EISSN 2148-5607 VOLUME 31 • ISSUE 5 • May 2020 TURKISH JOURNAL OF Gastroenterology O F F I C I A L J O U R N A L O F T H E T U R K I S H S O C I E T Y O F G A S T R O E N T E R O L O G Y COVID-19 in Hepatology and Liver transplantation See page 348 356 FAS gene and IBD 362 Measurement of distensibility index in achalasia patients 368 pCR after preoperative CRT in rectal cancer 378 Polidocanol vs phenol in oil in haemorrhoids 384 Metabolic changes in HCV patients with new treatments 393 Family physicians’ role in hepatitis c infection turkjgastroenterol.org INDEXED IN SCIENCE CITATION INDEX EXPANDED, AND PUBMED/MEDLINE TURK J GASTROENTEROL • APRIL 2020 Editor in Chief Murat Törüner Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey Senior Associate Editors Hale Akpınar Department of Gastroenterology, Dokuz Eylül University School of Medicine, İzmir, Turkey Ramazan İdilman Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey Associate Editors Meral Akdoğan Hale Gökcan Yeşim Öztürk Clinic of Gastroenterology, Ankara City Clinic of Gastroenterology, Ankara City Department of Pediatric Gastroenterology, Hospital, Ankara, Turkey Hospital, Ankara, Turkey Dokuz Eylül University School of Medicine, İzmir, Turkey Canan Alkım İbrahim Hatemi Fatih Tekin Clinic of Gastroenterology, Şişli Etfal Department of Gastroenterology, İstanbul Department of Gastroenterology, Ege Training and Research Hospital, İstanbul, University-Cerrahpaşa, Cerrahpaşa School University School of Medicine, İzmir, Turkey Turkey of Medicine, İstanbul, Turkey İlker Turan Ayhan Hilmi Çekin Gökhan Kabaçam Department of Gastroenterology, Ege University of Health Sciencies; Clinic of Department of Gastroenterology, Ankara University School of Medicine, İzmir, Turkey Gastroenterology Antalya Training and Güven Hospital, Ankara, Turkey Research Hospital, Antalya, Turkey Enver Üçbilek Fatih Oğuz Önder Department of Gastroenterology, Mersin Dinç Dinçer Department of Gastroenterology, University School of Medicine, Mersin, Department of Gastroenterology, Akdeniz Acıbadem University School of Medicine, Turkey University School of Medicine, Antalya, Turkey Turkey Ödül Eğritaş Gürkan Volkan Öter Department of Pediatric Gastroenterology, Clinic of Gastrointestinal Surgery, Ankara Ankara University School of Medicine, City Hospital, Ankara, Turkey Ankara, Turkey International Associate Editor Statistical Editor Ahmet Gürakar Gülşah Şeydaoğlu Department of Gastroenterology and Department of Biostatistics, Çukurova Hepatology, Johns Hopkins University University School of Medicine, Adana, School of Medicine, Baltimore, USA Turkey Publisher Publication Coordinators Project Coordinators Address: Büyükdere Cad. No: İbrahim KARA İrem DELİÇAY Doğan ORUÇ 105/9 34394 Mecidiyeköy, Şişli, Publication Director Arzu YILDIRIM Sİnem KOZ İstanbul-Turkey Ali ŞAHİN Deniz KAYA Graphics Department Phone: +90 212 217 17 00 Gülnur MERCAN Ünal ÖZER Fax: +90 212 217 22 92 Editorial Development Bahar ALBAYRAK E-mail: [email protected] Gizem KAYAN TEKAÜT Deniz Elif DURAN Finance and Administration Beyzanur KARABULUT Deputy Publication Director Zeynep YAKIŞIRER ÜREN Gökhan ÇİMEN Betül ÇİMEN A-I Aims and Scope Turkish Journal of Gastroenterology (Turk J Gastroenterol) is All expenses of the journal are covered by the Turkish Society the double-blind peer-reviewed, open access, international of Gastroenterology. Potential advertisers should contact publication organ of the Turkish Society of Gastroenterology. the Editorial Office. Advertisement images are published The journal is published monthly and its publication language only upon the Editor-in-Chief’s approval. is English. Statements or opinions expressed in the manuscripts Turkish Journal of Gastroenterology aims to publish published in the journal reflect the views of the author(s) and international at the highest clinical and scientific level on not the opinions of the Turkish Society of Gastroenterology, original issues of gastroenterology and hepatology. The editors, editorial board, and/or publisher; the editors, editorial journal publishes original papers, review articles, and letters board, and publisher disclaim any responsibility or liability for to the editor on clinical and experimental gastroenterology such materials. and hepatology. All published content is available online, free of charge at The editorial and publication processes of the journal are turkjgastroenterol.org. shaped in accordance with the guidelines of the International Committee of Medical Journal Editors (ICMJE), World Turkish Society of Gastroenterology holds the international Association of Medical Editors (WAME), Council of Science copyright of all the content published in the journal. Editors (CSE), Committee on Publication Ethics (COPE), European Association of Science Editors (EASE), and National Editor in Chief: Prof. Murat Törüner Information Standards Organization (NISO). The journal is Address: Mustafa Kemal Mahallesi, 2126 Sokak, Kolbay İş in conformity with the Principles of Transparency and Best Merkezi, C blok, No.: 6-9, Çankaya, Ankara, TURKEY Practice in Scholarly Publishing (doaj.org/bestpractice). Phone: +90 312 284 15 11 Fax: +90 312 284 80 75 The Turkish Journal of Gastroenterology is indexed in Science E-mail: [email protected] Citation Index Expanded, PubMed/MEDLINE, Scopus, and TUBITAK ULAKBIM TR Index. Publisher: AVES Address: Büyükdere Cad., 105/9 34394 Mecidiyeköy, Şişli, Processing and publication are free of charge with the İstanbul, TURKEY journal. No fees are requested from the authors at any Phone: +90 212 217 17 00 point throughout the evaluation and publication process. All Fax: +90 212 217 22 92 manuscripts must be submitted via the online submission E-mail: [email protected] system, which is available at turkjgastroenterol.org. The Web page: avesyayincilik.com journal guidelines, technical information, and the required forms are available on the journal’s web page. A-II Instructions to Authors Turkish Journal of Gastroenterology (Turk J Gastroenterol) is the ethics committee reports or an equivalent official document will double-blind peer-reviewed, open access, international publication be requested from the authors. For manuscripts concerning exper- organ of the Turkish Society of Gastroenterology. The journal is pub- imental research on humans, a statement should be included that lished monthly and its publication language is English. shows that written informed consent of patients and volunteers was obtained following a detailed explanation of the procedures that Turkish Journal of Gastroenterology aims to publish international they may undergo. For studies carried out on animals, the measures at the highest clinical and scientific level on original issues of gas- taken to prevent pain and suffering of the animals should be stat- troenterology and hepatology. The journal publishes original papers, ed clearly. Information on patient consent, the name of the ethics review articles and letters to the editor on clinical and experimental committee, and the ethics committee approval number should also gastroenterology and hepatology. be stated in the Materials and Methods section of the manuscript. It is the authors’ responsibility to carefully protect the patients’ ano- The editorial and publication processes of the journal are shaped in nymity. For photographs that may reveal the identity of the patients, accordance with the guidelines of the International Council of Med- releases signed by the patient or their legal representative should be ical Journal Editors (ICMJE), the World Association of Medical Edi- enclosed. tors (WAME), the Council of Science Editors (CSE), the Committee on Publication Ethics (COPE), the European Association of Science All submissions are screened by a similarity detection software Editors (EASE), and National Information Standards Organization (iThenticate by CrossCheck). (NISO). The journal conforms to the Principles of Transparency and Best Practice in Scholarly Publishing (doaj.org/bestpractice). In the event of alleged or suspected research misconduct, e.g., pla- giarism, citation manipulation, and data falsification/fabrication, the Originality, high scientific quality, and citation potential are the most Editorial Board will follow and act in accordance with COPE guide- important criteria for a manuscript to be accepted for publication. lines. Manuscripts submitted for evaluation should not have been previ- ously presented or already published in an electronic or printed me- Each individual listed as an author should fulfill the authorship crite- dium. The journal should be informed of manuscripts that have been ria recommended by the International Committee of Medical Jour- submitted to another journal for evaluation and rejected for pub- nal Editors (ICMJE-www.icmje.org). The ICMJE recommends that lication. The submission of previous reviewer reports will expedite authorship be based on the following 4 criteria: the evaluation process. Manuscripts that have been presented in a meeting should be submitted with detailed information on the orga- 1. Substantial contributions to the conception or design of the work; nization, including the name, date, and location of the organization. or the acquisition, analysis, or interpretation of data for the work; AND Manuscripts submitted to the Turkish Journal of Gastroenterology 2. Drafting the work or revising it critically for important intellectual will go through a double-blind