Electronic Supplementary Material (ESI) for Molecular BioSystems. This journal is © The Royal Society of Chemistry 2016 Average Average spectral spectral Fold UniProt IDGene Protein Name counts- counts- enrichm negative positive ent sample sample P12821 ACE HUMAN - ACE Angiotensin-converting enzyme 0 79.75 #DIV/0! Q71U36 TBA1A HUMAN - TUBA1A Tubulin alpha-1A chain 0 59.5 #DIV/0! P17812 PYRG1 HUMAN - CTPS1 CTP synthase 1 0 43.5 #DIV/0! P23921 RIR1 HUMAN - RRM1 Ribonucleoside-diphosphate reductase large subunit 0 35 #DIV/0! P49915GUAA HUMAN - GMPS GMP synthase 0 30.5 #DIV/0! P30153 2AAA HUMAN - PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa0 regulatory subunit29 A#DIV/0! alpha isoform P55786 PSA HUMAN - NPEPPS Puromycin-sensitive aminopeptidase 0 28.75 #DIV/0! O43143 DHX15 HUMAN - DHX15 Putative pre-mRNA-splicing factor ATP-dependent RNA0 helicase28.25 DHX15#DIV/0! P15170 ERF3A HUMAN - GSPT1 Eukaryotic peptide chain release factor GTP-binding0 subunit ERF3A24.75 #DIV/0! P09874PARP1HUMAN - PARP1 Poly 0 23.5 #DIV/0! Q9BXJ9 NAA15 HUMAN - NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit0 23 #DIV/0! B0V043 B0V043 HUMAN - VARS Valyl-tRNA synthetase 0 20 #DIV/0! Q86VP6 CAND1 HUMAN - CAND1 Cullin-associated NEDD8-dissociated protein 1 0 19.5 #DIV/0! P04080CYTB HUMAN - CSTB Cystatin-B 0 19 #DIV/0! Q93009 UBP7 HUMAN - USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 18 #DIV/0! Q9Y2L1 RRP44 HUMAN - DIS3 Exosome complex exonuclease RRP44 0 18 #DIV/0! Q13748 TBA3C HUMAN - TUBA3D Tubulin alpha-3C/D chain 0 18 #DIV/0! P29144 TPP2 HUMAN - TPP2 Tripeptidyl-peptidase 2 0 17.5 #DIV/0! Q16576 RBBP7 HUMAN - RBBP7 Histone-binding protein RBBP7 0 16.75 #DIV/0! O95757 HS74L HUMAN - HSPA4L Heat shock 70 kDa protein 4L 0 16.75 #DIV/0! P27816 MAP4 HUMAN - MAP4 Microtubule-associated protein 4 0 16.25 #DIV/0! Q92598 HS105 HUMAN - HSPH1 Heat shock protein 105 kDa 0 15.75 #DIV/0! O75663 TIPRL HUMAN - TIPRL TIP41-like protein 0 14.75 #DIV/0! Q7Z6Z7 HUWE1 HUMAN - HUWE1 E3 ubiquitin-protein ligase HUWE1 0 14.75 #DIV/0! P63151 2ABA HUMAN - PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa0 regulatory14.5 subunit B#DIV/0! alpha isoform Q9BTE3 MCMBP HUMAN - MCMBP Mini-chromosome maintenance complex-binding protein0 14.25 #DIV/0! A0AVT1 UBA6 HUMAN - UBA6 Ubiquitin-like modifier-activating enzyme 6 0 14.25 #DIV/0! P45974 UBP5 HUMAN - USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 14.25 #DIV/0! O75643 U520 HUMAN - SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase0 14.25 #DIV/0! P21266 GSTM3 HUMAN - GSTM3 Glutathione S-transferase Mu 3 0 14 #DIV/0! O00429 DNM1L HUMAN - DNM1L Dynamin-1-like protein 0 14 #DIV/0! Q92945 FUBP2 HUMAN - KHSRP Far upstream element-binding protein 2 0 14 #DIV/0! Q13155 AIMP2 HUMAN - AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional0 protein14 2 #DIV/0! Q13310 PABP4 HUMAN - PABPC4 Polyadenylate-binding protein 4 0 14 #DIV/0! Q15021 CND1 HUMAN - NCAPD2 Condensin complex subunit 1 0 14 #DIV/0! P56192 SYMC HUMAN - MARS Methionine--tRNA ligase, cytoplasmic 0 13.75 #DIV/0! Q9H3U1 UN45A HUMAN - UNC45A Protein unc-45 homolog A 0 13.75 #DIV/0! P31948 STIP1 HUMAN - STIP1 Stress-induced-phosphoprotein 1 0 13.5 #DIV/0! Q9ULV4COR1CHUMAN - CORO1C Coronin-1C 0 12.75 #DIV/0! P52701 MSH6 HUMAN - MSH6 DNA mismatch repair protein Msh6 0 12.5 #DIV/0! P41252 SYIC HUMAN - IARS Isoleucine--tRNA ligase, cytoplasmic 0 12.5 #DIV/0! P11940 PABP1 HUMAN - PABPC1 Polyadenylate-binding protein 1 0 12 #DIV/0! Q04637 IF4G1 HUMAN - EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 12 #DIV/0! O60271 JIP4 HUMAN - SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 11.5 #DIV/0! Q07666 KHDR1 HUMAN - KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated0 11.5 #DIV/0!protein 1 Q13200 PSMD2 HUMAN - PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 11.25 #DIV/0! P61221 ABCE1 HUMAN - ABCE1 ATP-binding cassette sub-family E member 1 0 11 #DIV/0! Q06210 GFPT1 HUMAN - GFPT1 Glucosamine--fructose-6-phosphate aminotransferase0 11 #DIV/0! Q7KZF4 SND1 HUMAN - SND1 Staphylococcal nuclease domain-containing protein 10 11 #DIV/0! Q9H4A4AMPB HUMAN - RNPEP Aminopeptidase B 0 10.75 #DIV/0! Q9NTJ3 SMC4 HUMAN - SMC4 Structural maintenance of chromosomes protein 4 0 10.75 #DIV/0! Q9UI26IPO11 HUMAN - IPO11 Importin-11 0 10.5 #DIV/0! Q93008 USP9X HUMAN - USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X0 10.5 #DIV/0! P46109 CRKL HUMAN - CRKL Crk-like protein 0 10.25 #DIV/0! Q9BTW9TBCD HUMAN - TBCD Tubulin-specific chaperone D 0 10.25 #DIV/0! Q99460 PSMD1 HUMAN - PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 10.25 #DIV/0! P78347 GTF2I HUMAN - GTF2I General transcription factor II-I 0 10.25 #DIV/0! Q6PKG0LARP1 HUMAN - LARP1 La-related protein 1 0 10.25 #DIV/0! Q14166 TTL12 HUMAN - TTLL12 Tubulin--tyrosine ligase-like protein 12 0 10 #DIV/0! Q9HB71 CYBP HUMAN - CACYBP Calcyclin-binding protein 0 9.75 #DIV/0! P42858HD HUMAN - HTT Huntingtin 0 9.75 #DIV/0! Q13838 DX39B HUMAN - DDX39B Spliceosome RNA helicase DDX39B 0 9.5 #DIV/0! Q96FW1OTUB1 HUMAN - OTUB1 Ubiquitin thioesterase OTUB1 0 9.5 #DIV/0! P43246 MSH2 HUMAN - MSH2 DNA mismatch repair protein Msh2 0 9.5 #DIV/0! P53618 COPB HUMAN - COPB1 Coatomer subunit beta 0 9.5 #DIV/0! Q9UHD1 CHRD1 HUMAN - CHORDC1 Cysteine and histidine-rich domain-containing protein0 1 9.25 #DIV/0! P34932 HSP74 HUMAN - HSPA4 Heat shock 70 kDa protein 4 0 9.25 #DIV/0! P55884 EIF3B HUMAN - EIF3B Eukaryotic translation initiation factor 3 subunit B 0 9.25 #DIV/0! Q96F07 CYFP2 HUMAN - CYFIP2 Cytoplasmic FMR1-interacting protein 2 0 9.25 #DIV/0! O60343 TBCD4 HUMAN - TBC1D4 TBC1 domain family member 4 0 9.25 #DIV/0! Q96P70IPO9 HUMAN - IPO9 Importin-9 0 9.25 #DIV/0! P54136 SYRC HUMAN - RARS Arginine--tRNA ligase, cytoplasmic 0 9 #DIV/0! Q86X55 CARM1 HUMAN - CARM1 Histone-arginine methyltransferase CARM1 0 9 #DIV/0! Q7L576 CYFP1 HUMAN - CYFIP1 Cytoplasmic FMR1-interacting protein 1 0 9 #DIV/0! P51610 HCFC1 HUMAN - HCFC1 Host cell factor 1 0 9 #DIV/0! Q9NRF8PYRG2 HUMAN - CTPS2 CTP synthase 2 0 9 #DIV/0! Q9UM54MYO6 HUMAN - MYO6 Unconventional myosin-VI 0 9 #DIV/0! P61088 UBE2N HUMAN - UBE2N Ubiquitin-conjugating enzyme E2 N 0 8.75 #DIV/0! Q15813 TBCE HUMAN - TBCE Tubulin-specific chaperone E 0 8.75 #DIV/0! P31689 DNJA1 HUMAN - DNAJA1 DnaJ homolog subfamily A member 1 0 8.75 #DIV/0! Q15645 PCH2 HUMAN - TRIP13 Pachytene checkpoint protein 2 homolog 0 8.5 #DIV/0! Q07866 KLC1 HUMAN - KLC1 Kinesin light chain 1 0 8.5 #DIV/0! E7EVH7E7EVH7HUMA - KLC1 Kinesin light chain 1 0 8.5 #DIV/0! Q8N3C0 ASCC3 HUMAN - ASCC3 Activating signal cointegrator 1 complex subunit 3 0 8.5 #DIV/0! P39019 RS19 HUMAN - RPS19 40S ribosomal protein S19 0 8.25 #DIV/0! P25786 PSA1 HUMAN - PSMA1 Proteasome subunit alpha type-1 0 8.25 #DIV/0! O60506 HNRPQ HUMAN - SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 8.25 #DIV/0! P49588 SYAC HUMAN - AARS Alanine--tRNA ligase, cytoplasmic 0 8.25 #DIV/0! P51812 KS6A3 HUMAN - RPS6KA3 Ribosomal protein S6 kinase alpha-3 0 8.25 #DIV/0! Q6IBS0TWF2 HUMAN - TWF2 Twinfilin-2 0 8 #DIV/0! Q06124 PTN11 HUMAN - PTPN11 Tyrosine-protein phosphatase non-receptor type 110 8 #DIV/0! Q9NTK5OLA1 HUMAN - OLA1 Obg-like ATPase 1 0 8 #DIV/0! Q9HAV4XPO5 HUMAN - XPO5 Exportin-5 0 8 #DIV/0! Q9NQ88 TIGAR HUMAN - TIGAR Fructose-2,6-bisphosphatase TIGAR 0 7.75 #DIV/0! P52888 THOP1 HUMAN - THOP1 Thimet oligopeptidase 0 7.75 #DIV/0! Q15366 PCBP2 HUMAN - PCBP2 Poly(rC)-binding protein 2 0 7.75 #DIV/0! P38606 VATA HUMAN - ATP6V1A V-type proton ATPase catalytic subunit A 0 7.75 #DIV/0! Q15042 RB3GP HUMAN - RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit0 7.75 #DIV/0! Q7Z4Q2 HEAT3 HUMAN - HEATR3 HEAT repeat-containing protein 3 0 7.75 #DIV/0! Q00341VIGLN HUMAN - HDLBP Vigilin 0 7.75 #DIV/0! Q14694 UBP10 HUMAN - USP10 Ubiquitin carboxyl-terminal hydrolase 10 0 7.75 #DIV/0! Q9Y2V2 CHSP1 HUMAN - CARHSP1 Calcium-regulated heat stable protein 1 0 7.5 #DIV/0! P60981DEST HUMAN - DSTN Destrin 0 7.5 #DIV/0! Q9NRN7 ADPPT HUMAN - AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl0 7.5 #DIV/0! transferase O00232 PSD12 HUMAN - PSMD12 26S proteasome non-ATPase regulatory subunit 120 7.5 #DIV/0! Q9NSD9 SYFB HUMAN - FARSB Phenylalanine--tRNA ligase beta subunit 0 7.5 #DIV/0! Q12874 SF3A3 HUMAN - SF3A3 Splicing factor 3A subunit 3 0 7.5 #DIV/0! Q9UNN5FAF1 HUMAN - FAF1 FAS-associated factor 1 0 7.5 #DIV/0! P55196AFAD HUMAN - MLLT4 Afadin 0 7.5 #DIV/0! Q15365 PCBP1 HUMAN - PCBP1 Poly(rC)-binding protein 1 0 7.25 #DIV/0! Q9C0B1 FTO HUMAN - FTO Alpha-ketoglutarate-dependent dioxygenase FTO 0 7.25 #DIV/0! P30520 PURA2 HUMAN - ADSS Adenylosuccinate synthetase isozyme 2 0 7.25 #DIV/0! Q13263 TIF1B HUMAN - TRIM28 Transcription intermediary factor 1-beta 0 7.25 #DIV/0! P57737CORO7HUMAN - CORO7 Coronin-7 0 7.25 #DIV/0! Q15233 NONO HUMAN - NONO Non-POU domain-containing octamer-binding protein0 7.25 #DIV/0! Q8WUM4 PDC6I HUMAN - PDCD6IP Programmed cell death 6-interacting protein 0 7 #DIV/0! Q9Y5L0TNPO3 HUMAN - TNPO3 Transportin-3 0 7 #DIV/0! Q9Y678 COPG1 HUMAN - COPG1 Coatomer subunit gamma-1 0 7 #DIV/0! Q00839 HNRPU HUMAN - HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 7 #DIV/0! Q92900 RENT1 HUMAN - UPF1 Regulator of nonsense transcripts 1 0 7 #DIV/0! Q13162PRDX4 HUMAN - PRDX4 Peroxiredoxin-4 0 6.75 #DIV/0! O60256 KPRB HUMAN - PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated0 protein6.75 2 #DIV/0! Q66LE6 2ABD HUMAN - PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa0 regulatory6.75 subunit B#DIV/0! delta isoform P51114 FXR1 HUMAN - FXR1 Fragile X mental retardation syndrome-related