole should not be used at a level such that the total concentration of safrole exceeds 0.01% in consumer products. Examples of essential oils with a high safrole content are Sassafras oil (Sassafras officinale Nees& Eberm.), Ocotea Cymbarum oil (Ocotea pretiosa Metz) and certain qualities of Camphor oils. The total concentration of safrole, isosafrole IFRA Standard – Safrole, Isosafrole, Dihydrosafrole 14-10-2009 1/2 th Amendment IFRA STANDARD Safrole, Isosafrole, Dihydrosafrole and dihydrosafrole should not exceed 0.01% in consumer products. CONTRIBUTION FROM OTHER SOURCES: N/A CRITICAL EFFECT: REXPAN RATIONALE/CONCLUSION REFERENCES: These recommendations are based on the conclusions of the Scientific Committee on Cosmetology of the EEC on safrole and on the similarity of the biological activity of these substances (Scientific Committee of Cosmetology of the EEC, opinion reached on September 2, 1980; Communication to the EEC Commission ENV/521/79 and IARC Monograph Vol. 10, 1976, 231-244). IFRA Standard – Safrole, Isosafrole, Dihydrosafrole 14-10-2009 2/2.

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